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Showing 541 to 543 of 543 entries
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The network analysis of depressive symptoms before and after two weeks of antidepressant treatment.

Journal of affective disorders

Zhou J, Liu S, Mayes TL, Feng Y, Fang M, Xiao L, Wang G.
PMID: 34838606
J Affect Disord. 2021 Nov 24;299:126-134. doi: 10.1016/j.jad.2021.11.059. Epub 2021 Nov 24.

BACKGROUND: A substantial proportion of patients do not benefit from selective serotonin reuptake inhibitors (SSRIs). We used network analysis to examine changes in symptom associations over time to identify SSRIs treatment targets for patients with major depressive disorder (MDD).METHODS:...

Antidepressant action of transcranial direct current stimulation in olfactory bulbectomised adolescent rats.

Journal of psychopharmacology (Oxford, England)

Waye SC, Dinesh OC, Hasan SN, Conway JD, Raymond R, Nobrega JN, Blundell J, Bambico FR.
PMID: 33908307
J Psychopharmacol. 2021 Aug;35(8):1003-1016. doi: 10.1177/02698811211000765. Epub 2021 Apr 28.

BACKGROUND: Antidepressant drugs in adolescent depression are sometimes mired by efficacy issues and paradoxical effects. Transcranial direct current stimulation (tDCS) could represent an alternative.AIMS/METHODS: We tested the antidepressant action of prefrontal tDCS and paroxetine (20 mg/kg, intraperitoneal) in olfactory...

Supplementation of taurine improves ionic homeostasis and mitochondrial function in the rats exhibiting post-traumatic stress disorder-like symptoms.

European journal of pharmacology

Bhattacharjee A, Prajapati SK, Krishnamurthy S.
PMID: 34297965
Eur J Pharmacol. 2021 Oct 05;908:174361. doi: 10.1016/j.ejphar.2021.174361. Epub 2021 Jul 21.

RATIONALE: Current pharmacotherapy for post-traumatic stress disorder (PTSD) is limited to few antidepressants. Mitochondrial dysfunction is observed in PTSD, along with altered potassium homeostasis. Nutritional supplementation of taurine can improve ionic homeostasis and thereby treat PTSD-like symptoms in rats.AIM:...

Showing 541 to 543 of 543 entries