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Showing 13 to 24 of 301 entries
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Oncogenic transformation and growth factor production of a human urothelial cell line.

Urologic oncology

Wang HH, Robinson S, Melvillej J, Riches A.
PMID: 21224120
Urol Oncol. 1995 Sep-Oct;1(5):208-14. doi: 10.1016/1078-1439(96)00002-6.

The objective of this study was to demonstrate that a nontumorigenic simian virus 40 (SV40) immortalized human urothelial cell line can be tumorigenically transformed following growth in a serum free, growth factor free, chemically defined culture system. The tumorigenicity...

The expression of KIT receptor dimers in gastrointestinal stromal tumors independent of c-kit mutation and SCF expression is associated with high-risk stratification.

Oncology letters

Qiu C, Liu X, Bai C, Ma DL.
PMID: 23205104
Oncol Lett. 2012 Oct;4(4):805-811. doi: 10.3892/ol.2012.797. Epub 2012 Jul 11.

Although the dimerization of KIT, a receptor tyrosine kinase, plays a major role in a number of tumors, correlations between the clinicopathological parameters and KIT receptor dimers have not been identified. In the current study, a method for the...

Current concepts on diagnosis and treatment of mastocytosis.

Translational medicine @ UniSa

Magliacane D, Parente R, Triggiani M.
PMID: 24778999
Transl Med UniSa. 2014 Feb 04;8:65-74. eCollection 2014 Jan.

Mastocytosis is a heterogeneous group of disorders characterized by a clonal proliferation and accumulation of mast cells in one or more organ, primarily in the skin and bone marrow. The clinical spectrum of the disease varies from relatively benign...

Expression of stem cell factor in gastrointestinal stromal tumors: Implications for proliferation and imatinib resistance.

Oncology letters

Hou XW, Bai CG, Liu XH, Qiu C, Huang L, Xu JJ, Ma DL.
PMID: 23420128
Oncol Lett. 2013 Feb;5(2):552-558. doi: 10.3892/ol.2012.1019. Epub 2012 Nov 09.

KIT autophosphorylation caused by mutation of KIT is considered to be a critical mechanism for the oncogenesis of gastrointestinal stromal tumors (GISTs). However, little is known regarding whether stem cell factor (SCF), the KIT ligand, is able to induce...

Curcumin improves expression of SCF/c-kit through attenuating oxidative stress and NF-κB activation in gastric tissues of diabetic gastroparesis rats.

Diabetology & metabolic syndrome

Jin QH, Shen HX, Wang H, Shou QY, Liu Q.
PMID: 23448582
Diabetol Metab Syndr. 2013 Mar 01;5(1):12. doi: 10.1186/1758-5996-5-12.

BACKGROUND: Diabetes mellitus is associated with many kinds of complications. Recent studies have shown that oxidative stress and inflammatory reactions have critical roles in the pathogenesis of diabetic gastroparesis. Curcumin is known to have antioxidant and anti-inflammatory properties. In...

In vitro growth of mouse preantral follicles: effect of animal age and stem cell factor/insulin-like growth factor supplementation.

Clinical and experimental reproductive medicine

Jee BC, Kim JH, Park DH, Youm H, Suh CS, Kim SH.
PMID: 23106041
Clin Exp Reprod Med. 2012 Sep;39(3):107-13. doi: 10.5653/cerm.2012.39.3.107. Epub 2012 Sep 30.

OBJECTIVE: To determine whether animal age impacts in vitro preantral follicle growth. Effects of hCG, stem cell factor (SCF), and/or insulin-like growth factor (IGF) supplementation in growth medium were also investigated.METHODS: Intact preantral follicles were mechanically isolated from fresh...

Migration of mouse-induced pluripotent stem cells to glioma-conditioned medium is mediated by tumor-associated specific growth factors.

Oncology letters

Koizumi S, Gu C, Amano S, Yamamoto S, Ihara H, Tokuyama T, Namba H.
PMID: 22866078
Oncol Lett. 2011 Mar;2(2):283-288. doi: 10.3892/ol.2011.234. Epub 2011 Jan 14.

Neural and mesenchymal stem cells have extensive tropism for malignant glioma. The tumor tropism of induced pluripotent stem (iPS) cells was tested using the Matrigel invasion assay. Mouse iPS cells showed a significant tropism to the conditioned media prepared...

Heart cells with regenerative potential from pediatric patients with end stage heart failure: a translatable method to enrich and propagate.

Stem cells international

Steele A, Boucek RJ, Jacobs JP, Steele P, Asante-Korang A, Chamizo W, Steele J, Chai PJ, Quintessenza JA.
PMID: 22936950
Stem Cells Int. 2012;2012:452102. doi: 10.1155/2012/452102. Epub 2012 Aug 14.

Background. Human cardiac-derived progenitor cells (hCPCs) have shown promise in treating heart failure (HF) in adults. The purpose of this study was to describe derivation of hCPCs from pediatric patients with end-stage HF. Methods. At surgery, discarded right atrial...

Protein Interaction Mapping of Translational Regulators Affecting Expression of the Critical Stem Cell Factor Nos.

Development & reproduction

Malik S, Jang W, Kim C.
PMID: 29354790
Dev Reprod. 2017 Dec;21(4):449-456. doi: 10.12717/DR.2017.21.4.449. Epub 2017 Dec 31.

The germline stem cells of the

Novel pathological features and potential therapeutic approaches for CADASIL: insights obtained from a mouse model of CADASIL.

Therapeutic targets for neurological diseases

Liu XY, Gonzalez-Toledo ME, Fagan A, Duan WM, Liu Y, Zhang S, Li B, Piao CS, Nelson L, Zhao LR.
PMID: 30090853
Ther Targets Neurol Dis. 2014;1. doi: 10.14800/ttnd.434. Epub 2014 Dec 02.

Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is the most common condition of hereditary stroke and vascular dementia. CADASIL is caused by Notch3 mutation, leading to progressive degeneration of vascular smooth muscle cells (vSMCs) of the...

Low plasma stem cell factor combined with high transforming growth factor-α identifies high-risk patients in pulmonary arterial hypertension.

ERJ open research

Bouzina H, Rådegran G.
PMID: 30443557
ERJ Open Res. 2018 Nov 12;4(4). doi: 10.1183/23120541.00035-2018. eCollection 2018 Oct.

In pulmonary arterial hypertension (PAH), severe vasoconstriction and remodelling of small pulmonary arteries result in high mortality. Receptor tyrosine kinases and their ligands, such as transforming growth factor (TGF)-α, modulate proliferation in PAH. Although the receptor tyrosine kinase c-Kit...

Spontaneously Ruptured Gastrointestinal Stromal Tumor With Pelvic Abscess: A Case Report and Review.

Gastroenterology research

Ulusan S, Koc Z, Kayaselcuk F.
PMID: 27990209
Gastroenterology Res. 2009 Dec;2(6):361-363. doi: 10.4021/gr2009.11.1324. Epub 2009 Nov 20.

Gastrointestinal stromal tumors (GISTs) originate from interstitial Cajal cells on intestinal pacemaker cells that arise from the muscularis propria of the gastrointestinal tract wall. GISTs are characterized by the expression of c-KIT protein (CD 117, stem cell factor receptor)...

Showing 13 to 24 of 301 entries