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Showing 217 to 221 of 221 entries
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RdRp inhibitors and COVID-19: Is molnupiravir a good option?.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Hashemian SMR, Pourhanifeh MH, Hamblin MR, Shahrzad MK, Mirzaei H.
PMID: 34902743
Biomed Pharmacother. 2021 Dec 09;146:112517. doi: 10.1016/j.biopha.2021.112517. Epub 2021 Dec 09.

Rapid changes in the viral genome allow viruses to evade threats posed by the host immune response or antiviral drugs, and can lead to viral persistence in the host cells. RNA-dependent RNA polymerase (RdRp) is an essential enzyme in...

Gingival tissue as a reservoir for human immunodeficiency virus type-1: Preliminary results of a cross-sectional observational study.

Journal of periodontology

Sereme Y, Pólvora TLS, Rochereau N, Santana RC, Paul S, da Fonseca BAL, Bourlet T, Pozzetto B, Lourenço AG, Motta ACF.
PMID: 34396525
J Periodontol. 2021 Aug 15; doi: 10.1002/JPER.21-0345. Epub 2021 Aug 15.

BACKGROUND: Despite combined antiretroviral therapy (cART), total cure of immunodeficiency virus type 1 (HIV-1) infection remains elusive. Chronic periodontitis (CP) is strongly associated with HIV-1 infection. This condition is characterized by an intense inflammatory infiltrate mainly constituted of immune...

Retinoic Acid-Inducible Gene I-Like Receptors Activate Snail To Limit RNA Viral Infections.

Journal of virology

Vedagiri D, Gupta D, Mishra A, Krishna G, Bhaskar M, Sah V, Basu A, Nayak D, Kalia M, Valiya Veettil M, Harshan KH.
PMID: 34379517
J Virol. 2021 Oct 13;95(21):e0121621. doi: 10.1128/JVI.01216-21. Epub 2021 Aug 11.

Retinoic acid-inducible gene I-like receptors (RLRs) are important cytosolic pattern recognition receptors (PRRs) that sense viral RNA before mounting a response leading to the activation of type I IFNs. Several viral infections induce epithelial-mesenchymal transition (EMT), even as its...

Switching efavirenz to rilpivirine in virologically suppressed adolescents with HIV: a multi-centre 48-week efficacy and safety study in Thailand.

Journal of the International AIDS Society

Phongsamart W, Jantarabenjakul W, Chantaratin S, Anugulruengkitt S, Suntarattiwong P, Sirikutt P, Kosalaraksa P, Maleesatharn A, Chokephaibulkit K.
PMID: 35001501
J Int AIDS Soc. 2022 Jan;25(1):e25862. doi: 10.1002/jia2.25862.

INTRODUCTION: Efavirenz (EFV) is commonly used for first-line antiretroviral therapy in children and adolescents with HIV, but is associated with neuropsychiatric and metabolic side effects. Rilpivirine (RPV) is better tolerated, and switching from EFV to RPV in virologically suppressed...

The Neighborhood of the Spike Gene Is a Hotspot for Modular Intertypic Homologous and Nonhomologous Recombination in Coronavirus Genomes.

Molecular biology and evolution

Nikolaidis M, Markoulatos P, Van de Peer Y, Oliver SG, Amoutzias GD.
PMID: 34638137
Mol Biol Evol. 2022 Jan 07;39(1). doi: 10.1093/molbev/msab292.

Coronaviruses (CoVs) have very large RNA viral genomes with a distinct genomic architecture of core and accessory open reading frames (ORFs). It is of utmost importance to understand their patterns and limits of homologous and nonhomologous recombination, because such...

Showing 217 to 221 of 221 entries