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Showing 1333 to 1337 of 1337 entries
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Comparison of clinically approved molecules on SARS-CoV-2 drug target proteins: a molecular docking study.

Turkish journal of chemistry

Çubuk H, Özbİl M.
PMID: 33679150
Turk J Chem. 2021 Feb 17;45(1):35-41. doi: 10.3906/kim-2008-35. eCollection 2021.

The new type of coronavirus, SARS-CoV-2 has affected more than 22.6 million people worldwide. Since the first day the virus was spotted in Wuhan, China, numerous drug design studies have been conducted all over the globe. Most of these...

Recent advances in fungal serine protease inhibitors.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Burchacka E, Pięta P, Łupicka-Słowik A.
PMID: 34902742
Biomed Pharmacother. 2021 Dec 10;146:112523. doi: 10.1016/j.biopha.2021.112523. Epub 2021 Dec 10.

Four types of antifungal drugs are available that include inhibitors of ergosterol synthesis, of fungal RNA biosynthesis, and of cell wall biosynthesis as well as physiochemical regulators of fungal membrane sterols. Increasing resistance to antifungal drugs can severely limit...

Atypical response to bacterial coinfection and persistent neutrophilic bronchoalveolar inflammation distinguish critical COVID-19 from influenza.

JCI insight

Cambier S, Metzemaekers M, de Carvalho AC, Nooyens A, Jacobs C, Vanderbeke L, Malengier-Devlies B, Gouwy M, Heylen E, Meersseman P, Hermans G, Wauters E, Wilmer A, Schols D, Matthys P, Opdenakker G, Marques RE, Wauters J, Vandooren J, Proost P.
PMID: 34793331
JCI Insight. 2022 Jan 11;7(1). doi: 10.1172/jci.insight.155055.

Neutrophils are recognized as important circulating effector cells in the pathophysiology of severe coronavirus disease 2019 (COVID-19). However, their role within the inflamed lungs is incompletely understood. Here, we collected bronchoalveolar lavage (BAL) fluids and parallel blood samples of...

Computational Simulation of HIV Protease Inhibitors to the Main Protease (Mpro) of SARS-CoV-2: Implications for COVID-19 Drugs Design.

Molecules (Basel, Switzerland)

Yu W, Wu X, Zhao Y, Chen C, Yang Z, Zhang X, Ren J, Wang Y, Wu C, Li C, Chen R, Wang X, Zheng W, Liao H, Yuan X.
PMID: 34885967
Molecules. 2021 Dec 05;26(23). doi: 10.3390/molecules26237385.

SARS-CoV-2 is highly homologous to SARS-CoV. To date, the main protease (Mpro) of SARS-CoV-2 is regarded as an important drug target for the treatment of Coronavirus Disease 2019 (COVID-19). Some experiments confirmed that several HIV protease inhibitors present the...

Profiles of liver fibrosis evolution during long-term tenofovir treatment in HIV-positive patients coinfected with hepatitis B.

Liver international : official journal of the International Association for the Study of the Liver

Dezanet LNC, Miailhes P, Lascoux-Combe C, Chas J, Maylin S, Gabassi A, Rougier H, Delaugerre C, Lacombe K, Boyd A.
PMID: 34297463
Liver Int. 2021 Jul 23; doi: 10.1111/liv.15019. Epub 2021 Jul 23.

BACKGROUND & AIMS: Data on liver fibrosis evolution and its involvement in liver-related morbidity are scarce in individuals with human immunodeficiency virus (HIV) and hepatitis B virus (HBV) co-infection during treatment. We identified profiles of liver fibrosis evolution in...

Showing 1333 to 1337 of 1337 entries