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Showing 1417 to 1422 of 1422 entries
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SAHA Overcomes 5-FU Resistance in IFIT2-Depleted Oral Squamous Cell Carcinoma Cells.

Cancers

Regmi P, Lai KC, Liu CJ, Lee TC.
PMID: 33256074
Cancers (Basel). 2020 Nov 26;12(12). doi: 10.3390/cancers12123527.

Interferon-induced protein with tetratricopeptide repeats 2 (IFIT2) is a member of the interferon-stimulated gene family that contains tetratricopeptide repeats (TPRs), which mediate protein-protein interactions in various biological systems. We previously showed the depletion of IFIT2 enhanced cell migration and...

STING-driven interferon signaling triggers metabolic alterations in pancreas cancer cells visualized by [.

Proceedings of the National Academy of Sciences of the United States of America

Liang K, Abt ER, Le TM, Cho A, Dann AM, Cui J, Li L, Rashid K, Creech AL, Wei L, Ghukasyan R, Rosser EW, Wu N, Carlucci G, Czernin J, Donahue TR, Radu CG.
PMID: 34480004
Proc Natl Acad Sci U S A. 2021 Sep 07;118(36). doi: 10.1073/pnas.2105390118.

Type I interferons (IFNs) are critical effectors of emerging cancer immunotherapies designed to activate pattern recognition receptors (PRRs). A challenge in the clinical translation of these agents is the lack of noninvasive pharmacodynamic biomarkers that indicate increased intratumoral IFN...

Roles of Mitochondrial Serine Hydroxymethyltransferase 2 (SHMT2) in Human Carcinogenesis.

Journal of Cancer

Zeng Y, Zhang J, Xu M, Chen F, Zi R, Yue J, Zhang Y, Chen N, Chin YE.
PMID: 34476002
J Cancer. 2021 Aug 08;12(19):5888-5894. doi: 10.7150/jca.60170. eCollection 2021.

In the last few years, cellular metabolic reprogramming has been acknowledged as a hallmark of human cancer and evaluated for its crucial role in supporting the proliferation and survival of human cancer cells. In a variety of human tumours,...

TARG1 protects against toxic DNA ADP-ribosylation.

Nucleic acids research

Tromans-Coia C, Sanchi A, Moeller GK, Timinszky G, Lopes M, Ahel I.
PMID: 34508355
Nucleic Acids Res. 2021 Oct 11;49(18):10477-10492. doi: 10.1093/nar/gkab771.

ADP-ribosylation is a modification that targets a variety of macromolecules and regulates a diverse array of important cellular processes. ADP-ribosylation is catalysed by ADP-ribosyltransferases and reversed by ADP-ribosylhydrolases. Recently, an ADP-ribosyltransferase toxin termed 'DarT' from bacteria, which is distantly...

DNA-Protein Cross-Linking Sequencing for Genome-Wide Mapping of Thymidine Glycol.

Journal of the American Chemical Society

Tang F, Yuan J, Yuan BF, Wang Y.
PMID: 34978433
J Am Chem Soc. 2022 Jan 12;144(1):454-462. doi: 10.1021/jacs.1c10490. Epub 2022 Jan 03.

Thymidine glycol (Tg) is the most prevalent form of oxidatively induced pyrimidine lesions in DNA. Tg can arise from direct oxidation of thymidine in DNA. In addition, 5-methyl-2'-deoxycytidine (5-mdC) can be oxidized to 5-mdC glycol, and its subsequent deamination...

Synthetic and Naturally Occurring Heterocyclic Anticancer Compounds with Multiple Biological Targets.

Molecules (Basel, Switzerland)

Amewu RK, Sakyi PO, Osei-Safo D, Addae-Mensah I.
PMID: 34885716
Molecules. 2021 Nov 25;26(23). doi: 10.3390/molecules26237134.

Cancer is a complex group of diseases initiated by abnormal cell division with the potential of spreading to other parts of the body. The advancement in the discoveries of omics and bio- and cheminformatics has led to the identification...

Showing 1417 to 1422 of 1422 entries