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Showing 13 to 24 of 425 entries
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Solid Lipid Nanoparticles of Atovaquone Based on 2(4) Full-Factorial Design.

Iranian journal of pharmaceutical research : IJPR

Mohtar N, A K Khan N, Darwis Y.
PMID: 26664366
Iran J Pharm Res. 2015;14(4):989-1000.

Solid lipid nanoparticles of atovaquone (ATQ-SLN) were prepared by high shear homogenization method using tripalmitin, trilaurin, and Compritol 888 ATO as the lipid matrices and Phospholipon 90H, Tween 80, and poloxamer 188 as the surfactants. Optimization of the formulations...

Effect of Poloxamer 188 on Collateral Blood Flow, Myocardial Infarct Size, and Left Ventricular Function in a Canine Model of Prolonged (3-Hour) Coronary Occlusion and Reperfusion.

Journal of thrombosis and thrombolysis

Kelly RF, Hursey TL, Patel RB, Parrillo JE, Schaer GL.
PMID: 10767120
J Thromb Thrombolysis. 1998 Jul;5(3):239-247. doi: 10.1023/A:1008848026759.

Poloxamer 188 is a surfactant with hemorheological, antithrombotic, and neutrophil-inhibitory properties. This agent has been demonstrated to reduce infarct size and to improve left ventricular function in animal models of myocardial infarction and reperfusion, and recently in a randomized...

FLOCOR: a new anti-adhesive, rheologic agent.

Expert opinion on investigational drugs

Emanuele RM.
PMID: 15992024
Expert Opin Investig Drugs. 1998 Jul;7(7):1193-200. doi: 10.1517/13543784.7.7.1193.

FLOCOR (purified poloxamer 188) is a surfactant molecule that represents a new class of pharmacological agent. FLOCOR is different in that its activity does not depend on high affinity receptor binding but rather on altering the way cells and...

Intrinsic bacterial contamination of a commercial iodophor solution: investigation of the implicated manufacturing plant.

Applied and environmental microbiology

Berkelman RL, Anderson RL, Davis BJ, Highsmith AK, Petersen NJ, Bond WW, Cook EH, Mackel DC, Favero MS, Martone WJ.
PMID: 16346513
Appl Environ Microbiol. 1984 Apr;47(4):752-6. doi: 10.1128/aem.47.4.752-756.1984.

After an outbreak of peritoneal infections attributed to intrinsic contamination of a poloxamer-iodine solution with Pseudomonas aeruginosa, the manufacturer of the contaminated solution permitted investigation and sampling of materials within the plant. Pseudomonas spp. were recovered from two different...

Cyclosporine a-nanosuspension: formulation, characterization and in vivo comparison with a marketed formulation.

Scientia pharmaceutica

Nakarani M, Patel P, Patel J, Patel P, Murthy RS, Vaghani SS.
PMID: 21179351
Sci Pharm. 2010 Apr-Jun;78(2):345-61. doi: 10.3797/scipharm.0908-12. Epub 2010 Apr 26.

Cyclosporine A-nanosuspensions were prepared using zirconium oxide beads as a milling media, Poloxamer 407 as a stabilizer and distilled water as an aqueous medium using the Pearl Milling technique. The optimized formulation was characterized in terms of particle size...

Tolerability and acceptability of Blephagel: a novel eyelid hygiene aqueous gel.

Clinical ophthalmology (Auckland, N.Z.)

Doan S.
PMID: 22275810
Clin Ophthalmol. 2012;6:71-7. doi: 10.2147/OPTH.S26105. Epub 2012 Jan 11.

Commonly associated with dry eye, blepharitis is the most commonly encountered disorder in general ophthalmologic practice. Although anti-infective and anti-inflammatory therapies are available, eyelid hygiene is the cornerstone of effective management. A variety of products have been used to...

The cardioprotective effect of microemulsion propofol against ischemia and reperfusion injury in isolated rat heart.

Korean journal of anesthesiology

Hur MJ, Kim H, Lee DK, Lim SH.
PMID: 22558503
Korean J Anesthesiol. 2012 Apr;62(4):358-64. doi: 10.4097/kjae.2012.62.4.358. Epub 2012 Apr 23.

BACKGROUND: Lipid-emulsion propofol (LP) has cardioprotective effects against ischemia-reperfusion injury, but it has lipid-related side effects. Microemulsion propofol (MP) is a lipid-free propofol emulsified with 10% purified poloxamer 188 (PP188). PP188 is a nonionic surfactant and has cardioprotective effects....

Stability of methimazole in poloxamer lecithin organogel to determine beyond-use date.

International journal of pharmaceutical compounding

Pignato A, Pankaskie M, Birnie C.
PMID: 23965656
Int J Pharm Compd. 2010 Nov-Dec;14(6):522-5.

The purpose of this stability study was to determine the beyond-use date of the active ingredient methimazole extemporaneously prepared for transdermal absorption to treat feline hyperthyroidism. The methimazole was prepared in poloxamer lecithin organogel and subjected to a three-month...

Preparation and evaluation of fenoterol hydrobromide suppositories.

Drug discoveries & therapeutics

Ghorab D, Refai H, Tag R.
PMID: 22466443
Drug Discov Ther. 2011 Dec;5(6):311-8. doi: 10.5582/ddt.2011.v5.6.311.

Fenoterol HBr is a bronchodilator known to be subject to first pass effect after oral administration. The aim of this study was to prepare and evaluate fenoterol HBr suppositories. Suppositories were prepared by a fusion method using different fatty...

In vitro dissolution study of atorvastatin binary solid dispersion.

Journal of advanced pharmaceutical technology & research

Jahan R, Islam MS, Tanwir A, Chowdhury JA.
PMID: 23662278
J Adv Pharm Technol Res. 2013 Jan;4(1):18-24. doi: 10.4103/2231-4040.107496.

The aim of the present study was to improve the solubility and dissolution rate of atorvastatin (ATV), a slight water-soluble drug, by solid dispersion (SD) technique using a hydrophilic carrier Poloxamer 188 (POL188). Physical mixing (PM) and solvent evaporation...

Clarithromycin dissolution enhancement by preparation of aqueous nanosuspensions using sonoprecipitation technique.

Iranian journal of pharmaceutical research : IJPR

Esfandi E׳, Ramezani V, Vatanara A, Rouholamini Najafabadi A, Hadipour Moghaddam SP.
PMID: 25276181
Iran J Pharm Res. 2014;13(3):809-18.

Clarithromycin (CLM) is a member of macrolide family with broad spectrum antibiotic activity. It is practically insoluble in water and its poor solubility is pH dependent. In this study, series of nanosuspensions containing CLM and stabilizer such as HPMC,...

Temperature responsive nanoparticles: poloxamers as a modulator of Förster resonance energy transfer (FRET).

Nanoscale

Klep O, Bandera Y, Foulger SH.
PMID: 29741544
Nanoscale. 2018 May 17;10(19):9401-9409. doi: 10.1039/c8nr01278d.

An effective strategy to control the Förster resonance energy transfer (FRET) of a donor/acceptor emitter pair that were attached to a 60 nm poly(propargyl acrylate)(PA) nanoparticle using temperature variations was developed. The size dependent properties of a poly-(ethylene oxide)-poly-(propylene...

Showing 13 to 24 of 425 entries