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Showing 25 to 36 of 1392 entries
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Biological Response Modifiers and Normal Tissue Injury After Irradiation.

Seminars in radiation oncology

Hendry JH.
PMID: 10717099
Semin Radiat Oncol. 1994 Apr;4(2):123-132. doi: 10.1053/SRAO00400123.

The reactions of tissues after irradiation can be modified using a variety of biologically based approaches. Cellular radiosensitivity can be changed using growth regulatory molecules (GRM) that have cell-cycle-mediated effects. Radiosensitivity can also be changed using prostaglandins, dose-miodifying factors...

Nonsteroidal Anti-inflammatory Drugs: Making the Right Choices.

The Journal of the American Academy of Orthopaedic Surgeons

Berger RG.
PMID: 10709017
J Am Acad Orthop Surg. 1994 Oct;2(5):255-260. doi: 10.5435/00124635-199409000-00003.

Nonsteroidal anti-inflammatory drugs (NSAIDs) are among the most prescribed pharmacologic agents in medicine. The ability of these drugs to decrease inflammation is linked to their inhibitory effect on the synthesis of prostaglandins. This mechanism also results in toxicity that...

Autoimmune Diseases: Problems of Pathogenesis, Diagnostics and Treatment.

Russian journal of immunology : RJI : official journal of Russian Society of Immunology

Shirinskiy VS.
PMID: 12687139
Russ J Immunol. 1999 Oct;4(3):261-263.

Autoimmune diseases (AID) are pathological states wherein a disturbance of the regulation of physiological autoimmune processes results in the appearance of antibodies, T lymphocytes, specific in respect to components of self tissues, causing structural and/or functional disturbances in target...

Enantioselective synthesis of cyclopentenones via rhodium-catalyzed kinetic resolution and desymmetrization of 4-alkynals.

Journal of the American Chemical Society

Tanaka K, Fu GC.
PMID: 12197729
J Am Chem Soc. 2002 Sep 04;124(35):10296-7. doi: 10.1021/ja0266161.

We have developed two new catalytic processes that provide efficient access to interesting chiral building blocks, cyclopentenones that bear tertiary and quaternary stereocenters, in high enantiomeric excess and very good yield. Structures such as these have potential utility in...

[Current conservative treatment of renal colic: value of prostaglandin synthesis inhibitors].

Schmerz (Berlin, Germany)

Zwergel U, Felgner J, Rombach H, Zwergel T.
PMID: 12799978
Schmerz. 1998 Apr 20;12(2):112-7. doi: 10.1007/s004829800049.

Prostaglandin synthesis inhibitors and parasympatholytic drugs are often used as analgetics in the case of renal colic. This paper analyzes how and whether these drug effects are important for the analgetic therapy. In an animal and in a human...

Effects of Misoprostol on Nonsteroidal Anti-Inflammatory Drug-Induced Renal Insufficiency in Patients with Stable Chronic Renal Failure: A Double-Blind, Crossover Study.

American journal of therapeutics

Whelton A, Scott H, Stout RL.
PMID: 11854799
Am J Ther. 1995 Nov;2(11):858-863. doi: 10.1097/00045391-199511000-00006.

Nonsteroidal anti-inflammatory drugs (NSAIDs) have the ability to induce acute deterioration in renal function by inhibiting the production of vasodilatory prostaglandins, thereby disrupting intrarenal hemodynamic balance in patients with stable, mild, chronic renal failure. Misoprostol is a synthetic prostaglandin...

The Influence of Misoprostol on the Adverse Renal Effects and Stereospecific Pharmacokinetics of Ibuprofen in Chronic Renal Insufficiency.

American journal of therapeutics

Rudy DW, Rudy AC, Black PK, Liu Y, Hamman M, Brater DC.
PMID: 11854800
Am J Ther. 1995 Nov;2(11):864-874. doi: 10.1097/00045391-199511000-00007.

The use of nonsteroidal anti-inflammatory drugs in patients with chronic renal insufficiency (CRI) may be complicated by renal functional abnormalities due to the inhibition of renal prostaglandins. We tested the hypothesis that administration of the oral PGE1 analog, misoprostol,...

The Role of Cyclooxygenase-2 in Inflammation.

American journal of therapeutics

Masferrer JL, Zweifel BS, Colburn SM, Ornberg RL, Salvemini D, Isakson P, Seibert K.
PMID: 11854834
Am J Ther. 1995 Sep;2(9):607-610. doi: 10.1097/00045391-199509000-00005.

Prostaglandins (PGs) can be synthetized via two isoforms of cyclooxygenase (COX). COX-1 is constitutively expressed in normal tissues, and its activity represent the normal physiological output of PGs. In inflammatory states, the newly discovered COX-2 is rapidly induced, and...

Effects of Misoprostol on Bone Resorption and Formation in Organ Culture.

American journal of therapeutics

Raisz LG, Woodiel FN.
PMID: 11859384
Am J Ther. 1996 Feb;3(2):134-138. doi: 10.1097/00045391-199602000-00007.

Prostaglandins are potent stimulators of bone resorption and formation. Because misoprostol is an analog of prostaglandin E(1) (PGE(1)), we have examined its effects on resorption and formation in organ culture. The results were compared with PGE(2) which can stimulate...

Nonsteroidal anti-inflammatory drugs and the induction of apoptosis in colon cells: evidence for PHS-dependent and PHS-independent mechanisms.

Apoptosis : an international journal on programmed cell death

Rigas B, Shiff SJ.
PMID: 14634340
Apoptosis. 1999 Oct;4(5):373-81. doi: 10.1023/a:1009699321946.

NSAIDs are potent chemopreventive agents for colon cancer. Although their mechanism of action is unknown, it probably relates to their modulation of colon epithelial cell kinetics, i.e. apoptosis and/or cell proliferation. NSAIDs are pleiotropic in their biochemical activities; their...

Cytoprotection and healing: two unequal brethren.

Inflammopharmacology

Halter F, Peskar B, Rainsford KD, Schmassmann A.
PMID: 17657618
Inflammopharmacology. 1997;5(4):407-14. doi: 10.1007/s10787-997-0036-3.

The promotion of the concept of cytoprotection has fostered hopes that the use of co-prescribed mucosal protective agents would revolutionize the prevention of NSAID-induced ulcers and supply the basis for novel ulcer therapy. Prostaglandins do not, however, accelerate ulcer...

Pro-algesic versus analgesic actions of immune cells.

Current opinion in anaesthesiology

Rittner HL, Brack A, Stein C.
PMID: 17021507
Curr Opin Anaesthesiol. 2003 Oct;16(5):527-33. doi: 10.1097/00001503-200310000-00014.

PURPOSE OF REVIEW: When tissue is destroyed, pain arises. Tissue destruction is associated with an inflammatory reaction. This leads to activation of nociceptors. The following review will concentrate on pro-algesic and analgesic mediators, which arise from immune cells or...

Showing 25 to 36 of 1392 entries