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Showing 25 to 36 of 2759 entries
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Lithium protects against paraquat neurotoxicity by NRF2 activation and miR-34a inhibition in SH-SY5Y cells.

Frontiers in cellular neuroscience

Alural B, Ozerdem A, Allmer J, Genc K, Genc S.
PMID: 26074776
Front Cell Neurosci. 2015 May 28;9:209. doi: 10.3389/fncel.2015.00209. eCollection 2015.

Lithium is a mood stabilizing agent commonly used for the treatment of bipolar disorder. Here, we investigated the potential neuroprotective effect of lithium against paraquat toxicity and its underlying mechanisms in vitro. SH-SY5Y human neuroblastoma cells were treated with...

Revolutionizing Alzheimer's disease and clinical trials through biomarkers.

Alzheimer's & dementia (Amsterdam, Netherlands)

Mattsson N, Carrillo MC, Dean RA, Devous MD, Nikolcheva T, Pesini P, Salter H, Potter WZ, Sperling RS, Bateman RJ, Bain LJ, Liu E.
PMID: 27239522
Alzheimers Dement (Amst). 2015 Oct 03;1(4):412-9. doi: 10.1016/j.dadm.2015.09.001. eCollection 2015 Dec.

The Alzheimer's Association's Research Roundtable met in May 2014 to explore recent progress in developing biomarkers to improve understanding of disease pathogenesis and expedite drug development. Although existing biomarkers have proved extremely useful for enrichment of subjects in clinical...

Exogenous spermine pretreatment confers tolerance to combined high-temperature and drought stress .

Biotechnology, biotechnological equipment

Fu XZ, Xing F, Wang NQ, Peng LZ, Chun CP, Cao L, Ling LL, Jiang CL.
PMID: 26019505
Biotechnol Biotechnol Equip. 2014 Mar 04;28(2):192-198. doi: 10.1080/13102818.2014.909152. Epub 2014 Jul 08.

Spermine (Spm) is thought to play an important role in drought or high-temperature (HT) tolerance. However, it is not clear whether Spm confers similar resistance in the presence of both drought and HT, which often occur simultaneously. In the...

Survival and severity in dominant cerebellar ataxias.

Annals of clinical and translational neurology

Monin ML, Tezenas du Montcel S, Marelli C, Cazeneuve C, Charles P, Tallaksen C, Forlani S, Stevanin G, Brice A, Durr A.
PMID: 25750924
Ann Clin Transl Neurol. 2015 Feb;2(2):202-7. doi: 10.1002/acn3.156. Epub 2015 Jan 07.

Inherited spinocerebellar ataxias (SCAs) are known to be genetically and clinically heterogeneous. Whether severity and survival are variable, however, is not known. We, therefore, studied survival and severity in 446 cases and 509 relatives with known mutations. Survival was...

Erratum: CCL19-CCR7-dependent reverse transendothelial migration of myeloid cells clears Chlamydia muridarum from the arterial intima.

Nature immunology

Roufaiel M, Gracey E, Siu A, Zhu SN, Lau A, Ibrahim H, Althagafi M, Tai K, Hyduk SJ, Cybulsky KO, Ensan S, Li A, Besla R, Becker HM, Xiao H, Luther SA, Inman RD, Robbins CS, Jongstra-Bilen J, Cybulsky MI.
PMID: 28518165
Nat Immunol. 2017 May 18;18(6):705. doi: 10.1038/ni0617-705d.

No abstract available.

A Practical Guide to Immunoassay Method Validation.

Frontiers in neurology

Andreasson U, Perret-Liaudet A, van Waalwijk van Doorn LJ, Blennow K, Chiasserini D, Engelborghs S, Fladby T, Genc S, Kruse N, Kuiperij HB, Kulic L, Lewczuk P, Mollenhauer B, Mroczko B, Parnetti L, Vanmechelen E, Verbeek MM, Winblad B, Zetterberg H, Koel-Simmelink M, Teunissen CE.
PMID: 26347708
Front Neurol. 2015 Aug 19;6:179. doi: 10.3389/fneur.2015.00179. eCollection 2015.

Biochemical markers have a central position in the diagnosis and management of patients in clinical medicine, and also in clinical research and drug development, also for brain disorders, such as Alzheimer's disease. The enzyme-linked immunosorbent assay (ELISA) is frequently...

MicroRNAs, polyamines, and the activities antioxidant enzymes are associated with in vitro rooting in white pine (Pinus strobus L.).

SpringerPlus

Fei Y, Xiao B, Yang M, Ding Q, Tang W.
PMID: 27069836
Springerplus. 2016 Apr 06;5:416. doi: 10.1186/s40064-016-2080-1. eCollection 2016.

Molecular mechanism of in vitro rooting in conifer is not fully understood. After establishment of a regeneration procedure in eastern white pine (Pinus strobus L.) using mature embryos as explants to induce shoot formation on medium containing 3 μM...

Platelet-rich plasma (PRP) treatment of sports-related severe acute hamstring injuries.

Muscles, ligaments and tendons journal

Guillodo Y, Madouas G, Simon T, Le Dauphin H, Saraux A.
PMID: 26958537
Muscles Ligaments Tendons J. 2016 Feb 13;5(4):284-8. doi: 10.11138/mltj/2015.5.4.284. eCollection 2015.

PURPOSE: hamstring injury is the most common musculoskeletal disorder and one of the main causes of missed sporting events. Shortening the time to return to play (TTRTP) is a priority for athletes and sports medicine practitioners.HYPOTHESIS: platelet-rich plasma (PRP)...

Polyamines Confer Salt Tolerance in Mung Bean (Vigna radiata L.) by Reducing Sodium Uptake, Improving Nutrient Homeostasis, Antioxidant Defense, and Methylglyoxal Detoxification Systems.

Frontiers in plant science

Nahar K, Hasanuzzaman M, Rahman A, Alam MM, Mahmud JA, Suzuki T, Fujita M.
PMID: 27516763
Front Plant Sci. 2016 Jul 28;7:1104. doi: 10.3389/fpls.2016.01104. eCollection 2016.

The physiological roles of PAs (putrescine, spermidine, and spermine) were investigated for their ability to confer salt tolerance (200 mM NaCl, 48 h) in mung bean seedlings (Vigna radiata L. cv. BARI Mung-2). Salt stress resulted in Na toxicity,...

Complications in reverse shoulder arthroplasty.

EFORT open reviews

Barco R, Savvidou OD, Sperling JW, Sanchez-Sotelo J, Cofield RH.
PMID: 28461931
EFORT Open Rev. 2017 Mar 13;1(3):72-80. doi: 10.1302/2058-5241.1.160003. eCollection 2016 Mar.

The reported rate of complications of reverse shoulder arthroplasty (RSA) seems to be higher than the complication rate of anatomical total shoulder arthroplasty.The reported overall complication rate of primary RSA is approximately 15%; when RSA is used in the...

Using magnetic nanoparticles for gene transfer to neural stem cells: stem cell propagation method influences outcomes.

Journal of functional biomaterials

Pickard MR, Adams CF, Barraud P, Chari DM.
PMID: 25918990
J Funct Biomater. 2015 Apr 24;6(2):259-76. doi: 10.3390/jfb6020259.

Genetically engineered neural stem cell (NSC) transplants offer a key strategy to augment neural repair by releasing therapeutic biomolecules into injury sites. Genetic modification of NSCs is heavily reliant on viral vectors but cytotoxic effects have prompted development of...

Over-Expression of Meteorin Drives Gliogenesis Following Striatal Injury.

Frontiers in cellular neuroscience

Wright JL, Ermine CM, Jørgensen JR, Parish CL, Thompson LH.
PMID: 27458346
Front Cell Neurosci. 2016 Jul 05;10:177. doi: 10.3389/fncel.2016.00177. eCollection 2016.

A number of studies have shown that damage to brain structures adjacent to neurogenic regions can result in migration of new neurons from neurogenic zones into the damaged tissue. The number of differentiated neurons that survive is low, however,...

Showing 25 to 36 of 2759 entries