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Showing 109 to 117 of 117 entries
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Dissecting the Anticancer Mechanism of Trifluoperazine on Pancreatic Ductal Adenocarcinoma.

Cancers

Huang C, Lan W, Fraunhoffer N, Meilerman A, Iovanna J, Santofimia-Castaño P.
PMID: 31769431
Cancers (Basel). 2019 Nov 26;11(12). doi: 10.3390/cancers11121869.

Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive cancers with almost no curative chemotherapeutic treatment. Besides the development of new compounds, repurposing of approved drugs to treat cancer, alone or in combination, has become an attractive strategy,...

Psychologic Stress Drives Progression of Malignant Tumors via DRD2/HIF1α Signaling.

Cancer research

Liu H, Yang J, Zhang Y, Han J, Yang Y, Zhao Z, Dai X, Wang H, Ding X, Liu Y, Zhong W, Gao W, Sun T.
PMID: 34321238
Cancer Res. 2021 Oct 15;81(20):5353-5365. doi: 10.1158/0008-5472.CAN-21-1043. Epub 2021 Jul 28.

Although it is established that the sustained psychologic stress conditions under which patients with tumors often reside accelerates malignant progression of tumors, the molecular mechanism behind this association is unclear. In this work, the effect of psychologic stress on...

An Unusual Occurrence of Trifluoperazine-Induced Nystagmus in Persistent Hallucinatory Disorder-A Case Report.

Journal of neurosciences in rural practice

Muthuramalingam A, Chandrasekaran V, Subramanian K.
PMID: 33144810
J Neurosci Rural Pract. 2020 Oct;11(4):661-662. doi: 10.1055/s-0040-1716791. Epub 2020 Sep 25.

Trifluoperazine is a conventional antipsychotic whose use has been limited with the arrival of relatively new atypical antipsychotics. However, conventional antipsychotics are utilized in the management of psychiatric illnesses comorbid with metabolic disorders such as diabetes or dyslipidemia. Though...

Involvement of calmodulin in regulation of primary root elongation by N-3-oxo-hexanoyl homoserine lactone in Arabidopsis thaliana.

Frontiers in plant science

Zhao Q, Zhang C, Jia Z, Huang Y, Li H, Song S.
PMID: 25628641
Front Plant Sci. 2015 Jan 13;5:807. doi: 10.3389/fpls.2014.00807. eCollection 2014.

Many bacteria use signal molecules of low molecular weight to monitor their local population density and to coordinate their collective behavior in a process called "quorum sensing" (QS). N-acyl-homoserine lactones (AHLs) are the primary QS signals among Gram-negative bacteria....

Control of Cilia in the Branchial Basket of Ciona intestinalis (Ascidacea).

The Biological bulletin

Bergles D, Tamm S.
PMID: 29304584
Biol Bull. 1992 Jun;182(3):382-390. doi: 10.2307/1542257.

We investigated arrest and inactivation responses of stigmatal cilia in the branchial basket of the ascidian, Ciona intestinalis. Using an improved preparation of living tissue for microscopic imaging of ciliary responses, we found that Ca-ionophore A23187 in seawater +...

Delusion of Parasitosis.

Indian journal of dermatology, venereology and leprology

Srinivasan TN, Anandan S, Suresh TR, Sukkumar P, Sarveswari KN.
PMID: 28128162
Indian J Dermatol Venereol Leprol. 1989 May-Jun;55(3):179-180.

Delusion of parasitosis is a type of mono-symptomatic hypo-chondriacal psychosis common in elderly females whose response to drug therapy, usually pimozide, is variable. Two male patients presented with the delusion on their skin being infested with minute insects. One...

Comparison of viral RNA-host protein interactomes across pathogenic RNA viruses informs rapid antiviral drug discovery for SARS-CoV-2.

Cell research

Zhang S, Huang W, Ren L, Ju X, Gong M, Rao J, Sun L, Li P, Ding Q, Wang J, Zhang QC.
PMID: 34737357
Cell Res. 2021 Nov 04; doi: 10.1038/s41422-021-00581-y. Epub 2021 Nov 04.

In contrast to the extensive research about viral protein-host protein interactions that has revealed major insights about how RNA viruses engage with host cells during infection, few studies have examined interactions between host factors and viral RNAs (vRNAs). Here,...

Psychologic Stress Drives Progression of Malignant Tumors via DRD2/HIF1α Signaling.

Cancer research

Liu H, Yang J, Zhang Y, Han J, Yang Y, Zhao Z, Dai X, Wang H, Ding X, Liu Y, Zhong W, Gao W, Sun T.
PMID: 34321238
Cancer Res. 2021 Oct 15;81(20):5353-5365. doi: 10.1158/0008-5472.CAN-21-1043. Epub 2021 Jul 28.

Although it is established that the sustained psychologic stress conditions under which patients with tumors often reside accelerates malignant progression of tumors, the molecular mechanism behind this association is unclear. In this work, the effect of psychologic stress on...

Experimental Treatments for Oedema in Spinal Cord Injury: A Systematic Review and Meta-Analysis.

Cells

Masterman E, Ahmed Z.
PMID: 34685662
Cells. 2021 Oct 07;10(10). doi: 10.3390/cells10102682.

The incidence of spinal cord injury (SCI) is ever-growing, resulting in life-changing neurological deficits which can have devastating long-term impacts on a person's quality of life. There is an unmet clinical need for a treatment which will prevent progression...

Showing 109 to 117 of 117 entries