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Showing 13 to 24 of 107 entries
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Involvement of the dopamine system in the effect of chronic social isolation during adolescence on social behaviors in male C57 mice.

Brain research

Zhang X, Xun Y, Wang L, Zhang J, Hou W, Ma H, Cai W, Li L, Guo Q, Li Y, Lv Z, Jia R, Tai F, He Z.
PMID: 33894223
Brain Res. 2021 Aug 15;1765:147497. doi: 10.1016/j.brainres.2021.147497. Epub 2021 Apr 21.

In the early stage of life, experiencing social isolation can generate long-lasting deleterious effects on behaviors and brain development. However, the effects of chronic social isolation during adolescence on social behaviors and its underlying neurobiological mechanisms remain unclear. The...

Dopamine and ghrelin receptor co-expression and interaction in the spinal defecation centers.

Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society

Furness JB, Pustovit RV, Syder AJ, Ringuet MT, Yoo EJ, Fanjul A, Wykosky J, Fothergill LJ, Whitfield EA, Furness SGB.
PMID: 33264473
Neurogastroenterol Motil. 2021 May;33(5):e14051. doi: 10.1111/nmo.14051. Epub 2020 Dec 02.

BACKGROUND: Dopamine receptor 2 (DRD2) and ghrelin receptor (GHSR1a) agonists both stimulate defecation by actions at the lumbosacral defecation center. Dopamine is in nerve terminals surrounding autonomic neurons of the defecation center, whereas ghrelin is not present in the...

Feeding status alters exploratory and anxiety-like behaviors in zebrafish larvae exposed to quinpirole.

Progress in neuro-psychopharmacology & biological psychiatry

Nabinger DD, Altenhofen S, Peixoto JV, da Silva JMK, Gerlai R, Bonan CD.
PMID: 33212194
Prog Neuropsychopharmacol Biol Psychiatry. 2021 Jun 08;108:110179. doi: 10.1016/j.pnpbp.2020.110179. Epub 2020 Nov 16.

The dysfunction of dopaminergic signaling is associated with several neurological disorders. The use of pharmacological agents that interact with this signaling system may be employed to understand mechanisms underlying such disorders. Nutritional status can impact dopamine reuptake, receptor affinity,...

Dopamine Modulates Excitatory Synaptic Transmission by Activating Presynaptic D1-like Dopamine Receptors in the RA Projection Neurons of Zebra Finches.

Frontiers in cellular neuroscience

Wang S, Liu S, Wang Q, Sun Y, Yao L, Li D, Meng W.
PMID: 32477072
Front Cell Neurosci. 2020 May 12;14:126. doi: 10.3389/fncel.2020.00126. eCollection 2020.

Songbirds are useful vertebrate study models for vocal learning and memory. The robust nucleus of the arcopallium (RA) receives synaptic inputs from both the posterior and anterior pathways of the song control system in songbirds. Hence, RA plays an...

The dopamine D2 agonist quinpirole impairs frontal mismatch responses to sound frequency deviations in freely moving rats.

Neuropsychopharmacology reports

Inaba H, Namba H, Kida S, Nawa H.
PMID: 34296531
Neuropsychopharmacol Rep. 2021 Sep;41(3):405-415. doi: 10.1002/npr2.12199. Epub 2021 Jul 23.

AIM: A reduced mismatch negativity (MMN) response is a promising electrophysiological endophenotype of schizophrenia that reflects neurocognitive impairment. Dopamine dysfunction is associated with symptoms of schizophrenia. However, whether the dopamine system is involved in MMN impairment remains controversial. In...

[18F]-FDG PET neuroimaging in rats with quinpirole-induced checking behavior as a model for obsessive compulsive disorder.

Psychiatry research. Neuroimaging

Servaes S, Glorie D, Verhaeghe J, Wyffels L, Stroobants S, Staelens S.
PMID: 27771554
Psychiatry Res Neuroimaging. 2016 Nov 30;257:31-38. doi: 10.1016/j.pscychresns.2016.10.003. Epub 2016 Oct 15.

No abstract available.

Distinct patterns of dyskinetic and dystonic features following D1 or D2 receptor stimulation in a mouse model of parkinsonism.

Neurobiology of disease

Andreoli L, Abbaszadeh M, Cao X, Cenci MA.
PMID: 34153463
Neurobiol Dis. 2021 Sep;157:105429. doi: 10.1016/j.nbd.2021.105429. Epub 2021 Jun 19.

L-DOPA-induced dyskinesia (LID) is a significant complication of dopamine replacement therapy in Parkinson's disease (PD), and the specific role of different dopamine receptors in this disorder is poorly understood. We set out to compare patterns of dyskinetic behaviours induced...

Effects of intrastriatal injection of the dopamine receptor agonist SKF38393 and quinpirole on locomotor behavior in hemiparkinsonism rats.

Behavioural brain research

Guo M, Xiang T, Li M, Sun Y, Sun S, Chen D, Jia Q, Li Y, Yao X, Wang X, Zhang X, He F, Wang M.
PMID: 33945831
Behav Brain Res. 2021 Aug 06;411:113339. doi: 10.1016/j.bbr.2021.113339. Epub 2021 May 01.

Dopamine (DA) in the striatum is essential to influence motor behavior and may lead to movement impairment in Parkinson's disease (PD). The present study examined the different functions of the DA D1 receptor (D1R) and DA D2 receptor (D2R)...

Keeping the Body Straight in the Unconstrained Locomotion of Normal and Dopamine-Stimulant-Treated Rats.

Journal of motor behavior

Golani I, Einat H, Tchernichovski O, Teitelbaum P.
PMID: 12453787
J Mot Behav. 1997 Jun;29(2):99-112. doi: 10.1080/00222899709600825.

During unconstrained locomotor behavior, rats move in and out of a straight posture of the body (including the head). In the present study, the stability of maintaining a straight body was examined in untreated rats and in rats treated...

The role of D1 and D2 dopamine receptors in the acquisition and expression of cocaine-induced conditioned increases in locomotor behavior.

Behavioural pharmacology

Fontana D, Post RM, Weiss SR, Pert A.
PMID: 11224206
Behav Pharmacol. 1993;4(4):375-387.

Certain motoric effects of cocaine increase in intensity with repetitive administration. Conditioned drug effects are among primary determinants of such sensitization. The purpose of these experiments was to evaluate the role of D1 and D2 dopamine (DA) receptor mechanisms...

Quinpirole-induced locomotor stimulation in rats develops rapid sensitization when combined with brief footshocks.

Behavioural pharmacology

Franklin SR, Tang AH.
PMID: 11224399
Behav Pharmacol. 1996 Jan;7(1):94-100.

In rats exploring a symmetrical Y-maze, an acute injection of quinpirole or intermittent brief footshocks did not change the level of locomotion. The combined treatment of quinpirole and footshocks elicited an immediate locomotor stimulation. When the experimental session was...

Validity of Quinpirole Sensitization Rat Model of OCD: Linking Evidence from Animal and Clinical Studies.

Frontiers in behavioral neuroscience

Stuchlik A, Radostová D, Hatalova H, Vales K, Nekovarova T, Koprivova J, Svoboda J, Horacek J.
PMID: 27833539
Front Behav Neurosci. 2016 Oct 26;10:209. doi: 10.3389/fnbeh.2016.00209. eCollection 2016.

Obsessive-compulsive disorder (OCD) is a neuropsychiatric disorder with 1-3% prevalence. OCD is characterized by recurrent thoughts (obsessions) and repetitive behaviors (compulsions). The pathophysiology of OCD remains unclear, stressing the importance of pre-clinical studies. The aim of this article is...

Showing 13 to 24 of 107 entries