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Use of a neuron-glia genome-scale metabolic reconstruction to model the metabolic consequences of the Arylsulphatase a deficiency through a systems biology approach.

Heliyon

Echeverri-Peña OY, Salazar-Barreto DA, Rodríguez-Lopez A, González J, Alméciga-Díaz CJ, Verano-Guevara CH, Barrera LA.
PMID: 34381909
Heliyon. 2021 Jul 27;7(7):e07671. doi: 10.1016/j.heliyon.2021.e07671. eCollection 2021 Jul.

Metachromatic leukodystrophy (MLD) is a human neurodegenerative disorder characterized by progressive damage on the myelin band in the nervous system. MLD is caused by the impaired function of the lysosomal enzyme Arylsulphatase A (ARSA). The physiopathology mechanisms and the...

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Echeverri-Peña OY, Salazar-Barreto DA, Rodríguez-Lopez A, et al. Use of a neuron-glia genome-scale metabolic reconstruction to model the metabolic consequences of the Arylsulphatase a deficiency through a systems biology approach. Heliyon. 2021;7(7):e07671doi: 10.1016/j.heliyon.2021.e07671.
Echeverri-Peña, O. Y., Salazar-Barreto, D. A., Rodríguez-Lopez, A., González, J., Alméciga-Díaz, C. J., Verano-Guevara, C. H., & Barrera, L. A. (2021). Use of a neuron-glia genome-scale metabolic reconstruction to model the metabolic consequences of the Arylsulphatase a deficiency through a systems biology approach. Heliyon, 7(7), e07671. https://doi.org/10.1016/j.heliyon.2021.e07671
Echeverri-Peña, Olga Y, et al. "Use of a neuron-glia genome-scale metabolic reconstruction to model the metabolic consequences of the Arylsulphatase a deficiency through a systems biology approach." Heliyon vol. 7,7 (2021): e07671. doi: https://doi.org/10.1016/j.heliyon.2021.e07671
Echeverri-Peña OY, Salazar-Barreto DA, Rodríguez-Lopez A, González J, Alméciga-Díaz CJ, Verano-Guevara CH, Barrera LA. Use of a neuron-glia genome-scale metabolic reconstruction to model the metabolic consequences of the Arylsulphatase a deficiency through a systems biology approach. Heliyon. 2021 Jul 27;7(7):e07671. doi: 10.1016/j.heliyon.2021.e07671. eCollection 2021 Jul. PMID: 34381909; PMCID: PMC8340118.
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Substrate binding modes of purine and pyrimidine nucleotides to human ecto-5'-nucleotidase (CD73) and inhibition by their bisphosphonic acid derivatives.

Purinergic signalling

Scaletti E, Huschmann FU, Mueller U, Weiss MS, Sträter N.
PMID: 34403084
Purinergic Signal. 2021 Dec;17(4):693-704. doi: 10.1007/s11302-021-09802-w. Epub 2021 Aug 17.

Human ecto-5-nucleotidase (CD73) is involved in purinergic signalling, which influences a diverse range of biological processes. CD73 hydrolyses AMP and is the major control point for the levels of extracellular adenosine. Inhibitors of CD73 thus block the immunosuppressive action...

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Scaletti E, Huschmann FU, Mueller U, et al. Substrate binding modes of purine and pyrimidine nucleotides to human ecto-5'-nucleotidase (CD73) and inhibition by their bisphosphonic acid derivatives. Purinergic Signal. 2021;17(4):693-704doi: 10.1007/s11302-021-09802-w.
Scaletti, E., Huschmann, F. U., Mueller, U., Weiss, M. S., & Sträter, N. (2021). Substrate binding modes of purine and pyrimidine nucleotides to human ecto-5'-nucleotidase (CD73) and inhibition by their bisphosphonic acid derivatives. Purinergic signalling, 17(4), 693-704. https://doi.org/10.1007/s11302-021-09802-w
Scaletti, Emma, et al. "Substrate binding modes of purine and pyrimidine nucleotides to human ecto-5'-nucleotidase (CD73) and inhibition by their bisphosphonic acid derivatives." Purinergic signalling vol. 17,4 (2021): 693-704. doi: https://doi.org/10.1007/s11302-021-09802-w
Scaletti E, Huschmann FU, Mueller U, Weiss MS, Sträter N. Substrate binding modes of purine and pyrimidine nucleotides to human ecto-5'-nucleotidase (CD73) and inhibition by their bisphosphonic acid derivatives. Purinergic Signal. 2021 Dec;17(4):693-704. doi: 10.1007/s11302-021-09802-w. Epub 2021 Aug 17. PMID: 34403084.
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Synthesis and evaluation of ursolic acid-based 1,2,4-triazolo[1,5-a]pyrimidines derivatives as anti-inflammatory agents.

Molecular diversity

Zhang TY, Li CS, Li P, Bai XQ, Guo SY, Jin Y, Piao SJ.
PMID: 33200293
Mol Divers. 2020 Nov 17; doi: 10.1007/s11030-020-10154-7. Epub 2020 Nov 17.

Here, two series of novel ursolic acid-based 1,2,4-triazolo[1,5-a]pyrimidines derivatives were synthesized and screened for their anti-inflammatory activity by evaluating their inhibition effect of using LPS-induced inflammatory response in RAW 264.7 macrophages in vitro; the effects of different concentrations of...

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Zhang TY, Li CS, Li P, et al. Synthesis and evaluation of ursolic acid-based 1,2,4-triazolo[1,5-a]pyrimidines derivatives as anti-inflammatory agents. Mol Divers. 2020;doi: 10.1007/s11030-020-10154-7.
Zhang, T. Y., Li, C. S., Li, P., Bai, X. Q., Guo, S. Y., Jin, Y., & Piao, S. J. (2020). Synthesis and evaluation of ursolic acid-based 1,2,4-triazolo[1,5-a]pyrimidines derivatives as anti-inflammatory agents. Molecular diversity, . https://doi.org/10.1007/s11030-020-10154-7
Zhang, Tian-Yi, et al. "Synthesis and evaluation of ursolic acid-based 1,2,4-triazolo[1,5-a]pyrimidines derivatives as anti-inflammatory agents." Molecular diversity vol. (2020). doi: https://doi.org/10.1007/s11030-020-10154-7
Zhang TY, Li CS, Li P, Bai XQ, Guo SY, Jin Y, Piao SJ. Synthesis and evaluation of ursolic acid-based 1,2,4-triazolo[1,5-a]pyrimidines derivatives as anti-inflammatory agents. Mol Divers. 2020 Nov 17; doi: 10.1007/s11030-020-10154-7. Epub 2020 Nov 17. PMID: 33200293.
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2,3-Diaminomaleonitrile: A Multifaceted Synthon in Organic Synthesis.

Current organic synthesis

Chaudhary A.
PMID: 34994313
Curr Org Synth. 2022 Jan 07; doi: 10.2174/1570179419666220107155346. Epub 2022 Jan 07.

2,3-Diaminomaleonitrile (DAMN), a tetramer of hydrogen cyanide, displays weakly basic properties and has reactivity comparable to o-phenylenediamine. It has emerged as a versatile, cheap as well as a readily accessible building block towards the synthesis of a variety of...

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Chaudhary A. 2,3-Diaminomaleonitrile: A Multifaceted Synthon in Organic Synthesis. Curr Org Synth. 2022;doi: 10.2174/1570179419666220107155346.
Chaudhary, A. (2022). 2,3-Diaminomaleonitrile: A Multifaceted Synthon in Organic Synthesis. Current organic synthesis, . https://doi.org/10.2174/1570179419666220107155346
Chaudhary, Ankita. "2,3-Diaminomaleonitrile: A Multifaceted Synthon in Organic Synthesis." Current organic synthesis vol. (2022). doi: https://doi.org/10.2174/1570179419666220107155346
Chaudhary A. 2,3-Diaminomaleonitrile: A Multifaceted Synthon in Organic Synthesis. Curr Org Synth. 2022 Jan 07; doi: 10.2174/1570179419666220107155346. Epub 2022 Jan 07. PMID: 34994313.
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A Dimroth rearrangement approach for the synthesis of selenopheno[2,3-e][1,2,4]triazolo[1,5-c]pyrimidines with cytotoxic activity on breast cancer cells.

Molecular diversity

Kohandel O, Sheikhi-Mohammareh S, Oroojalian F, Memariani T, Mague J, Shiri A.
PMID: 34357512
Mol Divers. 2021 Aug 06; doi: 10.1007/s11030-021-10290-8. Epub 2021 Aug 06.

New selenopheno[2,3-e][1,2,4]triazolo[1,5-c]pyrimidine derivatives have been synthesized via Dimroth rearrangement by cyclocondensation of 7-cyano-4-hydrazinyl-6-(pyrrolidin-1-yl)selenopheno[3,2-d]pyrimidine with electrophilic carbons of either orthoesters in acetic acid or carbon disulfide in pyridine followed by S-alkylation. All the newly synthesized products have been structurally elucidated....

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Kohandel O, Sheikhi-Mohammareh S, Oroojalian F, et al. A Dimroth rearrangement approach for the synthesis of selenopheno[2,3-e][1,2,4]triazolo[1,5-c]pyrimidines with cytotoxic activity on breast cancer cells. Mol Divers. 2021;doi: 10.1007/s11030-021-10290-8.
Kohandel, O., Sheikhi-Mohammareh, S., Oroojalian, F., Memariani, T., Mague, J., & Shiri, A. (2021). A Dimroth rearrangement approach for the synthesis of selenopheno[2,3-e][1,2,4]triazolo[1,5-c]pyrimidines with cytotoxic activity on breast cancer cells. Molecular diversity, . https://doi.org/10.1007/s11030-021-10290-8
Kohandel, Omid, et al. "A Dimroth rearrangement approach for the synthesis of selenopheno[2,3-e][1,2,4]triazolo[1,5-c]pyrimidines with cytotoxic activity on breast cancer cells." Molecular diversity vol. (2021). doi: https://doi.org/10.1007/s11030-021-10290-8
Kohandel O, Sheikhi-Mohammareh S, Oroojalian F, Memariani T, Mague J, Shiri A. A Dimroth rearrangement approach for the synthesis of selenopheno[2,3-e][1,2,4]triazolo[1,5-c]pyrimidines with cytotoxic activity on breast cancer cells. Mol Divers. 2021 Aug 06; doi: 10.1007/s11030-021-10290-8. Epub 2021 Aug 06. PMID: 34357512.
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The Biochemistry of CAD.

[No authors listed]
UIID-NSF: 1196

; R o o t E n t r y F N C o m p O b j b W o r d D o c u m e n t T O b j e c t...

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The Biochemistry of CAD. ;
(). The Biochemistry of CAD. .
"The Biochemistry of CAD." vol. ().
The Biochemistry of CAD. UIID-NSF: 1196.
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Showing 505 to 510 of 510 entries