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Showing 13 to 15 of 15 entries
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The Common Follicle-Stimulating Hormone Receptor (FSHR) Promoter Polymorphism FSHR -29G > A Affects Androgen Production in Normal Human Small Antral Follicles.

Frontiers in endocrinology

Borgbo T, Klučková H, Macek M, Chrudimska J, Kristensen SG, Hansen LL, Andersen CY.
PMID: 28626448
Front Endocrinol (Lausanne). 2017 Jun 02;8:122. doi: 10.3389/fendo.2017.00122. eCollection 2017.

Follicle-stimulating hormone receptors (FSHRs) are almost exclusively expressed on granulosa cells, and FSH action is probably most clearly reflected in intrafollicular hormone milieu of antral follicles. Little is known about the possible effects of the common single nucleotide polymorphism...

Rescue of Cell Surface Expression and Signaling of Mutant Follicle-Stimulating Hormone Receptors.

Endocrinology

Hanyroup S, Anderson RC, Nataraja S, Yu HN, Millar RP, Newton CL.
PMID: 34192304
Endocrinology. 2021 Dec 01;162(12). doi: 10.1210/endocr/bqab134.

Mutations in G protein-coupled receptors (GPCRs) underlie numerous diseases. Many cause receptor misfolding and failure to reach the cell surface. Pharmacological chaperones are cell-permeant small molecules that engage nascent mutant GPCRs in the endoplasmic reticulum, stabilizing folding and "rescuing"...

Crocus sativus (saffron) petals extract and its active ingredient, anthocyanin improves ovarian dysfunction, regulation of inflammatory genes and antioxidant factors in testosterone-induced PCOS mice.

Journal of ethnopharmacology

Moshfegh F, Balanejad SZ, Shahrokhabady K, Attaranzadeh A.
PMID: 34480994
J Ethnopharmacol. 2022 Jan 10;282:114594. doi: 10.1016/j.jep.2021.114594. Epub 2021 Sep 02.

ETHNOPHARMACOLOGICAL RELEVANCE: Saffron petal has traditionally been used to treat a variety of diseases, such as gynecological disease such as primary dysmenorrhea and premenstrual tension. Polycystic Ovary Syndrome (PCOS) is a form of gynecological disease that causes amenorrhea, infertility,...

Showing 13 to 15 of 15 entries