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A possible way to prevent the progression of bone lesions in multiple myeloma via Src-homology-region-2-domain-containing-phosphatase-1 activation.

Journal of cellular biochemistry

Kanegasaki S, Tsuchiya T.
PMID: 33969922
J Cell Biochem. 2021 Oct;122(10):1313-1325. doi: 10.1002/jcb.29949. Epub 2021 May 10.

On the basis of our recent findings, in which multiple receptor-mediated mast cell functions are regulated via a common signaling cascade, we posit that the formation and functioning of osteoclasts are also controlled by a similar common mechanism. These...

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Kanegasaki S, Tsuchiya T. A possible way to prevent the progression of bone lesions in multiple myeloma via Src-homology-region-2-domain-containing-phosphatase-1 activation. J Cell Biochem. 2021;122(10):1313-1325doi: 10.1002/jcb.29949.
Kanegasaki, S., & Tsuchiya, T. (2021). A possible way to prevent the progression of bone lesions in multiple myeloma via Src-homology-region-2-domain-containing-phosphatase-1 activation. Journal of cellular biochemistry, 122(10), 1313-1325. https://doi.org/10.1002/jcb.29949
Kanegasaki, Shiro, and Tsuchiya, Tomoko. "A possible way to prevent the progression of bone lesions in multiple myeloma via Src-homology-region-2-domain-containing-phosphatase-1 activation." Journal of cellular biochemistry vol. 122,10 (2021): 1313-1325. doi: https://doi.org/10.1002/jcb.29949
Kanegasaki S, Tsuchiya T. A possible way to prevent the progression of bone lesions in multiple myeloma via Src-homology-region-2-domain-containing-phosphatase-1 activation. J Cell Biochem. 2021 Oct;122(10):1313-1325. doi: 10.1002/jcb.29949. Epub 2021 May 10. PMID: 33969922.
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Alzheimer's Disease and Its Association With Bone Health: A Case-Control Study.

Cureus

Kumar S, Chandnani A, Aung NH, Shahid S, Bukhari D, Shahzad S, Kumar B, Memon S.
PMID: 33842148
Cureus. 2021 Mar 08;13(3):e13772. doi: 10.7759/cureus.13772.

Introduction Alzheimer's disease is associated with low bone mineral density. Various studies have linked early-onset Alzheimer's disease with bone health. In this study, we will determine the association between bone health and recently diagnosed Alzheimer's disease in the local...

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Kumar S, Chandnani A, Aung NH, et al. Alzheimer's Disease and Its Association With Bone Health: A Case-Control Study. Cureus. 2021;13(3):e13772doi: 10.7759/cureus.13772.
Kumar, S., Chandnani, A., Aung, N. H., Shahid, S., Bukhari, D., Shahzad, S., Kumar, B., & Memon, S. (2021). Alzheimer's Disease and Its Association With Bone Health: A Case-Control Study. Cureus, 13(3), e13772. https://doi.org/10.7759/cureus.13772
Kumar, Sameet, et al. "Alzheimer's Disease and Its Association With Bone Health: A Case-Control Study." Cureus vol. 13,3 (2021): e13772. doi: https://doi.org/10.7759/cureus.13772
Kumar S, Chandnani A, Aung NH, Shahid S, Bukhari D, Shahzad S, Kumar B, Memon S. Alzheimer's Disease and Its Association With Bone Health: A Case-Control Study. Cureus. 2021 Mar 08;13(3):e13772. doi: 10.7759/cureus.13772. PMID: 33842148; PMCID: PMC8027098.
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Arhgap21 Deficiency Results in Increase of Osteoblastic Lineage Cells in the Murine Bone Marrow Microenvironment.

Frontiers in cell and developmental biology

Pissarra MF, Torello CO, Gomes RGB, Shiraishi RN, Santos I, Vieira Ferro KP, Lopes MR, Bergamo Favaro PM, Olalla Saad ST, Lazarini M.
PMID: 34917608
Front Cell Dev Biol. 2021 Nov 30;9:718560. doi: 10.3389/fcell.2021.718560. eCollection 2021.

ARHGAP21 is a member of the RhoGAP family of proteins involved in cell growth, differentiation, and adhesion. We have previously shown that the heterozygous Arhgap21 knockout mouse model (Arhgap21

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Pissarra MF, Torello CO, Gomes RGB, et al. Arhgap21 Deficiency Results in Increase of Osteoblastic Lineage Cells in the Murine Bone Marrow Microenvironment. Front Cell Dev Biol. 2021;9:718560doi: 10.3389/fcell.2021.718560.
Pissarra, M. F., Torello, C. O., Gomes, R. G. B., Shiraishi, R. N., Santos, I., Vieira Ferro, K. P., Lopes, M. R., Bergamo Favaro, P. M., Olalla Saad, S. T., & Lazarini, M. (2021). Arhgap21 Deficiency Results in Increase of Osteoblastic Lineage Cells in the Murine Bone Marrow Microenvironment. Frontiers in cell and developmental biology, 9718560. https://doi.org/10.3389/fcell.2021.718560
Pissarra, Mariana Ferreira, et al. "Arhgap21 Deficiency Results in Increase of Osteoblastic Lineage Cells in the Murine Bone Marrow Microenvironment." Frontiers in cell and developmental biology vol. 9 (2021): 718560. doi: https://doi.org/10.3389/fcell.2021.718560
Pissarra MF, Torello CO, Gomes RGB, Shiraishi RN, Santos I, Vieira Ferro KP, Lopes MR, Bergamo Favaro PM, Olalla Saad ST, Lazarini M. Arhgap21 Deficiency Results in Increase of Osteoblastic Lineage Cells in the Murine Bone Marrow Microenvironment. Front Cell Dev Biol. 2021 Nov 30;9:718560. doi: 10.3389/fcell.2021.718560. eCollection 2021. PMID: 34917608; PMCID: PMC8670086.
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Effects of burosumab on osteocalcin and bone mineral density in patient with 15-year history of nonremission tumor-induced osteomalacia initially treated with conventional therapy: Case report.

Bone reports

Miyaoka D, Imanishi Y, Yano M, Toi N, Nagata Y, Kurajoh M, Yamada S, Morioka T, Emoto M.
PMID: 33294501
Bone Rep. 2020 Nov 21;13:100736. doi: 10.1016/j.bonr.2020.100736. eCollection 2020 Dec.

Excess fibroblast growth factor 23 (FGF23) causes hypophosphatemic osteomalacia, which is associated with impaired bone matrix mineralization. Tumor-induced osteomalacia (TIO) is a rare paraneoplastic syndrome caused by over-secretion of FGF23 from a tumor. Burosumab, a fully human monoclonal antibody...

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Miyaoka D, Imanishi Y, Yano M, et al. Effects of burosumab on osteocalcin and bone mineral density in patient with 15-year history of nonremission tumor-induced osteomalacia initially treated with conventional therapy: Case report. Bone Rep. 2020;13:100736doi: 10.1016/j.bonr.2020.100736.
Miyaoka, D., Imanishi, Y., Yano, M., Toi, N., Nagata, Y., Kurajoh, M., Yamada, S., Morioka, T., & Emoto, M. (2020). Effects of burosumab on osteocalcin and bone mineral density in patient with 15-year history of nonremission tumor-induced osteomalacia initially treated with conventional therapy: Case report. Bone reports, 13100736. https://doi.org/10.1016/j.bonr.2020.100736
Miyaoka, Daichi, et al. "Effects of burosumab on osteocalcin and bone mineral density in patient with 15-year history of nonremission tumor-induced osteomalacia initially treated with conventional therapy: Case report." Bone reports vol. 13 (2020): 100736. doi: https://doi.org/10.1016/j.bonr.2020.100736
Miyaoka D, Imanishi Y, Yano M, Toi N, Nagata Y, Kurajoh M, Yamada S, Morioka T, Emoto M. Effects of burosumab on osteocalcin and bone mineral density in patient with 15-year history of nonremission tumor-induced osteomalacia initially treated with conventional therapy: Case report. Bone Rep. 2020 Nov 21;13:100736. doi: 10.1016/j.bonr.2020.100736. eCollection 2020 Dec. PMID: 33294501; PMCID: PMC7701316.
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Collagen and nano-hydroxyapatite interactions in alginate-based microcapsule provide an appropriate osteogenic microenvironment for modular bone tissue formation.

Carbohydrate polymers

Hassani A, Khoshfetrat AB, Rahbarghazi R, Sakai S.
PMID: 34893227
Carbohydr Polym. 2022 Feb 01;277:118807. doi: 10.1016/j.carbpol.2021.118807. Epub 2021 Oct 30.

The addition of nano-hydroxyapatite (nHA) and collagen (Col) to the alginate (Alg) microcapsule hydrogel reduced swelling and degradation ratios while the compressive strength increased compared to Alg, Alg-Col, and Alg-nHA groups. MTT assay and Calcein-AM staining revealed an enhanced...

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Hassani A, Khoshfetrat AB, Rahbarghazi R, et al. Collagen and nano-hydroxyapatite interactions in alginate-based microcapsule provide an appropriate osteogenic microenvironment for modular bone tissue formation. Carbohydr Polym. 2021;277:118807doi: 10.1016/j.carbpol.2021.118807.
Hassani, A., Khoshfetrat, A. B., Rahbarghazi, R., & Sakai, S. (2022). Collagen and nano-hydroxyapatite interactions in alginate-based microcapsule provide an appropriate osteogenic microenvironment for modular bone tissue formation. Carbohydrate polymers, 277118807. https://doi.org/10.1016/j.carbpol.2021.118807
Hassani, Ayla, et al. "Collagen and nano-hydroxyapatite interactions in alginate-based microcapsule provide an appropriate osteogenic microenvironment for modular bone tissue formation." Carbohydrate polymers vol. 277 (2022): 118807. doi: https://doi.org/10.1016/j.carbpol.2021.118807
Hassani A, Khoshfetrat AB, Rahbarghazi R, Sakai S. Collagen and nano-hydroxyapatite interactions in alginate-based microcapsule provide an appropriate osteogenic microenvironment for modular bone tissue formation. Carbohydr Polym. 2022 Feb 01;277:118807. doi: 10.1016/j.carbpol.2021.118807. Epub 2021 Oct 30. PMID: 34893227.
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Treadmill exercise influences the microRNA profiles in the bone tissues of mice.

Experimental and therapeutic medicine

Yang H, Cao Z, Wang Y, Wang J, Gao J, Han B, Yu F, Qin Y, Guo Y.
PMID: 34373721
Exp Ther Med. 2021 Sep;22(3):1035. doi: 10.3892/etm.2021.10467. Epub 2021 Jul 19.

As an important regulator involved in cell activity, microRNAs (miRNAs) are important in the process of exercise influencing bone metabolism. The present study aimed to detect and select differentially expressed miRNAs in the bone tissues of mice trained on...

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Yang H, Cao Z, Wang Y, et al. Treadmill exercise influences the microRNA profiles in the bone tissues of mice. Exp Ther Med. 2021;22(3):1035doi: 10.3892/etm.2021.10467.
Yang, H., Cao, Z., Wang, Y., Wang, J., Gao, J., Han, B., Yu, F., Qin, Y., & Guo, Y. (2021). Treadmill exercise influences the microRNA profiles in the bone tissues of mice. Experimental and therapeutic medicine, 22(3), 1035. https://doi.org/10.3892/etm.2021.10467
Yang, Huan, et al. "Treadmill exercise influences the microRNA profiles in the bone tissues of mice." Experimental and therapeutic medicine vol. 22,3 (2021): 1035. doi: https://doi.org/10.3892/etm.2021.10467
Yang H, Cao Z, Wang Y, Wang J, Gao J, Han B, Yu F, Qin Y, Guo Y. Treadmill exercise influences the microRNA profiles in the bone tissues of mice. Exp Ther Med. 2021 Sep;22(3):1035. doi: 10.3892/etm.2021.10467. Epub 2021 Jul 19. PMID: 34373721; PMCID: PMC8343800.
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Influence of Culture Period on Osteoblast Differentiation of Tissue-Engineered Bone Constructed by Apatite-Fiber Scaffolds Using Radial-Flow Bioreactor.

International journal of molecular sciences

Suzuki K, Fukasawa J, Miura M, Lim PN, Honda M, Matsuura T, Aizawa M.
PMID: 34884885
Int J Mol Sci. 2021 Dec 03;22(23). doi: 10.3390/ijms222313080.

With the limitation of autografts, the development of alternative treatments for bone diseases to alleviate autograft-related complications is highly demanded. In this study, a tissue-engineered bone was formed by culturing rat bone marrow cells (RBMCs) onto porous apatite-fiber scaffolds...

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Suzuki K, Fukasawa J, Miura M, et al. Influence of Culture Period on Osteoblast Differentiation of Tissue-Engineered Bone Constructed by Apatite-Fiber Scaffolds Using Radial-Flow Bioreactor. Int J Mol Sci. 2021;22(23)doi: 10.3390/ijms222313080.
Suzuki, K., Fukasawa, J., Miura, M., Lim, P. N., Honda, M., Matsuura, T., & Aizawa, M. (2021). Influence of Culture Period on Osteoblast Differentiation of Tissue-Engineered Bone Constructed by Apatite-Fiber Scaffolds Using Radial-Flow Bioreactor. International journal of molecular sciences, 22(23), . https://doi.org/10.3390/ijms222313080
Suzuki, Kitaru, et al. "Influence of Culture Period on Osteoblast Differentiation of Tissue-Engineered Bone Constructed by Apatite-Fiber Scaffolds Using Radial-Flow Bioreactor." International journal of molecular sciences vol. 22,23 (2021). doi: https://doi.org/10.3390/ijms222313080
Suzuki K, Fukasawa J, Miura M, Lim PN, Honda M, Matsuura T, Aizawa M. Influence of Culture Period on Osteoblast Differentiation of Tissue-Engineered Bone Constructed by Apatite-Fiber Scaffolds Using Radial-Flow Bioreactor. Int J Mol Sci. 2021 Dec 03;22(23). doi: 10.3390/ijms222313080. PMID: 34884885.
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Chloroquine ameliorates bone loss induced by d-galactose in male rats via inhibition of ERK associated osteoclastogenesis and antioxidant effect.

Toxicology reports

Mahmoud MAA, Saleh DO, Safar MM, Agha AM, Khattab MM.
PMID: 33665135
Toxicol Rep. 2021 Feb 15;8:366-375. doi: 10.1016/j.toxrep.2021.02.007. eCollection 2021.

Chloroquine (CQ); a lysosomotropic agent used for decade ago as anti-malarial, was tested against aging induced osteoporosis. Osteoporosis in male rats was induced using d-galactose (D-gal) as a reducing sugar at a dose of 200 mg/kg/day; i.p. Osteoporotic rats...

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Mahmoud MAA, Saleh DO, Safar MM, et al. Chloroquine ameliorates bone loss induced by d-galactose in male rats via inhibition of ERK associated osteoclastogenesis and antioxidant effect. Toxicol Rep. 2021;8:366-375doi: 10.1016/j.toxrep.2021.02.007.
Mahmoud, M. A. A., Saleh, D. O., Safar, M. M., Agha, A. M., & Khattab, M. M. (2021). Chloroquine ameliorates bone loss induced by d-galactose in male rats via inhibition of ERK associated osteoclastogenesis and antioxidant effect. Toxicology reports, 8366-375. https://doi.org/10.1016/j.toxrep.2021.02.007
Mahmoud, Mohamed A Aziz, et al. "Chloroquine ameliorates bone loss induced by d-galactose in male rats via inhibition of ERK associated osteoclastogenesis and antioxidant effect." Toxicology reports vol. 8 (2021): 366-375. doi: https://doi.org/10.1016/j.toxrep.2021.02.007
Mahmoud MAA, Saleh DO, Safar MM, Agha AM, Khattab MM. Chloroquine ameliorates bone loss induced by d-galactose in male rats via inhibition of ERK associated osteoclastogenesis and antioxidant effect. Toxicol Rep. 2021 Feb 15;8:366-375. doi: 10.1016/j.toxrep.2021.02.007. eCollection 2021. PMID: 33665135; PMCID: PMC7905189.
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Osteocalcin influences lifelong adrenal function.

Nature reviews. Endocrinology

Starling S.
PMID: 34992234
Nat Rev Endocrinol. 2022 Jan 06; doi: 10.1038/s41574-021-00632-9. Epub 2022 Jan 06.

No abstract available.

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Starling S. Osteocalcin influences lifelong adrenal function. Nat Rev Endocrinol. 2022;doi: 10.1038/s41574-021-00632-9.
Starling, S. (2022). Osteocalcin influences lifelong adrenal function. Nature reviews. Endocrinology, . https://doi.org/10.1038/s41574-021-00632-9
Starling, Shimona. "Osteocalcin influences lifelong adrenal function." Nature reviews. Endocrinology vol. (2022). doi: https://doi.org/10.1038/s41574-021-00632-9
Starling S. Osteocalcin influences lifelong adrenal function. Nat Rev Endocrinol. 2022 Jan 06; doi: 10.1038/s41574-021-00632-9. Epub 2022 Jan 06. PMID: 34992234.
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Effects of a Lifestyle Intervention on Bone Turnover in Persons with Type 2 Diabetes: A Post Hoc Analysis of the U-TURN Trial.

Medicine and science in sports and exercise

Abildgaard J, Johansen MY, Skov-Jeppesen K, Andersen LB, Karstoft K, Hansen KB, Hartmann B, Holst JJ, Pedersen BK, Ried-Larsen M.
PMID: 34431828
Med Sci Sports Exerc. 2022 Jan 01;54(1):38-46. doi: 10.1249/MSS.0000000000002776.

INTRODUCTION/PURPOSE: The increased risk of fractures with type 2 diabetes (T2D) is suggested to be caused by decreased bone turnover. Current international guidelines recommend lifestyle modifications, including exercise, as first-line treatment for T2D. The aim of this study was...

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Abildgaard J, Johansen MY, Skov-Jeppesen K, et al. Effects of a Lifestyle Intervention on Bone Turnover in Persons with Type 2 Diabetes: A Post Hoc Analysis of the U-TURN Trial. Med Sci Sports Exerc. 2022;54(1):38-46doi: 10.1249/MSS.0000000000002776.
Abildgaard, J., Johansen, M. Y., Skov-Jeppesen, K., Andersen, L. B., Karstoft, K., Hansen, K. B., Hartmann, B., Holst, J. J., Pedersen, B. K., & Ried-Larsen, M. (2022). Effects of a Lifestyle Intervention on Bone Turnover in Persons with Type 2 Diabetes: A Post Hoc Analysis of the U-TURN Trial. Medicine and science in sports and exercise, 54(1), 38-46. https://doi.org/10.1249/MSS.0000000000002776
Abildgaard, Julie, et al. "Effects of a Lifestyle Intervention on Bone Turnover in Persons with Type 2 Diabetes: A Post Hoc Analysis of the U-TURN Trial." Medicine and science in sports and exercise vol. 54,1 (2022): 38-46. doi: https://doi.org/10.1249/MSS.0000000000002776
Abildgaard J, Johansen MY, Skov-Jeppesen K, Andersen LB, Karstoft K, Hansen KB, Hartmann B, Holst JJ, Pedersen BK, Ried-Larsen M. Effects of a Lifestyle Intervention on Bone Turnover in Persons with Type 2 Diabetes: A Post Hoc Analysis of the U-TURN Trial. Med Sci Sports Exerc. 2022 Jan 01;54(1):38-46. doi: 10.1249/MSS.0000000000002776. PMID: 34431828.
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Influence of Culture Period on Osteoblast Differentiation of Tissue-Engineered Bone Constructed by Apatite-Fiber Scaffolds Using Radial-Flow Bioreactor.

International journal of molecular sciences

Suzuki K, Fukasawa J, Miura M, Lim PN, Honda M, Matsuura T, Aizawa M.
PMID: 34884885
Int J Mol Sci. 2021 Dec 03;22(23). doi: 10.3390/ijms222313080.

With the limitation of autografts, the development of alternative treatments for bone diseases to alleviate autograft-related complications is highly demanded. In this study, a tissue-engineered bone was formed by culturing rat bone marrow cells (RBMCs) onto porous apatite-fiber scaffolds...

Cite
Suzuki K, Fukasawa J, Miura M, et al. Influence of Culture Period on Osteoblast Differentiation of Tissue-Engineered Bone Constructed by Apatite-Fiber Scaffolds Using Radial-Flow Bioreactor. Int J Mol Sci. 2021;22(23)doi: 10.3390/ijms222313080.
Suzuki, K., Fukasawa, J., Miura, M., Lim, P. N., Honda, M., Matsuura, T., & Aizawa, M. (2021). Influence of Culture Period on Osteoblast Differentiation of Tissue-Engineered Bone Constructed by Apatite-Fiber Scaffolds Using Radial-Flow Bioreactor. International journal of molecular sciences, 22(23), . https://doi.org/10.3390/ijms222313080
Suzuki, Kitaru, et al. "Influence of Culture Period on Osteoblast Differentiation of Tissue-Engineered Bone Constructed by Apatite-Fiber Scaffolds Using Radial-Flow Bioreactor." International journal of molecular sciences vol. 22,23 (2021). doi: https://doi.org/10.3390/ijms222313080
Suzuki K, Fukasawa J, Miura M, Lim PN, Honda M, Matsuura T, Aizawa M. Influence of Culture Period on Osteoblast Differentiation of Tissue-Engineered Bone Constructed by Apatite-Fiber Scaffolds Using Radial-Flow Bioreactor. Int J Mol Sci. 2021 Dec 03;22(23). doi: 10.3390/ijms222313080. PMID: 34884885; PMCID: PMC8657963.
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SPTBN1 Prevents Primary Osteoporosis by Modulating Osteoblasts Proliferation and Differentiation and Blood Vessels Formation in Bone.

Frontiers in cell and developmental biology

Xu X, Yang J, Ye Y, Chen G, Zhang Y, Wu H, Song Y, Feng M, Feng X, Chen X, Wang X, Lin X, Bai X, Shen J.
PMID: 33816505
Front Cell Dev Biol. 2021 Mar 19;9:653724. doi: 10.3389/fcell.2021.653724. eCollection 2021.

Osteoporosis is a common systemic skeletal disorder that leads to increased bone fragility and increased risk of fracture. Although βII-Spectrin (SPTBN1) has been reported to be involved in the development of various human cancers, the function and underlying molecular...

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Xu X, Yang J, Ye Y, et al. SPTBN1 Prevents Primary Osteoporosis by Modulating Osteoblasts Proliferation and Differentiation and Blood Vessels Formation in Bone. Front Cell Dev Biol. 2021;9:653724doi: 10.3389/fcell.2021.653724.
Xu, X., Yang, J., Ye, Y., Chen, G., Zhang, Y., Wu, H., Song, Y., Feng, M., Feng, X., Chen, X., Wang, X., Lin, X., Bai, X., & Shen, J. (2021). SPTBN1 Prevents Primary Osteoporosis by Modulating Osteoblasts Proliferation and Differentiation and Blood Vessels Formation in Bone. Frontiers in cell and developmental biology, 9653724. https://doi.org/10.3389/fcell.2021.653724
Xu, Xuejuan, et al. "SPTBN1 Prevents Primary Osteoporosis by Modulating Osteoblasts Proliferation and Differentiation and Blood Vessels Formation in Bone." Frontiers in cell and developmental biology vol. 9 (2021): 653724. doi: https://doi.org/10.3389/fcell.2021.653724
Xu X, Yang J, Ye Y, Chen G, Zhang Y, Wu H, Song Y, Feng M, Feng X, Chen X, Wang X, Lin X, Bai X, Shen J. SPTBN1 Prevents Primary Osteoporosis by Modulating Osteoblasts Proliferation and Differentiation and Blood Vessels Formation in Bone. Front Cell Dev Biol. 2021 Mar 19;9:653724. doi: 10.3389/fcell.2021.653724. eCollection 2021. PMID: 33816505; PMCID: PMC8017174.
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