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Prevalence and concentrations of sedative-hypnotic drugs in blood of drivers involved in road traffic crashes in the Padova region of Italy - not so easy to interpret.

Forensic science international

Favretto D, Visentin S, Jones AW.
PMID: 34814082
Forensic Sci Int. 2021 Nov 06;330:111097. doi: 10.1016/j.forsciint.2021.111097. Epub 2021 Nov 06.

BACKGROUND & OBJECTIVES: This study reports the prevalence and concentrations of sedative-hypnotic drugs as exemplified by benzodiazepines (BZD) and zolpidem (Z-hypnotic) in blood samples from drivers involved in road traffic accidents (RTA) in the Padova region of Italy. Another...

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Favretto D, Visentin S, Jones AW. Prevalence and concentrations of sedative-hypnotic drugs in blood of drivers involved in road traffic crashes in the Padova region of Italy - not so easy to interpret. Forensic Sci Int. 2021;330:111097doi: 10.1016/j.forsciint.2021.111097.
Favretto, D., Visentin, S., & Jones, A. W. (2021). Prevalence and concentrations of sedative-hypnotic drugs in blood of drivers involved in road traffic crashes in the Padova region of Italy - not so easy to interpret. Forensic science international, 330111097. https://doi.org/10.1016/j.forsciint.2021.111097
Favretto, Donata, et al. "Prevalence and concentrations of sedative-hypnotic drugs in blood of drivers involved in road traffic crashes in the Padova region of Italy - not so easy to interpret." Forensic science international vol. 330 (2021): 111097. doi: https://doi.org/10.1016/j.forsciint.2021.111097
Favretto D, Visentin S, Jones AW. Prevalence and concentrations of sedative-hypnotic drugs in blood of drivers involved in road traffic crashes in the Padova region of Italy - not so easy to interpret. Forensic Sci Int. 2021 Nov 06;330:111097. doi: 10.1016/j.forsciint.2021.111097. Epub 2021 Nov 06. PMID: 34814082.
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Determination of triazolam by GC-MS in two autopsy cases: distribution in body fluids and organs.

Legal medicine (Tokyo, Japan)

Takayasu T, Kondo T, Sato Y, Ohshima T.
PMID: 12935707
Leg Med (Tokyo). 2000 Dec;2(4):206-11. doi: 10.1016/s1344-6223(00)80042-5.

A detailed procedure for analysis of triazolam by GC-MS was constructed in our laboratory. At the concentration of 100 ng/ml, recoveries of triazolam in plasma and urine were 84.9 and 91.0%, respectively. The coefficients of variation in terms of...

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Takayasu T, Kondo T, Sato Y, et al. Determination of triazolam by GC-MS in two autopsy cases: distribution in body fluids and organs. Leg Med (Tokyo). 2000;2(4):206-11doi: 10.1016/s1344-6223(00)80042-5.
Takayasu, T., Kondo, T., Sato, Y., & Ohshima, T. (2000). Determination of triazolam by GC-MS in two autopsy cases: distribution in body fluids and organs. Legal medicine (Tokyo, Japan), 2(4), 206-11. https://doi.org/10.1016/s1344-6223(00)80042-5
Takayasu, T, et al. "Determination of triazolam by GC-MS in two autopsy cases: distribution in body fluids and organs." Legal medicine (Tokyo, Japan) vol. 2,4 (2000): 206-11. doi: https://doi.org/10.1016/s1344-6223(00)80042-5
Takayasu T, Kondo T, Sato Y, Ohshima T. Determination of triazolam by GC-MS in two autopsy cases: distribution in body fluids and organs. Leg Med (Tokyo). 2000 Dec;2(4):206-11. doi: 10.1016/s1344-6223(00)80042-5. PMID: 12935707.
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1,4-Disubstituted 1.

Frontiers in chemistry

Schröder DC, Kracker O, Fröhr T, Góra J, Jewginski M, Nieß A, Antes I, Latajka R, Marion A, Sewald N.
PMID: 30972322
Front Chem. 2019 Mar 26;7:155. doi: 10.3389/fchem.2019.00155. eCollection 2019.

Peptidotriazolamers are hybrid foldamers with features of peptides and triazolamers, containing alternation of amide bonds and 1,4-disubstituted 1

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Schröder DC, Kracker O, Fröhr T, et al. 1,4-Disubstituted 1. Front Chem. 2019;7:155doi: 10.3389/fchem.2019.00155.
Schröder, D. C., Kracker, O., Fröhr, T., Góra, J., Jewginski, M., Nieß, A., Antes, I., Latajka, R., Marion, A., & Sewald, N. (2019). 1,4-Disubstituted 1. Frontiers in chemistry, 7155. https://doi.org/10.3389/fchem.2019.00155
Schröder, David C, et al. "1,4-Disubstituted 1." Frontiers in chemistry vol. 7 (2019): 155. doi: https://doi.org/10.3389/fchem.2019.00155
Schröder DC, Kracker O, Fröhr T, Góra J, Jewginski M, Nieß A, Antes I, Latajka R, Marion A, Sewald N. 1,4-Disubstituted 1. Front Chem. 2019 Mar 26;7:155. doi: 10.3389/fchem.2019.00155. eCollection 2019. PMID: 30972322; PMCID: PMC6443886.
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1,5-Disubstituted 1,2,3-Triazole-Containing Peptidotriazolamers: Design Principles for a Class of Versatile Peptidomimetics.

Chemistry (Weinheim an der Bergstrasse, Germany)

Kracker O, Góra J, Krzciuk-Gula J, Marion A, Neumann B, Stammler HG, Nieß A, Antes I, Latajka R, Sewald N.
PMID: 29160605
Chemistry. 2018 Jan 19;24(4):953-961. doi: 10.1002/chem.201704583. Epub 2017 Dec 13.

Peptidotriazolamers are hybrid foldamers combining features of peptides and triazolamers-repetitive peptidomimetic structures with triazoles replacing peptide bonds. We report on the synthesis of a new class of peptidomimetics, containing 1,5-disubstituted 1,2,3-triazoles in an alternating fashion with amide bonds and...

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Kracker O, Góra J, Krzciuk-Gula J, et al. 1,5-Disubstituted 1,2,3-Triazole-Containing Peptidotriazolamers: Design Principles for a Class of Versatile Peptidomimetics. Chemistry. 2017;24(4):953-961doi: 10.1002/chem.201704583.
Kracker, O., Góra, J., Krzciuk-Gula, J., Marion, A., Neumann, B., Stammler, H. G., Nieß, A., Antes, I., Latajka, R., & Sewald, N. (2018). 1,5-Disubstituted 1,2,3-Triazole-Containing Peptidotriazolamers: Design Principles for a Class of Versatile Peptidomimetics. Chemistry (Weinheim an der Bergstrasse, Germany), 24(4), 953-961. https://doi.org/10.1002/chem.201704583
Kracker, Oliver, et al. "1,5-Disubstituted 1,2,3-Triazole-Containing Peptidotriazolamers: Design Principles for a Class of Versatile Peptidomimetics." Chemistry (Weinheim an der Bergstrasse, Germany) vol. 24,4 (2018): 953-961. doi: https://doi.org/10.1002/chem.201704583
Kracker O, Góra J, Krzciuk-Gula J, Marion A, Neumann B, Stammler HG, Nieß A, Antes I, Latajka R, Sewald N. 1,5-Disubstituted 1,2,3-Triazole-Containing Peptidotriazolamers: Design Principles for a Class of Versatile Peptidomimetics. Chemistry. 2018 Jan 19;24(4):953-961. doi: 10.1002/chem.201704583. Epub 2017 Dec 13. PMID: 29160605.
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Potential triazole derivatives having significant antiepileptic effect- A Review.

Mini reviews in medicinal chemistry

Singhal N, Sharma PK, Kumar N, Dudhe R.
PMID: 22876955
Mini Rev Med Chem. 2012 Jul 30; Epub 2012 Jul 30.

Triazole is a five membered heterocyclic moiety of two carbon and three nitrogen atom, triazole are present in two isomeric forms, 1,2,4-triazole and 1,2,3-triazole. Alprazolam, Triazolam and Midazolam are established drugs used in epilepsy which have triazole moiety. Epilepsy...

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Singhal N, Sharma PK, Kumar N, et al. Potential triazole derivatives having significant antiepileptic effect- A Review. Mini Rev Med Chem. 2012;
Singhal, N., Sharma, P. K., Kumar, N., & Dudhe, R. (2012). Potential triazole derivatives having significant antiepileptic effect- A Review. Mini reviews in medicinal chemistry, .
Singhal, N, et al. "Potential triazole derivatives having significant antiepileptic effect- A Review." Mini reviews in medicinal chemistry vol. (2012).
Singhal N, Sharma PK, Kumar N, Dudhe R. Potential triazole derivatives having significant antiepileptic effect- A Review. Mini Rev Med Chem. 2012 Jul 30; Epub 2012 Jul 30. PMID: 22876955.
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Is there a problem with benzodiazepine prescribing in maritime Canada?.

Canadian family physician Medecin de famille canadien

Sketris IS, Maccara ME, Purkis IE, Curry L.
PMID: 21274169
Can Fam Physician. 1985 Sep;31:1591-6.

The benzodiazepine prescribing habits of 64 maritime doctors were studied through collection and examination of carbon copies of all prescriptions over a 22 week period. Diazepam was the most frequently prescribed anxiolytic benzodiazepine, followed by chlordiazepoxide, then oxazepam. These...

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Sketris IS, Maccara ME, Purkis IE, et al. Is there a problem with benzodiazepine prescribing in maritime Canada?. Can Fam Physician. 1985;31:1591-6
Sketris, I. S., Maccara, M. E., Purkis, I. E., & Curry, L. (1985). Is there a problem with benzodiazepine prescribing in maritime Canada?. Canadian family physician Medecin de famille canadien, 311591-6.
Sketris, I S, et al. "Is there a problem with benzodiazepine prescribing in maritime Canada?." Canadian family physician Medecin de famille canadien vol. 31 (1985): 1591-6.
Sketris IS, Maccara ME, Purkis IE, Curry L. Is there a problem with benzodiazepine prescribing in maritime Canada?. Can Fam Physician. 1985 Sep;31:1591-6. PMID: 21274169; PMCID: PMC2327851.
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Triazolam Effects On Explicit Memory, Implicit Memory and Metamemory: Lister RG, Joyce EM, Weingartner HJ, Eckardt MJ Laboratory of Clinical Studies, NIAAA, DICBR, Bldg 10 Rm 3C102, 9000 Rockville Pike, Bethesda, MD 20892, USA.

Journal of psychopharmacology (Oxford, England)

[No authors listed]
PMID: 22291318
J Psychopharmacol. 1992 Jan;6(1):133. doi: 10.1177/026988119200600190.

No abstract available.

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Triazolam Effects On Explicit Memory, Implicit Memory and Metamemory: Lister RG, Joyce EM, Weingartner HJ, Eckardt MJ Laboratory of Clinical Studies, NIAAA, DICBR, Bldg 10 Rm 3C102, 9000 Rockville Pike, Bethesda, MD 20892, USA. J Psychopharmacol. 1992;6(1):133doi: 10.1177/026988119200600190.
(1992). Triazolam Effects On Explicit Memory, Implicit Memory and Metamemory: Lister RG, Joyce EM, Weingartner HJ, Eckardt MJ Laboratory of Clinical Studies, NIAAA, DICBR, Bldg 10 Rm 3C102, 9000 Rockville Pike, Bethesda, MD 20892, USA. Journal of psychopharmacology (Oxford, England), 6(1), 133. https://doi.org/10.1177/026988119200600190
"Triazolam Effects On Explicit Memory, Implicit Memory and Metamemory: Lister RG, Joyce EM, Weingartner HJ, Eckardt MJ Laboratory of Clinical Studies, NIAAA, DICBR, Bldg 10 Rm 3C102, 9000 Rockville Pike, Bethesda, MD 20892, USA." Journal of psychopharmacology (Oxford, England) vol. 6,1 (1992): 133. doi: https://doi.org/10.1177/026988119200600190
Triazolam Effects On Explicit Memory, Implicit Memory and Metamemory: Lister RG, Joyce EM, Weingartner HJ, Eckardt MJ Laboratory of Clinical Studies, NIAAA, DICBR, Bldg 10 Rm 3C102, 9000 Rockville Pike, Bethesda, MD 20892, USA. J Psychopharmacol. 1992 Jan;6(1):133. doi: 10.1177/026988119200600190. PMID: 22291318.
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Placebo-effects contribute to differences in the acquisition of drug discrimination by humans: a retrospective analysis.

Behavioural pharmacology

Kamien JB, Bickel WK, Oliveto AH, Higgins ST, Hughes JR, Richards AT, Badger GJ.
PMID: 11224326
Behav Pharmacol. 1995 Mar;6(2):187-194.

Adult human volunteers (n = 50) were trained to discriminate triazolam (TRZ, 0.32mg/70kg, p.o.) from placebo. Based on a criterion that required greater than 80% capsule-appropriate responding during each of four test sessions, 19 subjects were designated non-discriminators (NDs)...

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Kamien JB, Bickel WK, Oliveto AH, et al. Placebo-effects contribute to differences in the acquisition of drug discrimination by humans: a retrospective analysis. Behav Pharmacol. 1995;6(2):187-194
Kamien, J. B., Bickel, W. K., Oliveto, A. H., Higgins, S. T., Hughes, J. R., Richards, A. T., & Badger, G. J. (1995). Placebo-effects contribute to differences in the acquisition of drug discrimination by humans: a retrospective analysis. Behavioural pharmacology, 6(2), 187-194.
Kamien, J.B., et al. "Placebo-effects contribute to differences in the acquisition of drug discrimination by humans: a retrospective analysis." Behavioural pharmacology vol. 6,2 (1995): 187-194.
Kamien JB, Bickel WK, Oliveto AH, Higgins ST, Hughes JR, Richards AT, Badger GJ. Placebo-effects contribute to differences in the acquisition of drug discrimination by humans: a retrospective analysis. Behav Pharmacol. 1995 Mar;6(2):187-194. PMID: 11224326.
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Successful treatment with clonazepam and pramipexole of a patient with sleep-related eating disorder associated with restless legs syndrome: a case report.

Case reports in medicine

Kobayashi N, Yoshimura R, Takano M.
PMID: 22481958
Case Rep Med. 2012;2012:893681. doi: 10.1155/2012/893681. Epub 2012 Mar 14.

Sleep-related eating disorder (SRED) is characterized by recurrent episodes of involuntary eating during sleep period and is often associated with restless legs syndrome (RLS). Although pharmacotherapy is recommended for SRED patients, no drug have shown promising effects so far....

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Kobayashi N, Yoshimura R, Takano M. Successful treatment with clonazepam and pramipexole of a patient with sleep-related eating disorder associated with restless legs syndrome: a case report. Case Rep Med. 2012;2012:893681doi: 10.1155/2012/893681.
Kobayashi, N., Yoshimura, R., & Takano, M. (2012). Successful treatment with clonazepam and pramipexole of a patient with sleep-related eating disorder associated with restless legs syndrome: a case report. Case reports in medicine, 2012893681. https://doi.org/10.1155/2012/893681
Kobayashi, Nobuyuki, et al. "Successful treatment with clonazepam and pramipexole of a patient with sleep-related eating disorder associated with restless legs syndrome: a case report." Case reports in medicine vol. 2012 (2012): 893681. doi: https://doi.org/10.1155/2012/893681
Kobayashi N, Yoshimura R, Takano M. Successful treatment with clonazepam and pramipexole of a patient with sleep-related eating disorder associated with restless legs syndrome: a case report. Case Rep Med. 2012;2012:893681. doi: 10.1155/2012/893681. Epub 2012 Mar 14. PMID: 22481958; PMCID: PMC3312196.
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Alcohol, drugs and driving: implications for evaluating driver impairment.

Annals of advances in automotive medicine. Association for the Advancement of Automotive Medicine. Annual Scientific Conference

Brown T, Milavetz G, Murry DJ.
PMID: 24406943
Ann Adv Automot Med. 2013;57:23-32.

Impaired driving is a significant traffic safety problem, and alcohol and drugs taken before driving contribute substantially to this problem. With the increase in use of prescription medication and the decriminalization of some drugs, it has become increasingly important...

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Brown T, Milavetz G, Murry DJ. Alcohol, drugs and driving: implications for evaluating driver impairment. Ann Adv Automot Med. 2013;57:23-32
Brown, T., Milavetz, G., & Murry, D. J. (2013). Alcohol, drugs and driving: implications for evaluating driver impairment. Annals of advances in automotive medicine. Association for the Advancement of Automotive Medicine. Annual Scientific Conference, 5723-32.
Brown, Timothy, et al. "Alcohol, drugs and driving: implications for evaluating driver impairment." Annals of advances in automotive medicine. Association for the Advancement of Automotive Medicine. Annual Scientific Conference vol. 57 (2013): 23-32.
Brown T, Milavetz G, Murry DJ. Alcohol, drugs and driving: implications for evaluating driver impairment. Ann Adv Automot Med. 2013;57:23-32. PMID: 24406943; PMCID: PMC3861813.
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Use of triazolam and alprazolam as premedication for general anesthesia.

Korean journal of anesthesiology

Kim D, Lee S, Pyeon T, Jeong S.
PMID: 26257846
Korean J Anesthesiol. 2015 Aug;68(4):346-51. doi: 10.4097/kjae.2015.68.4.346. Epub 2015 Jul 28.

BACKGROUND: Triazolam has similar pharmacological properties as other benzodiazepines and is generally used as a sedative to treat insomnia. Alprazolam represents a possible alternative to midazolam for the premedication of surgical patients. The purpose of this study was to...

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Kim D, Lee S, Pyeon T, et al. Use of triazolam and alprazolam as premedication for general anesthesia. Korean J Anesthesiol. 2015;68(4):346-51doi: 10.4097/kjae.2015.68.4.346.
Kim, D., Lee, S., Pyeon, T., & Jeong, S. (2015). Use of triazolam and alprazolam as premedication for general anesthesia. Korean journal of anesthesiology, 68(4), 346-51. https://doi.org/10.4097/kjae.2015.68.4.346
Kim, Doyun, et al. "Use of triazolam and alprazolam as premedication for general anesthesia." Korean journal of anesthesiology vol. 68,4 (2015): 346-51. doi: https://doi.org/10.4097/kjae.2015.68.4.346
Kim D, Lee S, Pyeon T, Jeong S. Use of triazolam and alprazolam as premedication for general anesthesia. Korean J Anesthesiol. 2015 Aug;68(4):346-51. doi: 10.4097/kjae.2015.68.4.346. Epub 2015 Jul 28. PMID: 26257846; PMCID: PMC4524932.
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GABA.

Drug and alcohol dependence

Berro LF, Rowlett JK.
PMID: 32474260
Drug Alcohol Depend. 2020 May 25;213:108076. doi: 10.1016/j.drugalcdep.2020.108076. Epub 2020 May 25.

BACKGROUND: Opioid-use disorder is associated with a high degree of co-abuse with benzodiazepines. While the mechanisms underlying the co-abuse of opioids and benzodiazepines remain unknown, α1 subunit-containing GABAMETHODS: The reinforcing effects of L-838,417 (partial intrinsic efficacy at α2, α3,...

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Berro LF, Rowlett JK. GABA. Drug Alcohol Depend. 2020;213:108076doi: 10.1016/j.drugalcdep.2020.108076.
Berro, L. F., & Rowlett, J. K. (2020). GABA. Drug and alcohol dependence, 213108076. https://doi.org/10.1016/j.drugalcdep.2020.108076
Berro, Lais F, and Rowlett, James K. "GABA." Drug and alcohol dependence vol. 213 (2020): 108076. doi: https://doi.org/10.1016/j.drugalcdep.2020.108076
Berro LF, Rowlett JK. GABA. Drug Alcohol Depend. 2020 May 25;213:108076. doi: 10.1016/j.drugalcdep.2020.108076. Epub 2020 May 25. PMID: 32474260; PMCID: PMC7371532.
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