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Showing 25 to 36 of 425 entries
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Autonomously isolated pseudo-polyrotaxane nanosheets fabricated via hierarchically ordered supramolecular self-assembly.

Chemical communications (Cambridge, England)

Uenuma S, Maeda R, Yokoyama H, Ito K.
PMID: 30821314
Chem Commun (Camb). 2019 Apr 04;55(29):4158-4161. doi: 10.1039/c9cc00511k.

We succeeded in obtaining autonomously isolated nanosheets consisting of pseudo-polyrotaxane (PPR) fabricated via hierarchically ordered supramolecular self-assembly of β-cyclodextrin and a poloxamer by introducing charged groups to the axis ends of the poloxamer. The isolated PPR nanosheets exhibited a...

Functional Magnetic Core-Shell System-Based Iron Oxide Nanoparticle Coated with Biocompatible Copolymer for Anticancer Drug Delivery.

Pharmaceutics

Hoang Thi TT, Nguyen Tran DH, Bach LG, Vu-Quang H, Nguyen DC, Park KD, Nguyen DH.
PMID: 30875948
Pharmaceutics. 2019 Mar 15;11(3). doi: 10.3390/pharmaceutics11030120.

Polymer coating has drawn increasing attention as a leading strategy to overcome the drawbacks of superparamagnetic iron oxide nanoparticles (SPIONs) in targeted delivery of anticancer drugs. In this study, SPIONs were modified with heparin-Poloxamer (HP) shell to form a...

Novel in-situ gel for intravesical administration of ketorolac.

Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society

Sherif AY, Mahrous GM, Alanazi FK.
PMID: 30202226
Saudi Pharm J. 2018 Sep;26(6):845-851. doi: 10.1016/j.jsps.2018.03.014. Epub 2018 Mar 27.

The urinary bladder stores urine until the time of urination. Systemic administration of drugs to treat bladder diseases faces several limitations. Therefore, intravesical drug delivery is a promising alternative route of administration. An in-situ gel is used to form...

Multilayer Assembly of Tannic Acid and an Amphiphilic Copolymer Poloxamer 188 on Planar Substrates toward Multifunctional Surfaces with Discrete Microdome-Shaped Features.

Langmuir : the ACS journal of surfaces and colloids

Peng L, Cheng F, Zheng Y, Shi Z, He W.
PMID: 30148369
Langmuir. 2018 Sep 11;34(36):10748-10756. doi: 10.1021/acs.langmuir.8b01982. Epub 2018 Aug 27.

Tannic acid (TA) is a natural polyphenol compound with a broad spectrum of biological activities, the most notable of which being antioxidation. Poloxamer 188 (P188), a synthetic triblock copolymer of poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide), is amphiphilic in nature and...

Effect of Surface Modification on the .

Journal of pharmacy & bioallied sciences

Sathyamoorthy N, Magharla DD, Vankayalu SD.
PMID: 28717337
J Pharm Bioallied Sci. 2017 Apr-Jun;9(2):135-143. doi: 10.4103/jpbs.JPBS_258_16.

CONTEXT: Nanocarriers possessing long-circulating abilities could take advantage of the pathophysiology of tumor vasculature to achieve spatial placement. To attain such qualities, the drug carriers should possess suitable physicochemical properties such as size and surface hydrophilicity.AIM: The aim of...

In vitro and in vivo evaluation of cubosomes containing 5-fluorouracil for liver targeting.

Acta pharmaceutica Sinica. B

Nasr M, Ghorab MK, Abdelazem A.
PMID: 26579429
Acta Pharm Sin B. 2015 Jan;5(1):79-88. doi: 10.1016/j.apsb.2014.12.001. Epub 2014 Dec 29.

The objective of this study was to prepare cubosomal nanoparticles containing a hydrophilic anticancer drug 5-fluorouracil (5-FU) for liver targeting. Cubosomal dispersions were prepared by disrupting a cubic gel phase of monoolein and water in the presence of Poloxamer...

Poloxamer 188 enhances apoptosis in a human leukemia cell line.

Molecular medicine reports

Aoki N, Tamura M, Ohyashiki JH, Sugaya M, Hisatomi H.
PMID: 21472296
Mol Med Rep. 2010 Jul-Aug;3(4):669-72. doi: 10.3892/mmr_00000314.

Poloxamer block copolymers have been studied in multiple applications as drug delivery systems (DDS). These A-B-A amphiphilic block copolymers up-regulate the expression of selected genes in cells and alter genetic responses to antineoplastic agents in cancer. One example is...

Efficacy of Poloxamer-Based Wound Dressings on .

Advances in wound care

Salisbury AM, Mullin M, Chen R, Percival SL.
PMID: 31456903
Adv Wound Care (New Rochelle). 2019 Oct 01;8(10):463-468. doi: 10.1089/wound.2018.0854. Epub 2019 Aug 21.

No abstract available.

Design and Characterization of Cyclosporine A-Loaded Nanofibers for Enhanced Drug Dissolution.

ACS omega

Dubey P, Barker SA, Craig DQM.
PMID: 31984256
ACS Omega. 2020 Jan 07;5(2):1003-1013. doi: 10.1021/acsomega.9b02616. eCollection 2020 Jan 21.

Despite widespread use as an immunosuppressant, the therapeutic efficacy of the undecapeptide cyclosporine A (CyA) is compromised when given by the oral route because of the innate hydrophobicity of the drug molecule, potentially leading to poor aqueous solubility and...

Improvement in Dissolution Rate of Cefuroxime Axetil by using Poloxamer 188 and Neusilin US2.

Indian journal of pharmaceutical sciences

Sruti J, Patra ChN, Swain SK, Beg S, Palatasingh HR, Dinda SC, Rao ME.
PMID: 23901163
Indian J Pharm Sci. 2013 Jan;75(1):67-75. doi: 10.4103/0250-474X.113551.

A combination of fusion and surface adsorption techniques was used to enhance the dissolution rate of cefuroxime axetil. Solid dispersions of cefuroxime axetil were prepared by two methods, namely fusion method using poloxamer 188 alone and combination of poloxamer...

Evaluation of Eleview.

Polymers

Giannino V, Salandin L, Macelloni C, Longo LM.
PMID: 32033452
Polymers (Basel). 2020 Feb 05;12(2). doi: 10.3390/polym12020346.

Submucosal injection is generally required for both endoscopic-mucosal resection (EMR) and submucosal dissection (ESD). SIC-8000 (Eleview®) is a new liquid composition in the form of a microemulsion for submucosal injection, approved by the Food and Drug Administration (FDA) 510(k)...

Development and Evaluation of Multifunctional Poly(Lactic-co-glycolic acid) Nanoparticles Embedded in Carboxymethyl β-Glucan Porous Microcapsules as a Novel Drug Delivery System for Gefitinib.

Pharmaceutics

Li X, Wang J, Li S, Liu Z, Zheng Z, Zhang Y.
PMID: 31547272
Pharmaceutics. 2019 Sep 12;11(9). doi: 10.3390/pharmaceutics11090469.

In this study, a new kind of folic acid (FA)-conjugated and chitosan (CS)-coated poloxamer 407 (P407)/poly(lactic-

Showing 25 to 36 of 425 entries