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Showing 25 to 36 of 416 entries
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Flow-injection spectrophotometric determination of reverse transcriptase inhibitors used for acquired immuno deficiency syndrome (AIDS) treatment: focus on strategies for dealing with the background components.

Analytica chimica acta

Checa A, Oliver R, Saurina J, Hernández-Cassou S.
PMID: 17723473
Anal Chim Acta. 2006 Jul 14;572(1):155-64. doi: 10.1016/j.aca.2006.05.041. Epub 2006 May 20.

This paper describes a rapid method for the quantification of reverse transcriptase inhibitors in mixtures of therapeutic interest containing zidovudine, zalcitabine and nevirapine. The method is based on a pH-gradient flow-injection system with diode array detection and further data...

Antiretroviral therapy: when to start and which drugs to use.

Current infectious disease reports

Anderson AM, Lennox JL.
PMID: 18765108
Curr Infect Dis Rep. 2008 Jul;10(4):332-9. doi: 10.1007/s11908-008-0053-4.

US guidelines for treating HIV infection now advocate antiretroviral therapy (ART) for all HIV-infected patients who have CD4(+) T-cell counts less than 350 cells/muL. Treatment is recommended for all pregnant women and patients with AIDS-defining illnesses. At least one...

Influence of non-nucleoside reverse transcriptase inhibitors (efavirenz and nevirapine) on the pharmacodynamic activity of gliclazide in animal models.

Diabetology & metabolic syndrome

Mastan S, Kumar KE.
PMID: 19825151
Diabetol Metab Syndr. 2009 Oct 09;1(1):15. doi: 10.1186/1758-5996-1-15.

BACKGROUND: Type 2 diabetes may occur as a result of HIV infection and/or its treatment. Gliclazide is a widely used drug for the treatment of type 2 diabetes. Efavirenz and nevirapine are widely used non-nucleoside reverse transcriptase inhibitors for...

Five-year follow up of genotypic resistance patterns in HIV-1 subtype C infected patients in Botswana after failure of thymidine analogue-based regimens.

Journal of the International AIDS Society

Doualla-Bell F, Gaolathe T, Avalos A, Cloutier S, Ndwapi N, Holcroft C, Moffat H, Dickinson D, Essex M, Wainberg MA, Mine M.
PMID: 19852859
J Int AIDS Soc. 2009 Oct 25;12:25. doi: 10.1186/1758-2652-12-25.

OBJECTIVE: Our objective was to establish genotypic resistance profiles among the 4% of Batswana patients who experienced virologic failure while being followed within Botswana's National Antiretroviral Treatment Program between 2002 and 2007.METHODS: At the beginning of the national program...

Nelfinavir and non-nucleoside reverse transcriptase inhibitor-based salvage regimens in heavily HIV pretreated patients.

The Canadian journal of infectious diseases = Journal canadien des maladies infectieuses

Baril JG, Lefebvre EA, Lalonde RG, Shafran SD, Conway B.
PMID: 18159457
Can J Infect Dis. 2003 Jul;14(4):201-5. doi: 10.1155/2003/309724.

OBJECTIVE: To assess the efficacy of nelfinavir mesylate (NFV) in combination with delavirdine mesylate (DLV) or efavirenz (EFV) and other antiretroviral agents following virological failure on other protease inhibitor (PI)-based regimens.DESIGN: Multicentre, retrospective chart review.METHODS: One hundred-one patients who...

Current therapy of HIV.

Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG

Potthoff AV, Brockmeyer NH.
PMID: 20096060
J Dtsch Dermatol Ges. 2010 Jan;8(1):45-56; quiz 57-8. doi: 10.1111/j.1610-0387.2009.07098_supp.x.

Antiretroviral therapy has improved continuously. Almost every year a new drug has been approved. Nucleoside analogs still build the backbone of antiretroviral therapy. They inhibit reverse transcriptase and thus the transcription of RNA to DNA. They are combined with...

6-Cyclo-hexyl-methyl-2-cyclo-hexyl-sul-fanyl-5-isopropyl-pyrimidin-4(3H)-one.

Acta crystallographica. Section E, Structure reports online

Zhang CS, Li DX, Zhang DH, He YP, Li C.
PMID: 21201750
Acta Crystallogr Sect E Struct Rep Online. 2008 Aug 16;64:o1768. doi: 10.1107/S1600536808025592.

The title compound, C(20)H(32)N(2)OS, was obtained during the course of our investigation on 2-alkylsulfanyl-6-benzyl-3,4-dihydropyrimidin-4(3H)-ones (S-DABOs) showing favourable anti-HIV-1 activity. Both cyclo-hexane rings adopt chair conformations. The angle at the methyl-ene C atom linking the pyrimidine and cyclo-hexane ring is...

The role of combinations of HIV protease inhibitors in the management of persons with HIV infection.

Expert opinion on investigational drugs

Moyle G.
PMID: 15991982
Expert Opin Investig Drugs. 1998 Mar;7(3):413-26. doi: 10.1517/13543784.7.3.413.

The current standard of care in antiretroviral therapy includes two nucleoside analogue reverse transcriptase inhibitors (NRTIs) plus a potent third agent, usually an HIV protease inhibitor (PI). However, around 20 - 30% of patients initiating therapy in clinical studies,...

Treatment of pediatric HIV infection.

Current infectious disease reports

d'Oulx EA, Chiappini E, de Martino M, Tovo PA.
PMID: 17880854
Curr Infect Dis Rep. 2007 Sep;9(5):425-33. doi: 10.1007/s11908-007-0065-5.

HIV-infected children require a peculiar management when compared to infected adults. Antiretroviral therapy has been quite well adapted to children, but new studies are needed to answer many unsolved questions, such as when to start therapy in asymptomatic infected...

Newer antiretroviral agents and how to use them.

Current infectious disease reports

Kim HH, Daar ES.
PMID: 19545503
Curr Infect Dis Rep. 2009 Jul;11(4):327-34. doi: 10.1007/s11908-009-0048-9.

Several relatively new antiretroviral drugs have been approved or are under investigation. These include nucleoside and nonnucleoside reverse transcriptase inhibitors, protease and integrase strand transfer inhibitors, CCR5 antagonists, and an entirely new class of maturation inhibitors. Although most of...

The Need for Development of New HIV-1 Reverse Transcriptase and Integrase Inhibitors in the Aftermath of Antiviral Drug Resistance.

Scientifica

Wainberg MA.
PMID: 24278679
Scientifica (Cairo). 2012;2012:238278. doi: 10.6064/2012/238278. Epub 2012 Dec 31.

The use of highly active antiretroviral therapy (HAART) involves combinations of drugs to achieve maximal virological response and reduce the potential for the emergence of antiviral resistance. There are two broad classes of reverse transcriptase inhibitors, the nucleoside reverse...

Tenofovir-associated renal dysfunction in clinical practice: An observational cohort from western India.

Indian journal of sexually transmitted diseases and AIDS

Patel KK, Patel AK, Ranjan RR, Patel AR, Patel JK.
PMID: 21808434
Indian J Sex Transm Dis AIDS. 2010 Jan;31(1):30-4. doi: 10.4103/0253-7184.68998.

BACKGROUND: Tenofovir (TDF) is preferred nucleoside reverse transcriptase inhibitors (NRTI) for the treatment of human immunodeficiency virus infection because of its potency and safety. Renal toxicity with TDF use is low and comparable with other NRTI in clinical trials,...

Showing 25 to 36 of 416 entries