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Showing 13 to 20 of 20 entries
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Endoscopic imaging of Cerenkov luminescence.

Biomedical optics express

Kothapalli SR, Liu H, Liao JC, Cheng Z, Gambhir SS.
PMID: 22741069
Biomed Opt Express. 2012 Jun 01;3(6):1215-25. doi: 10.1364/BOE.3.001215. Epub 2012 May 03.

We demonstrate feasibility of endoscopic imaging of Cerenkov light originated when charged nuclear particles, emitted from radionuclides, travel through a biological tissue of living subjects at superluminal velocity. The endoscopy imaging system consists of conventional optical fiber bundle/ clinical...

Novel benzo-bis(1,2,5-thiadiazole) fluorophores for .

Chemical science

Sun Y, Qu C, Chen H, He M, Tang C, Shou K, Hong S, Yang M, Jiang Y, Ding B, Xiao Y, Xing L, Hong X, Cheng Z.
PMID: 30034761
Chem Sci. 2016 Sep 01;7(9):6203-6207. doi: 10.1039/c6sc01561a. Epub 2016 Jun 16.

Optical imaging of diseases represents a highly dynamic and multidisciplinary research area, and second near-infrared window (NIR-II, 1000-1700 nm) imaging is at the forefront of the research on optical imaging techniques. Small-molecule based NIR-II (1000-1700 nm) dyes are highly...

Rapid intracerebroventricular delivery of Cu-DOTA-etanercept after peripheral administration demonstrated by PET imaging.

BMC research notes

Tobinick EL, Chen K, Chen X.
PMID: 19284700
BMC Res Notes. 2009 Feb 27;2:28. doi: 10.1186/1756-0500-2-28.

BACKGROUND: The cytokines interleukin-1 and tumor necrosis factor (TNF), and the cytokine blocker interleukin-1 receptor antagonist, all have been demonstrated to enter the cerebrospinal fluid (CSF) following peripheral administration. Recent reports of rapid clinical improvement in patients with Alzheimer's...

Integrin alpha(v)beta(3)-Targeted Cancer Therapy.

Drug development research

Liu Z, Wang F, Chen X.
PMID: 20628538
Drug Dev Res. 2008;69(6):329-339. doi: 10.1002/ddr.20265.

Anti-angiogenesis is a promising strategy for the treatment of cancer. Integrins, consisting of two noncovalently bound transmembrane alpha and beta subunits, are an important molecular family involved in tumor angiogenesis. The blockade of integrin signaling has been demonstrated to...

Single-Cell Analysis of [18F]Fluorodeoxyglucose Uptake by Droplet Radiofluidics.

Analytical chemistry

Türkcan S, Nguyen J, Vilalta M, Shen B, Chin FT, Pratx G, Abbyad P.
PMID: 26035453
Anal Chem. 2015 Jul 07;87(13):6667-73. doi: 10.1021/acs.analchem.5b00792. Epub 2015 Jun 15.

Radiolabels can be used to detect small biomolecules with high sensitivity and specificity without interfering with the biochemical activity of the labeled molecule. For instance, the radiolabeled glucose analogue, [18F]fluorodeoxyglucose (FDG), is routinely used in positron emission tomography (PET)...

Molecular imaging with surface-enhanced Raman spectroscopy nanoparticle reporters.

MRS bulletin

Jokerst JV, Pohling C, Gambhir SS.
PMID: 24293809
MRS Bull. 2013 Aug;38(8). doi: 10.1557/mrs.2013.157.

Molecular imaging scans cellular and molecular targets in living subjects through the introduction of imaging agents that bind to these targets and report their presence through a measurable signal. The picomolar sensitivity, signal stability, and high multiplexing capacity of...

Real-time, continuous, fluorescence sensing in a freely-moving subject with an implanted hybrid VCSEL/CMOS biosensor.

Biomedical optics express

O'Sullivan TD, Heitz RT, Parashurama N, Barkin DB, Wooley BA, Gambhir SS, Harris JS, Levi O.
PMID: 24009996
Biomed Opt Express. 2013 Jul 15;4(8):1332-41. doi: 10.1364/BOE.4.001332. eCollection 2013.

Performance improvements in instrumentation for optical imaging have contributed greatly to molecular imaging in living subjects. In order to advance molecular imaging in freely moving, untethered subjects, we designed a miniature vertical-cavity surface-emitting laser (VCSEL)-based biosensor measuring 1cm(3) and...

Robust surface coating for a fast, facile fluorine-18 labeling of iron oxide nanoparticles for PET/MR dual-modality imaging.

Nanoscale

Sun Z, Cheng K, Wu F, Liu H, Ma X, Su X, Liu Y, Xia L, Cheng Z.
PMID: 27858030
Nanoscale. 2016 Dec 01;8(47):19644-19653. doi: 10.1039/c6nr07298d.

Grafting a robust organic shell around inorganic nanoparticles can optimize their colloidal features to dramatically improve their physicochemical properties. Here, we have developed a polymer coating procedure for providing colloidal stability to the nanoparticles and, more importantly, for applying...

Showing 13 to 20 of 20 entries