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Investigation of Calcium Channel Blockers as Antiprotozoal Agents and Their Interference in the Metabolism of Leishmania (L.) infantum.

Evidence-based complementary and alternative medicine : eCAM

Reimão JQ, Mesquita JT, Ferreira DD, Tempone AG.
PMID: 26941821
Evid Based Complement Alternat Med. 2016;2016:1523691. doi: 10.1155/2016/1523691. Epub 2016 Jan 28.

Leishmaniasis and Chagas disease are neglected parasitic diseases endemic in developing countries; efforts to find new therapies remain a priority. Calcium channel blockers (CCBs) are drugs in clinical use for hypertension and other heart pathologies. Based on previous reports...

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Reimão JQ, Mesquita JT, Ferreira DD, et al. Investigation of Calcium Channel Blockers as Antiprotozoal Agents and Their Interference in the Metabolism of Leishmania (L.) infantum. Evid Based Complement Alternat Med. 2016;2016:1523691doi: 10.1155/2016/1523691.
Reimão, J. Q., Mesquita, J. T., Ferreira, D. D., & Tempone, A. G. (2016). Investigation of Calcium Channel Blockers as Antiprotozoal Agents and Their Interference in the Metabolism of Leishmania (L.) infantum. Evidence-based complementary and alternative medicine : eCAM, 20161523691. https://doi.org/10.1155/2016/1523691
Reimão, Juliana Quero, et al. "Investigation of Calcium Channel Blockers as Antiprotozoal Agents and Their Interference in the Metabolism of Leishmania (L.) infantum." Evidence-based complementary and alternative medicine : eCAM vol. 2016 (2016): 1523691. doi: https://doi.org/10.1155/2016/1523691
Reimão JQ, Mesquita JT, Ferreira DD, Tempone AG. Investigation of Calcium Channel Blockers as Antiprotozoal Agents and Their Interference in the Metabolism of Leishmania (L.) infantum. Evid Based Complement Alternat Med. 2016;2016:1523691. doi: 10.1155/2016/1523691. Epub 2016 Jan 28. PMID: 26941821; PMCID: PMC4749844.
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Transport proteins determine drug sensitivity and resistance in a protozoan parasite, Trypanosoma brucei.

Frontiers in pharmacology

Munday JC, Settimo L, de Koning HP.
PMID: 25814953
Front Pharmacol. 2015 Mar 09;6:32. doi: 10.3389/fphar.2015.00032. eCollection 2015.

Drug resistance in pathogenic protozoa is very often caused by changes to the 'transportome' of the parasites. In Trypanosoma brucei, several transporters have been implicated in uptake of the main classes of drugs, diamidines and melaminophenyl arsenicals. The resistance...

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Munday JC, Settimo L, de Koning HP. Transport proteins determine drug sensitivity and resistance in a protozoan parasite, Trypanosoma brucei. Front Pharmacol. 2015;6:32doi: 10.3389/fphar.2015.00032.
Munday, J. C., Settimo, L., & de Koning, H. P. (2015). Transport proteins determine drug sensitivity and resistance in a protozoan parasite, Trypanosoma brucei. Frontiers in pharmacology, 632. https://doi.org/10.3389/fphar.2015.00032
Munday, Jane C, et al. "Transport proteins determine drug sensitivity and resistance in a protozoan parasite, Trypanosoma brucei." Frontiers in pharmacology vol. 6 (2015): 32. doi: https://doi.org/10.3389/fphar.2015.00032
Munday JC, Settimo L, de Koning HP. Transport proteins determine drug sensitivity and resistance in a protozoan parasite, Trypanosoma brucei. Front Pharmacol. 2015 Mar 09;6:32. doi: 10.3389/fphar.2015.00032. eCollection 2015. PMID: 25814953; PMCID: PMC4356943.
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[No title available]

Journal of fungi (Basel, Switzerland)

Mantadakis E.
PMID: 33276699
J Fungi (Basel). 2020 Dec 02;6(4). doi: 10.3390/jof6040331.

No abstract available.

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Mantadakis E. . J Fungi (Basel). 2020;6(4)doi: 10.3390/jof6040331.
Mantadakis, E. (2020). . Journal of fungi (Basel, Switzerland), 6(4), . https://doi.org/10.3390/jof6040331
Mantadakis, Elpis. "." Journal of fungi (Basel, Switzerland) vol. 6,4 (2020). doi: https://doi.org/10.3390/jof6040331
Mantadakis E. . J Fungi (Basel). 2020 Dec 02;6(4). doi: 10.3390/jof6040331. PMID: 33276699; PMCID: PMC7761543.
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S100B Protein as a Therapeutic Target in Multiple Sclerosis: The S100B Inhibitor Arundic Acid Protects from Chronic Experimental Autoimmune Encephalomyelitis.

International journal of molecular sciences

Camponeschi C, De Carluccio M, Amadio S, Clementi ME, Sampaolese B, Volonté C, Tredicine M, Romano Spica V, Di Liddo R, Ria F, Michetti F, Di Sante G.
PMID: 34948360
Int J Mol Sci. 2021 Dec 17;22(24). doi: 10.3390/ijms222413558.

S100B is an astrocytic protein behaving at high concentration as a damage-associated molecular pattern molecule. A direct correlation between the increased amount of S100B and inflammatory processes has been demonstrated, and in particular, the inhibitor of S100B activity pentamidine...

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Camponeschi C, De Carluccio M, Amadio S, et al. S100B Protein as a Therapeutic Target in Multiple Sclerosis: The S100B Inhibitor Arundic Acid Protects from Chronic Experimental Autoimmune Encephalomyelitis. Int J Mol Sci. 2021;22(24)doi: 10.3390/ijms222413558.
Camponeschi, C., De Carluccio, M., Amadio, S., Clementi, M. E., Sampaolese, B., Volonté, C., Tredicine, M., Romano Spica, V., Di Liddo, R., Ria, F., Michetti, F., & Di Sante, G. (2021). S100B Protein as a Therapeutic Target in Multiple Sclerosis: The S100B Inhibitor Arundic Acid Protects from Chronic Experimental Autoimmune Encephalomyelitis. International journal of molecular sciences, 22(24), . https://doi.org/10.3390/ijms222413558
Camponeschi, Chiara, et al. "S100B Protein as a Therapeutic Target in Multiple Sclerosis: The S100B Inhibitor Arundic Acid Protects from Chronic Experimental Autoimmune Encephalomyelitis." International journal of molecular sciences vol. 22,24 (2021). doi: https://doi.org/10.3390/ijms222413558
Camponeschi C, De Carluccio M, Amadio S, Clementi ME, Sampaolese B, Volonté C, Tredicine M, Romano Spica V, Di Liddo R, Ria F, Michetti F, Di Sante G. S100B Protein as a Therapeutic Target in Multiple Sclerosis: The S100B Inhibitor Arundic Acid Protects from Chronic Experimental Autoimmune Encephalomyelitis. Int J Mol Sci. 2021 Dec 17;22(24). doi: 10.3390/ijms222413558. PMID: 34948360.
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[Adequacy to diagnostic recommendations in patients with Pneumocystis jirovecii pneumonia treated with intravenous pentamidine].

Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia

Cantarelli L, Gutiérrez Nicolás F, Nazco Casariego GJ, García Gil S.
PMID: 34854660
Rev Esp Quimioter. 2021 Dec 01; doi: 10.37201/req/064.2021. Epub 2021 Dec 01.

OBJECTIVE: To determine the rate of microbiological confirmation in the diagnosis of Pneumocystis jirovecii pneumonia in patients treated with intravenous pentamidine and the potential correlation with treatment effectiveness and safety.METHODS: Single-centre retrospective study (2010-2020), which included those patients who...

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Cantarelli L, Gutiérrez Nicolás F, Nazco Casariego GJ, et al. Adecuación a las recomendaciones diagnósticas en pacientes con neumonía por Pneumocystis jirovecii tratados con pentamidina intravenosa. [Adequacy to diagnostic recommendations in patients with Pneumocystis jirovecii pneumonia treated with intravenous pentamidine]. Rev Esp Quimioter. 2021;doi: 10.37201/req/064.2021.
Cantarelli, L., Gutiérrez Nicolás, F., Nazco Casariego, G. J., & García Gil, S. (2021). Adecuación a las recomendaciones diagnósticas en pacientes con neumonía por Pneumocystis jirovecii tratados con pentamidina intravenosa. [Adequacy to diagnostic recommendations in patients with Pneumocystis jirovecii pneumonia treated with intravenous pentamidine]. Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia, . https://doi.org/10.37201/req/064.2021
Cantarelli, L, et al. "Adecuación a las recomendaciones diagnósticas en pacientes con neumonía por Pneumocystis jirovecii tratados con pentamidina intravenosa." [Adequacy to diagnostic recommendations in patients with Pneumocystis jirovecii pneumonia treated with intravenous pentamidine]. Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia vol. (2021). doi: https://doi.org/10.37201/req/064.2021
Cantarelli L, Gutiérrez Nicolás F, Nazco Casariego GJ, García Gil S. Adecuación a las recomendaciones diagnósticas en pacientes con neumonía por Pneumocystis jirovecii tratados con pentamidina intravenosa. [Adequacy to diagnostic recommendations in patients with Pneumocystis jirovecii pneumonia treated with intravenous pentamidine]. Rev Esp Quimioter. 2021 Dec 01; doi: 10.37201/req/064.2021. Epub 2021 Dec 01. Spanish. PMID: 34854660.
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Discovery of triazine mimetics as potent antileishmanial agents.

ACS medicinal chemistry letters

Chauhan K, Sharma M, Shivahare R, Debnath U, Gupta S, Prabhakar YS, Chauhan PM.
PMID: 24900613
ACS Med Chem Lett. 2013 Oct 01;4(11):1108-13. doi: 10.1021/ml400317e. eCollection 2013 Nov 14.

The World Health Organization has classified the leishmaniasis as a major tropical disease. The discovery of new compounds for leishmaniasis is therefore a pressing concern for the anti-infective research program. We have synthesized 19 compounds of triazine dimers as...

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Chauhan K, Sharma M, Shivahare R, et al. Discovery of triazine mimetics as potent antileishmanial agents. ACS Med Chem Lett. 2013;4(11):1108-13doi: 10.1021/ml400317e.
Chauhan, K., Sharma, M., Shivahare, R., Debnath, U., Gupta, S., Prabhakar, Y. S., & Chauhan, P. M. (2013). Discovery of triazine mimetics as potent antileishmanial agents. ACS medicinal chemistry letters, 4(11), 1108-13. https://doi.org/10.1021/ml400317e
Chauhan, Kuldeep, et al. "Discovery of triazine mimetics as potent antileishmanial agents." ACS medicinal chemistry letters vol. 4,11 (2013): 1108-13. doi: https://doi.org/10.1021/ml400317e
Chauhan K, Sharma M, Shivahare R, Debnath U, Gupta S, Prabhakar YS, Chauhan PM. Discovery of triazine mimetics as potent antileishmanial agents. ACS Med Chem Lett. 2013 Oct 01;4(11):1108-13. doi: 10.1021/ml400317e. eCollection 2013 Nov 14. PMID: 24900613; PMCID: PMC4027224.
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In vitro selection of ketoconazole-pentamidine-resistant Leishmania (Viannia) braziliensis strains.

Experimental parasitology

Salazar-Villamizar ME, Escobar P.
PMID: 34973293
Exp Parasitol. 2021 Dec 29;233:108206. doi: 10.1016/j.exppara.2021.108206. Epub 2021 Dec 29.

The use of ketoconazole (KTZ) plus pentamidine (PMD) could be an interesting treatment option for New World cutaneous leishmaniasis. The aim of this work was to generate KTZ- and PMD-resistant strains and to determine some characteristics of the selection...

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Salazar-Villamizar ME, Escobar P. In vitro selection of ketoconazole-pentamidine-resistant Leishmania (Viannia) braziliensis strains. Exp Parasitol. 2021;233:108206doi: 10.1016/j.exppara.2021.108206.
Salazar-Villamizar, M. E., & Escobar, P. (2021). In vitro selection of ketoconazole-pentamidine-resistant Leishmania (Viannia) braziliensis strains. Experimental parasitology, 233108206. https://doi.org/10.1016/j.exppara.2021.108206
Salazar-Villamizar, Mary Elízabeth, and Escobar, Patricia. "In vitro selection of ketoconazole-pentamidine-resistant Leishmania (Viannia) braziliensis strains." Experimental parasitology vol. 233 (2021): 108206. doi: https://doi.org/10.1016/j.exppara.2021.108206
Salazar-Villamizar ME, Escobar P. In vitro selection of ketoconazole-pentamidine-resistant Leishmania (Viannia) braziliensis strains. Exp Parasitol. 2021 Dec 29;233:108206. doi: 10.1016/j.exppara.2021.108206. Epub 2021 Dec 29. PMID: 34973293.
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Direct, Late-Stage Mono-N-arylation of Pentamidine: Method Development, Mechanistic Insight, and Expedient Access to Novel Antiparastitics against Diamidine-Resistant Parasites.

ChemMedChem

Robertson J, Ungogo MA, Aldfer MM, Lemgruber L, McWhinnie FS, Bode BE, Jones KL, Watson AJB, de Koning HP, Burley GA.
PMID: 34357687
ChemMedChem. 2021 Nov 19;16(22):3396-3401. doi: 10.1002/cmdc.202100509. Epub 2021 Sep 02.

A selective mono-N-arylation strategy of amidines under Chan-Lam conditions is described. During the reaction optimization phase, the isolation of a mononuclear Cu(II) complex provided unique mechanistic insight into the operation of Chan-Lam mono-N-arylation. The scope of the process is...

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Robertson J, Ungogo MA, Aldfer MM, et al. Direct, Late-Stage Mono-N-arylation of Pentamidine: Method Development, Mechanistic Insight, and Expedient Access to Novel Antiparastitics against Diamidine-Resistant Parasites. ChemMedChem. 2021;16(22):3396-3401doi: 10.1002/cmdc.202100509.
Robertson, J., Ungogo, M. A., Aldfer, M. M., Lemgruber, L., McWhinnie, F. S., Bode, B. E., Jones, K. L., Watson, A. J. B., de Koning, H. P., & Burley, G. A. (2021). Direct, Late-Stage Mono-N-arylation of Pentamidine: Method Development, Mechanistic Insight, and Expedient Access to Novel Antiparastitics against Diamidine-Resistant Parasites. ChemMedChem, 16(22), 3396-3401. https://doi.org/10.1002/cmdc.202100509
Robertson, Jack, et al. "Direct, Late-Stage Mono-N-arylation of Pentamidine: Method Development, Mechanistic Insight, and Expedient Access to Novel Antiparastitics against Diamidine-Resistant Parasites." ChemMedChem vol. 16,22 (2021): 3396-3401. doi: https://doi.org/10.1002/cmdc.202100509
Robertson J, Ungogo MA, Aldfer MM, Lemgruber L, McWhinnie FS, Bode BE, Jones KL, Watson AJB, de Koning HP, Burley GA. Direct, Late-Stage Mono-N-arylation of Pentamidine: Method Development, Mechanistic Insight, and Expedient Access to Novel Antiparastitics against Diamidine-Resistant Parasites. ChemMedChem. 2021 Nov 19;16(22):3396-3401. doi: 10.1002/cmdc.202100509. Epub 2021 Sep 02. PMID: 34357687.
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In vitro selection of ketoconazole-pentamidine-resistant Leishmania (Viannia) braziliensis strains.

Experimental parasitology

Salazar-Villamizar ME, Escobar P.
PMID: 34973293
Exp Parasitol. 2021 Dec 29;108206. doi: 10.1016/j.exppara.2021.108206. Epub 2021 Dec 29.

The use of ketoconazole (KTZ) plus pentamidine (PMD) could be an interesting treatment option for New World cutaneous leishmaniasis. The aim of this work was to generate KTZ- and PMD-resistant strains and to determine some characteristics of the selection...

Cite
Salazar-Villamizar ME, Escobar P. In vitro selection of ketoconazole-pentamidine-resistant Leishmania (Viannia) braziliensis strains. Exp Parasitol. 2021;108206doi: 10.1016/j.exppara.2021.108206.
Salazar-Villamizar, M. E., & Escobar, P. (2021). In vitro selection of ketoconazole-pentamidine-resistant Leishmania (Viannia) braziliensis strains. Experimental parasitology, 108206. https://doi.org/10.1016/j.exppara.2021.108206
Salazar-Villamizar, Mary Elízabeth, and Escobar, Patricia. "In vitro selection of ketoconazole-pentamidine-resistant Leishmania (Viannia) braziliensis strains." Experimental parasitology vol. (2021): 108206. doi: https://doi.org/10.1016/j.exppara.2021.108206
Salazar-Villamizar ME, Escobar P. In vitro selection of ketoconazole-pentamidine-resistant Leishmania (Viannia) braziliensis strains. Exp Parasitol. 2021 Dec 29;108206. doi: 10.1016/j.exppara.2021.108206. Epub 2021 Dec 29. PMID: 34973293.
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Structure-Activity Studies with Bis-Amidines That Potentiate Gram-Positive Specific Antibiotics against Gram-Negative Pathogens.

ACS infectious diseases

Wesseling CMJ, Slingerland CJ, Veraar S, Lok S, Martin NI.
PMID: 34766746
ACS Infect Dis. 2021 Dec 10;7(12):3314-3335. doi: 10.1021/acsinfecdis.1c00466. Epub 2021 Nov 12.

Pentamidine, an FDA-approved antiparasitic drug, was recently identified as an outer membrane disrupting synergist that potentiates erythromycin, rifampicin, and novobiocin against Gram-negative bacteria. The same study also described a preliminary structure-activity relationship using commercially available pentamidine analogues. We here...

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Wesseling CMJ, Slingerland CJ, Veraar S, et al. Structure-Activity Studies with Bis-Amidines That Potentiate Gram-Positive Specific Antibiotics against Gram-Negative Pathogens. ACS Infect Dis. 2021;7(12):3314-3335doi: 10.1021/acsinfecdis.1c00466.
Wesseling, C. M. J., Slingerland, C. J., Veraar, S., Lok, S., & Martin, N. I. (2021). Structure-Activity Studies with Bis-Amidines That Potentiate Gram-Positive Specific Antibiotics against Gram-Negative Pathogens. ACS infectious diseases, 7(12), 3314-3335. https://doi.org/10.1021/acsinfecdis.1c00466
Wesseling, Charlotte M J, et al. "Structure-Activity Studies with Bis-Amidines That Potentiate Gram-Positive Specific Antibiotics against Gram-Negative Pathogens." ACS infectious diseases vol. 7,12 (2021): 3314-3335. doi: https://doi.org/10.1021/acsinfecdis.1c00466
Wesseling CMJ, Slingerland CJ, Veraar S, Lok S, Martin NI. Structure-Activity Studies with Bis-Amidines That Potentiate Gram-Positive Specific Antibiotics against Gram-Negative Pathogens. ACS Infect Dis. 2021 Dec 10;7(12):3314-3335. doi: 10.1021/acsinfecdis.1c00466. Epub 2021 Nov 12. PMID: 34766746.
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Evaluation of in vitro activity of five antimicrobial agents on Acanthamoeba isolates and their toxicity on human corneal epithelium.

Eye (London, England)

Megha K, Sharma M, Sharma C, Gupta A, Sehgal R, Khurana S.
PMID: 34548636
Eye (Lond). 2021 Sep 21; doi: 10.1038/s41433-021-01768-8. Epub 2021 Sep 21.

BACKGROUND: Acanthamoeba keratitis (AK) is an important cause of ocular morbidity in both contact lens wearers and non wearers. Medical management comprises prolonged empiric treatment with multiple drugs, leading to adverse effects and suboptimal cure. The present study evaluated...

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Megha K, Sharma M, Sharma C, et al. Evaluation of in vitro activity of five antimicrobial agents on Acanthamoeba isolates and their toxicity on human corneal epithelium. Eye (Lond). 2021;doi: 10.1038/s41433-021-01768-8.
Megha, K., Sharma, M., Sharma, C., Gupta, A., Sehgal, R., & Khurana, S. (2021). Evaluation of in vitro activity of five antimicrobial agents on Acanthamoeba isolates and their toxicity on human corneal epithelium. Eye (London, England), . https://doi.org/10.1038/s41433-021-01768-8
Megha, Kirti, et al. "Evaluation of in vitro activity of five antimicrobial agents on Acanthamoeba isolates and their toxicity on human corneal epithelium." Eye (London, England) vol. (2021). doi: https://doi.org/10.1038/s41433-021-01768-8
Megha K, Sharma M, Sharma C, Gupta A, Sehgal R, Khurana S. Evaluation of in vitro activity of five antimicrobial agents on Acanthamoeba isolates and their toxicity on human corneal epithelium. Eye (Lond). 2021 Sep 21; doi: 10.1038/s41433-021-01768-8. Epub 2021 Sep 21. PMID: 34548636.
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Management of Pneumocystis Jirovecii pneumonia in HIV infected patients: current options, challenges and future directions.

HIV/AIDS (Auckland, N.Z.)

Castro JG, Morrison-Bryant M.
PMID: 22096390
HIV AIDS (Auckl). 2010;2:123-34. doi: 10.2147/hiv.s7720. Epub 2010 Feb 18.

The discovery of the Human Immunodeficiency Virus (HIV) was led by the merge of clustered cases of Pneumocystis jirovecii Pneumonia (PCP) in otherwise healthy people in the early 80's.1,2 In the face of sophisticated treatment now available for HIV...

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Castro JG, Morrison-Bryant M. Management of Pneumocystis Jirovecii pneumonia in HIV infected patients: current options, challenges and future directions. HIV AIDS (Auckl). 2010;2:123-34doi: 10.2147/hiv.s7720.
Castro, J. G., & Morrison-Bryant, M. (2010). Management of Pneumocystis Jirovecii pneumonia in HIV infected patients: current options, challenges and future directions. HIV/AIDS (Auckland, N.Z.), 2123-34. https://doi.org/10.2147/hiv.s7720
Castro, Jose G, and Morrison-Bryant, Maya. "Management of Pneumocystis Jirovecii pneumonia in HIV infected patients: current options, challenges and future directions." HIV/AIDS (Auckland, N.Z.) vol. 2 (2010): 123-34. doi: https://doi.org/10.2147/hiv.s7720
Castro JG, Morrison-Bryant M. Management of Pneumocystis Jirovecii pneumonia in HIV infected patients: current options, challenges and future directions. HIV AIDS (Auckl). 2010;2:123-34. doi: 10.2147/hiv.s7720. Epub 2010 Feb 18. PMID: 22096390; PMCID: PMC3218692.
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Showing 25 to 36 of 78 entries