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Showing 229 to 232 of 232 entries
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Outer Membrane Vesicles of Bordetella pertussis Encapsulated into Sodium Alginate Nanoparticles as Novel Vaccine Delivery System.

Current pharmaceutical design

Rami A, Kazemi-Lomedasht F, Mirjalili A, Noofeli M, Shahcheraghi F, Dounighi NM.
PMID: 34493192
Curr Pharm Des. 2021;27(42):4341-4354. doi: 10.2174/1381612827666210907154715.

BACKGROUND: Outer membrane vesicles (OMVs) release from Gram-negative bacteria and are interesting alternatives that can replace those vaccines that contain naturally incorporated bacterial surface antigens, lipopolysaccharides (LPS) and outer membrane proteins (OMPs). Nanoparticles can be used to encapsulate vesicles...

A Dissolvable Microneedle Formulation of .

ACS applied bio materials

Zhu DD, Wang XL, Zhang XP, Ma JJ, Kong L, Zhang MM, Guo XD, Wang C.
PMID: 35021503
ACS Appl Bio Mater. 2019 Nov 18;2(11):5053-5061. doi: 10.1021/acsabm.9b00730. Epub 2019 Oct 16.

This study evaluated the feasibility of microneedle (MN) technology as an alternative approach for pertussis toxin (PT) vaccine delivery. The characterization of PT vaccine MNs ensured sufficient mechanical property to deliver antigens to intradermal tissues of mice for intensive...

Effect of resolvins on sensitisation of TRPV1 and visceral hypersensitivity in IBS.

Gut

Perna E, Aguilera-Lizarraga J, Florens MV, Jain P, Theofanous SA, Hanning N, De Man JG, Berg M, De Winter B, Alpizar YA, Talavera K, Vanden Berghe P, Wouters M, Boeckxstaens G.
PMID: 33023902
Gut. 2021 Jul;70(7):1275-1286. doi: 10.1136/gutjnl-2020-321530. Epub 2020 Oct 06.

OBJECTIVE: Resolvins (RvD1, RvD2 and RvE1) are endogenous anti-inflammatory lipid mediators that display potent analgesic properties in somatic pain by modulating transient receptor potential vanilloid 1 (TRPV1) activation. To what extent these molecules could also have a beneficial effect...

Prenatal Stress Impairs Spinal Cord Oligodendrocyte Maturation via BDNF Signaling in the Experimental Autoimmune Encephalomyelitis Model of Multiple Sclerosis.

Cellular and molecular neurobiology

Paladini MS, Marangon D, Rossetti AC, Guidi A, Coppolino GT, Negri C, Spero V, Abbracchio MP, Lecca D, Molteni R.
PMID: 33259004
Cell Mol Neurobiol. 2020 Dec 01; doi: 10.1007/s10571-020-01014-x. Epub 2020 Dec 01.

One of the most substantial and established environmental risk factors for neurological and psychiatric disorders is stress exposure, whose detrimental consequences hinge on several variables including time. In this regard the gestational period is known to present an intrinsic...

Showing 229 to 232 of 232 entries