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Showing 25 to 36 of 75 entries
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Change in Blood and Benign Breast Biomarkers in Women Undergoing a Weight-Loss Intervention Randomized to High-Dose ω-3 Fatty Acids versus Placebo.

Cancer prevention research (Philadelphia, Pa.)

Fabian CJ, Befort CA, Phillips TA, Nydegger JL, Kreutzjans AL, Powers KR, Metheny T, Klemp JR, Carlson SE, Sullivan DK, Zalles CM, Giles ED, Hursting SD, Hu J, Kimler BF.
PMID: 34244155
Cancer Prev Res (Phila). 2021 Sep;14(9):893-904. doi: 10.1158/1940-6207.CAPR-20-0656. Epub 2021 Jul 09.

The inflammation-resolving and insulin-sensitizing properties of eicosapentaenoic (EPA) and docosahexaenoic (DHA) fatty acids have potential to augment effects of weight loss on breast cancer risk. In a feasibility study, 46 peri/postmenopausal women at increased risk for breast cancer with...

Correlation of Skin Carotenoid Content with 3-Day Dietary Intake in Community Dwelling Older Adults.

Journal of food composition and analysis : an official publication of the United Nations University, International Network of Food Data Systems

Keller JE, Taylor MK, Smith AN, Littrell J, Spaeth K, Boeckman CR, Burns JM, Sullivan DK.
PMID: 34795468
J Food Compost Anal. 2022 Jan;105. doi: 10.1016/j.jfca.2021.104243. Epub 2021 Nov 02.

Pressure-mediated reflection spectroscopy (RS) measures skin carotenoid content (SCC). Continued validation of this method is pertinent to validate its use as an objective measure of fruit and vegetable intake. This study aimed to assess relationships between SCC scores and...

Differences in Breast and Colorectal Cancer Screening Adherence Among Women Residing in Urban and Rural Communities in the United States.

JAMA network open

Shete S, Deng Y, Shannon J, Faseru B, Middleton D, Iachan R, Bernardo B, Balkrishnan R, Kim SJ, Huang B, Millar MM, Fuemmler B, Jensen JD, Mendoza JA, Hu J, Lazovich D, Robertson L, Demark-Wahnefried W, Paskett ED.
PMID: 34605915
JAMA Netw Open. 2021 Oct 01;4(10):e2128000. doi: 10.1001/jamanetworkopen.2021.28000.

IMPORTANCE: Screening for breast and colorectal cancer has resulted in reductions in mortality; however, questions remain regarding how these interventions are being diffused to all segments of the population. If an intervention is less amenable to diffusion, it could...

Letter to the Editor: on the stability and internal consistency of component-wise sparse mixture regression-based clustering.

Briefings in bioinformatics

Zhang B, He J, Hu J, Koestler DC, Chalise P.
PMID: 34953466
Brief Bioinform. 2021 Dec 26; doi: 10.1093/bib/bbab532. Epub 2021 Dec 26.

Understanding the relationship between molecular markers and a phenotype of interest is often obfuscated by patient-level heterogeneity. To address this challenge, Chang et al. recently published a novel method called Component-wise Sparse Mixture Regression (CSMR), a regression-based clustering method...

Disrupting interferon-alpha and NF-kappaB crosstalk suppresses IFITM1 expression attenuating triple-negative breast cancer progression.

Cancer letters

Provance OK, Geanes ES, Lui AJ, Roy A, Holloran SM, Gunewardena S, Hagan CR, Weir S, Lewis-Wambi J.
PMID: 34022283
Cancer Lett. 2021 Aug 28;514:12-29. doi: 10.1016/j.canlet.2021.05.006. Epub 2021 May 20.

Overexpression of interferon induced transmembrane protein-1 (IFITM1) enhances tumor progression in multiple cancers, but its role in triple-negative breast cancer (TNBC) is unknown. Here, we explore the functional significance and regulation of IFITM1 in TNBC and strategies to target...

WJMSC-derived small extracellular vesicle enhance T cell suppression through PD-L1.

Journal of extracellular vesicles

Li M, Soder R, Abhyankar S, Abdelhakim H, Braun MW, Trinidad CV, Pathak HB, Pessetto Z, Deighan C, Ganguly S, Dawn B, McGuirk J, Dunavin N, Godwin AK.
PMID: 33598108
J Extracell Vesicles. 2021 Feb;10(4):e12067. doi: 10.1002/jev2.12067. Epub 2021 Feb 08.

Both mesenchymal stem cells (MSCs) and their corresponding small extracellular vesicles (sEVs, commonly referred to as exosomes) share similar immunomodulatory properties that are potentially beneficial for the treatment of acute graft versus host disease (aGvHD). We report that clinical...

Analytical methods : advancing methods and applications

Li Q, Xiao L, Harihar S, Welch DR, Vargis E, Zhou A.
PMID: 26744605
Anal Methods. 2015 Dec 21;7(24):10162-10169. doi: 10.1039/C5AY01810B. Epub 2015 Nov 03.

The Breast Cancer Metastasis Suppressor 1 (BRMS1) is a nucleo-cytoplasmic protein that suppresses cancer metastasis without affecting the growth of the primary tumor. Previous work has shown that it decreases the expression of protein mediators involved in chemoresistance. This...

The prognostic value of .

Journal of cancer therapeutics & research

Sharma P, Stecklein SR, Kimler BF, Sethi G, Petroff BK, Phillips TA, Tawfik OW, Godwin AK, Jensen RA.
PMID: 25177489
J Cancer Ther Res. 2014 Mar 19;3(2):1-11. doi: 10.7243/2049-7962-3-2.

INTRODUCTION: Methylation of the METHODS: Subjects with stage I-III TNBC treated with chemotherapy were identified and their formalin-fixed paraffin-embedded (FFPE) tumor specimens retrieved. Genomic DNA was isolated and subjected to methylation-specific PCR (MSPCR).RESULTS: DNA was isolated from primary tumor...

A novel method for expediting the development of patient-reported outcome measures and an evaluation across several populations.

Applied psychological measurement

Garrard L, Price LR, Bott MJ, Gajewski BJ.
PMID: 27667878
Appl Psychol Meas. 2016 Oct;40(7):455-468. doi: 10.1177/0146621616652634. Epub 2016 Jun 14.

Item response theory (IRT) models provide an appropriate alternative to the classical ordinal confirmatory factor analysis (CFA) during the development of patient-reported outcome measures (PROMs). Current literature has identified the assessment of IRT model fit as both challenging and...

NGF reprograms metastatic melanoma to a bipotent glial-melanocyte neural crest-like precursor.

Biology open

Kasemeier-Kulesa JC, Romine MH, Morrison JA, Bailey CM, Welch DR, Kulesa PM.
PMID: 29175861
Biol Open. 2018 Jan 11;7(1). doi: 10.1242/bio.030817.

Melanoma pathogenesis from normal neural crest-derived melanocytes is often fatal due to aggressive cell invasion throughout the body. The identification of signals that reprogram de-differentiated, metastatic melanoma cells to a less aggressive and stable phenotype would provide a novel...

Targeting transcription factor TCF4 by γ-Mangostin, a natural xanthone.

Oncotarget

Krishnamachary B, Subramaniam D, Dandawate P, Ponnurangam S, Srinivasan P, Ramamoorthy P, Umar S, Thomas SM, Dhar A, Septer S, Weir SJ, Attard T, Anant S.
PMID: 31608135
Oncotarget. 2019 Sep 24;10(54):5576-5591. doi: 10.18632/oncotarget.27159. eCollection 2019 Sep 24.

Given that colon cancer is the third most common cancer in incidence and cause of death in the United States, and current treatment modalities are insufficient, there is a need to develop novel agents. Towards this, here we focus...

Overcoming resistance to immunotherapy by teaching old drugs new tricks.

Molecular & cellular oncology

Perry JM, Li L.
PMID: 32944648
Mol Cell Oncol. 2020 Aug 12;7(5):1801088. doi: 10.1080/23723556.2020.1801088. eCollection 2020.

Cancer stem cells (CSCs) underlie resistance to therapy. Cancer develops only in the context of failing immunosurveillance, and stem cells occupy immune privileged microenvironments. Recent evidence demonstrates that CSCs borrow immune privilege from their normal counterparts. However, low doses...

Showing 25 to 36 of 75 entries