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Showing 25 to 36 of 181 entries
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HIF-Dependent CKB Expression Promotes Breast Cancer Metastasis, Whereas Cyclocreatine Therapy Impairs Cellular Invasion and Improves Chemotherapy Efficacy.

Cancers

Krutilina RI, Playa H, Brooks DL, Schwab LP, Parke DN, Oluwalana D, Layman DR, Fan M, Johnson DL, Yue J, Smallwood H, Seagroves TN.
PMID: 35008190
Cancers (Basel). 2021 Dec 22;14(1). doi: 10.3390/cancers14010027.

The oxygen-responsive hypoxia inducible factor (HIF)-1 promotes several steps of the metastatic cascade. A hypoxic gene signature is enriched in triple-negative breast cancers (TNBCs) and is correlated with poor patient survival. Inhibiting the HIF transcription factors with small molecules...

MR Spectroscopy of the Insula: Within- and between-Session Reproducibility of MEGA-PRESS Measurements of GABA+ and Other Metabolites.

Brain sciences

Shyu C, Elsaid S, Truong P, Chavez S, Le Foll B.
PMID: 34827537
Brain Sci. 2021 Nov 19;11(11). doi: 10.3390/brainsci11111538.

The insula plays a critical role in many neuropsychological disorders. Research investigating its neurochemistry with magnetic resonance spectroscopy (MRS) has been limited compared with cortical regions. Here, we investigate the within-session and between-session reproducibility of metabolite measurements in the...

Association of Age, Antipsychotic Medication, and Symptom Severity in Schizophrenia With Proton Magnetic Resonance Spectroscopy Brain Glutamate Level: A Mega-analysis of Individual Participant-Level Data.

JAMA psychiatry

Merritt K, McGuire PK, Egerton A, Aleman A, Block W, Bloemen OJN, Borgan F, Bustillo JR, Capizzano AA, Coughlin JM, De la Fuente-Sandoval C, Demjaha A, Dempster K, Do KQ, Du F, Falkai P, Galinska-Skok B, Gallinat J, Gasparovic C, Ginestet CE, Goto N, Graff-Guerrero A, Ho BC, Howes OD, Jauhar S, Jeon P, Kato T, Kaufmann CA, Kegeles LS, Keshavan M, Kim SY, Kunugi H, Lauriello J, Liemburg EJ, Mcilwain ME, Modinos G, Mouchlianitis ED, Nakamura J, Nenadic I, Öngür D, Ota M, Palaniyappan L, Pantelis C, Plitman E, Posporelis S, Purdon SE, Reichenbach JR, Renshaw PF, Russell BR, Sawa A, Schaefer M, Shungu DC, Smesny S, Stanley JA, Stone JM, Szulc A, Taylor R, Thakkar K, Théberge J, Tibbo PG, van Amelsvoort T, Walecki J, Williamson PC, Wood SJ, Xin L, Yamasue H.
PMID: 33881460
JAMA Psychiatry. 2021 Jun 01;78(6):667-681. doi: 10.1001/jamapsychiatry.2021.0380.

IMPORTANCE: Proton magnetic resonance spectroscopy (1H-MRS) studies indicate that altered brain glutamatergic function may be associated with the pathophysiology of schizophrenia and the response to antipsychotic treatment. However, the association of altered glutamatergic function with clinical and demographic factors...

Metabolite signatures of heart failure, sleep apnoea, their interaction, and outcomes in the community.

ESC heart failure

Dutta S, Li D, Wang A, Ishak M, Cook K, Farnham M, Dissanayake H, Cistulli P, Hunyor I, Liu R, Wilcox I, Koay YC, Yang J, Lal S, O'Sullivan JF.
PMID: 34657379
ESC Heart Fail. 2021 Dec;8(6):5392-5402. doi: 10.1002/ehf2.13631. Epub 2021 Oct 17.

AIMS: Sleep apnoea and congestive heart failure (CHF) commonly co-exist, but their interaction is unclear. Metabolomics may clarify their interaction and relationships to outcome.METHODS AND RESULTS: We assayed 372 circulating metabolites and lipids in 1919 and 1524 participants of...

Energy metabolism measured by 31P magnetic resonance spectroscopy in the healthy human brain.

Journal of neuroradiology = Journal de neuroradiologie

Rietzler A, Steiger R, Mangesius S, Walchhofer LM, Gothe RM, Schocke M, Gizewski ER, Grams AE.
PMID: 34871672
J Neuroradiol. 2021 Dec 04; doi: 10.1016/j.neurad.2021.11.006. Epub 2021 Dec 04.

BACKGROUND AND PURPOSE: Phosphorous magnetic resonance spectroscopy (31P-MRS) allows a non-invasive analysis of phosphorus-containing compounds in vivo. The present study investigated the influence of brain region, hemisphere, age, sex and brain volume on 31P-MRS metabolites in healthy adults.MATERIALS AND...

Neurometabolite correlates with personality and stress in healthy emerging adults: A focus on sex differences.

NeuroImage

Tuovinen N, Yalcin-Siedentopf N, Welte AS, Siedentopf CM, Steiger R, Gizewski ER, Hofer A.
PMID: 34954024
Neuroimage. 2021 Dec 22;247:118847. doi: 10.1016/j.neuroimage.2021.118847. Epub 2021 Dec 22.

Personality traits have been linked with both brain structure and function. However, the exact relationship between personality traits and other behavioural measures with neurometabolites, measured with proton magnetic resonance spectroscopy, is not clear. Here we investigated the association between...

Neurometabolite correlates with personality and stress in healthy emerging adults: A focus on sex differences.

NeuroImage

Tuovinen N, Yalcin-Siedentopf N, Welte AS, Siedentopf CM, Steiger R, Gizewski ER, Hofer A.
PMID: 34954024
Neuroimage. 2021 Dec 22;247:118847. doi: 10.1016/j.neuroimage.2021.118847. Epub 2021 Dec 22.

Personality traits have been linked with both brain structure and function. However, the exact relationship between personality traits and other behavioural measures with neurometabolites, measured with proton magnetic resonance spectroscopy, is not clear. Here we investigated the association between...

ATP-consuming futile cycles as energy dissipating mechanisms to counteract obesity.

Reviews in endocrine & metabolic disorders

Brownstein AJ, Veliova M, Acin-Perez R, Liesa M, Shirihai OS.
PMID: 34741717
Rev Endocr Metab Disord. 2021 Nov 06; doi: 10.1007/s11154-021-09690-w. Epub 2021 Nov 06.

Obesity results from an imbalance in energy homeostasis, whereby excessive energy intake exceeds caloric expenditure. Energy can be dissipated out of an organism by producing heat (thermogenesis), explaining the long-standing interest in exploiting thermogenic processes to counteract obesity. Mitochondrial...

The regulation and expression of the creatine transporter: a brief review of creatine supplementation in humans and animals.

Journal of the International Society of Sports Nutrition

Schoch RD, Willoughby D, Greenwood M.
PMID: 18500965
J Int Soc Sports Nutr. 2006 Jun 23;3:60-6. doi: 10.1186/1550-2783-3-1-60.

Creatine monohydrate has become one of the most popular ergogenic sport supplements used today. It is a nonessential dietary compound that is both endogenously synthesized and naturally ingested through diet. Creatine ingested through supplementation has been observed to be...

Determining MAOD Using a Single Exhaustive Severe Intensity Test.

International journal of exercise science

Valenzuela JR, Riojas AE, McFARLIN BK, Vingren JL, Hill DW.
PMID: 32509128
Int J Exerc Sci. 2020 May 01;13(4):702-713. eCollection 2020.

Maximal accumulated oxygen deficit (MAOD) provides a measure of anaerobic capacity. However, its measurement is a time-consuming process. The purpose of this study was to evaluate a measure of anaerobic capacity that avoids contentious assumptions and demands of the...

MR compatible ergometers for dynamic .

Journal of applied biomedicine

Sedivy P, Dezortova M, Rydlo J, Drobny M, Krssak M, Valkovic L, Hajek M.
PMID: 34907736
J Appl Biomed. 2019 Jun;17(2):91-98. doi: 10.32725/jab.2019.006. Epub 2019 Apr 15.

Magnetic Resonance (MR) compatible ergometers are specialized ergometers used inside the MR scanners for the characterization of tissue metabolism changes during physical stress. They are most commonly used for dynamic phosphorous magnetic resonance spectroscopy (31P MRS), but can also...

Short-term GAA loading: Responders versus nonresponders analysis.

Food science & nutrition

Ostojic SM.
PMID: 32884724
Food Sci Nutr. 2020 Jun 26;8(8):4446-4448. doi: 10.1002/fsn3.1744. eCollection 2020 Aug.

Dietary guanidinoacetic acid (GAA) has been suggested to be advantageous for favorable changes in tissue bioenergetics in terms of responder versus nonresponder performance, yet no studies so far explored the proportion of two distinct populations following short-term GAA intervention....

Showing 25 to 36 of 181 entries