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Triple-nucleoside analog antiretroviral therapy: is there still a role in clinical practice? A review.

Journal of the International AIDS Society

Kessler HA.
PMID: 19825128
J Int AIDS Soc. 2005 Jun 02;7(2):70. doi: 10.1186/1758-2652-7-2-70.

The development and widespread clinical use of coformulated abacavir/lamivudine/zidovudine (ABC/3TC/ZDV) as Trizivir represented an important advance in the management of HIV-infected patients, especially those with adherence challenges. With a low pill burden, no food restrictions, limited drug-drug interactions, and...

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Kessler HA. Triple-nucleoside analog antiretroviral therapy: is there still a role in clinical practice? A review. J Int AIDS Soc. 2005;7(2):70doi: 10.1186/1758-2652-7-2-70.
Kessler, H. A. (2005). Triple-nucleoside analog antiretroviral therapy: is there still a role in clinical practice? A review. Journal of the International AIDS Society, 7(2), 70. https://doi.org/10.1186/1758-2652-7-2-70
Kessler, Harold A. "Triple-nucleoside analog antiretroviral therapy: is there still a role in clinical practice? A review." Journal of the International AIDS Society vol. 7,2 (2005): 70. doi: https://doi.org/10.1186/1758-2652-7-2-70
Kessler HA. Triple-nucleoside analog antiretroviral therapy: is there still a role in clinical practice? A review. J Int AIDS Soc. 2005 Jun 02;7(2):70. doi: 10.1186/1758-2652-7-2-70. PMID: 19825128; PMCID: PMC2740786.
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Five-year follow up of genotypic resistance patterns in HIV-1 subtype C infected patients in Botswana after failure of thymidine analogue-based regimens.

Journal of the International AIDS Society

Doualla-Bell F, Gaolathe T, Avalos A, Cloutier S, Ndwapi N, Holcroft C, Moffat H, Dickinson D, Essex M, Wainberg MA, Mine M.
PMID: 19852859
J Int AIDS Soc. 2009 Oct 25;12:25. doi: 10.1186/1758-2652-12-25.

OBJECTIVE: Our objective was to establish genotypic resistance profiles among the 4% of Batswana patients who experienced virologic failure while being followed within Botswana's National Antiretroviral Treatment Program between 2002 and 2007.METHODS: At the beginning of the national program...

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Doualla-Bell F, Gaolathe T, Avalos A, et al. Five-year follow up of genotypic resistance patterns in HIV-1 subtype C infected patients in Botswana after failure of thymidine analogue-based regimens. J Int AIDS Soc. 2009;12:25doi: 10.1186/1758-2652-12-25.
Doualla-Bell, F., Gaolathe, T., Avalos, A., Cloutier, S., Ndwapi, N., Holcroft, C., Moffat, H., Dickinson, D., Essex, M., Wainberg, M. A., & Mine, M. (2009). Five-year follow up of genotypic resistance patterns in HIV-1 subtype C infected patients in Botswana after failure of thymidine analogue-based regimens. Journal of the International AIDS Society, 1225. https://doi.org/10.1186/1758-2652-12-25
Doualla-Bell, Florence, et al. "Five-year follow up of genotypic resistance patterns in HIV-1 subtype C infected patients in Botswana after failure of thymidine analogue-based regimens." Journal of the International AIDS Society vol. 12 (2009): 25. doi: https://doi.org/10.1186/1758-2652-12-25
Doualla-Bell F, Gaolathe T, Avalos A, Cloutier S, Ndwapi N, Holcroft C, Moffat H, Dickinson D, Essex M, Wainberg MA, Mine M. Five-year follow up of genotypic resistance patterns in HIV-1 subtype C infected patients in Botswana after failure of thymidine analogue-based regimens. J Int AIDS Soc. 2009 Oct 25;12:25. doi: 10.1186/1758-2652-12-25. PMID: 19852859; PMCID: PMC2770537.
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Ionotropically Gelled Novel Hydrogel Beads: Preparation, Characterization and In vitro Evaluation.

Indian journal of pharmaceutical sciences

Patil JS, Kamalapur MV, Marapur SC, Shiralshetti SS.
PMID: 22923862
Indian J Pharm Sci. 2011 Sep;73(5):504-9. doi: 10.4103/0250-474X.98988.

Prolonged release drug delivery system of stavudine was made by ionotropic gelation and polyelectrolyte complexation technique. Cross-linking reinforced chitosan-gellan complex beads were prepared by gelation of anionic gellan gum, the primary polymer, with oppositely charged counter ion to form...

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Patil JS, Kamalapur MV, Marapur SC, et al. Ionotropically Gelled Novel Hydrogel Beads: Preparation, Characterization and In vitro Evaluation. Indian J Pharm Sci. 2011;73(5):504-9doi: 10.4103/0250-474X.98988.
Patil, J. S., Kamalapur, M. V., Marapur, S. C., & Shiralshetti, S. S. (2011). Ionotropically Gelled Novel Hydrogel Beads: Preparation, Characterization and In vitro Evaluation. Indian journal of pharmaceutical sciences, 73(5), 504-9. https://doi.org/10.4103/0250-474X.98988
Patil, J S, et al. "Ionotropically Gelled Novel Hydrogel Beads: Preparation, Characterization and In vitro Evaluation." Indian journal of pharmaceutical sciences vol. 73,5 (2011): 504-9. doi: https://doi.org/10.4103/0250-474X.98988
Patil JS, Kamalapur MV, Marapur SC, Shiralshetti SS. Ionotropically Gelled Novel Hydrogel Beads: Preparation, Characterization and In vitro Evaluation. Indian J Pharm Sci. 2011 Sep;73(5):504-9. doi: 10.4103/0250-474X.98988. PMID: 22923862; PMCID: PMC3425061.
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Antiretroviral therapy in resource-limited settings: is there still a role for stavudine?.

Antiviral therapy

Gallant JE.
PMID: 23220760
Antivir Ther. 2012;17(8):1507-9. doi: 10.3851/IMP2498. Epub 2012 Dec 07.

Phanuphak et al. compared three strategies for first-line antiretroviral therapy in 150 Thai patients: initiating therapy with zidovudine (AZT), tenofovir disoproxil fumarate (TDF), or a 24-week lead-in phase with stavudine (d4T) followed by a switch to AZT. Those taking...

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Gallant JE. Antiretroviral therapy in resource-limited settings: is there still a role for stavudine?. Antivir Ther. 2012;17(8):1507-9doi: 10.3851/IMP2498.
Gallant, J. E. (2012). Antiretroviral therapy in resource-limited settings: is there still a role for stavudine?. Antiviral therapy, 17(8), 1507-9. https://doi.org/10.3851/IMP2498
Gallant, Joel E. "Antiretroviral therapy in resource-limited settings: is there still a role for stavudine?." Antiviral therapy vol. 17,8 (2012): 1507-9. doi: https://doi.org/10.3851/IMP2498
Gallant JE. Antiretroviral therapy in resource-limited settings: is there still a role for stavudine?. Antivir Ther. 2012;17(8):1507-9. doi: 10.3851/IMP2498. Epub 2012 Dec 07. PMID: 23220760.
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An innovative approach to reducing pain in patients with peripheral neuropathy related to HIV: A single case study.

African journal of disability

Benjamin NA, Jelsma J.
PMID: 28730001
Afr J Disabil. 2014 Aug 07;3(1):118. doi: 10.4102/ajod.v3i1.118. eCollection 2014.

INTRODUCTION: Peripheral neuropathy (PN) is the most common neurological condition seen in people living with human immunodeficiency virus (HIV) and has been estimated to be present in up to 30% of people with AIDS. Prevalence may be increasing as...

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Benjamin NA, Jelsma J. An innovative approach to reducing pain in patients with peripheral neuropathy related to HIV: A single case study. Afr J Disabil. 2014;3(1):118doi: 10.4102/ajod.v3i1.118.
Benjamin, N. A., & Jelsma, J. (2014). An innovative approach to reducing pain in patients with peripheral neuropathy related to HIV: A single case study. African journal of disability, 3(1), 118. https://doi.org/10.4102/ajod.v3i1.118
Benjamin, Natalie A, and Jelsma, Jennifer. "An innovative approach to reducing pain in patients with peripheral neuropathy related to HIV: A single case study." African journal of disability vol. 3,1 (2014): 118. doi: https://doi.org/10.4102/ajod.v3i1.118
Benjamin NA, Jelsma J. An innovative approach to reducing pain in patients with peripheral neuropathy related to HIV: A single case study. Afr J Disabil. 2014 Aug 07;3(1):118. doi: 10.4102/ajod.v3i1.118. eCollection 2014. PMID: 28730001; PMCID: PMC5443043.
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Evaluation of Adverse Drug Reaction Profile of Drugs Used as First-Line Antiretroviral Therapy.

Interdisciplinary perspectives on infectious diseases

Chowta MN, Kamath P, Ramapuram JT, Shenoy KA, Hadigal S.
PMID: 30174689
Interdiscip Perspect Infect Dis. 2018 Aug 02;2018:8095609. doi: 10.1155/2018/8095609. eCollection 2018.

BACKGROUND AND OBJECTIVES: The objective was to study the adverse drug reaction (ADR) profile in HIV patients receiving first-line antiretroviral therapy.METHODS: This was a prospective, observational study that included 171 HIV patients with a follow-up at six months. Demographic...

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Chowta MN, Kamath P, Ramapuram JT, et al. Evaluation of Adverse Drug Reaction Profile of Drugs Used as First-Line Antiretroviral Therapy. Interdiscip Perspect Infect Dis. 2018;2018:8095609doi: 10.1155/2018/8095609.
Chowta, M. N., Kamath, P., Ramapuram, J. T., Shenoy, K. A., & Hadigal, S. (2018). Evaluation of Adverse Drug Reaction Profile of Drugs Used as First-Line Antiretroviral Therapy. Interdisciplinary perspectives on infectious diseases, 20188095609. https://doi.org/10.1155/2018/8095609
Chowta, Mukta N, et al. "Evaluation of Adverse Drug Reaction Profile of Drugs Used as First-Line Antiretroviral Therapy." Interdisciplinary perspectives on infectious diseases vol. 2018 (2018): 8095609. doi: https://doi.org/10.1155/2018/8095609
Chowta MN, Kamath P, Ramapuram JT, Shenoy KA, Hadigal S. Evaluation of Adverse Drug Reaction Profile of Drugs Used as First-Line Antiretroviral Therapy. Interdiscip Perspect Infect Dis. 2018 Aug 02;2018:8095609. doi: 10.1155/2018/8095609. eCollection 2018. PMID: 30174689; PMCID: PMC6098889.
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A novel (11)C-labeled thymidine analog, [(11)C]AZT, for tumor imaging by positron emission tomography.

EJNMMI research

Tahara T, Zhang Z, Ohno M, Hirao Y, Hosaka N, Doi H, Suzuki M, Onoe H.
PMID: 26337804
EJNMMI Res. 2015 Dec;5(1):124. doi: 10.1186/s13550-015-0124-0. Epub 2015 Sep 04.

BACKGROUND: Nucleoside analogs labeled with positrons, such as (11)C and (18)F, are considered valuable in visualizing the proliferative activity of tumor cells in vivo using positron emission tomography (PET). We recently developed the (11)C-labeled thymidine analogs [(11)C]zidovudine ([(11)C]AZT) and...

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Tahara T, Zhang Z, Ohno M, et al. A novel (11)C-labeled thymidine analog, [(11)C]AZT, for tumor imaging by positron emission tomography. EJNMMI Res. 2015;5(1):124doi: 10.1186/s13550-015-0124-0.
Tahara, T., Zhang, Z., Ohno, M., Hirao, Y., Hosaka, N., Doi, H., Suzuki, M., & Onoe, H. (2015). A novel (11)C-labeled thymidine analog, [(11)C]AZT, for tumor imaging by positron emission tomography. EJNMMI research, 5(1), 124. https://doi.org/10.1186/s13550-015-0124-0
Tahara, Tsuyoshi, et al. "A novel (11)C-labeled thymidine analog, [(11)C]AZT, for tumor imaging by positron emission tomography." EJNMMI research vol. 5,1 (2015): 124. doi: https://doi.org/10.1186/s13550-015-0124-0
Tahara T, Zhang Z, Ohno M, Hirao Y, Hosaka N, Doi H, Suzuki M, Onoe H. A novel (11)C-labeled thymidine analog, [(11)C]AZT, for tumor imaging by positron emission tomography. EJNMMI Res. 2015 Dec;5(1):124. doi: 10.1186/s13550-015-0124-0. Epub 2015 Sep 04. PMID: 26337804; PMCID: PMC4597405.
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Pharmacological and Epigenetic Regulators of NLRP3 Inflammasome Activation in Alzheimer's Disease.

Pharmaceuticals (Basel, Switzerland)

La Rosa F, Mancuso R, Agostini S, Piancone F, Marventano I, Saresella M, Hernis A, Fenoglio C, Galimberti D, Scarpini E, Clerici M.
PMID: 34832969
Pharmaceuticals (Basel). 2021 Nov 20;14(11). doi: 10.3390/ph14111187.

Activation of the NLRP3 inflammasome complex results in the production of IL-18, Caspase-1 and IL-1β. These cytokines have a beneficial role in promoting inflammation, but an excessive activation of the inflammasome and the consequent constitutive inflammatory status is a...

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La Rosa F, Mancuso R, Agostini S, et al. Pharmacological and Epigenetic Regulators of NLRP3 Inflammasome Activation in Alzheimer's Disease. Pharmaceuticals (Basel). 2021;14(11)doi: 10.3390/ph14111187.
La Rosa, F., Mancuso, R., Agostini, S., Piancone, F., Marventano, I., Saresella, M., Hernis, A., Fenoglio, C., Galimberti, D., Scarpini, E., & Clerici, M. (2021). Pharmacological and Epigenetic Regulators of NLRP3 Inflammasome Activation in Alzheimer's Disease. Pharmaceuticals (Basel, Switzerland), 14(11), . https://doi.org/10.3390/ph14111187
La Rosa, Francesca, et al. "Pharmacological and Epigenetic Regulators of NLRP3 Inflammasome Activation in Alzheimer's Disease." Pharmaceuticals (Basel, Switzerland) vol. 14,11 (2021). doi: https://doi.org/10.3390/ph14111187
La Rosa F, Mancuso R, Agostini S, Piancone F, Marventano I, Saresella M, Hernis A, Fenoglio C, Galimberti D, Scarpini E, Clerici M. Pharmacological and Epigenetic Regulators of NLRP3 Inflammasome Activation in Alzheimer's Disease. Pharmaceuticals (Basel). 2021 Nov 20;14(11). doi: 10.3390/ph14111187. PMID: 34832969; PMCID: PMC8623160.
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Mechanisms of resistance associated with excision of incorporated nucleotide analogue inhibitors of HIV-1 reverse transcriptase.

Current opinion in HIV and AIDS

Götte M.
PMID: 19372874
Curr Opin HIV AIDS. 2007 Mar;2(2):103-7. doi: 10.1097/COH.0b013e3280287a60.

PURPOSE OF REVIEW: Nucleoside analogue reverse transcriptase inhibitors are important components in current drug regimens used to treat infection with HIV. Despite the potency of drug combinations that involve two nucleoside reverse transcriptase inhibitors and a non-nucleoside analogue or...

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Götte M. Mechanisms of resistance associated with excision of incorporated nucleotide analogue inhibitors of HIV-1 reverse transcriptase. Curr Opin HIV AIDS. 2007;2(2):103-7doi: 10.1097/COH.0b013e3280287a60.
Götte, M. (2007). Mechanisms of resistance associated with excision of incorporated nucleotide analogue inhibitors of HIV-1 reverse transcriptase. Current opinion in HIV and AIDS, 2(2), 103-7. https://doi.org/10.1097/COH.0b013e3280287a60
Götte, Matthias. "Mechanisms of resistance associated with excision of incorporated nucleotide analogue inhibitors of HIV-1 reverse transcriptase." Current opinion in HIV and AIDS vol. 2,2 (2007): 103-7. doi: https://doi.org/10.1097/COH.0b013e3280287a60
Götte M. Mechanisms of resistance associated with excision of incorporated nucleotide analogue inhibitors of HIV-1 reverse transcriptase. Curr Opin HIV AIDS. 2007 Mar;2(2):103-7. doi: 10.1097/COH.0b013e3280287a60. PMID: 19372874.
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Mutations of mtDNA polymerase-γ and hyperlactataemia in the HIV-infected Zulu population of South Africa.

South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde

Ojwach DB, Aldous C, Kochleff P, Sartorius B.
PMID: 27917773
S Afr Med J. 2016 Dec 01;106(12):1254-1259. doi: 10.7196/SAMJ.2016.v106.i12.10818.

BACKGROUND: Mitochondrial toxicity, particularly symptomatic hyperlactataemia or lactic acidosis (SHL/LA), has been attributed to the use of nucleoside reverse transcriptase inhibitors (NRTIs), possibly because of their capacity to impede human mitochondrial DNA polymerase-γ (POLG), which is responsible for the...

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Ojwach DB, Aldous C, Kochleff P, et al. Mutations of mtDNA polymerase-γ and hyperlactataemia in the HIV-infected Zulu population of South Africa. S Afr Med J. 2016;106(12):1254-1259doi: 10.7196/SAMJ.2016.v106.i12.10818.
Ojwach, D. B., Aldous, C., Kochleff, P., & Sartorius, B. (2016). Mutations of mtDNA polymerase-γ and hyperlactataemia in the HIV-infected Zulu population of South Africa. South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 106(12), 1254-1259. https://doi.org/10.7196/SAMJ.2016.v106.i12.10818
Ojwach, D B A, et al. "Mutations of mtDNA polymerase-γ and hyperlactataemia in the HIV-infected Zulu population of South Africa." South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde vol. 106,12 (2016): 1254-1259. doi: https://doi.org/10.7196/SAMJ.2016.v106.i12.10818
Ojwach DB, Aldous C, Kochleff P, Sartorius B. Mutations of mtDNA polymerase-γ and hyperlactataemia in the HIV-infected Zulu population of South Africa. S Afr Med J. 2016 Dec 01;106(12):1254-1259. doi: 10.7196/SAMJ.2016.v106.i12.10818. PMID: 27917773.
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Modulation of long interspersed nuclear element-1 in the mouse hippocampus during maturation.

Mobile genetic elements

Ueno M, Okamura T, Mishina M, Ishizaka Y.
PMID: 27583186
Mob Genet Elements. 2016 Jul 13;6(4):e1211980. doi: 10.1080/2159256X.2016.1211980. eCollection 2016.

BACKGROUND: Retrotransposition of long interspersed nuclear element-1 (L1-RTP) is proposed to contribute to central nervous system (CNS) plasticity by inducing mosaicism of neuronal cells. Clinical studies have identified increased L1 copy numbers in the brains of patients with psychiatric...

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Ueno M, Okamura T, Mishina M, et al. Modulation of long interspersed nuclear element-1 in the mouse hippocampus during maturation. Mob Genet Elements. 2016;6(4):e1211980doi: 10.1080/2159256X.2016.1211980.
Ueno, M., Okamura, T., Mishina, M., & Ishizaka, Y. (2016). Modulation of long interspersed nuclear element-1 in the mouse hippocampus during maturation. Mobile genetic elements, 6(4), e1211980. https://doi.org/10.1080/2159256X.2016.1211980
Ueno, Mikako, et al. "Modulation of long interspersed nuclear element-1 in the mouse hippocampus during maturation." Mobile genetic elements vol. 6,4 (2016): e1211980. doi: https://doi.org/10.1080/2159256X.2016.1211980
Ueno M, Okamura T, Mishina M, Ishizaka Y. Modulation of long interspersed nuclear element-1 in the mouse hippocampus during maturation. Mob Genet Elements. 2016 Jul 13;6(4):e1211980. doi: 10.1080/2159256X.2016.1211980. eCollection 2016. PMID: 27583186; PMCID: PMC4993569.
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Associations between Central Obesity and Life-Long Antiviral Therapy in Adults Living with HIV Acquired from Early Childhood.

Journal of acquired immune deficiency syndromes (1999)

Sahagun SJ, Yeramosu T, Purdy JB, Reynolds JC, Hadigan CM.
PMID: 34693931
J Acquir Immune Defic Syndr. 2021 Oct 19; doi: 10.1097/QAI.0000000000002841. Epub 2021 Oct 19.

BACKGROUND: Little is known regarding the long-term effects of antiretroviral (ARV) exposure on body composition for people living with HIV (PLWH) since early childhood. This study explores changes in body fat distribution in relation to ARV exposure.METHODS: We conducted...

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Sahagun SJ, Yeramosu T, Purdy JB, et al. Associations between Central Obesity and Life-Long Antiviral Therapy in Adults Living with HIV Acquired from Early Childhood. J Acquir Immune Defic Syndr. 2021;doi: 10.1097/QAI.0000000000002841.
Sahagun, S. J., Yeramosu, T., Purdy, J. B., Reynolds, J. C., & Hadigan, C. M. (2021). Associations between Central Obesity and Life-Long Antiviral Therapy in Adults Living with HIV Acquired from Early Childhood. Journal of acquired immune deficiency syndromes (1999), . https://doi.org/10.1097/QAI.0000000000002841
Sahagun, Seynt Jiro, et al. "Associations between Central Obesity and Life-Long Antiviral Therapy in Adults Living with HIV Acquired from Early Childhood." Journal of acquired immune deficiency syndromes (1999) vol. (2021). doi: https://doi.org/10.1097/QAI.0000000000002841
Sahagun SJ, Yeramosu T, Purdy JB, Reynolds JC, Hadigan CM. Associations between Central Obesity and Life-Long Antiviral Therapy in Adults Living with HIV Acquired from Early Childhood. J Acquir Immune Defic Syndr. 2021 Oct 19; doi: 10.1097/QAI.0000000000002841. Epub 2021 Oct 19. PMID: 34693931.
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Showing 13 to 24 of 127 entries