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Showing 13 to 24 of 53 entries
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Inhibitory Effects of Antipsychotics on the Contractile Response to Acetylcholine in Rat Urinary Bladder Smooth Muscles.

Biological & pharmaceutical bulletin

Obara K, Matsuoka Y, Iwata N, Abe Y, Ikegami Y, Shioda N, Hattori Y, Hamamatsu S, Yoshioka K, Yamaki F, Matsuo K, Yoshio T, Tanaka Y.
PMID: 34334499
Biol Pharm Bull. 2021;44(8):1140-1150. doi: 10.1248/bpb.b21-00363.

The clinical applications of antipsychotics for symptoms unrelated to schizophrenia, such as behavioral and psychological symptoms, in patients with Alzheimer's disease, and the likelihood of doctors prescribing antipsychotics for elderly people are increasing. In elderly people, drug-induced and aging-associated...

Placental pathology and fetal demise at 35 weeks of gestation in a woman with SARS-CoV-2 infection: A case report.

Case reports in women's health

Poisson TM, Pierone G.
PMID: 33527073
Case Rep Womens Health. 2021 Apr;30:e00289. doi: 10.1016/j.crwh.2021.e00289. Epub 2021 Jan 28.

The consequences of SARS-CoV-2 infection in pregnancy have not been well defined. However, there have been a number of reports of poor maternal and fetal outcomes worldwide. This report presents a case of stillbirth with associated placental pathology during...

Multiple high-affinity binding sites for.

The Journal of experimental biology

Winberg S, Nilsson G.
PMID: 9320352
J Exp Biol. 1996;199:2429-35.

Binding of [3H]serotonin (5-HT) to membranes prepared from Arctic charr brain homogenates was most consistent with a one-site model for [3H]5-HT binding, with KD and Bmax values of 5.7±0.3 nmol l-1 and 60.7±7.3 fmol mg-1 protein, respectively. Similarly, 5-HT...

Intrastriatal Dopamine-rich Implants Reverse the Increase of Dopamine D2 Receptor mRNA Levels Caused by Lesion of the Nigrostriatal Pathway: A Quantitative In Situ Hybridization Study.

The European journal of neuroscience

Chritin M, Savasta M, Mennicken F, Bal A, Abrous DN, Le Moal M, Feuerstein C, Herman JP.
PMID: 12106330
Eur J Neurosci. 1992;4(7):663-672. doi: 10.1111/j.1460-9568.1992.tb00175.x.

Changes in striatal dopamine D2 receptor mRNA levels provoked by unilateral 6-hydroxydopamine-induced lesion of the nigrostriatal dopamine pathway were studied by in situ hybridization. The influence of embryonic dopaminergic neurons implanted into the dopamine-depleted striatum on the lesion-induced changes...

Intravenous self-administration of cathinone by rats.

Behavioural pharmacology

Gosnell BA, Yracheta JM, Bell SM, Lane KE.
PMID: 11224449
Behav Pharmacol. 1996 Nov;7(6):526-531.

Cathinone is the principal psychoactive constituent in leaves of the khat shrub. In some parts of the world, khat leaves are commonly chewed for their stimulant effects. While it has been demonstrated that rhesus monkeys will self-administer cathinone, there...

Stimulation of central 5-HT1D receptors causes hypothermia in the guinea-pig.

Journal of psychopharmacology (Oxford, England)

Skingle M, Higgins GA, Feniuk W.
PMID: 22298475
J Psychopharmacol. 1994 Jan;8(1):14-21. doi: 10.1177/026988119400800103.

The 5-HT(1) receptor agonist GR46611 (3-30 mg/kg s.c.) caused a dose-related decrease in rectal temperature in the adult guinea-pig. A lower dose (20 μg) administered directly into the lateral cerebral ventricle also caused a hypothermic response, suggesting that this...

BMY 7378: Partial agonist at spinal cord 5-HT(1A) receptors.

Neurochemistry international

Zemlan FP, Zieleniewski-Murphy A, Maureen Murphy R, Behbehani MM.
PMID: 20504590
Neurochem Int. 1990;16(4):515-22. doi: 10.1016/0197-0186(90)90011-h.

Recent data indicate that BMY 7378 demonstrates high affinity, selectivity and low intrinsic activity at hippocampal 5-HT(1A) receptors, suggesting that BMY 7378 may represent the first selective 5-HT(1A) functional antagonist. The present study examined the agonist and antagonist properties...

Effects of bicarbonate ion on serotonin binding to rat frontal cortex membranes.

Neurochemistry international

Fujita M, Seo T, Nishio H, Segawa T.
PMID: 20493052
Neurochem Int. 1986;8(2):235-42. doi: 10.1016/0197-0186(86)90169-5.

Several factors are known to regulate ligand binding to 5-hydroxytryptamine (5-HT) receptors. In the present experiments we have investigated the mechanism by which bicarbonate ion modify central 5-HT receptor sensitivity in rats. Mn(2+) (10(?6)-10(?3)M) increased specific [(3)H]5-HT binding to...

Effects of NaCl and sultopride on striatal [(3)H]spiperone binding in neonatal, adult and senescent rats.

International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience

Makihata J, Nomura Y.
PMID: 24874236
Int J Dev Neurosci. 1984;2(5):421-6. doi: 10.1016/0736-5748(84)90043-1.

Effects of NaCl, (+)-and (-)-sultopride on striatal [(3)H]spiperone binding was investigated in 7-day, 70-day and 2-year-old rats. The amount of specific [(3)H]spiperone binding was the highest at 70 days and the value at adult stage was significantly (P <...

Electroacupuncture-Induced Neuroprotection against Cerebral Ischemia in Rats: Role of the Dopamine D2 Receptor.

Evidence-based complementary and alternative medicine : eCAM

Xu MS, Zhang SJ, Zhao D, Liu CY, Li CZ, Chen CY, Li LH, Li MZ, Xu J, Ge LB.
PMID: 24348687
Evid Based Complement Alternat Med. 2013;2013:137631. doi: 10.1155/2013/137631. Epub 2013 Nov 21.

Background. Cerebral ischemia is known to produce brain damage and related behavioural deficits, including memory deficits and motor disorders. Evidence shows that EA significantly promotes recovery of neurological function and thus improves quality of life. Objective. Evidence exists for...

Pharmacological analysis of dopamine modulation in the Drosophila melanogaster larval heart.

Physiological reports

Titlow JS, Rufer JM, King KE, Cooper RL.
PMID: 24303109
Physiol Rep. 2013 Jul;1(2):e00020. doi: 10.1002/phy2.20. Epub 2013 Jun 26.

Dopamine (DA) and other neurotransmitters affect nonneuronal tissues in insects by circulating in the hemolymph. In several organisms, DA has been shown to modulate distinct aspects of cardiac function but the signal transduction pathways that mediate dopaminergic effects on...

Using transects to disentangle the environmental drivers of plant-microbiome assembly.

Plant, cell & environment

Mittelstrass J, Sperone FG, Horton MW.
PMID: 34562029
Plant Cell Environ. 2021 Dec;44(12):3515-3525. doi: 10.1111/pce.14190. Epub 2021 Oct 03.

Environmental heterogeneity is a major driver of plant-microbiome assembly, but the specific climate and soil conditions that are involved remain poorly understood. To better understand plant microbiome formation, we examined the bacteria and fungi that colonize wild strawberry (Fragaria...

Showing 13 to 24 of 53 entries