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Co-crystal screening of diclofenac.

Pharmaceutics

Aakeröy CB, Grommet AB, Desper J.
PMID: 24310599
Pharmaceutics. 2011 Aug 31;3(3):601-14. doi: 10.3390/pharmaceutics3030601.

In the pharmaceutical industry, co-crystals are becoming increasingly valuable as crystalline solids that can offer altered/improved physical properties of an active pharmaceutical ingredient (API) without changing its chemical identity or biological activity. In order to identify new solid forms...

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Aakeröy CB, Grommet AB, Desper J. Co-crystal screening of diclofenac. Pharmaceutics. 2011;3(3):601-14doi: 10.3390/pharmaceutics3030601.
Aakeröy, C. B., Grommet, A. B., & Desper, J. (2011). Co-crystal screening of diclofenac. Pharmaceutics, 3(3), 601-14. https://doi.org/10.3390/pharmaceutics3030601
Aakeröy, Christer B, et al. "Co-crystal screening of diclofenac." Pharmaceutics vol. 3,3 (2011): 601-14. doi: https://doi.org/10.3390/pharmaceutics3030601
Aakeröy CB, Grommet AB, Desper J. Co-crystal screening of diclofenac. Pharmaceutics. 2011 Aug 31;3(3):601-14. doi: 10.3390/pharmaceutics3030601. PMID: 24310599; PMCID: PMC3857085.
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An Improved Synthesis of 7-Substituted Pyrrolo[3,2-d]pyrimidines.

The Journal of organic chemistry

Elliott AJ, Morris PE, Petty SL, Williams CH.
PMID: 11671913
J Org Chem. 1997 Nov 14;62(23):8071-8075. doi: 10.1021/jo971062j.

Base (NaOMe)-catalyzed condensation of 3,3-dimethoxypropionitrile with aldehydes followed by hydrolysis with 6 N HCl gives the unsaturated cyano aldehydes 5. Catalytic reduction of the double bond followed by reaction with diethyl aminomalonate affords the enamines 7, which cyclize to...

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Elliott AJ, Morris PE, Petty SL, et al. An Improved Synthesis of 7-Substituted Pyrrolo[3,2-d]pyrimidines. J Org Chem. 1997;62(23):8071-8075doi: 10.1021/jo971062j.
Elliott, A. J., Morris, P. E., Petty, S. L., & Williams, C. H. (1997). An Improved Synthesis of 7-Substituted Pyrrolo[3,2-d]pyrimidines. The Journal of organic chemistry, 62(23), 8071-8075. https://doi.org/10.1021/jo971062j
Elliott, Arthur J., et al. "An Improved Synthesis of 7-Substituted Pyrrolo[3,2-d]pyrimidines." The Journal of organic chemistry vol. 62,23 (1997): 8071-8075. doi: https://doi.org/10.1021/jo971062j
Elliott AJ, Morris PE, Petty SL, Williams CH. An Improved Synthesis of 7-Substituted Pyrrolo[3,2-d]pyrimidines. J Org Chem. 1997 Nov 14;62(23):8071-8075. doi: 10.1021/jo971062j. PMID: 11671913.
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Synthesis and Conformational Study of 3-Hydroxy-4-(Hydroxymethyl)-1-Cyclohexanyl Purines and Pyrimidines.

The Journal of organic chemistry

Maurinsh Y, Schraml J, De Winter H, Blaton N, Peeters O, Lescrinier E, Rozenski J, Van Aerschot A, De Clercq E, Busson R, Herdewijn P.
PMID: 11671649
J Org Chem. 1997 May 02;62(9):2861-2871. doi: 10.1021/jo962204x.

The cyclohexane nucleosides with a 1,4-relationship between nucleoside base and hydroxymethyl moiety were synthesized using a conjugated addition reaction of the nucleobases to ethyl 1,3-cyclohexadiene-1-carboxylate and hydroboration of the cyclohexenyl precursor. The lack of antiviral activity of the compounds...

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Maurinsh Y, Schraml J, De Winter H, et al. Synthesis and Conformational Study of 3-Hydroxy-4-(Hydroxymethyl)-1-Cyclohexanyl Purines and Pyrimidines. J Org Chem. 1997;62(9):2861-2871doi: 10.1021/jo962204x.
Maurinsh, Y., Schraml, J., De Winter, H., Blaton, N., Peeters, O., Lescrinier, E., Rozenski, J., Van Aerschot, A., De Clercq, E., Busson, R., & Herdewijn, P. (1997). Synthesis and Conformational Study of 3-Hydroxy-4-(Hydroxymethyl)-1-Cyclohexanyl Purines and Pyrimidines. The Journal of organic chemistry, 62(9), 2861-2871. https://doi.org/10.1021/jo962204x
Maurinsh, Yuris, et al. "Synthesis and Conformational Study of 3-Hydroxy-4-(Hydroxymethyl)-1-Cyclohexanyl Purines and Pyrimidines." The Journal of organic chemistry vol. 62,9 (1997): 2861-2871. doi: https://doi.org/10.1021/jo962204x
Maurinsh Y, Schraml J, De Winter H, Blaton N, Peeters O, Lescrinier E, Rozenski J, Van Aerschot A, De Clercq E, Busson R, Herdewijn P. Synthesis and Conformational Study of 3-Hydroxy-4-(Hydroxymethyl)-1-Cyclohexanyl Purines and Pyrimidines. J Org Chem. 1997 May 02;62(9):2861-2871. doi: 10.1021/jo962204x. PMID: 11671649.
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An efficient synthesis of pyrrolo[2,3-d]pyrimidines via inverse electron demand diels-alder reactions of 2-amino-4-cyanopyrroles with 1,3,5-triazines.

The Journal of organic chemistry

Dang Q, Gomez-Galeno JE.
PMID: 12444666
J Org Chem. 2002 Nov 29;67(24):8703-5. doi: 10.1021/jo026309d.

The scope of the inverse electron demand Diels-Alder reaction of 2-amino-4-cyanopyrroles (3a-e) with 1,3,5-triazines (1, 2) is reported. This methodology is suitable for one-pot syntheses of highly substituted and highly functionalized pyrrolo[2,3-d]pyrimidines that are the central heterocyclic nucleus of...

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Dang Q, Gomez-Galeno JE. An efficient synthesis of pyrrolo[2,3-d]pyrimidines via inverse electron demand diels-alder reactions of 2-amino-4-cyanopyrroles with 1,3,5-triazines. J Org Chem. 2002;67(24):8703-5doi: 10.1021/jo026309d.
Dang, Q., & Gomez-Galeno, J. E. (2002). An efficient synthesis of pyrrolo[2,3-d]pyrimidines via inverse electron demand diels-alder reactions of 2-amino-4-cyanopyrroles with 1,3,5-triazines. The Journal of organic chemistry, 67(24), 8703-5. https://doi.org/10.1021/jo026309d
Dang, Qun, and Gomez-Galeno, Jorge E. "An efficient synthesis of pyrrolo[2,3-d]pyrimidines via inverse electron demand diels-alder reactions of 2-amino-4-cyanopyrroles with 1,3,5-triazines." The Journal of organic chemistry vol. 67,24 (2002): 8703-5. doi: https://doi.org/10.1021/jo026309d
Dang Q, Gomez-Galeno JE. An efficient synthesis of pyrrolo[2,3-d]pyrimidines via inverse electron demand diels-alder reactions of 2-amino-4-cyanopyrroles with 1,3,5-triazines. J Org Chem. 2002 Nov 29;67(24):8703-5. doi: 10.1021/jo026309d. PMID: 12444666.
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New entry to a three-component pyrimidine synthesis by TMS-Ynones via Sonogashira coupling.

Organic letters

Karpov AS, Müller TJ.
PMID: 12967297
Org Lett. 2003 Sep 18;5(19):3451-4. doi: 10.1021/ol035212q.

[reaction: see text] TMS-ynones are versatile synthetic equivalents of beta-keto aldehydes and can be readily synthesized in an atom-economical fashion by coupling (het)aroyl chlorides and (TMS)-acetylene with only one equiv (!) of triethylamine under Sonogashira conditions. This mild ynone...

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Karpov AS, Müller TJ. New entry to a three-component pyrimidine synthesis by TMS-Ynones via Sonogashira coupling. Org Lett. 2003;5(19):3451-4doi: 10.1021/ol035212q.
Karpov, A. S., & Müller, T. J. (2003). New entry to a three-component pyrimidine synthesis by TMS-Ynones via Sonogashira coupling. Organic letters, 5(19), 3451-4. https://doi.org/10.1021/ol035212q
Karpov, Alexei S, and Müller, Thomas J J. "New entry to a three-component pyrimidine synthesis by TMS-Ynones via Sonogashira coupling." Organic letters vol. 5,19 (2003): 3451-4. doi: https://doi.org/10.1021/ol035212q
Karpov AS, Müller TJ. New entry to a three-component pyrimidine synthesis by TMS-Ynones via Sonogashira coupling. Org Lett. 2003 Sep 18;5(19):3451-4. doi: 10.1021/ol035212q. PMID: 12967297.
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Inhibition of Growth, Synthesis, and Permeability in Neurospora crassa by Phenethyl Alcohol.

Journal of bacteriology

Lester G.
PMID: 16562036
J Bacteriol. 1965 Jul;90(1):29-37. doi: 10.1128/jb.90.1.29-37.1965.

Lester, Gabriel (Reed College, Portland, Ore.). Inhibition of growth, synthesis, and permeability in Neurospora crassa by phenethyl alcohol. J. Bacteriol. 90: 29-37. 1965.-Inhibition of the growth of Neurospora crassa in still culture was detected at 0.05% and was complete...

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Lester G. Inhibition of Growth, Synthesis, and Permeability in Neurospora crassa by Phenethyl Alcohol. J Bacteriol. 1965;90(1):29-37doi: 10.1128/jb.90.1.29-37.1965.
Lester, G. (1965). Inhibition of Growth, Synthesis, and Permeability in Neurospora crassa by Phenethyl Alcohol. Journal of bacteriology, 90(1), 29-37. https://doi.org/10.1128/jb.90.1.29-37.1965
Lester, G. "Inhibition of Growth, Synthesis, and Permeability in Neurospora crassa by Phenethyl Alcohol." Journal of bacteriology vol. 90,1 (1965): 29-37. doi: https://doi.org/10.1128/jb.90.1.29-37.1965
Lester G. Inhibition of Growth, Synthesis, and Permeability in Neurospora crassa by Phenethyl Alcohol. J Bacteriol. 1965 Jul;90(1):29-37. doi: 10.1128/jb.90.1.29-37.1965. PMID: 16562036; PMCID: PMC315590.
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One-pot synthesis of novel 1H-pyrimido[4,5-c][1,2]diazepines and pyrazolo[3,4-d]pyrimidines.

Beilstein journal of organic chemistry

Prajapati D, Baruah PP, Gogoi BJ, Sandhu JS.
PMID: 16556308
Beilstein J Org Chem. 2006 Mar 23;2:5. doi: 10.1186/1860-5397-2-5.

Novel 1H-pyrimido [4,5-c][1,2]diazepines 3 & 4 and pyrazolo [3,4-d]pyrimidines 6 were regioselectively synthesised by the reaction of 1,3-dimethyl-6-hydrazinouracils 1 with various alpha,beta-unsaturated compounds 2 and alpha-ketoalkynes 8 in excellent yields.

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Prajapati D, Baruah PP, Gogoi BJ, et al. One-pot synthesis of novel 1H-pyrimido[4,5-c][1,2]diazepines and pyrazolo[3,4-d]pyrimidines. Beilstein J Org Chem. 2006;2:5doi: 10.1186/1860-5397-2-5.
Prajapati, D., Baruah, P. P., Gogoi, B. J., & Sandhu, J. S. (2006). One-pot synthesis of novel 1H-pyrimido[4,5-c][1,2]diazepines and pyrazolo[3,4-d]pyrimidines. Beilstein journal of organic chemistry, 25. https://doi.org/10.1186/1860-5397-2-5
Prajapati, Dipak, et al. "One-pot synthesis of novel 1H-pyrimido[4,5-c][1,2]diazepines and pyrazolo[3,4-d]pyrimidines." Beilstein journal of organic chemistry vol. 2 (2006): 5. doi: https://doi.org/10.1186/1860-5397-2-5
Prajapati D, Baruah PP, Gogoi BJ, Sandhu JS. One-pot synthesis of novel 1H-pyrimido[4,5-c][1,2]diazepines and pyrazolo[3,4-d]pyrimidines. Beilstein J Org Chem. 2006 Mar 23;2:5. doi: 10.1186/1860-5397-2-5. PMID: 16556308; PMCID: PMC1470455.
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Metabolism of Common Substrates by the Reiter Strain of Treponema pallidum.

Infection and immunity

Allen SL, Johnson RC, Peterson D.
PMID: 16558046
Infect Immun. 1971 Jun;3(6):727-34. doi: 10.1128/iai.3.6.727-734.1971.

The utilization of glucose, amino acids, fatty acids, bicarbonate, purines, and pyrimidines by the Reiter treponeme was studied by using carbon 14-labeled substrates. The distribution of carbon from the substrates into various cell components was determined. Radioactivity from labeled...

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Allen SL, Johnson RC, Peterson D. Metabolism of Common Substrates by the Reiter Strain of Treponema pallidum. Infect Immun. 1971;3(6):727-34doi: 10.1128/iai.3.6.727-734.1971.
Allen, S. L., Johnson, R. C., & Peterson, D. (1971). Metabolism of Common Substrates by the Reiter Strain of Treponema pallidum. Infection and immunity, 3(6), 727-34. https://doi.org/10.1128/iai.3.6.727-734.1971
Allen, S L, et al. "Metabolism of Common Substrates by the Reiter Strain of Treponema pallidum." Infection and immunity vol. 3,6 (1971): 727-34. doi: https://doi.org/10.1128/iai.3.6.727-734.1971
Allen SL, Johnson RC, Peterson D. Metabolism of Common Substrates by the Reiter Strain of Treponema pallidum. Infect Immun. 1971 Jun;3(6):727-34. doi: 10.1128/iai.3.6.727-734.1971. PMID: 16558046; PMCID: PMC416229.
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Note on the preparation of purines and pyrimidines from nucleic acid.

The Biochemical journal

Hunter G, Hlynka I.
PMID: 16746361
Biochem J. 1937 Mar;31(3):486-7. doi: 10.1042/bj0310486.

No abstract available.

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Hunter G, Hlynka I. Note on the preparation of purines and pyrimidines from nucleic acid. Biochem J. 1937;31(3):486-7doi: 10.1042/bj0310486.
Hunter, G., & Hlynka, I. (1937). Note on the preparation of purines and pyrimidines from nucleic acid. The Biochemical journal, 31(3), 486-7. https://doi.org/10.1042/bj0310486
Hunter, G, and Hlynka, I. "Note on the preparation of purines and pyrimidines from nucleic acid." The Biochemical journal vol. 31,3 (1937): 486-7. doi: https://doi.org/10.1042/bj0310486
Hunter G, Hlynka I. Note on the preparation of purines and pyrimidines from nucleic acid. Biochem J. 1937 Mar;31(3):486-7. doi: 10.1042/bj0310486. PMID: 16746361; PMCID: PMC1266959.
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Heterocyclizations with tosylmethyl isocyanide derivatives. A new approach to substituted azolopyrimidines.

The Journal of organic chemistry

Baeza A, Mendiola J, Burgos C, Alvarez-Builla J, Vaquero JJ.
PMID: 15932336
J Org Chem. 2005 Jun 10;70(12):4879-82. doi: 10.1021/jo050029r.

An efficient synthesis of substituted azolopyrimidines such as pyrido[3',2':4,5]pyrrolo[1,2-c]pyrimidines, pyrimido[1,6-a]indoles, benzo[4,5]imidazo-[1,2-c]pyrimidines, an imidazo[1,2-c]pyrimidine, and pyrazolo[1,5-c]pyrimidines is described. The method involves the reaction of N-protected bromomethylazoles and tosylmethyl isocyanide (TosMIC) derivatives in nonanhydrous media. The study of the reaction conditions...

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Baeza A, Mendiola J, Burgos C, et al. Heterocyclizations with tosylmethyl isocyanide derivatives. A new approach to substituted azolopyrimidines. J Org Chem. 2005;70(12):4879-82doi: 10.1021/jo050029r.
Baeza, A., Mendiola, J., Burgos, C., Alvarez-Builla, J., & Vaquero, J. J. (2005). Heterocyclizations with tosylmethyl isocyanide derivatives. A new approach to substituted azolopyrimidines. The Journal of organic chemistry, 70(12), 4879-82. https://doi.org/10.1021/jo050029r
Baeza, Alejandro, et al. "Heterocyclizations with tosylmethyl isocyanide derivatives. A new approach to substituted azolopyrimidines." The Journal of organic chemistry vol. 70,12 (2005): 4879-82. doi: https://doi.org/10.1021/jo050029r
Baeza A, Mendiola J, Burgos C, Alvarez-Builla J, Vaquero JJ. Heterocyclizations with tosylmethyl isocyanide derivatives. A new approach to substituted azolopyrimidines. J Org Chem. 2005 Jun 10;70(12):4879-82. doi: 10.1021/jo050029r. PMID: 15932336.
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RESEARCHES ON PYRIMIDINES. CLIII. THE STRUCTURE OF VITAMIN B1.

Science (New York, N.Y.)

Johnson TB, Litzinger A.
PMID: 17830336
Science. 1936 Jul 03;84(2166):25-6. doi: 10.1126/science.84.2166.25.

No abstract available.

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Johnson TB, Litzinger A. RESEARCHES ON PYRIMIDINES. CLIII. THE STRUCTURE OF VITAMIN B1. Science. 1936;84(2166):25-6doi: 10.1126/science.84.2166.25.
Johnson, T. B., & Litzinger, A. (1936). RESEARCHES ON PYRIMIDINES. CLIII. THE STRUCTURE OF VITAMIN B1. Science (New York, N.Y.), 84(2166), 25-6. https://doi.org/10.1126/science.84.2166.25
Johnson, T B, and Litzinger, A. "RESEARCHES ON PYRIMIDINES. CLIII. THE STRUCTURE OF VITAMIN B1." Science (New York, N.Y.) vol. 84,2166 (1936): 25-6. doi: https://doi.org/10.1126/science.84.2166.25
Johnson TB, Litzinger A. RESEARCHES ON PYRIMIDINES. CLIII. THE STRUCTURE OF VITAMIN B1. Science. 1936 Jul 03;84(2166):25-6. doi: 10.1126/science.84.2166.25. PMID: 17830336.
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Thiyl radical interaction with pyrimidine C5-C6 double bond.

The journal of physical chemistry. B

Wójcik A, Naumov S, Marciniak B, Hermann R, Brede O.
PMID: 16852915
J Phys Chem B. 2005 Aug 11;109(31):15135-44. doi: 10.1021/jp051711s.

Addition and elimination interaction of thiyl radicals with the C5-C6 double bond in pyrimidines was studied by the pulse radiolysis technique in aqueous solution with the use of different monitoring systems. For this purpose, p-thiocresol, cysteamine hydrochloride, and mercaptoethanol...

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Wójcik A, Naumov S, Marciniak B, et al. Thiyl radical interaction with pyrimidine C5-C6 double bond. J Phys Chem B. 2005;109(31):15135-44doi: 10.1021/jp051711s.
Wójcik, A., Naumov, S., Marciniak, B., Hermann, R., & Brede, O. (2005). Thiyl radical interaction with pyrimidine C5-C6 double bond. The journal of physical chemistry. B, 109(31), 15135-44. https://doi.org/10.1021/jp051711s
Wójcik, Aleksandra, et al. "Thiyl radical interaction with pyrimidine C5-C6 double bond." The journal of physical chemistry. B vol. 109,31 (2005): 15135-44. doi: https://doi.org/10.1021/jp051711s
Wójcik A, Naumov S, Marciniak B, Hermann R, Brede O. Thiyl radical interaction with pyrimidine C5-C6 double bond. J Phys Chem B. 2005 Aug 11;109(31):15135-44. doi: 10.1021/jp051711s. PMID: 16852915.
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