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Prevalence and concentrations of sedative-hypnotic drugs in blood of drivers involved in road traffic crashes in the Padova region of Italy - not so easy to interpret.

Forensic science international

Favretto D, Visentin S, Jones AW.
PMID: 34814082
Forensic Sci Int. 2022 Jan;330:111097. doi: 10.1016/j.forsciint.2021.111097. Epub 2021 Nov 06.

BACKGROUND & OBJECTIVES: This study reports the prevalence and concentrations of sedative-hypnotic drugs as exemplified by benzodiazepines (BZD) and zolpidem (Z-hypnotic) in blood samples from drivers involved in road traffic accidents (RTA) in the Padova region of Italy. Another...

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Favretto D, Visentin S, Jones AW. Prevalence and concentrations of sedative-hypnotic drugs in blood of drivers involved in road traffic crashes in the Padova region of Italy - not so easy to interpret. Forensic Sci Int. 2021;330:111097doi: 10.1016/j.forsciint.2021.111097.
Favretto, D., Visentin, S., & Jones, A. W. (2022). Prevalence and concentrations of sedative-hypnotic drugs in blood of drivers involved in road traffic crashes in the Padova region of Italy - not so easy to interpret. Forensic science international, 330111097. https://doi.org/10.1016/j.forsciint.2021.111097
Favretto, Donata, et al. "Prevalence and concentrations of sedative-hypnotic drugs in blood of drivers involved in road traffic crashes in the Padova region of Italy - not so easy to interpret." Forensic science international vol. 330 (2022): 111097. doi: https://doi.org/10.1016/j.forsciint.2021.111097
Favretto D, Visentin S, Jones AW. Prevalence and concentrations of sedative-hypnotic drugs in blood of drivers involved in road traffic crashes in the Padova region of Italy - not so easy to interpret. Forensic Sci Int. 2022 Jan;330:111097. doi: 10.1016/j.forsciint.2021.111097. Epub 2021 Nov 06. PMID: 34814082.
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Past year use or misuse of an opioid is associated with use of a sedative-hypnotic medication: a NSDUH study.

Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine

Tubbs AS, Ghani SB, Naps M, Grandner MA, Stein MD, Chakravorty S.
PMID: 34666879
J Clin Sleep Med. 2021 Oct 20; doi: 10.5664/jcsm.9724. Epub 2021 Oct 20.

STUDY OBJECTIVES: Prescription use and misuse of opioids are linked to greater sleep disturbance. However, there are limited data on the prevalence of sedative-hypnotic medication use among persons who use opioids. Therefore, this study examined whether past year sedative-hypnotic...

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Tubbs AS, Ghani SB, Naps M, et al. Past year use or misuse of an opioid is associated with use of a sedative-hypnotic medication: a NSDUH study. J Clin Sleep Med. 2021;doi: 10.5664/jcsm.9724.
Tubbs, A. S., Ghani, S. B., Naps, M., Grandner, M. A., Stein, M. D., & Chakravorty, S. (2021). Past year use or misuse of an opioid is associated with use of a sedative-hypnotic medication: a NSDUH study. Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, . https://doi.org/10.5664/jcsm.9724
Tubbs, Andrew S, et al. "Past year use or misuse of an opioid is associated with use of a sedative-hypnotic medication: a NSDUH study." Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine vol. (2021). doi: https://doi.org/10.5664/jcsm.9724
Tubbs AS, Ghani SB, Naps M, Grandner MA, Stein MD, Chakravorty S. Past year use or misuse of an opioid is associated with use of a sedative-hypnotic medication: a NSDUH study. J Clin Sleep Med. 2021 Oct 20; doi: 10.5664/jcsm.9724. Epub 2021 Oct 20. PMID: 34666879.
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A one carbon staple for orthogonal copper-catalyzed azide-alkyne cycloadditions.

Chemical communications (Cambridge, England)

Wright K, Quinodoz P, Drouillat B, Couty F.
PMID: 27929149
Chem Commun (Camb). 2016 Dec 22;53(2):321-323. doi: 10.1039/c6cc08294g.

We describe herein the use of α-hydroxy-β-azidotetrazoles, easily prepared in one step from α,β-epoxynitriles, as new scaffolds for orthogonal CuAAC reactions performed on the same carbon atom. After a first ligation involving an alkyne with the β-azido moiety, treatment...

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Wright K, Quinodoz P, Drouillat B, et al. A one carbon staple for orthogonal copper-catalyzed azide-alkyne cycloadditions. Chem Commun (Camb). 2016;53(2):321-323doi: 10.1039/c6cc08294g.
Wright, K., Quinodoz, P., Drouillat, B., & Couty, F. (2016). A one carbon staple for orthogonal copper-catalyzed azide-alkyne cycloadditions. Chemical communications (Cambridge, England), 53(2), 321-323. https://doi.org/10.1039/c6cc08294g
Wright, Karen, et al. "A one carbon staple for orthogonal copper-catalyzed azide-alkyne cycloadditions." Chemical communications (Cambridge, England) vol. 53,2 (2016): 321-323. doi: https://doi.org/10.1039/c6cc08294g
Wright K, Quinodoz P, Drouillat B, Couty F. A one carbon staple for orthogonal copper-catalyzed azide-alkyne cycloadditions. Chem Commun (Camb). 2016 Dec 22;53(2):321-323. doi: 10.1039/c6cc08294g. PMID: 27929149.
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Fluoxetine Does Not Enhance Visual Perceptual Learning and Triazolam Specifically Impairs Learning Transfer.

Frontiers in human neuroscience

Lagas AK, Black JM, Byblow WD, Fleming MK, Goodman LK, Kydd RR, Russell BR, Stinear CM, Thompson B.
PMID: 27807412
Front Hum Neurosci. 2016 Oct 19;10:532. doi: 10.3389/fnhum.2016.00532. eCollection 2016.

The selective serotonin reuptake inhibitor fluoxetine significantly enhances adult visual cortex plasticity within the rat. This effect is related to decreased gamma-aminobutyric acid (GABA) mediated inhibition and identifies fluoxetine as a potential agent for enhancing plasticity in the adult...

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Lagas AK, Black JM, Byblow WD, et al. Fluoxetine Does Not Enhance Visual Perceptual Learning and Triazolam Specifically Impairs Learning Transfer. Front Hum Neurosci. 2016;10:532doi: 10.3389/fnhum.2016.00532.
Lagas, A. K., Black, J. M., Byblow, W. D., Fleming, M. K., Goodman, L. K., Kydd, R. R., Russell, B. R., Stinear, C. M., & Thompson, B. (2016). Fluoxetine Does Not Enhance Visual Perceptual Learning and Triazolam Specifically Impairs Learning Transfer. Frontiers in human neuroscience, 10532. https://doi.org/10.3389/fnhum.2016.00532
Lagas, Alice K, et al. "Fluoxetine Does Not Enhance Visual Perceptual Learning and Triazolam Specifically Impairs Learning Transfer." Frontiers in human neuroscience vol. 10 (2016): 532. doi: https://doi.org/10.3389/fnhum.2016.00532
Lagas AK, Black JM, Byblow WD, Fleming MK, Goodman LK, Kydd RR, Russell BR, Stinear CM, Thompson B. Fluoxetine Does Not Enhance Visual Perceptual Learning and Triazolam Specifically Impairs Learning Transfer. Front Hum Neurosci. 2016 Oct 19;10:532. doi: 10.3389/fnhum.2016.00532. eCollection 2016. PMID: 27807412; PMCID: PMC5069436.
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Serotonin syndrome in a patient with chronic pain taking analgesic drugs mistaken for psychogenic nonepileptic seizure.

Yeungnam University journal of medicine

Boudier-Revéret M, Chang MC.
PMID: 33813810
Yeungnam Univ J Med. 2021 Apr 05; doi: 10.12701/yujm.2021.00948. Epub 2021 Apr 05.

Serotonin syndrome (SS) is a potentially life-threatening condition that is caused by the administration of drugs that increase serotonergic activity in the central nervous system. We report a case of serotonin syndrome in a patient with chronic pain who...

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Boudier-Revéret M, Chang MC. Serotonin syndrome in a patient with chronic pain taking analgesic drugs mistaken for psychogenic nonepileptic seizure. Yeungnam Univ J Med. 2021;doi: 10.12701/yujm.2021.00948.
Boudier-Revéret, M., & Chang, M. C. (2021). Serotonin syndrome in a patient with chronic pain taking analgesic drugs mistaken for psychogenic nonepileptic seizure. Yeungnam University journal of medicine, . https://doi.org/10.12701/yujm.2021.00948
Boudier-Revéret, Mathieu, and Chang, Min Cheol. "Serotonin syndrome in a patient with chronic pain taking analgesic drugs mistaken for psychogenic nonepileptic seizure." Yeungnam University journal of medicine vol. (2021). doi: https://doi.org/10.12701/yujm.2021.00948
Boudier-Revéret M, Chang MC. Serotonin syndrome in a patient with chronic pain taking analgesic drugs mistaken for psychogenic nonepileptic seizure. Yeungnam Univ J Med. 2021 Apr 05; doi: 10.12701/yujm.2021.00948. Epub 2021 Apr 05. PMID: 33813810.
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Group-Targeting SERS Screening of Total Benzodiazepines Based on Large-Size (111) Faceted Silver Nanosheets Decorated with Zinc Oxide Nanoparticles.

Analytical chemistry

Wang C, Xu X, Qiu G, Ye W, Li Y, Harris RA, Jiang C.
PMID: 33556238
Anal Chem. 2021 Feb 23;93(7):3403-3410. doi: 10.1021/acs.analchem.0c04399. Epub 2021 Feb 08.

Rapid, quantitative, and group-targeting detection of total benzodiazepines (BZDs) is critical to create an accurate judgement in emergent medical and forensic settings. Large-size (111) faceted Ag nanosheets decorated with small ZnO nanoparticles were designed as the prominent surface-enhanced Raman...

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Wang C, Xu X, Qiu G, et al. Group-Targeting SERS Screening of Total Benzodiazepines Based on Large-Size (111) Faceted Silver Nanosheets Decorated with Zinc Oxide Nanoparticles. Anal Chem. 2021;93(7):3403-3410doi: 10.1021/acs.analchem.0c04399.
Wang, C., Xu, X., Qiu, G., Ye, W., Li, Y., Harris, R. A., & Jiang, C. (2021). Group-Targeting SERS Screening of Total Benzodiazepines Based on Large-Size (111) Faceted Silver Nanosheets Decorated with Zinc Oxide Nanoparticles. Analytical chemistry, 93(7), 3403-3410. https://doi.org/10.1021/acs.analchem.0c04399
Wang, Changding, et al. "Group-Targeting SERS Screening of Total Benzodiazepines Based on Large-Size (111) Faceted Silver Nanosheets Decorated with Zinc Oxide Nanoparticles." Analytical chemistry vol. 93,7 (2021): 3403-3410. doi: https://doi.org/10.1021/acs.analchem.0c04399
Wang C, Xu X, Qiu G, Ye W, Li Y, Harris RA, Jiang C. Group-Targeting SERS Screening of Total Benzodiazepines Based on Large-Size (111) Faceted Silver Nanosheets Decorated with Zinc Oxide Nanoparticles. Anal Chem. 2021 Feb 23;93(7):3403-3410. doi: 10.1021/acs.analchem.0c04399. Epub 2021 Feb 08. PMID: 33556238.
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Leveraging Human Plasma-Derived Small Extracellular Vesicles as Liquid Biopsy to Study the Induction of Cytochrome P450 3A4 by Modafinil.

Clinical pharmacology and therapeutics

Rodrigues AD, Wood LS, Vourvahis M, Rowland A.
PMID: 34623637
Clin Pharmacol Ther. 2022 Feb;111(2):425-434. doi: 10.1002/cpt.2440. Epub 2021 Nov 02.

Preparations of plasma-derived small extracellular vesicles (sEVs) were deployed as liquid biopsy to study cytochrome P450 (CYP) 3A4 (CYP3A4) induction following modafinil 400 mg once daily × 14 days (young healthy volunteers, N = 10 subjects). Induction was confirmed...

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Rodrigues AD, Wood LS, Vourvahis M, et al. Leveraging Human Plasma-Derived Small Extracellular Vesicles as Liquid Biopsy to Study the Induction of Cytochrome P450 3A4 by Modafinil. Clin Pharmacol Ther. 2021;111(2):425-434doi: 10.1002/cpt.2440.
Rodrigues, A. D., Wood, L. S., Vourvahis, M., & Rowland, A. (2022). Leveraging Human Plasma-Derived Small Extracellular Vesicles as Liquid Biopsy to Study the Induction of Cytochrome P450 3A4 by Modafinil. Clinical pharmacology and therapeutics, 111(2), 425-434. https://doi.org/10.1002/cpt.2440
Rodrigues, A David, et al. "Leveraging Human Plasma-Derived Small Extracellular Vesicles as Liquid Biopsy to Study the Induction of Cytochrome P450 3A4 by Modafinil." Clinical pharmacology and therapeutics vol. 111,2 (2022): 425-434. doi: https://doi.org/10.1002/cpt.2440
Rodrigues AD, Wood LS, Vourvahis M, Rowland A. Leveraging Human Plasma-Derived Small Extracellular Vesicles as Liquid Biopsy to Study the Induction of Cytochrome P450 3A4 by Modafinil. Clin Pharmacol Ther. 2022 Feb;111(2):425-434. doi: 10.1002/cpt.2440. Epub 2021 Nov 02. PMID: 34623637.
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Pharmacodynamic profile of Zaleplon, a new non-benzodiazepine hypnotic agent.

Human psychopharmacology

Patat A, Paty I, Hindmarch I.
PMID: 12404558
Hum Psychopharmacol. 2001 Jul;16(5):369-392. doi: 10.1002/hup.310.

The challenge in developing hypnotic agents for the treatment of insomnia is to balance the sedative effect needed at bedtime with the residual sedation on awakening. Zaleplon is a novel pyrazolopyrimidine hypnotic agent that acts as a selective agonist...

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Patat A, Paty I, Hindmarch I. Pharmacodynamic profile of Zaleplon, a new non-benzodiazepine hypnotic agent. Hum Psychopharmacol. 2001;16(5):369-392doi: 10.1002/hup.310.
Patat, A., Paty, I., & Hindmarch, I. (2001). Pharmacodynamic profile of Zaleplon, a new non-benzodiazepine hypnotic agent. Human psychopharmacology, 16(5), 369-392. https://doi.org/10.1002/hup.310
Patat, Alain, et al. "Pharmacodynamic profile of Zaleplon, a new non-benzodiazepine hypnotic agent." Human psychopharmacology vol. 16,5 (2001): 369-392. doi: https://doi.org/10.1002/hup.310
Patat A, Paty I, Hindmarch I. Pharmacodynamic profile of Zaleplon, a new non-benzodiazepine hypnotic agent. Hum Psychopharmacol. 2001 Jul;16(5):369-392. doi: 10.1002/hup.310. PMID: 12404558.
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Substitution by NMDA antagonists and other drugs in rats trained to discriminate ethanol.

Behavioural pharmacology

Sanger DJ.
PMID: 11224220
Behav Pharmacol. 1993 Oct;4(5):523-528.

It has been reported that, in animals trained to discriminate ethanol, stimulus control generalized to the non-competitive NMDA antagonists phencyclidine, ketamine and dizocilpine. In the present study, rats were trained to discriminate a dose of ethanol (1g/kg, i.p.) and...

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Sanger DJ. Substitution by NMDA antagonists and other drugs in rats trained to discriminate ethanol. Behav Pharmacol. 1993;4(5):523-528
Sanger, D. J. (1993). Substitution by NMDA antagonists and other drugs in rats trained to discriminate ethanol. Behavioural pharmacology, 4(5), 523-528.
Sanger, D.J.. "Substitution by NMDA antagonists and other drugs in rats trained to discriminate ethanol." Behavioural pharmacology vol. 4,5 (1993): 523-528.
Sanger DJ. Substitution by NMDA antagonists and other drugs in rats trained to discriminate ethanol. Behav Pharmacol. 1993 Oct;4(5):523-528. PMID: 11224220.
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Benzodiazepine prescribing trend after its inclusion as a dangerous drug under the Hong Kong Dangerous Drugs Ordinance.

Hong Kong medical journal = Xianggang yi xue za zhi

Chung KF.
PMID: 11847351
Hong Kong Med J. 1997 Mar;3(1):16-20.

Since January 1992, all benzodiazepines have been classified as dangerous drugs under the Dangerous Drugs Ordinance in Hong Kong. This legislative provision requires medical practitioners and pharmacists to keep a detailed record of their prescriptions of benzodiazepines The present...

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Chung KF. Benzodiazepine prescribing trend after its inclusion as a dangerous drug under the Hong Kong Dangerous Drugs Ordinance. Hong Kong Med J. 1997;3(1):16-20
Chung, K. F. (1997). Benzodiazepine prescribing trend after its inclusion as a dangerous drug under the Hong Kong Dangerous Drugs Ordinance. Hong Kong medical journal = Xianggang yi xue za zhi, 3(1), 16-20.
Chung, K F. "Benzodiazepine prescribing trend after its inclusion as a dangerous drug under the Hong Kong Dangerous Drugs Ordinance." Hong Kong medical journal = Xianggang yi xue za zhi vol. 3,1 (1997): 16-20.
Chung KF. Benzodiazepine prescribing trend after its inclusion as a dangerous drug under the Hong Kong Dangerous Drugs Ordinance. Hong Kong Med J. 1997 Mar;3(1):16-20. PMID: 11847351.
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Applications of linking PBPK and PD models to predict the impact of genotypic variability, formulation differences, differences in target binding capacity and target site drug concentrations on drug responses and variability.

Frontiers in pharmacology

Chetty M, Rose RH, Abduljalil K, Patel N, Lu G, Cain T, Jamei M, Rostami-Hodjegan A.
PMID: 25505415
Front Pharmacol. 2014 Nov 26;5:258. doi: 10.3389/fphar.2014.00258. eCollection 2014.

This study aimed to demonstrate the added value of integrating prior in vitro data and knowledge-rich physiologically based pharmacokinetic (PBPK) models with pharmacodynamics (PDs) models. Four distinct applications that were developed and tested are presented here. PBPK models were...

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Chetty M, Rose RH, Abduljalil K, et al. Applications of linking PBPK and PD models to predict the impact of genotypic variability, formulation differences, differences in target binding capacity and target site drug concentrations on drug responses and variability. Front Pharmacol. 2014;5:258doi: 10.3389/fphar.2014.00258.
Chetty, M., Rose, R. H., Abduljalil, K., Patel, N., Lu, G., Cain, T., Jamei, M., & Rostami-Hodjegan, A. (2014). Applications of linking PBPK and PD models to predict the impact of genotypic variability, formulation differences, differences in target binding capacity and target site drug concentrations on drug responses and variability. Frontiers in pharmacology, 5258. https://doi.org/10.3389/fphar.2014.00258
Chetty, Manoranjenni, et al. "Applications of linking PBPK and PD models to predict the impact of genotypic variability, formulation differences, differences in target binding capacity and target site drug concentrations on drug responses and variability." Frontiers in pharmacology vol. 5 (2014): 258. doi: https://doi.org/10.3389/fphar.2014.00258
Chetty M, Rose RH, Abduljalil K, Patel N, Lu G, Cain T, Jamei M, Rostami-Hodjegan A. Applications of linking PBPK and PD models to predict the impact of genotypic variability, formulation differences, differences in target binding capacity and target site drug concentrations on drug responses and variability. Front Pharmacol. 2014 Nov 26;5:258. doi: 10.3389/fphar.2014.00258. eCollection 2014. PMID: 25505415; PMCID: PMC4244809.
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Mobitz type 1 second-degree atrioventricular block by triazolam and brotizolam overdose.

Acute medicine & surgery

Hisamura M, Taguchi H, Hiraide A.
PMID: 29123752
Acute Med Surg. 2015 Apr 27;3(1):57-58. doi: 10.1002/ams2.121. eCollection 2016 Jan.

No abstract available.

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Hisamura M, Taguchi H, Hiraide A. Mobitz type 1 second-degree atrioventricular block by triazolam and brotizolam overdose. Acute Med Surg. 2015;3(1):57-58doi: 10.1002/ams2.121.
Hisamura, M., Taguchi, H., & Hiraide, A. (2016). Mobitz type 1 second-degree atrioventricular block by triazolam and brotizolam overdose. Acute medicine & surgery, 3(1), 57-58. https://doi.org/10.1002/ams2.121
Hisamura, Masaki, et al. "Mobitz type 1 second-degree atrioventricular block by triazolam and brotizolam overdose." Acute medicine & surgery vol. 3,1 (2016): 57-58. doi: https://doi.org/10.1002/ams2.121
Hisamura M, Taguchi H, Hiraide A. Mobitz type 1 second-degree atrioventricular block by triazolam and brotizolam overdose. Acute Med Surg. 2015 Apr 27;3(1):57-58. doi: 10.1002/ams2.121. eCollection 2016 Jan. PMID: 29123752; PMCID: PMC5667231.
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Showing 25 to 36 of 62 entries