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A Minireview of the Promising Drugs and Vaccines in Pipeline for the Treatment of COVID-19 and Current Update on Clinical Trials.

Frontiers in molecular biosciences

Venkadapathi J, Govindarajan VK, Sekaran S, Venkatapathy S.
PMID: 34179072
Front Mol Biosci. 2021 Jun 09;8:637378. doi: 10.3389/fmolb.2021.637378. eCollection 2021.

The COVID-19 is affecting thousands of peoples day by day and continues to spread across the world. The present review has focused on promising repurposing drugs, including remdesivir, lopinvar/retinovar, favipiravir, hydroxychloroquine, monoclonal antibodies and vaccines against the SARS-CoV-2 infection....

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Venkadapathi J, Govindarajan VK, Sekaran S, et al. A Minireview of the Promising Drugs and Vaccines in Pipeline for the Treatment of COVID-19 and Current Update on Clinical Trials. Front Mol Biosci. 2021;8:637378doi: 10.3389/fmolb.2021.637378.
Venkadapathi, J., Govindarajan, V. K., Sekaran, S., & Venkatapathy, S. (2021). A Minireview of the Promising Drugs and Vaccines in Pipeline for the Treatment of COVID-19 and Current Update on Clinical Trials. Frontiers in molecular biosciences, 8637378. https://doi.org/10.3389/fmolb.2021.637378
Venkadapathi, Jeyanthi, et al. "A Minireview of the Promising Drugs and Vaccines in Pipeline for the Treatment of COVID-19 and Current Update on Clinical Trials." Frontiers in molecular biosciences vol. 8 (2021): 637378. doi: https://doi.org/10.3389/fmolb.2021.637378
Venkadapathi J, Govindarajan VK, Sekaran S, Venkatapathy S. A Minireview of the Promising Drugs and Vaccines in Pipeline for the Treatment of COVID-19 and Current Update on Clinical Trials. Front Mol Biosci. 2021 Jun 09;8:637378. doi: 10.3389/fmolb.2021.637378. eCollection 2021. PMID: 34179072; PMCID: PMC8219860.
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RNF19a inhibits antiviral immune response to RNA viruses through degradation of TBK1.

Molecular immunology

Yang Y, Cao X, Huang L, Yang A.
PMID: 34990937
Mol Immunol. 2022 Jan 03;143:1-6. doi: 10.1016/j.molimm.2021.12.021. Epub 2022 Jan 03.

TANK-binding kinase 1 (TBK1) plays a pivotal role in antiviral innate immunity. TBK1 mediates the activation of interferon regulatory factor (IRF) 3, leading to the induction of type I IFNs (IFN-α/β) and of NF-κB signal transduction following viral infections....

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Yang Y, Cao X, Huang L, et al. RNF19a inhibits antiviral immune response to RNA viruses through degradation of TBK1. Mol Immunol. 2022;143:1-6doi: 10.1016/j.molimm.2021.12.021.
Yang, Y., Cao, X., Huang, L., & Yang, A. (2022). RNF19a inhibits antiviral immune response to RNA viruses through degradation of TBK1. Molecular immunology, 1431-6. https://doi.org/10.1016/j.molimm.2021.12.021
Yang, Yingyun, et al. "RNF19a inhibits antiviral immune response to RNA viruses through degradation of TBK1." Molecular immunology vol. 143 (2022): 1-6. doi: https://doi.org/10.1016/j.molimm.2021.12.021
Yang Y, Cao X, Huang L, Yang A. RNF19a inhibits antiviral immune response to RNA viruses through degradation of TBK1. Mol Immunol. 2022 Jan 03;143:1-6. doi: 10.1016/j.molimm.2021.12.021. Epub 2022 Jan 03. PMID: 34990937.
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Novel RNA Viral Vectors for Chemically Regulated Gene Expression in Embryonic Stem Cells.

ACS synthetic biology

Kim N, Yokobayashi Y.
PMID: 34676762
ACS Synth Biol. 2021 Nov 19;10(11):2959-2967. doi: 10.1021/acssynbio.1c00214. Epub 2021 Oct 22.

RNA viral vectors that replicate without DNA intermediates are attractive platforms for manipulation of cells for biomedical and veterinary applications because they have minimal risk of chromosomal integration. Vesicular stomatitis virus (VSV) vectors are among the most well-studied RNA...

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Kim N, Yokobayashi Y. Novel RNA Viral Vectors for Chemically Regulated Gene Expression in Embryonic Stem Cells. ACS Synth Biol. 2021;10(11):2959-2967doi: 10.1021/acssynbio.1c00214.
Kim, N., & Yokobayashi, Y. (2021). Novel RNA Viral Vectors for Chemically Regulated Gene Expression in Embryonic Stem Cells. ACS synthetic biology, 10(11), 2959-2967. https://doi.org/10.1021/acssynbio.1c00214
Kim, Narae, and Yokobayashi, Yohei. "Novel RNA Viral Vectors for Chemically Regulated Gene Expression in Embryonic Stem Cells." ACS synthetic biology vol. 10,11 (2021): 2959-2967. doi: https://doi.org/10.1021/acssynbio.1c00214
Kim N, Yokobayashi Y. Novel RNA Viral Vectors for Chemically Regulated Gene Expression in Embryonic Stem Cells. ACS Synth Biol. 2021 Nov 19;10(11):2959-2967. doi: 10.1021/acssynbio.1c00214. Epub 2021 Oct 22. PMID: 34676762.
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Genetic diversity through social heterosis can increase virulence in RNA viral infections and cancer progression.

Royal Society open science

Ebrahimi S, Nonacs P.
PMID: 34035948
R Soc Open Sci. 2021 May 05;8(5):202219. doi: 10.1098/rsos.202219.

In viral infections and cancer tumours, negative health outcomes often correlate with increasing genetic diversity. Possible evolutionary processes for such relationships include mutant lineages escaping host control or diversity,

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Ebrahimi S, Nonacs P. Genetic diversity through social heterosis can increase virulence in RNA viral infections and cancer progression. R Soc Open Sci. 2021;8(5):202219doi: 10.1098/rsos.202219.
Ebrahimi, S., & Nonacs, P. (2021). Genetic diversity through social heterosis can increase virulence in RNA viral infections and cancer progression. Royal Society open science, 8(5), 202219. https://doi.org/10.1098/rsos.202219
Ebrahimi, Saba, and Nonacs, Peter. "Genetic diversity through social heterosis can increase virulence in RNA viral infections and cancer progression." Royal Society open science vol. 8,5 (2021): 202219. doi: https://doi.org/10.1098/rsos.202219
Ebrahimi S, Nonacs P. Genetic diversity through social heterosis can increase virulence in RNA viral infections and cancer progression. R Soc Open Sci. 2021 May 05;8(5):202219. doi: 10.1098/rsos.202219. PMID: 34035948; PMCID: PMC8097216.
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Exploring the nasopharyngeal microbiota composition in infants with whooping cough: A test-negative case-control study.

PloS one

Rocafort M, Henares D, Brotons P, Barrabeig I, Launes C, Merdrignac L, Valenciano M, Domínguez A, Godoy P, Muñoz-Almagro C.
PMID: 34714887
PLoS One. 2021 Oct 29;16(10):e0259318. doi: 10.1371/journal.pone.0259318. eCollection 2021.

PURPOSE: The purpose of this study was to characterize the nasopharyngeal microbiota of infants with possible and confirmed pertussis compared to healthy controls.METHODS: This prospective study included all infants

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Rocafort M, Henares D, Brotons P, et al. Exploring the nasopharyngeal microbiota composition in infants with whooping cough: A test-negative case-control study. PLoS One. 2021;16(10):e0259318doi: 10.1371/journal.pone.0259318.
Rocafort, M., Henares, D., Brotons, P., Barrabeig, I., Launes, C., Merdrignac, L., Valenciano, M., Domínguez, A., Godoy, P., & Muñoz-Almagro, C. (2021). Exploring the nasopharyngeal microbiota composition in infants with whooping cough: A test-negative case-control study. PloS one, 16(10), e0259318. https://doi.org/10.1371/journal.pone.0259318
Rocafort, Muntsa, et al. "Exploring the nasopharyngeal microbiota composition in infants with whooping cough: A test-negative case-control study." PloS one vol. 16,10 (2021): e0259318. doi: https://doi.org/10.1371/journal.pone.0259318
Rocafort M, Henares D, Brotons P, Barrabeig I, Launes C, Merdrignac L, Valenciano M, Domínguez A, Godoy P, Muñoz-Almagro C. Exploring the nasopharyngeal microbiota composition in infants with whooping cough: A test-negative case-control study. PLoS One. 2021 Oct 29;16(10):e0259318. doi: 10.1371/journal.pone.0259318. eCollection 2021. PMID: 34714887; PMCID: PMC8555781.
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Minimally Invasive Tissue Sampling: A Tool to Guide Efforts to Reduce AIDS-Related Mortality in Resource-Limited Settings.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

Letang E, Rakislova N, Martinez MJ, Carlos Hurtado J, Carrilho C, Bene R, Mandomando I, Quintó L, Nhampossa T, Chicamba V, Luis E, Ismail MR, Fernandes F, Lorenzoni C, Ferreira L, Freire M, Teresa Rodrigo-Calvo M, Guerrero J, Munguambe K, Maixenchs M, Navarro M, Casas I, Marimon L, Ferrando M, Macete E, Lacerda M, Bassat Q, Menéndez C, Ordi J.
PMID: 34910173
Clin Infect Dis. 2021 Dec 15;73:S343-S350. doi: 10.1093/cid/ciab789.

BACKGROUND: Available information on the causes of death among people living with human immunodeficiency virus (PLHIV) in low- and middle-income countries (LMICs) remains scarce. We aimed to provide data on causes of death in PLHIV from two LMICs, Brazil...

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Letang E, Rakislova N, Martinez MJ, et al. Minimally Invasive Tissue Sampling: A Tool to Guide Efforts to Reduce AIDS-Related Mortality in Resource-Limited Settings. Clin Infect Dis. 2021;73:S343-S350doi: 10.1093/cid/ciab789.
Letang, E., Rakislova, N., Martinez, M. J., Carlos Hurtado, J., Carrilho, C., Bene, R., Mandomando, I., Quintó, L., Nhampossa, T., Chicamba, V., Luis, E., Ismail, M. R., Fernandes, F., Lorenzoni, C., Ferreira, L., Freire, M., Teresa Rodrigo-Calvo, M., Guerrero, J., Munguambe, K., Maixenchs, M., Navarro, M., Casas, I., Marimon, L., Ferrando, M., Macete, E., Lacerda, M., Bassat, Q., Menéndez, C., & Ordi, J. (2021). Minimally Invasive Tissue Sampling: A Tool to Guide Efforts to Reduce AIDS-Related Mortality in Resource-Limited Settings. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 73S343-S350. https://doi.org/10.1093/cid/ciab789
Letang, Emilio, et al. "Minimally Invasive Tissue Sampling: A Tool to Guide Efforts to Reduce AIDS-Related Mortality in Resource-Limited Settings." Clinical infectious diseases : an official publication of the Infectious Diseases Society of America vol. 73 (2021): S343-S350. doi: https://doi.org/10.1093/cid/ciab789
Letang E, Rakislova N, Martinez MJ, Carlos Hurtado J, Carrilho C, Bene R, Mandomando I, Quintó L, Nhampossa T, Chicamba V, Luis E, Ismail MR, Fernandes F, Lorenzoni C, Ferreira L, Freire M, Teresa Rodrigo-Calvo M, Guerrero J, Munguambe K, Maixenchs M, Navarro M, Casas I, Marimon L, Ferrando M, Macete E, Lacerda M, Bassat Q, Menéndez C, Ordi J. Minimally Invasive Tissue Sampling: A Tool to Guide Efforts to Reduce AIDS-Related Mortality in Resource-Limited Settings. Clin Infect Dis. 2021 Dec 15;73:S343-S350. doi: 10.1093/cid/ciab789. PMID: 34910173.
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Awareness and Epidemiology of Chronic Hepatitis C Virus Infections in Florida.

Infectious diseases and therapy

Thomas E, Cheng WH, Dylla DE, Marx SE, Carabino J, Xu Q.
PMID: 34914078
Infect Dis Ther. 2021 Dec 16; doi: 10.1007/s40121-021-00578-5. Epub 2021 Dec 16.

INTRODUCTION: Progress towards achieving hepatitis C virus (HCV) elimination in Florida has been hampered by barriers to screening, linkage to care, and treatment. This study aims to describe the HCV care cascade and patient characteristics in Florida.METHODS: This analysis...

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Thomas E, Cheng WH, Dylla DE, et al. Awareness and Epidemiology of Chronic Hepatitis C Virus Infections in Florida. Infect Dis Ther. 2021;doi: 10.1007/s40121-021-00578-5.
Thomas, E., Cheng, W. H., Dylla, D. E., Marx, S. E., Carabino, J., & Xu, Q. (2021). Awareness and Epidemiology of Chronic Hepatitis C Virus Infections in Florida. Infectious diseases and therapy, . https://doi.org/10.1007/s40121-021-00578-5
Thomas, Emmanuel, et al. "Awareness and Epidemiology of Chronic Hepatitis C Virus Infections in Florida." Infectious diseases and therapy vol. (2021). doi: https://doi.org/10.1007/s40121-021-00578-5
Thomas E, Cheng WH, Dylla DE, Marx SE, Carabino J, Xu Q. Awareness and Epidemiology of Chronic Hepatitis C Virus Infections in Florida. Infect Dis Ther. 2021 Dec 16; doi: 10.1007/s40121-021-00578-5. Epub 2021 Dec 16. PMID: 34914078.
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Minimally Invasive Tissue Sampling: A Tool to Guide Efforts to Reduce AIDS-Related Mortality in Resource-Limited Settings.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

Letang E, Rakislova N, Martinez MJ, Carlos Hurtado J, Carrilho C, Bene R, Mandomando I, Quintó L, Nhampossa T, Chicamba V, Luis E, Ismail MR, Fernandes F, Lorenzoni C, Ferreira L, Freire M, Teresa Rodrigo-Calvo M, Guerrero J, Munguambe K, Maixenchs M, Navarro M, Casas I, Marimon L, Ferrando M, Macete E, Lacerda M, Bassat Q, Menéndez C, Ordi J.
PMID: 34910173
Clin Infect Dis. 2021 Dec 15;73:S343-S350. doi: 10.1093/cid/ciab789.

BACKGROUND: Available information on the causes of death among people living with human immunodeficiency virus (PLHIV) in low- and middle-income countries (LMICs) remains scarce. We aimed to provide data on causes of death in PLHIV from two LMICs, Brazil...

Cite
Letang E, Rakislova N, Martinez MJ, et al. Minimally Invasive Tissue Sampling: A Tool to Guide Efforts to Reduce AIDS-Related Mortality in Resource-Limited Settings. Clin Infect Dis. 2021;73:S343-S350doi: 10.1093/cid/ciab789.
Letang, E., Rakislova, N., Martinez, M. J., Carlos Hurtado, J., Carrilho, C., Bene, R., Mandomando, I., Quintó, L., Nhampossa, T., Chicamba, V., Luis, E., Ismail, M. R., Fernandes, F., Lorenzoni, C., Ferreira, L., Freire, M., Teresa Rodrigo-Calvo, M., Guerrero, J., Munguambe, K., Maixenchs, M., Navarro, M., Casas, I., Marimon, L., Ferrando, M., Macete, E., Lacerda, M., Bassat, Q., Menéndez, C., & Ordi, J. (2021). Minimally Invasive Tissue Sampling: A Tool to Guide Efforts to Reduce AIDS-Related Mortality in Resource-Limited Settings. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 73S343-S350. https://doi.org/10.1093/cid/ciab789
Letang, Emilio, et al. "Minimally Invasive Tissue Sampling: A Tool to Guide Efforts to Reduce AIDS-Related Mortality in Resource-Limited Settings." Clinical infectious diseases : an official publication of the Infectious Diseases Society of America vol. 73 (2021): S343-S350. doi: https://doi.org/10.1093/cid/ciab789
Letang E, Rakislova N, Martinez MJ, Carlos Hurtado J, Carrilho C, Bene R, Mandomando I, Quintó L, Nhampossa T, Chicamba V, Luis E, Ismail MR, Fernandes F, Lorenzoni C, Ferreira L, Freire M, Teresa Rodrigo-Calvo M, Guerrero J, Munguambe K, Maixenchs M, Navarro M, Casas I, Marimon L, Ferrando M, Macete E, Lacerda M, Bassat Q, Menéndez C, Ordi J. Minimally Invasive Tissue Sampling: A Tool to Guide Efforts to Reduce AIDS-Related Mortality in Resource-Limited Settings. Clin Infect Dis. 2021 Dec 15;73:S343-S350. doi: 10.1093/cid/ciab789. PMID: 34910173; PMCID: PMC8672756.
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SARS-CoV-2 is detectable using sensitive RNA saliva testing days before viral load reaches detection range of low-sensitivity nasal swab tests.

medRxiv : the preprint server for health sciences

Savela ES, Winnett A, Romano AE, Porter MK, Shelby N, Akana R, Ji J, Cooper MM, Schlenker NW, Reyes JA, Carter AM, Barlow JT, Tognazzini C, Feaster M, Goh YY, Ismagilov RF.
PMID: 33851180
medRxiv. 2021 Apr 07; doi: 10.1101/2021.04.02.21254771.

Early detection of SARS-CoV-2 infection is critical to reduce asymptomatic and pre-symptomatic spread of COVID-19, curb the spread of viral variants by travelers, and maximize efficacy of therapeutic treatments. We designed a study to evaluate the preferred test sensitivity...

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Savela ES, Winnett A, Romano AE, et al. SARS-CoV-2 is detectable using sensitive RNA saliva testing days before viral load reaches detection range of low-sensitivity nasal swab tests. medRxiv. 2021;doi: 10.1101/2021.04.02.21254771.
Savela, E. S., Winnett, A., Romano, A. E., Porter, M. K., Shelby, N., Akana, R., Ji, J., Cooper, M. M., Schlenker, N. W., Reyes, J. A., Carter, A. M., Barlow, J. T., Tognazzini, C., Feaster, M., Goh, Y. Y., & Ismagilov, R. F. (2021). SARS-CoV-2 is detectable using sensitive RNA saliva testing days before viral load reaches detection range of low-sensitivity nasal swab tests. medRxiv : the preprint server for health sciences, . https://doi.org/10.1101/2021.04.02.21254771
Savela, Emily S, et al. "SARS-CoV-2 is detectable using sensitive RNA saliva testing days before viral load reaches detection range of low-sensitivity nasal swab tests." medRxiv : the preprint server for health sciences vol. (2021). doi: https://doi.org/10.1101/2021.04.02.21254771
Savela ES, Winnett A, Romano AE, Porter MK, Shelby N, Akana R, Ji J, Cooper MM, Schlenker NW, Reyes JA, Carter AM, Barlow JT, Tognazzini C, Feaster M, Goh YY, Ismagilov RF. SARS-CoV-2 is detectable using sensitive RNA saliva testing days before viral load reaches detection range of low-sensitivity nasal swab tests. medRxiv. 2021 Apr 07; doi: 10.1101/2021.04.02.21254771. PMID: 33851180; PMCID: PMC8043477.
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Selenium and RNA Virus Interactions: Potential Implications for SARS-CoV-2 Infection (COVID-19).

Frontiers in nutrition

Hiffler L, Rakotoambinina B.
PMID: 33015130
Front Nutr. 2020 Sep 04;7:164. doi: 10.3389/fnut.2020.00164. eCollection 2020.

SARS-CoV-2 is an RNA virus responsible for the COVID-19 pandemic that already claimed more than 340,000 lives worldwide as of May 23, 2020, the majority of which are elderly. Selenium (Se), a natural trace element, has a key and...

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Hiffler L, Rakotoambinina B. Selenium and RNA Virus Interactions: Potential Implications for SARS-CoV-2 Infection (COVID-19). Front Nutr. 2020;7:164doi: 10.3389/fnut.2020.00164.
Hiffler, L., & Rakotoambinina, B. (2020). Selenium and RNA Virus Interactions: Potential Implications for SARS-CoV-2 Infection (COVID-19). Frontiers in nutrition, 7164. https://doi.org/10.3389/fnut.2020.00164
Hiffler, Laurent, and Rakotoambinina, Benjamin. "Selenium and RNA Virus Interactions: Potential Implications for SARS-CoV-2 Infection (COVID-19)." Frontiers in nutrition vol. 7 (2020): 164. doi: https://doi.org/10.3389/fnut.2020.00164
Hiffler L, Rakotoambinina B. Selenium and RNA Virus Interactions: Potential Implications for SARS-CoV-2 Infection (COVID-19). Front Nutr. 2020 Sep 04;7:164. doi: 10.3389/fnut.2020.00164. eCollection 2020. PMID: 33015130; PMCID: PMC7498630.
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RdRp inhibitors and COVID-19: Is molnupiravir a good option?.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Hashemian SMR, Pourhanifeh MH, Hamblin MR, Shahrzad MK, Mirzaei H.
PMID: 34902743
Biomed Pharmacother. 2021 Dec 09;146:112517. doi: 10.1016/j.biopha.2021.112517. Epub 2021 Dec 09.

Rapid changes in the viral genome allow viruses to evade threats posed by the host immune response or antiviral drugs, and can lead to viral persistence in the host cells. RNA-dependent RNA polymerase (RdRp) is an essential enzyme in...

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Hashemian SMR, Pourhanifeh MH, Hamblin MR, et al. RdRp inhibitors and COVID-19: Is molnupiravir a good option?. Biomed Pharmacother. 2021;146:112517doi: 10.1016/j.biopha.2021.112517.
Hashemian, S. M. R., Pourhanifeh, M. H., Hamblin, M. R., Shahrzad, M. K., & Mirzaei, H. (2021). RdRp inhibitors and COVID-19: Is molnupiravir a good option?. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 146112517. https://doi.org/10.1016/j.biopha.2021.112517
Hashemian, Seyed Mohammad Reza, et al. "RdRp inhibitors and COVID-19: Is molnupiravir a good option?." Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie vol. 146 (2021): 112517. doi: https://doi.org/10.1016/j.biopha.2021.112517
Hashemian SMR, Pourhanifeh MH, Hamblin MR, Shahrzad MK, Mirzaei H. RdRp inhibitors and COVID-19: Is molnupiravir a good option?. Biomed Pharmacother. 2021 Dec 09;146:112517. doi: 10.1016/j.biopha.2021.112517. Epub 2021 Dec 09. PMID: 34902743; PMCID: PMC8654603.
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Identification and Functional Characterization of Argonaute (Ago) Proteins in Insect Genomes.

Methods in molecular biology (Clifton, N.J.)

Moussian B, Casadei N.
PMID: 34495503
Methods Mol Biol. 2022;2360:9-17. doi: 10.1007/978-1-0716-1633-8_2.

RNA processing is a vital process in all organisms. In eukaryotes, the RNA induced silencing complex (RISC) mediates this function during development and physiological processes and, at least in arthropods, during RNA-viral infections. Argonaute-like RNA-binding proteins are central components...

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Moussian B, Casadei N. Identification and Functional Characterization of Argonaute (Ago) Proteins in Insect Genomes. Methods Mol Biol. 2022;2360:9-17doi: 10.1007/978-1-0716-1633-8_2.
Moussian, B., & Casadei, N. (2022). Identification and Functional Characterization of Argonaute (Ago) Proteins in Insect Genomes. Methods in molecular biology (Clifton, N.J.), 23609-17. https://doi.org/10.1007/978-1-0716-1633-8_2
Moussian, Bernard, and Casadei, Nicolas. "Identification and Functional Characterization of Argonaute (Ago) Proteins in Insect Genomes." Methods in molecular biology (Clifton, N.J.) vol. 2360 (2022): 9-17. doi: https://doi.org/10.1007/978-1-0716-1633-8_2
Moussian B, Casadei N. Identification and Functional Characterization of Argonaute (Ago) Proteins in Insect Genomes. Methods Mol Biol. 2022;2360:9-17. doi: 10.1007/978-1-0716-1633-8_2. PMID: 34495503.
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