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Showing 73 to 78 of 78 entries
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Pneumocystis carinii: A review of an important opportunistic pathogen in AIDS.

The Canadian journal of infectious diseases = Journal canadien des maladies infectieuses

Gill MJ, Read R.
PMID: 22451747
Can J Infect Dis. 1991;2(1):12-8. doi: 10.1155/1991/989875.

Since the first report of human infection with Pneumocystis carinii in 1942, cases of pneumonia due to this opportunistic pathogen have become increasingly common. Animal studies and clinical observations show that a significant depletion or dysfunction of T helper...

Structure-Based Discovery of a Novel Pentamidine-Related Inhibitor of the Calcium-Binding Protein S100B.

ACS medicinal chemistry letters

McKnight LE, Raman EP, Bezawada P, Kudrimoti S, Wilder PT, Hartman KG, Godoy-Ruiz R, Toth EA, Coop A, Mackerell AD, Weber DJ.
PMID: 23264854
ACS Med Chem Lett. 2012 Dec 13;3(12):975-979. doi: 10.1021/ml300166s. Epub 2012 Sep 25.

Molecular Dynamics simulations of the pentamidine-S100B complex, where two molecules of pentamidine bind per monomer of S100B, were performed in an effort to determine what properties would be desirable in a pentamidine-derived compound as an inhibitor for S100B. These...

S100B Protein as a Therapeutic Target in Multiple Sclerosis: The S100B Inhibitor Arundic Acid Protects from Chronic Experimental Autoimmune Encephalomyelitis.

International journal of molecular sciences

Camponeschi C, De Carluccio M, Amadio S, Clementi ME, Sampaolese B, Volonté C, Tredicine M, Romano Spica V, Di Liddo R, Ria F, Michetti F, Di Sante G.
PMID: 34948360
Int J Mol Sci. 2021 Dec 17;22(24). doi: 10.3390/ijms222413558.

S100B is an astrocytic protein behaving at high concentration as a damage-associated molecular pattern molecule. A direct correlation between the increased amount of S100B and inflammatory processes has been demonstrated, and in particular, the inhibitor of S100B activity pentamidine...

Bilateral upper lobe Pneumocystis pneumonia during aerosolized pentamidine prophylaxis.

QJM : monthly journal of the Association of Physicians

Ohara Y, Asakura T, Ueda S, Yamada Y, Ishii M, Betsuyaku T.
PMID: 29211898
QJM. 2018 May 01;111(5):337-338. doi: 10.1093/qjmed/hcx233.

No abstract available.

Neolignans isolated from twigs of .

The journal of venomous animals and toxins including tropical diseases

Grecco SS, Costa-Silva TA, Sousa FS, Cargnelutti SB, Umehara E, Mendonça PS, Tempone AG, Lago JHG.
PMID: 30275819
J Venom Anim Toxins Incl Trop Dis. 2018 Sep 27;24:27. doi: 10.1186/s40409-018-0164-9. eCollection 2018.

BACKGROUND: The therapeutic arsenal for the treatment of Leishmaniasis is limited and includes toxic compounds (antimonials, amphotericin B, pentamidine and miltefosine). Given these aspects, the search for new compounds based on floristic biodiversity is crucial. In the present work,...

In Vitro Activity of Pentamidine Alone and in Combination with Antibiotics against Multidrug-Resistant Clinical .

Antibiotics (Basel, Switzerland)

Herrera-Espejo S, Cebrero-Cangueiro T, Labrador-Herrera G, Pachón J, Pachón-Ibáñez ME, Álvarez-Marín R.
PMID: 33317111
Antibiotics (Basel). 2020 Dec 09;9(12). doi: 10.3390/antibiotics9120885.

Multidrug-resistant (MDR)

Showing 73 to 78 of 78 entries