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Showing 349 to 356 of 356 entries
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ROCK2 inhibition attenuates profibrogenic immune cell function to reverse thioacetamide-induced liver fibrosis.

JHEP reports : innovation in hepatology

Nalkurthi C, Schroder WA, Melino M, Irvine KM, Nyuydzefe M, Chen W, Liu J, Teng MWL, Hill GR, Bertolino P, Blazar BR, Miller GC, Clouston AD, Zanin-Zhorov A, MacDonald KPA.
PMID: 34917911
JHEP Rep. 2021 Oct 06;4(1):100386. doi: 10.1016/j.jhepr.2021.100386. eCollection 2022 Jan.

BACKGROUND & AIMS: Fibrosis, the primary cause of morbidity in chronic liver disease, is induced by pro-inflammatory cytokines, immune cell infiltrates, and tissue resident cells that drive excessive myofibroblast activation, collagen production, and tissue scarring. Rho-associated kinase 2 (ROCK2)...

Berberine alleviates liver fibrosis through inducing ferrous redox to activate ROS-mediated hepatic stellate cells ferroptosis.

Cell death discovery

Yi J, Wu S, Tan S, Qin Y, Wang X, Jiang J, Liu H, Wu B.
PMID: 34864819
Cell Death Discov. 2021 Dec 04;7(1):374. doi: 10.1038/s41420-021-00768-7.

Berberine (BBR) has been explored as a potential anti-liver fibrosis agent, but the underlying mechanisms are unknown. In the current study, we aimed to investigate the molecular mechanisms underlying the effect of BBR against liver fibrogenesis in thioacetamide (TAA)...

Thioacetamide-induced Ce.

Journal of colloid and interface science

Li H, Qiu Y, Yue S, Xu R, Guo X.
PMID: 34933193
J Colloid Interface Sci. 2022 Apr;611:82-92. doi: 10.1016/j.jcis.2021.12.079. Epub 2021 Dec 14.

Here, Rare-earth metal oxysulfide Ce

The involvement of TGF-β1 /FAK/α-SMA pathway in the antifibrotic impact of rice bran oil on thioacetamide-induced liver fibrosis in rats.

PloS one

Abdel-Rahman RF, Fayed HM, Asaad GF, Ogaly HA, Hessin AF, Salama AAA, Abd El-Rahman SS, Arbid MS, Mohamed MAE.
PMID: 34965258
PLoS One. 2021 Dec 29;16(12):e0260130. doi: 10.1371/journal.pone.0260130. eCollection 2021.

The objective of the current study is to investigate the effect of rice bran oil (RBO) on hepatic fibrosis as a characteristic response to persistent liver injuries. Rats were randomly allocated into five groups: the negative control group, thioacetamide...

Macro-encapsulation of mesenchymal stem cells in acute and chronic liver injury animal models.

Journal of gastroenterology and hepatology

Kang HT, Jang K, Jun DW, Yoon EL, Lee SM, Saeed WK, Lee JH.
PMID: 33554346
J Gastroenterol Hepatol. 2021 Jul;36(7):1997-2007. doi: 10.1111/jgh.15434. Epub 2021 Feb 18.

BACKGROUND AND AIM: Stem cell treatments using scaffolds for liver disease have been well studied. However, macro-encapsulation of mesenchymal stem cells (MSCs) to minimize or inhibit stem cell homing has not been evaluated. Here, we conducted a proof-of-concept study...

Novel heterostructured Bi2S3/BiOI photocatalyst: facile preparation, characterization and visible light photocatalytic performance.

Dalton transactions (Cambridge, England : 2003)

Cao J, Xu B, Lin H, Luo B, Chen S.
PMID: 22892685
Dalton Trans. 2012 Oct 07;41(37):11482-90. doi: 10.1039/c2dt30883e. Epub 2012 Aug 14.

Novel Bi(2)S(3)/BiOI heterostructures were successfully synthesized through a facile and economical ion exchange method between BiOI and thioacetamide (CH(3)CSNH(2)), and characterized by multiform techniques, such as XRD, Raman, FT-IR, XPS, SEM, TEM, HRTEM, SAED, BET and DRS. The obtained...

Chlorogenic acid alleviates thioacetamide-induced toxicity and promotes liver development in zebrafish (Danio rerio) through the Wnt signaling pathway.

Aquatic toxicology (Amsterdam, Netherlands)

Liu Y, Guo J, Zhang J, Deng Y, Xiong G, Fu J, Wei L, Lu H.
PMID: 34856462
Aquat Toxicol. 2021 Nov 21;242:106039. doi: 10.1016/j.aquatox.2021.106039. Epub 2021 Nov 21.

Chlorogenic acid (CGA) is a phenylpropanoid compound that is well known to improve the antioxidant capacity and other biological activities. However, the roles of CGA in the liver development of organisms are unclear. In the present study, we aimed...

Genomics and metabolomics of early-stage thioacetamide-induced liver injury: An interspecies study between guinea pig and rat.

Toxicology and applied pharmacology

Schyman P, Printz RL, Pannala VR, AbdulHameed MDM, Estes SK, Shiota C, Boyd KL, Shiota M, Wallqvist A.
PMID: 34492290
Toxicol Appl Pharmacol. 2021 Nov 01;430:115713. doi: 10.1016/j.taap.2021.115713. Epub 2021 Sep 04.

To study the complex processes involved in liver injuries, researchers rely on animal investigations, using chemically or surgically induced liver injuries, to extrapolate findings and infer human health risks. However, this presents obvious challenges in performing a detailed comparison...

Showing 349 to 356 of 356 entries