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Showing 37 to 42 of 42 entries
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Stretching the limits of antiarrhythmic drug therapy: The promise of small-conductance calcium-activated potassium channel blockers.

International journal of cardiology. Heart & vasculature

Heijman J, Rahm AK, Dobrev D.
PMID: 34917752
Int J Cardiol Heart Vasc. 2021 Dec 01;37:100924. doi: 10.1016/j.ijcha.2021.100924. eCollection 2021 Dec.

No abstract available.

Potassium Channel Blockers Inhibit Adoptive Transfer of Experimental Allergic Encephalomyelitis by Myelin-Basic-Protein-Stimulated Rat T Lymphocytes.

Journal of biomedical science

Judge SI, Yeh JZ, Mannie MD, Pope Seifert L, Paterson PY.
PMID: 11725150
J Biomed Sci. 1997 Jul-Aug;4(4):169-178. doi: 10.1007/BF02255646.

Agents which block T cell K(+) currents can prohibit both proliferative and effector cell functions in T cells activated by mitogens or phorbol esters. This study examined the effects of some of these blocking agents on the immune responsiveness...

De novo Folding of Two-Helix Potassium Channel Blockers with Free-Energy Models and Molecular Dynamics.

Journal of chemical theory and computation

Quintilla A, Starikov E, Wenzel W.
PMID: 26627437
J Chem Theory Comput. 2007 May;3(3):1183-92. doi: 10.1021/ct600274a.

We report the predictive de novo folding of three two-helix proteins using the free-energy protein forcefield PFF01. Starting from random initial conformations 40-90% of the members of the simulated ensembles converge to near-native conformations. The energetically lowest conformations approach...

Presynaptic calcium signalling in cerebellar mossy fibres.

Frontiers in neural circuits

Thomsen LB, Jörntell H, Midtgaard J.
PMID: 20162034
Front Neural Circuits. 2010 Feb 08;4:1. doi: 10.3389/neuro.04.001.2010. eCollection 2010.

Whole-cell recordings were obtained from mossy fibre terminals in adult turtles in order to characterize the basic membrane properties. Calcium imaging of presynaptic calcium signals was carried out in order to analyse calcium dynamics and presynaptic GABA B inhibition....

Fatty Acid and Related Potassium Kv2 Channel Blockers: Toxicity and Physiological Actions on Mosquitoes.

Insects

Démares F, Coquerel Q, Richoux G, Linthicum K, Bloomquist J.
PMID: 30388752
Insects. 2018 Nov 01;9(4). doi: 10.3390/insects9040155.

Potassium channels constitute a very diverse group involved in neural signaling, neuronal activity, membrane potential maintenance, and action potential generation. Here, we tested the mammalian potassium channel blockers TRAM-34 and 5-hydroxydecanoate (5-HDC), as well as certain fatty acids (FA)...

Potassium channel blockers restore axonal conduction in CNS trauma and diseases.

Neural regeneration research

Page JC, Shi R.
PMID: 27651761
Neural Regen Res. 2016 Aug;11(8):1226-7. doi: 10.4103/1673-5374.189172.

No abstract available.

Showing 37 to 42 of 42 entries