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Showing 13 to 24 of 1115 entries
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Differential expression of intracellular and secreted osteopontin isoforms by murine macrophages in response to Toll-like receptor agonists.

The Journal of biological chemistry

[No authors listed]
PMID: 26002950
J Biol Chem. 2015 May 22;290(21):13040. doi: 10.1074/jbc.A110.110312.

No abstract available.

Plasma Osteopontin Level in Chronic Liver Disease and Hepatocellular Carcinoma.

Hepatitis monthly

Fouad SA, Mohamed NA, Fawzy MW, Moustafa DA.
PMID: 26500684
Hepat Mon. 2015 Sep 01;15(9):e30753. doi: 10.5812/hepatmon.30753. eCollection 2015 Sep.

BACKGROUND: Osteopontin (OPN) is a secreted glycoprotein and is frequently associated with various tumors.OBJECTIVES: We sought to investigate the clinical usefulness of the level of plasma OPN, compared to α-fetoprotein (AFP), as a biomarker for hepatocellular carcinoma (HCC) and...

Different Methylation Patterns of RUNX2, OSX, DLX5 and BSP in Osteoblastic Differentiation of Mesenchymal Stem Cells.

Cell journal

Farshdousti Hagh M, Noruzinia M, Mortazavi Y, Soleimani M, Kaviani S, Abroun S, Dehghani Fard A, Mahmoodinia M.
PMID: 25870836
Cell J. 2015;17(1):71-82. doi: 10.22074/cellj.2015.513. Epub 2015 Apr 08.

OBJECTIVE: Runt-related transcription factor 2 (RUNX2) and osterix (OSX) as two specific osteoblast transcription factors and distal-less homeobox 5 (DLX5) as a non-specific one are of paramount importance in regulating osteoblast related genes including osteocalcin, bone sialoprotein (BSP), osteopontin...

Osteopontin can decrease the expression of Col-II and COMP in cartilage cells in vitro.

International journal of clinical and experimental medicine

Zhang Y, Wang T, Cao Y.
PMID: 25932159
Int J Clin Exp Med. 2015 Feb 15;8(2):2254-60. eCollection 2015.

OBJECTIVE: To observe the effect of osteopontin (OPN) on the expression of collagen type II (Col-II) and oligomeric matrix protein COMP in cartilage cells of knee osteoarthritis, and explore the mechanism of OPN in the knee osteoarthritis.METHODS: Cartilage cells...

CELLULAR MECHANISMS OF BONE REGENERATION: ROLE OF WNT-1 IN BONE-MUSCLE INTERACTION DURING PHYSICAL ACTIVITY39.

Journal of biological regulators and homeostatic agents

Colaianni G, Cuscito C, Mongelli T, Pignataro P, Tamma R, Oranger A, Colucci S, Grano M.
PMID: 26652489
J Biol Regul Homeost Agents. 2015 Oct-Dec;29(4):39-45.

Wnt1 is one of the several glycoproteins activating Wnt signaling, critical for normal skeletal development and bone homeostasis. Wnt1 was previously believed to solely regulate central nervous system development, in particular in midbrain and cerebellum. However, remarkable findings have...

Osteopontin: A novel regulator at the cross roads of inflammation, obesity and diabetes.

Molecular metabolism

Kahles F, Findeisen HM, Bruemmer D.
PMID: 24944898
Mol Metab. 2014 Mar 22;3(4):384-93. doi: 10.1016/j.molmet.2014.03.004. eCollection 2014 Jul.

Since its first description more than 20 years ago osteopontin has emerged as an active player in many physiological and pathological processes, including biomineralization, tissue remodeling and inflammation. As an extracellular matrix protein and proinflammatory cytokine osteopontin is thought...

Regenerating the liver: not so simple after all?.

F1000Research

Alison MR, Lin WR.
PMID: 27508069
F1000Res. 2016 Jul 26;5. doi: 10.12688/f1000research.8827.1. eCollection 2016.

Under normal homeostatic conditions, hepatocyte renewal is a slow process and complete turnover likely takes at least a year. Studies of hepatocyte regeneration after a two-thirds partial hepatectomy (2/3 PH) have strongly suggested that periportal hepatocytes are the driving...

Uterine Histotroph and Conceptus Development. II. Arginine and Secreted Phosphoprotein 1 Cooperatively Stimulate Migration and Adhesion of Ovine Trophectoderm Cells via Focal Adhesion-MTORC2 Mediated Cytoskeleton Reorganization.

Biology of reproduction

Wang X, Johnson GA, Burghardt RC, Wu G, Bazer FW.
PMID: 27512152
Biol Reprod. 2016 Sep;95(3):71. doi: 10.1095/biolreprod.115.137943. Epub 2016 Aug 10.

In all mammalian species, critical events, including uterine receptivity and development of the conceptus (embryo/fetus and its associated extraembryonic membranes), must be intricately orchestrated and carefully timed during the window of implantation. Otherwise, failure of conceptuses to implant is...

Oxygen supply maps for hypoxic microenvironment visualization in prostate cancer.

Journal of pathology informatics

Rupp NJ, Schüffler PJ, Zhong Q, Falkner F, Rechsteiner M, Rüschoff JH, Fankhauser C, Drach M, Largo R, Tremp M, Poyet C, Sulser T, Kristiansen G, Moch H, Buhmann J, Müntener M, Wild PJ.
PMID: 26955501
J Pathol Inform. 2016 Jan 29;7:3. doi: 10.4103/2153-3539.175376. eCollection 2016.

BACKGROUND: Intratumoral hypoxia plays an important role with regard to tumor biology and susceptibility to radio- and chemotherapy. For further investigation of hypoxia-related changes, areas of certain hypoxia must be reliably detected within cancer tissues. Pimonidazole, a 2-nitroimindazole, accumulates...

Roles of osteopontin and matrix metalloproteinase-7 in occurrence, progression, and prognosis of nonsmall cell lung cancer.

Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences

Sun Y, Li D, Lv XH, Hua SC, Han JC, Xu F, Li XD.
PMID: 26958047
J Res Med Sci. 2015 Dec;20(12):1138-46. doi: 10.4103/1735-1995.172980.

BACKGROUND: This study detected osteopontin (OPN) and matrix metalloproteinase-7 (MMP-7) expressions to explore the roles of OPN and MMP-7 in the occurrence, progression, and prognosis of nonsmall cell lung cancer (NSCLC).MATERIALS AND METHODS: A retrospective study was conducted on...

Platelet-rich concentrate in serum free medium enhances osteogenic differentiation of bone marrow-derived human mesenchymal stromal cells.

PeerJ

Samuel S, Ahmad RE, Ramasamy TS, Karunanithi P, Naveen SV, Murali MR, Abbas AA, Kamarul T.
PMID: 27651984
PeerJ. 2016 Sep 07;4:e2347. doi: 10.7717/peerj.2347. eCollection 2016.

Previous studies have shown that platelet concentrates used in conjunction with appropriate growth media enhance osteogenic differentiation of human mesenchymal stromal cells (hMSCs). However, their potential in inducing osteogenesis of hMSCs when cultured in serum free medium has not...

Association of osteopontin polymorphism with cancer risk: a meta-analysis.

International journal of clinical and experimental medicine

Yang G, Peng X, Guo P, Yang G.
PMID: 26885018
Int J Clin Exp Med. 2015 Nov 15;8(11):20911-7. eCollection 2015.

To investigate the association of osteopontin gene -443 C>T, -156 G>GG, and -1748 A>G polymorphisms with cancer risk. The Medline, PubMed, PUBMED, EMBASE and Web of Science databases were searched. Meta-analyses were conducted using RevMan 5.2 software. After searching...

Showing 13 to 24 of 1115 entries