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Showing 25 to 36 of 127 entries
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Effect of six antiretroviral drugs (delavirdine, stavudine, lamivudine, nelfinavir, amprenavir and lopinavir/ritonavir in association) on albino pregnant rats (Rattus norvegicus Albinus, Rodentia, Mammalia): biological assay.

Ceska gynekologie

Nakamura MU, Araujo Júnior E, Simões JM, Oliveria RM, Kulay LJ.
PMID: 25398151
Ceska Gynekol. 2014 Aug;79(4):295-304.

OBJECTIVE: To compare the chronic effects of antiretrovirals (lamivudine, stavudine, delavirdine, nelfinavir, amprenavir and an association of lopinavir/ritonavir) on albino pregnant rats.DESIGN: Review.SETTING: Department of Obstetrics, Federal University of São Paulo (UNIFESP), São Paulo, SP, Brazil.METHODS: This was a...

Higher rates of metabolic syndrome among women taking zidovudine as compared to tenofovir in rural Africa: preliminary data from the CART-1 study.

Journal of the International AIDS Society

Labhardt ND, Cheleboi M, Faturyiele O, Motlatsi MM, Pfeiffer K, Lejone TI, Cerutti B, Muser J, Gupta RS, Lynen L, Hatz C.
PMID: 25394059
J Int AIDS Soc. 2014 Nov 02;17(4):19552. doi: 10.7448/IAS.17.4.19552. eCollection 2014.

INTRODUCTION: Due to its side effects stavudine (D4T) has been replaced by zidovudine (AZT) and tenofovir (TDF) in most low- and middle-income countries (LMICs). In 2014 about 38% of adult first-line regimens contain AZT and 62% TDF [1]. Whereas...

Estimation of the true incidence of lactic acidosis within the Lighthouse Clinic cohort, and the likely magnitude of missed diagnoses in the region.

Journal of the International AIDS Society

Speight C, Gabriel L, Phiri S, Tweya H, Sutherland R.
PMID: 25394065
J Int AIDS Soc. 2014 Nov 02;17(4):19558. doi: 10.7448/IAS.17.4.19558. eCollection 2014.

INTRODUCTION: Lactic acidosis is one of the most serious side effects associated with ART, most commonly associated with stavudine. Clinical features are non-specific and specialist laboratory capabilities are essential to confirm the diagnosis, making under-diagnosis likely in resource-constrained settings....

Stavudine: A Review.

The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases

Fuchs JE, Pollard RB.
PMID: 11101906
Braz J Infect Dis. 1998 Feb;2(1):10-17.

Stavudine was the fourth nucleoside analog to be approved in the United States for the management of HIV-1 infections. It is a dideoxy analog of thymidine and is structurally similar to zidovudine. In adults, the usual dose is 40mg...

Neuropsychiatric Effects of Antiviral Drugs.

Cureus

Zareifopoulos N, Lagadinou M, Karela A, Kyriakopoulou O, Velissaris D.
PMID: 32905132
Cureus. 2020 Aug 03;12(8):e9536. doi: 10.7759/cureus.9536.

The adverse events of antiviral drugs are dose-dependent and often reversible. The nervous system is often affected and to date, many studies have been published regarding the central nervous system toxicity of antiviral agents. They may cause significant neuropsychiatric...

Lipodystrophy among HIV-Infected Patients Attending Care and Treatment Clinics in Dar es Salaam.

AIDS research and treatment

Njelekela M, Mpembeni R, Muhihi A, Ulenga N, Aris E, Kakoko D.
PMID: 29158917
AIDS Res Treat. 2017;2017:3896539. doi: 10.1155/2017/3896539. Epub 2017 Oct 11.

BACKGROUND: HIV infection and long-term HAART use are associated with metabolic and morphological changes. We assessed prevalence, types, and risk factors associated with lipodystrophy among HIV-infected adults attending CTC in Dar es Salaam, Tanzania.METHODS: Analysis included 466 HIV-infected patients....

Mitochondrial toxicities of nucleoside analogue reverse transcriptase inhibitors in AIDS cases.

Indian journal of sexually transmitted diseases and AIDS

Marfatia YS, Talwar M, Agrawal M, Sharma A, Mehta K.
PMID: 26396441
Indian J Sex Transm Dis AIDS. 2014 Jul-Dec;35(2):96-9. doi: 10.4103/0253-7184.142395.

UNLABELLED: The development of antiretroviral therapy (ART) has been one of the most dramatic progressions in the history of medicine. Concomitant with this momentous therapeutic advance, the mitochondrial toxicities of ART were recognized as an important clinical entity.AIM: The...

Severe antiretroviral therapy-induced toxic epidermal necrolysis in a child.

Case reports in dermatology

Norris JM, Stuttaford LH, Dowds LF.
PMID: 22611363
Case Rep Dermatol. 2012 Jan;4(1):31-6. doi: 10.1159/000336569. Epub 2012 Feb 08.

Toxic epidermal necrolysis (TEN) is a rare and life-threatening condition characterised by extensive epidermal detachment and mucosal erosion. Adverse drug reaction is a strongly correlated causative factor and TEN is currently considered the most severe end of a spectrum...

Chronic ethanol use in alcoholic beverages by HIV-infected patients affects the therapeutic window of stavudine, lamivudine and nevirapine during the 9-month follow-up period: using chronic alcohol-use biomarkers.

Journal of basic and clinical physiology and pharmacology

Bbosa GS, Kyegombe DB, Anokbonggo WW, Ogwal-Okeng J, Musoke D, Odda J, Lubega A, Ntale M.
PMID: 24468616
J Basic Clin Physiol Pharmacol. 2014 Jan 27;1-12. doi: 10.1515/jbcpp-2013-0089. Epub 2014 Jan 27.

Abstract Background: Chronic ethanol use is a global problem including among HIV-infected patients on stavudine/lamivudine/nevirapine (d4T/3TC/NVP) regimen. The study determined the effect of chronic ethanol use on the therapeutic window of d4T, 3TC and NVP in HIV-infected patients using...

Stavudine:pharmacology,clinical use and future role.

Expert opinion on investigational drugs

Moyle GJ.
PMID: 15989602
Expert Opin Investig Drugs. 1997 Feb;6(2):191-200. doi: 10.1517/13543784.6.2.191.

Stavudine is a nucleoside analogue reverse transcriptase inhibitor of HIV-1 and HIV-2 and demonstrates in vitro activity with an acceptable therapeutic index in a range of T-lymphocyte and haematopoietic precursor cell lines. It is additive or synergistic in vitro...

Lack of association between stavudine exposure and lipoatrophy, dysglycaemia, hyperlactataemia and hypertriglyceridaemia: a prospective cross sectional study.

AIDS research and therapy

Sinxadi PZ, van der Walt JS, McIlleron HM, Badri M, Smith PJ, Dave JA, Levitt NS, Maartens G.
PMID: 20630064
AIDS Res Ther. 2010 Jul 14;7:23. doi: 10.1186/1742-6405-7-23.

BACKGROUND: Stavudine continues to be widely used in resource poor settings despite its toxicity. Our objective was to determine association between plasma stavudine concentrations and lipoatrophy, concentrations of glucose, lactate and triglycerides.METHODS: Participants were enrolled in a cross-sectional study...

Plasma drug level validates self-reported adherence but predicts limited specificity for nonadherence to antiretroviral therapy.

ISRN pharmacology

Balikuddembe R, Kayiwa J, Musoke D, Ntale M, Baveewo S, Waako P, Obua C.
PMID: 22530137
ISRN Pharmacol. 2012;2012:274978. doi: 10.5402/2012/274978. Epub 2012 Mar 06.

Introduction. Adherence to antiretroviral therapy (ART) in low-income countries is mainly assessed by self-reported adherence (S-RA) without drug level determination. Nonadherence is an important factor in the emergence of resistance to ART, presenting a need for drug level determination....

Showing 25 to 36 of 127 entries