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Showing 133 to 140 of 140 entries
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Evaluating the virucidal activity of four disinfectants against SARS-CoV-2.

American journal of infection control

Huang Y, Xiao S, Song D, Yuan Z.
PMID: 34774899
Am J Infect Control. 2021 Nov 12; doi: 10.1016/j.ajic.2021.10.035. Epub 2021 Nov 12.

BACKGROUND: The recent COVID-19 pandemic highlights the need for efficacious virucidal products to limit the spread of SARS-CoV-2. Several studies have suggested that alcohol-based sanitizers and some disinfectants are effective. While virucidal activity data of low-level disinfectants are lacking...

Alternatives to Conventional Antibiotic Therapy: Potential Therapeutic Strategies of Combating Antimicrobial-Resistance and Biofilm-Related Infections.

Molecular biotechnology

Xu Q, Hu X, Wang Y.
PMID: 34309796
Mol Biotechnol. 2021 Dec;63(12):1103-1124. doi: 10.1007/s12033-021-00371-2. Epub 2021 Jul 26.

Antibiotics have been denoted as the orthodox therapeutic agents for fighting bacteria-related infections in clinical practices for decades. Nevertheless, overuse of antibiotics has led to the upsurge of species with antimicrobial resistance (AMR) or multi-drug resistance. Bacteria can also...

Pillar[5]arene-Based Acid-Triggered Supramolecular Porphyrin Photosensitizer for Combating Bacterial Infections and Biofilm Dispersion.

Advanced healthcare materials

Xia L, Tian J, Yue T, Cao H, Chu J, Cai H, Zhang W.
PMID: 34787954
Adv Healthc Mater. 2021 Nov 17;e2102015. doi: 10.1002/adhm.202102015. Epub 2021 Nov 17.

The treatment of pathogenic bacterial infection has long been the most serious threat to human life and attracted widespread attention. Herein, a supramolecular photosensitizer platform based on carboxylatopillar[5]arene (CP5) and tetrafluorophenyl porphyrin functionalized with a quaternary ammonium group (TFPP-QA)...

Novel Phenyl-Based Bis-quaternary Ammonium Compounds as Broad-Spectrum Biocides.

ChemMedChem

Frolov NA, Fedoseeva KA, Hansford KA, Vereshchagin AN.
PMID: 34252992
ChemMedChem. 2021 Oct 06;16(19):2954-2959. doi: 10.1002/cmdc.202100284. Epub 2021 Jul 28.

Herein we report the synthesis and microbiological evaluation of novel phenyl based bis-quaternary ammonium compounds (bis-QACs). Using a simple 2-step synthetic route from dibromo- and dihydroxybenzenes, we obtained a structurally diverse broad panel of bis-QACs with topologically distinct bridging...

Contact sensitizations to disinfectants containing alcohols or quaternary ammonium compounds are rarely of clinical relevance.

Contact dermatitis

Kreipe K, Forkel S, Heinemann KE, Amschler K, Fuchs T, Geier J, Buhl T.
PMID: 33763911
Contact Dermatitis. 2021 Mar 24; doi: 10.1111/cod.13844. Epub 2021 Mar 24.

BACKGROUND: The use of disinfectants is part of the everyday life of people, especially in the medical profession. During the coronavirus disease 2019 (COVID-19) pandemic, the use of disinfectants continues to increase and is of fundamental importance in infection...

Reproductive toxicity assessment of alkyl dimethyl benzyl ammonium chloride and didecyl dimethyl ammonium chloride in CD® rats.

Birth defects research

Hostetler KA, Fisher LC, Burruss BL.
PMID: 34549546
Birth Defects Res. 2021 Nov 15;113(19):1368-1389. doi: 10.1002/bdr2.1955. Epub 2021 Sep 21.

AIM: To determine the potential of alkyl dimethyl benzyl ammonium chloride (ADBAC) and didecyl dimethyl ammonium chloride (DDAC) to induce reproductive toxicity in CD® rats in two independent 2-generation reproduction studies conducted according to Good Laboratory Practices and standardized...

Physicochemical susceptibility of SARS-CoV-2 to disinfection and physical approach of prophylaxis.

Health science reports

Saadatpour F, Mohammadipanah F.
PMID: 33305015
Health Sci Rep. 2020 Dec 02;3(4):e213. doi: 10.1002/hsr2.213. eCollection 2020 Dec.

The transmission control of the newly emerged severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the most effective strategy by the absence of its specified vaccine or drug. Although the aerosol mediated transmission of SARS-CoV-2 has been confirmed, the...

The silent pandemic: Emergent antibiotic resistances following the global response to SARS-CoV-2.

iScience

Mahoney AR, Safaee MM, Wuest WM, Furst AL.
PMID: 33748695
iScience. 2021 Apr 23;24(4):102304. doi: 10.1016/j.isci.2021.102304. Epub 2021 Mar 13.

The ongoing SARS-CoV-2 pandemic has highlighted the importance of the rapid development of vaccines and antivirals. However, the potential for the emergence of antibiotic resistances due to the increased use of antibacterial cleaning products and therapeutics presents an additional,...

Showing 133 to 140 of 140 entries