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Showing 13 to 24 of 69 entries
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Extreme and Cyclical Blood Pressure Elevation in a Pheochromocytoma Hypertensive Crisis.

Case reports in endocrinology

Larouche V, Garfield N, Mitmaker E.
PMID: 30112225
Case Rep Endocrinol. 2018 Jul 15;2018:4073536. doi: 10.1155/2018/4073536. eCollection 2018.

Pheochromocytomas are rare adrenal neoplasms characterized by excess secretion of catecholamines. We describe the case of a 65-year-old man, known for hypertension, with no family history of hereditary pheochromocytoma syndromes. He reported a two-year history of flushing, systolic blood...

Doxazosin Stimulates Galectin-3 Expression and Collagen Synthesis in HL-1 Cardiomyocytes Independent of Protein Kinase C Pathway.

Frontiers in pharmacology

Qian X, Li M, Wagner MB, Chen G, Song X.
PMID: 28066244
Front Pharmacol. 2016 Dec 20;7:495. doi: 10.3389/fphar.2016.00495. eCollection 2016.

Doxazosin, a drug commonly prescribed for hypertension and prostate disease, increases heart failure risk. However, the underlying mechanism remains unclear. Galectin-3 is an important mediator that plays a pathogenic role in cardiac hypertrophy and heart failure. In the present...

Childhood neuroblastoma masquerading as pheochromocytoma: case report.

International medical case reports journal

Moon SB.
PMID: 27051319
Int Med Case Rep J. 2016 Mar 17;9:65-7. doi: 10.2147/IMCRJ.S100479. eCollection 2016.

Neuroblastoma is the most common extracranial solid tumor in children. Mild hypertension is a frequent symptom, presumably an effect of catecholamines that tumors release. Reported herein is the rare occurrence of severe hypertension and subsequent heart failure attributable to...

Phenoxybenzamine in complex regional pain syndrome: potential role and novel mechanisms.

Anesthesiology research and practice

Inchiosa MA.
PMID: 24454356
Anesthesiol Res Pract. 2013;2013:978615. doi: 10.1155/2013/978615. Epub 2013 Dec 19.

There is a relatively long history of the use of the α -adrenergic antagonist, phenoxybenzamine, for the treatment of complex regional pain syndrome (CRPS). One form of this syndrome, CRPS I, was originally termed reflex sympathetic dystrophy (RSD) because...

The evolution of alpha-blockers for the treatment of benign prostatic hyperplasia.

Reviews in urology

Lepor H.
PMID: 17215999
Rev Urol. 2006;8:S3-9.

Alpha-blockers have been evaluated for the treatment of benign prostatic hyperplasia (BPH) for 30 years, from early trials with the nonselective alpha-inhibitor phenoxybenzamine to short-acting (prazosin) then long-acting (terazosin, doxazosin, tamsulosin, alfuzosin) selective alpha(1)-antagonists. All of the alpha-blockers evaluated...

Response of blood cells to hemorrahagic shock in the dog.

Journal of anesthesia

Kudo S, Onai H, Ogawa R.
PMID: 15237305
J Anesth. 1987 Mar 01;1(1):51-61. doi: 10.1007/s0054070010051.

Response of canine blood cells to hemorrhagic shock was examined using ultrastructural and ultracytochemical techniques. Blood platelets responded to hemorrhagic shock with a decrease of alpha-granules and the simultaneous development of the platelet canalicular system which opened to the...

Analysis of the gastrointestinal relaxing effect of the stem extract of Gongronema latifolium.

Phytomedicine : international journal of phytotherapy and phytopharmacology

Gamaniel KS, Akah PA.
PMID: 23194764
Phytomedicine. 1996 Mar;2(4):293-6. doi: 10.1016/S0944-7113(96)80071-7.

Aqueous extract of the stem of Gongronema latifolium was screened for effects on the gastrointestinal tract of rats and mice. On the isolated rat intestine, the extract (5-80 μg) evoked reproducible and concentration-related relaxation which were attenuated by yohimbine...

Reinstatement of motor deficits in recovered brain-injured animals: the role of cerebellar norepinephrine.

Restorative neurology and neuroscience

Boyeson MG, Krobert KA, Scherer PJ, Grade CM.
PMID: 21551714
Restor Neurol Neurosci. 1993 Jan 01;5(4):283-90. doi: 10.3233/RNN-1993-5404.

Previous research has indicated that antagonists of locus ceruleus functioning, when administered during the acute phase of an injury, slow recovery of motor function following unilateral sensorimotor cortex injury. Following a recovery plateau in animals, it is possible to...

Effect of noradrenaline and vanadate on sodium, potassium-activated ATPase of human brain cortical homogenate.

Neurochemistry international

Serfözö P, Sylvester Vizi E.
PMID: 20487946
Neurochem Int. 1983;5(2):237-44. doi: 10.1016/0197-0186(83)90120-1.

Human brain cortical homogenate derived from surgical operations exhibited Na(+), K(+)-ATPase and K-p-nitrophenylphosphatase activity values of 2.12 +/- 0.08 ?mol P(i)/mg protein/15 min and 0.38 +/- 0.01 ?mol p-nitrophenol/mg protein/15 min, respectively which is in the range of those...

History and nomenclature of alpha1-adrenoceptors .

European urology

Langer SZ.
PMID: 10393465
Eur Urol. 1999;36:2-6. doi: 10.1159/000052310.

Until 1974 it was widely accepted that alpha-adrenoceptors represented a homogeneous population of receptors. Following the discovery of presynaptic, release-modulating receptors and based on differences in potency for the alpha-adrenoceptor antagonist phenoxybenzamine, it was proposed in 1974 that alpha-adrenoceptors...

Relation between Proepileptic Activity of Indomethacin and AdrenalGland Hormones.

Iranian journal of pharmaceutical research : IJPR

Hacimuftuoglu A, Suleyman H, Cadirci E, Albayrak A, Polat B, Hakan Alp H, Halici Z.
PMID: 24250522
Iran J Pharm Res. 2012;11(3):939-48.

The role of inflammation has been shown in the pathogenesis of epilepsy, while glucocorticoids and adrenaline have anti-inflammatory effects. The aim of the present study was to investigate the effects of adrenaline, prednisolone, and indomethacin on caffeine-induced epilepsy (epileptiform...

Muscarinic receptor regulation in the sympathetically innervated avian expansor secundariorum.

International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience

Rush RA, Crouch MF.
PMID: 24873958
Int J Dev Neurosci. 1984;2(2):149-53. doi: 10.1016/0736-5748(84)90006-6.

We sought to examine further the regulation of muscarinic receptors in the developing expansor secundariorum, a smooth muscle of the avian wing. [(3)H]Quinuclidinyl benzilate binding was used as a measure of muscarinic receptors present in the muscle, which gradually...

Showing 13 to 24 of 69 entries