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The effect of casein glycomacropeptide versus free synthetic amino acids for early treatment of phenylketonuria in a mice model.

PloS one

Ahring KK, Dagnæs-Hansen F, Brüel A, Christensen M, Jensen E, Jensen TG, Johannsen M, Johansen KS, Lund AM, Madsen JG, Brøndum-Nielsen K, Pedersen M, Sørensen LK, Kjolby M, Møller LB.
PMID: 35015767
PLoS One. 2022 Jan 11;17(1):e0261150. doi: 10.1371/journal.pone.0261150. eCollection 2022.

INTRODUCTION: Management of phenylketonuria (PKU) is mainly achieved through dietary control with limited intake of phenylalanine (Phe) from food, supplemented with low protein (LP) food and a mixture of free synthetic (FS) amino acids (AA) (FSAA). Casein glycomacropeptide (CGMP)...

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Ahring KK, Dagnæs-Hansen F, Brüel A, et al. The effect of casein glycomacropeptide versus free synthetic amino acids for early treatment of phenylketonuria in a mice model. PLoS One. 2022;17(1):e0261150doi: 10.1371/journal.pone.0261150.
Ahring, K. K., Dagnæs-Hansen, F., Brüel, A., Christensen, M., Jensen, E., Jensen, T. G., Johannsen, M., Johansen, K. S., Lund, A. M., Madsen, J. G., Brøndum-Nielsen, K., Pedersen, M., Sørensen, L. K., Kjolby, M., & Møller, L. B. (2022). The effect of casein glycomacropeptide versus free synthetic amino acids for early treatment of phenylketonuria in a mice model. PloS one, 17(1), e0261150. https://doi.org/10.1371/journal.pone.0261150
Ahring, Kirsten K, et al. "The effect of casein glycomacropeptide versus free synthetic amino acids for early treatment of phenylketonuria in a mice model." PloS one vol. 17,1 (2022): e0261150. doi: https://doi.org/10.1371/journal.pone.0261150
Ahring KK, Dagnæs-Hansen F, Brüel A, Christensen M, Jensen E, Jensen TG, Johannsen M, Johansen KS, Lund AM, Madsen JG, Brøndum-Nielsen K, Pedersen M, Sørensen LK, Kjolby M, Møller LB. The effect of casein glycomacropeptide versus free synthetic amino acids for early treatment of phenylketonuria in a mice model. PLoS One. 2022 Jan 11;17(1):e0261150. doi: 10.1371/journal.pone.0261150. eCollection 2022. PMID: 35015767; PMCID: PMC8751992.
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Discovery of bone morphogenetic protein 7-derived peptide sequences that attenuate the human osteoarthritic chondrocyte phenotype.

Molecular therapy. Methods & clinical development

Caron MMJ, Ripmeester EGJ, van den Akker G, Wijnands NKAP, Steijns J, Surtel DAM, Cremers A, Emans PJ, van Rhijn LW, Welting TJM.
PMID: 33850953
Mol Ther Methods Clin Dev. 2021 Mar 17;21:247-261. doi: 10.1016/j.omtm.2021.03.009. eCollection 2021 Jun 11.

Treatment of osteoarthritis (OA) is mainly symptomatic by alleviating pain to postpone total joint replacement. Bone morphogenetic protein 7 (BMP7) is a candidate morphogen for experimental OA treatment that favorably alters the chondrocyte and cartilage phenotype. Intra-articular delivery and...

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Caron MMJ, Ripmeester EGJ, van den Akker G, et al. Discovery of bone morphogenetic protein 7-derived peptide sequences that attenuate the human osteoarthritic chondrocyte phenotype. Mol Ther Methods Clin Dev. 2021;21:247-261doi: 10.1016/j.omtm.2021.03.009.
Caron, M. M. J., Ripmeester, E. G. J., van den Akker, G., Wijnands, N. K. A. P., Steijns, J., Surtel, D. A. M., Cremers, A., Emans, P. J., van Rhijn, L. W., & Welting, T. J. M. (2021). Discovery of bone morphogenetic protein 7-derived peptide sequences that attenuate the human osteoarthritic chondrocyte phenotype. Molecular therapy. Methods & clinical development, 21247-261. https://doi.org/10.1016/j.omtm.2021.03.009
Caron, Marjolein M J, et al. "Discovery of bone morphogenetic protein 7-derived peptide sequences that attenuate the human osteoarthritic chondrocyte phenotype." Molecular therapy. Methods & clinical development vol. 21 (2021): 247-261. doi: https://doi.org/10.1016/j.omtm.2021.03.009
Caron MMJ, Ripmeester EGJ, van den Akker G, Wijnands NKAP, Steijns J, Surtel DAM, Cremers A, Emans PJ, van Rhijn LW, Welting TJM. Discovery of bone morphogenetic protein 7-derived peptide sequences that attenuate the human osteoarthritic chondrocyte phenotype. Mol Ther Methods Clin Dev. 2021 Mar 17;21:247-261. doi: 10.1016/j.omtm.2021.03.009. eCollection 2021 Jun 11. PMID: 33850953; PMCID: PMC8022858.
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Dataset on the mass spectrometry-based proteomic profiling of mouse embryonic fibroblasts from a wild type and DYT-TOR1A mouse model of dystonia, basally and during stress.

Data in brief

Shroff K, Caffall ZF, Soderblom EJ, Waitt G, Ho T, Calakos N.
PMID: 34901342
Data Brief. 2021 Nov 20;39:107609. doi: 10.1016/j.dib.2021.107609. eCollection 2021 Dec.

Here, we present quantitative subcellular compartment-specific proteomic data from wildtype and DYT-TOR1A heterozygous mouse embryonic fibroblasts (MEFs) basally and following thapsigargin (Tg) treatment [1]. In this experiment, we generated MEFs from wild type (WT) and a heterozygous DYT-TOR1A mouse...

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Shroff K, Caffall ZF, Soderblom EJ, et al. Dataset on the mass spectrometry-based proteomic profiling of mouse embryonic fibroblasts from a wild type and DYT-TOR1A mouse model of dystonia, basally and during stress. Data Brief. 2021;39:107609doi: 10.1016/j.dib.2021.107609.
Shroff, K., Caffall, Z. F., Soderblom, E. J., Waitt, G., Ho, T., & Calakos, N. (2021). Dataset on the mass spectrometry-based proteomic profiling of mouse embryonic fibroblasts from a wild type and DYT-TOR1A mouse model of dystonia, basally and during stress. Data in brief, 39107609. https://doi.org/10.1016/j.dib.2021.107609
Shroff, Kunal, et al. "Dataset on the mass spectrometry-based proteomic profiling of mouse embryonic fibroblasts from a wild type and DYT-TOR1A mouse model of dystonia, basally and during stress." Data in brief vol. 39 (2021): 107609. doi: https://doi.org/10.1016/j.dib.2021.107609
Shroff K, Caffall ZF, Soderblom EJ, Waitt G, Ho T, Calakos N. Dataset on the mass spectrometry-based proteomic profiling of mouse embryonic fibroblasts from a wild type and DYT-TOR1A mouse model of dystonia, basally and during stress. Data Brief. 2021 Nov 20;39:107609. doi: 10.1016/j.dib.2021.107609. eCollection 2021 Dec. PMID: 34901342; PMCID: PMC8640233.
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Evaluating Cancer-Related Biomarkers Based on Pathological Images: A Systematic Review.

Frontiers in oncology

Xie X, Wang X, Liang Y, Yang J, Wu Y, Li L, Sun X, Bing P, He B, Tian G, Shi X.
PMID: 34900711
Front Oncol. 2021 Nov 10;11:763527. doi: 10.3389/fonc.2021.763527. eCollection 2021.

Many diseases are accompanied by changes in certain biochemical indicators called biomarkers in cells or tissues. A variety of biomarkers, including proteins, nucleic acids, antibodies, and peptides, have been identified. Tumor biomarkers have been widely used in cancer risk...

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Xie X, Wang X, Liang Y, et al. Evaluating Cancer-Related Biomarkers Based on Pathological Images: A Systematic Review. Front Oncol. 2021;11:763527doi: 10.3389/fonc.2021.763527.
Xie, X., Wang, X., Liang, Y., Yang, J., Wu, Y., Li, L., Sun, X., Bing, P., He, B., Tian, G., & Shi, X. (2021). Evaluating Cancer-Related Biomarkers Based on Pathological Images: A Systematic Review. Frontiers in oncology, 11763527. https://doi.org/10.3389/fonc.2021.763527
Xie, Xiaoliang, et al. "Evaluating Cancer-Related Biomarkers Based on Pathological Images: A Systematic Review." Frontiers in oncology vol. 11 (2021): 763527. doi: https://doi.org/10.3389/fonc.2021.763527
Xie X, Wang X, Liang Y, Yang J, Wu Y, Li L, Sun X, Bing P, He B, Tian G, Shi X. Evaluating Cancer-Related Biomarkers Based on Pathological Images: A Systematic Review. Front Oncol. 2021 Nov 10;11:763527. doi: 10.3389/fonc.2021.763527. eCollection 2021. PMID: 34900711; PMCID: PMC8660076.
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Characterization of pepcan-23 as pro-peptide of RVD-hemopressin (pepcan-12) and stability of hemopressins in mice.

Advances in biological regulation

Glasmacher S, Gertsch J.
PMID: 33799079
Adv Biol Regul. 2021 May;80:100808. doi: 10.1016/j.jbior.2021.100808. Epub 2021 Mar 24.

Hemopressins ((x)-PVNFKLLSH) or peptide endocannabinoids (pepcans) can bind to cannabinoid receptors. RVD-hemopressin (pepcan-12) was shown to act as endogenous allosteric modulator of cannabinoid receptors, with opposite effects on CB1 and CB2, respectively. Moreover, the N-terminally elongated pepcan-23 was detected...

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Glasmacher S, Gertsch J. Characterization of pepcan-23 as pro-peptide of RVD-hemopressin (pepcan-12) and stability of hemopressins in mice. Adv Biol Regul. 2021;80:100808doi: 10.1016/j.jbior.2021.100808.
Glasmacher, S., & Gertsch, J. (2021). Characterization of pepcan-23 as pro-peptide of RVD-hemopressin (pepcan-12) and stability of hemopressins in mice. Advances in biological regulation, 80100808. https://doi.org/10.1016/j.jbior.2021.100808
Glasmacher, Sandra, and Gertsch, Jürg. "Characterization of pepcan-23 as pro-peptide of RVD-hemopressin (pepcan-12) and stability of hemopressins in mice." Advances in biological regulation vol. 80 (2021): 100808. doi: https://doi.org/10.1016/j.jbior.2021.100808
Glasmacher S, Gertsch J. Characterization of pepcan-23 as pro-peptide of RVD-hemopressin (pepcan-12) and stability of hemopressins in mice. Adv Biol Regul. 2021 May;80:100808. doi: 10.1016/j.jbior.2021.100808. Epub 2021 Mar 24. PMID: 33799079.
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Phase I dose escalation safety and feasibility study of autologous WT1-sensitized T cells for the treatment of patients with recurrent ovarian cancer.

Journal for immunotherapy of cancer

Kyi C, Doubrovina E, Zhou Q, Kravetz S, Iasonos A, Aghajanian C, Sabbatini P, Spriggs D, O'Reilly RJ, O'Cearbhaill RE.
PMID: 34433633
J Immunother Cancer. 2021 Aug;9(8). doi: 10.1136/jitc-2021-002752.

BACKGROUND: This phase I dose escalation trial evaluated the feasibility of production, safety, maximum tolerated dose, and preliminary efficacy of autologous T cells sensitized with peptides encoding Wilms' tumor protein 1 (WT1) administered alone or following lymphodepleting chemotherapy, in...

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Kyi C, Doubrovina E, Zhou Q, et al. Phase I dose escalation safety and feasibility study of autologous WT1-sensitized T cells for the treatment of patients with recurrent ovarian cancer. J Immunother Cancer. 2021;9(8)doi: 10.1136/jitc-2021-002752.
Kyi, C., Doubrovina, E., Zhou, Q., Kravetz, S., Iasonos, A., Aghajanian, C., Sabbatini, P., Spriggs, D., O'Reilly, R. J., & O'Cearbhaill, R. E. (2021). Phase I dose escalation safety and feasibility study of autologous WT1-sensitized T cells for the treatment of patients with recurrent ovarian cancer. Journal for immunotherapy of cancer, 9(8), . https://doi.org/10.1136/jitc-2021-002752
Kyi, Chrisann, et al. "Phase I dose escalation safety and feasibility study of autologous WT1-sensitized T cells for the treatment of patients with recurrent ovarian cancer." Journal for immunotherapy of cancer vol. 9,8 (2021). doi: https://doi.org/10.1136/jitc-2021-002752
Kyi C, Doubrovina E, Zhou Q, Kravetz S, Iasonos A, Aghajanian C, Sabbatini P, Spriggs D, O'Reilly RJ, O'Cearbhaill RE. Phase I dose escalation safety and feasibility study of autologous WT1-sensitized T cells for the treatment of patients with recurrent ovarian cancer. J Immunother Cancer. 2021 Aug;9(8). doi: 10.1136/jitc-2021-002752. PMID: 34433633; PMCID: PMC8388302.
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Perinatal exposure to a glyphosate-based herbicide causes dysregulation of dynorphins and an increase of neural precursor cells in the brain of adult male rats.

Toxicology

Cattani D, Struyf N, Steffensen V, Bergquist J, Zamoner A, Brittebo E, Andersson M.
PMID: 34474092
Toxicology. 2021 Sep;461:152922. doi: 10.1016/j.tox.2021.152922. Epub 2021 Aug 30.

Glyphosate, the most used herbicide worldwide, has been suggested to induce neurotoxicity and behavioral changes in rats after developmental exposure. Studies of human glyphosate intoxication have reported adverse effects on the nervous system, particularly in substantia nigra (SN). Here...

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Cattani D, Struyf N, Steffensen V, et al. Perinatal exposure to a glyphosate-based herbicide causes dysregulation of dynorphins and an increase of neural precursor cells in the brain of adult male rats. Toxicology. 2021;461:152922doi: 10.1016/j.tox.2021.152922.
Cattani, D., Struyf, N., Steffensen, V., Bergquist, J., Zamoner, A., Brittebo, E., & Andersson, M. (2021). Perinatal exposure to a glyphosate-based herbicide causes dysregulation of dynorphins and an increase of neural precursor cells in the brain of adult male rats. Toxicology, 461152922. https://doi.org/10.1016/j.tox.2021.152922
Cattani, Daiane, et al. "Perinatal exposure to a glyphosate-based herbicide causes dysregulation of dynorphins and an increase of neural precursor cells in the brain of adult male rats." Toxicology vol. 461 (2021): 152922. doi: https://doi.org/10.1016/j.tox.2021.152922
Cattani D, Struyf N, Steffensen V, Bergquist J, Zamoner A, Brittebo E, Andersson M. Perinatal exposure to a glyphosate-based herbicide causes dysregulation of dynorphins and an increase of neural precursor cells in the brain of adult male rats. Toxicology. 2021 Sep;461:152922. doi: 10.1016/j.tox.2021.152922. Epub 2021 Aug 30. PMID: 34474092.
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An overlooked UV spectroscopic tool for sensing coil-to-helix and helix-to-coil conformational transitions of proteins and peptides.

Analytical biochemistry

Zsila F.
PMID: 34875249
Anal Biochem. 2022 Feb 15;639:114512. doi: 10.1016/j.ab.2021.114512. Epub 2021 Dec 04.

A simple spectrophotometric approach is proposed for sensing coil-to-helix and helix-to-coil conformational transitions of intrinsically disordered and folded peptide/protein sequences. Helix formation induced by a variety of physico-chemical factors results in a substantial intensity reduction (hypochromism) of the intense...

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Zsila F. An overlooked UV spectroscopic tool for sensing coil-to-helix and helix-to-coil conformational transitions of proteins and peptides. Anal Biochem. 2021;639:114512doi: 10.1016/j.ab.2021.114512.
Zsila, F. (2022). An overlooked UV spectroscopic tool for sensing coil-to-helix and helix-to-coil conformational transitions of proteins and peptides. Analytical biochemistry, 639114512. https://doi.org/10.1016/j.ab.2021.114512
Zsila, Ferenc. "An overlooked UV spectroscopic tool for sensing coil-to-helix and helix-to-coil conformational transitions of proteins and peptides." Analytical biochemistry vol. 639 (2022): 114512. doi: https://doi.org/10.1016/j.ab.2021.114512
Zsila F. An overlooked UV spectroscopic tool for sensing coil-to-helix and helix-to-coil conformational transitions of proteins and peptides. Anal Biochem. 2022 Feb 15;639:114512. doi: 10.1016/j.ab.2021.114512. Epub 2021 Dec 04. PMID: 34875249.
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Peptide-Bismuth Bicycles: In Situ Access to Stable Constrained Peptides with Superior Bioactivity.

Angewandte Chemie (International ed. in English)

Voss S, Rademann J, Nitsche C.
PMID: 34825756
Angew Chem Int Ed Engl. 2022 Jan 21;61(4):e202113857. doi: 10.1002/anie.202113857. Epub 2021 Dec 09.

Constrained peptides are promising next-generation therapeutics. We report here a fundamentally new strategy for the facile generation of bicyclic peptides using linear precursor peptides with three cysteine residues and a non-toxic trivalent bismuth(III) salt. Peptide-bismuth bicycles form instantaneously at...

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Voss S, Rademann J, Nitsche C. Peptide-Bismuth Bicycles: In Situ Access to Stable Constrained Peptides with Superior Bioactivity. Angew Chem Int Ed Engl. 2021;61(4):e202113857doi: 10.1002/anie.202113857.
Voss, S., Rademann, J., & Nitsche, C. (2022). Peptide-Bismuth Bicycles: In Situ Access to Stable Constrained Peptides with Superior Bioactivity. Angewandte Chemie (International ed. in English), 61(4), e202113857. https://doi.org/10.1002/anie.202113857
Voss, Saan, et al. "Peptide-Bismuth Bicycles: In Situ Access to Stable Constrained Peptides with Superior Bioactivity." Angewandte Chemie (International ed. in English) vol. 61,4 (2022): e202113857. doi: https://doi.org/10.1002/anie.202113857
Voss S, Rademann J, Nitsche C. Peptide-Bismuth Bicycles: In Situ Access to Stable Constrained Peptides with Superior Bioactivity. Angew Chem Int Ed Engl. 2022 Jan 21;61(4):e202113857. doi: 10.1002/anie.202113857. Epub 2021 Dec 09. PMID: 34825756.
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DisCoTune: versatile auxiliary plasmids for the production of disulphide-containing proteins and peptides in the E. coli T7 system.

Microbial biotechnology

Bertelsen AB, Hackney CM, Bayer CN, Kjelgaard LD, Rennig M, Christensen B, Sørensen ES, Safavi-Hemami H, Wulff T, Ellgaard L, Nørholm MHH.
PMID: 34405535
Microb Biotechnol. 2021 Nov;14(6):2566-2580. doi: 10.1111/1751-7915.13895. Epub 2021 Aug 18.

Secreted proteins and peptides hold large potential both as therapeutics and as enzyme catalysts in biotechnology. The high stability of many secreted proteins helps maintain functional integrity in changing chemical environments and is a contributing factor to their commercial...

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Bertelsen AB, Hackney CM, Bayer CN, et al. DisCoTune: versatile auxiliary plasmids for the production of disulphide-containing proteins and peptides in the E. coli T7 system. Microb Biotechnol. 2021;14(6):2566-2580doi: 10.1111/1751-7915.13895.
Bertelsen, A. B., Hackney, C. M., Bayer, C. N., Kjelgaard, L. D., Rennig, M., Christensen, B., Sørensen, E. S., Safavi-Hemami, H., Wulff, T., Ellgaard, L., & Nørholm, M. H. H. (2021). DisCoTune: versatile auxiliary plasmids for the production of disulphide-containing proteins and peptides in the E. coli T7 system. Microbial biotechnology, 14(6), 2566-2580. https://doi.org/10.1111/1751-7915.13895
Bertelsen, Andreas B, et al. "DisCoTune: versatile auxiliary plasmids for the production of disulphide-containing proteins and peptides in the E. coli T7 system." Microbial biotechnology vol. 14,6 (2021): 2566-2580. doi: https://doi.org/10.1111/1751-7915.13895
Bertelsen AB, Hackney CM, Bayer CN, Kjelgaard LD, Rennig M, Christensen B, Sørensen ES, Safavi-Hemami H, Wulff T, Ellgaard L, Nørholm MHH. DisCoTune: versatile auxiliary plasmids for the production of disulphide-containing proteins and peptides in the E. coli T7 system. Microb Biotechnol. 2021 Nov;14(6):2566-2580. doi: 10.1111/1751-7915.13895. Epub 2021 Aug 18. PMID: 34405535; PMCID: PMC8601162.
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Identification of Potential Peptide Inhibitors of ACE-2 Target of SARS-CoV-2 from Buckwheat & Quinoa.

International journal of peptide research and therapeutics

Rangaswamy AN, Ashok A, Hanumanthappa P, Chandrashekaramurthy AS, Kumbaiah M, Hiregouda P, Sharma V, Sosalegowda AH.
PMID: 33850482
Int J Pept Res Ther. 2021 Apr 08;1-15. doi: 10.1007/s10989-021-10211-1. Epub 2021 Apr 08.

It is well established fact that peptides from various foods offer human health benefits displaying diverse functionalities. Millets considered as super foods is a major alternative in recent days for traditional diet being rich in proteins and fibre along...

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Rangaswamy AN, Ashok A, Hanumanthappa P, et al. Identification of Potential Peptide Inhibitors of ACE-2 Target of SARS-CoV-2 from Buckwheat & Quinoa. Int J Pept Res Ther. 2021;1-15doi: 10.1007/s10989-021-10211-1.
Rangaswamy, A. N., Ashok, A., Hanumanthappa, P., Chandrashekaramurthy, A. S., Kumbaiah, M., Hiregouda, P., Sharma, V., & Sosalegowda, A. H. (2021). Identification of Potential Peptide Inhibitors of ACE-2 Target of SARS-CoV-2 from Buckwheat & Quinoa. International journal of peptide research and therapeutics, 1-15. https://doi.org/10.1007/s10989-021-10211-1
Rangaswamy, Ashok Nanjaiah, et al. "Identification of Potential Peptide Inhibitors of ACE-2 Target of SARS-CoV-2 from Buckwheat & Quinoa." International journal of peptide research and therapeutics vol. (2021): 1-15. doi: https://doi.org/10.1007/s10989-021-10211-1
Rangaswamy AN, Ashok A, Hanumanthappa P, Chandrashekaramurthy AS, Kumbaiah M, Hiregouda P, Sharma V, Sosalegowda AH. Identification of Potential Peptide Inhibitors of ACE-2 Target of SARS-CoV-2 from Buckwheat & Quinoa. Int J Pept Res Ther. 2021 Apr 08;1-15. doi: 10.1007/s10989-021-10211-1. Epub 2021 Apr 08. PMID: 33850482; PMCID: PMC8030649.
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Extension of Mitogenome Enrichment Based on Single Long-Range PCR: mtDNAs and Putative Mitochondrial-Derived Peptides of Five Rodent Hibernators.

Frontiers in genetics

Emser SV, Schaschl H, Millesi E, Steinborn R.
PMID: 35027919
Front Genet. 2021 Dec 13;12:685806. doi: 10.3389/fgene.2021.685806. eCollection 2021.

Enriching mitochondrial DNA (mtDNA) for sequencing entire mitochondrial genomes (mitogenomes) can be achieved by single long-range PCR. This avoids interference from the omnipresent nuclear mtDNA sequences (NUMTs). The approach is currently restricted to the use of samples collected from...

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Emser SV, Schaschl H, Millesi E, et al. Extension of Mitogenome Enrichment Based on Single Long-Range PCR: mtDNAs and Putative Mitochondrial-Derived Peptides of Five Rodent Hibernators. Front Genet. 2021;12:685806doi: 10.3389/fgene.2021.685806.
Emser, S. V., Schaschl, H., Millesi, E., & Steinborn, R. (2021). Extension of Mitogenome Enrichment Based on Single Long-Range PCR: mtDNAs and Putative Mitochondrial-Derived Peptides of Five Rodent Hibernators. Frontiers in genetics, 12685806. https://doi.org/10.3389/fgene.2021.685806
Emser, Sarah V, et al. "Extension of Mitogenome Enrichment Based on Single Long-Range PCR: mtDNAs and Putative Mitochondrial-Derived Peptides of Five Rodent Hibernators." Frontiers in genetics vol. 12 (2021): 685806. doi: https://doi.org/10.3389/fgene.2021.685806
Emser SV, Schaschl H, Millesi E, Steinborn R. Extension of Mitogenome Enrichment Based on Single Long-Range PCR: mtDNAs and Putative Mitochondrial-Derived Peptides of Five Rodent Hibernators. Front Genet. 2021 Dec 13;12:685806. doi: 10.3389/fgene.2021.685806. eCollection 2021. PMID: 35027919; PMCID: PMC8749263.
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