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Showing 421 to 425 of 425 entries
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Heliyon

Kurniawansyah IS, Rusdiana T, Sopyan I, Ramoko H, Wahab HA, Subarnas A.
PMID: 33251348
Heliyon. 2020 Nov 13;6(11):e05365. doi: 10.1016/j.heliyon.2020.e05365. eCollection 2020 Nov.

BACKGROUND: Conventional drug delivery systems have some major drawbacks such as low bioavailability, short residence time and rapid precorneal drainage. An METHODS: The effects of independent variables (poloxamer 407 and hydroxypropyl methyl cellulose (HPMC) concentration) on various dependent variables...

Surface-Modified Multifunctional Thymol-Loaded Biodegradable Nanoparticles for Topical Acne Treatment.

Pharmaceutics

Folle C, Díaz-Garrido N, Sánchez-López E, Marqués AM, Badia J, Baldomà L, Espina M, Calpena AC, García ML.
PMID: 34575577
Pharmaceutics. 2021 Sep 18;13(9). doi: 10.3390/pharmaceutics13091501.

The present work is focused on the development of novel surface-functionalized poly(lactic-co-glycolic acid) nanoparticles loaded with thymol (TH-NPs) for topical administration enhancing thymol anti-inflammatory, antioxidant and wound healing activities against acne. TH-NPs were prepared by solvent evaporation method using...

Rheological and Drug Delivery Characteristics of Poloxamer-Based Diclofenac Sodium Formulations for Chronic Wound Site Analgesia.

Pharmaceutics

Russo J, Fiegel J, Brogden NK.
PMID: 33333773
Pharmaceutics. 2020 Dec 15;12(12). doi: 10.3390/pharmaceutics12121214.

Chronic wounds are a significant and growing health problem, and clinical treatment is often a painful experience. A topical dosage form would be optimal to treat this pain. Poloxamer 407, a thermosensitive polymer that is a liquid at low...

Improving the in vitro dissolution rate and pharmacokinetic performance of fenbendazole in sheep using drug nanocrystals.

Research in veterinary science

Melian ME, Ibarra M, Ceballos L, Paredes AJ, Munguía B, Faccio R, Palma S, Álvarez LI, Domínguez L.
PMID: 34922278
Res Vet Sci. 2021 Dec 07;142:110-116. doi: 10.1016/j.rvsc.2021.12.001. Epub 2021 Dec 07.

Benzimidazole methylcarbamate anthelmintics, including fenbendazole (FBZ), have only limited water solubility and small differences in drug solubility may have a major influence on their absorption, pharmacokinetic behavior and anthelmintic efficacy. To improve FBZ water solubility and dissolution rate, novel...

Repurposing of nifedipine loaded in situ ophthalmic gel as a novel approach for glaucoma treatment.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

El-Feky YA, Fares AR, Zayed G, El-Telbany RFA, Ahmed KA, El-Telbany DFA.
PMID: 34385102
Biomed Pharmacother. 2021 Oct;142:112008. doi: 10.1016/j.biopha.2021.112008. Epub 2021 Aug 09.

Glaucoma is a chronic eye disease characterized by elevated intraocular pressure (IOP) which causes severe complications to the eyes and may lead to vision loss. The effective treatment of such diseases motivated the search for novel and unique drugs...

Showing 421 to 425 of 425 entries