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Showing 37 to 48 of 2808 entries
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[Dysthymia in the Clinical Context].

Revista colombiana de psiquiatria

Jiménez-Maldonado ME, Gallardo-Moreno GB, Villaseñor-Cabrera T, González-Garrido AA.
PMID: 26572816
Rev Colomb Psiquiatr. 2013 Jun;42(2):212-8. doi: 10.1016/S0034-7450(13)70008-8. Epub 2013 Aug 03.

Dysthymia is defined as a chronic mood disorder that persists for at least two years in adults, and one year in adolescents and children. According to DSM IV-TR, Dysthymia is classified into two subtypes: early-onset, when it begins before...

Ketamine and other N-methyl-D-aspartate receptor antagonists in the treatment of depression: a perspective review.

Therapeutic advances in chronic disease

Iadarola ND, Niciu MJ, Richards EM, Vande Voort JL, Ballard ED, Lundin NB, Nugent AC, Machado-Vieira R, Zarate CA.
PMID: 25954495
Ther Adv Chronic Dis. 2015 May;6(3):97-114. doi: 10.1177/2040622315579059.

Current pharmacotherapies for major depressive disorder (MDD) and bipolar depression (BDep) have a distinct lag of onset that can generate great distress and impairment in patients. Furthermore, as demonstrated by several real-world effectiveness trials, their efficacy is limited. All...

Levomilnacipran: A New Serotonin-Norepinephrine Reuptake Inhibitor for the Treatment of Major Depressive Disorder.

The Annals of pharmacotherapy

Palmer EC, Binns LN, Carey H.
PMID: 24811398
Ann Pharmacother. 2014 Aug;48(8):1030-1039. doi: 10.1177/1060028014535074. Epub 2014 May 08.

OBJECTIVE: To provide a clinical overview of the antidepressant levomilnacipran.DATA SOURCES: Articles were identified by searching the MEDLINE, PubMed, Cochrane Library, and Clinicaltrials.gov databases through March 2014 using the keyword levomilnacipran. The manufacturer provided additional information from unpublished phase...

The Accompanying Changes in Brain Structure of a Remitted Depression Patient with the Bupropion Treatment.

Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology

Hou YC, Lai CH.
PMID: 26598593
Clin Psychopharmacol Neurosci. 2015 Dec 31;13(3):319-20. doi: 10.9758/cpn.2015.13.3.319.

The impacts from the bupropion on the brain structures have seldom been mentioned in the literature. The bupropion is a kind of antidepressant with dual action in the norepinephrine and dopamine receptors. Here we have a case to share...

Atomoxetine Augmentation in a Case of Treatment Resistant Panic Disorder with Multiple Augments Failure: A Case Report.

Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology

Ram D, Patil S, Gowdappa B, Rajalakshmi I.
PMID: 26598594
Clin Psychopharmacol Neurosci. 2015 Dec 31;13(3):321-3. doi: 10.9758/cpn.2015.13.3.321.

Atomoxetine, a selective norepinephrine inhibitor, is effective in comorbid anxiety and attention deficit hyperactivity disorder, however its role in panic disorder is unknown. We are presenting a case of panic disorder, who initially partially responded to clonazepam. When clonazepam...

Degeneration in Arousal Neurons in Chronic Sleep Disruption Modeling Sleep Apnea.

Frontiers in neurology

Zhu Y, Fenik P, Zhan G, Xin R, Veasey SC.
PMID: 26074865
Front Neurol. 2015 May 26;6:109. doi: 10.3389/fneur.2015.00109. eCollection 2015.

Chronic sleep disruption (CSD) is a cardinal feature of sleep apnea that predicts impaired wakefulness. Despite effective treatment of apneas and sleep disruption, patients with sleep apnea may have persistent somnolence. Lasting wake disturbances in treated sleep apnea raise...

Functional specificity of the locus coeruleus-norepinephrine system in the attentional networks.

Frontiers in behavioral neuroscience

Ambrosini E, Vastano R, Montefinese M, Ciavarro M.
PMID: 24376406
Front Behav Neurosci. 2013 Dec 12;7:201. doi: 10.3389/fnbeh.2013.00201. eCollection 2013.

No abstract available.

Design and synthesis of 4-heteroaryl 1,2,3,4-tetrahydroisoquinolines as triple reuptake inhibitors.

ACS medicinal chemistry letters

Liu S, Zha C, Nacro K, Hu M, Cui W, Yang YL, Bhatt U, Sambandam A, Isherwood M, Yet L, Herr MT, Ebeltoft S, Hassler C, Fleming L, Pechulis AD, Payen-Fornicola A, Holman N, Milanowski D, Cotterill I, Mozhaev V, Khmelnitsky Y, Guzzo PR, Sargent BJ, Molino BF, Olson R, King D, Lelas S, Li YW, Johnson K, Molski T, Orie A, Ng A, Haskell R, Clarke W, Bertekap R, O'Connell J, Lodge N, Sinz M, Adams S, Zaczek R, Macor JE.
PMID: 25050161
ACS Med Chem Lett. 2014 May 13;5(7):760-5. doi: 10.1021/ml500053b. eCollection 2014 Jul 10.

A series of 4-bicyclic heteroaryl 1,2,3,4-tetrahydroisoquinoline inhibitors of the serotonin transporter (SERT), norepinephrine transporter (NET), and dopamine transporter (DAT) was discovered. The synthesis and structure-activity relationship (SAR) of these triple reuptake inhibitors (TRIs) will be discussed. Compound 10i (AMR-2),...

Altered serous levels of monoamine neurotransmitter metabolites in patients with refractory and non-refractory depression.

Neural regeneration research

Zhang G, Zhang Y, Yang J, Hu M, Zhang Y, Liang X.
PMID: 25722703
Neural Regen Res. 2012 May 15;7(14):1113-8. doi: 10.3969/j.issn.1673-5374.2012.14.011.

The study examined plasma metabolite changes of monoamine neurotransmitters in patients with treatment-resistant depression (TRD) and non-TRD before and after therapy. All 30 TRD and 30 non-TRD patients met the diagnostic criteria for a depressive episode in accordance with...

Revisiting Antagonist Effects in Hypoglossal Nucleus: Brainstem Circuit for the State-Dependent Control of Hypoglossal Motoneurons: A Hypothesis.

Frontiers in neurology

Fenik VB.
PMID: 26648908
Front Neurol. 2015 Dec 01;6:254. doi: 10.3389/fneur.2015.00254. eCollection 2015.

We reassessed and provided new insights into the findings that were obtained in our previous experiments that employed the injections of combined adrenergic, serotonergic, GABAergic, and glycinergic antagonists into the hypoglossal nucleus in order to pharmacologically abolish the depression...

Pathological Gambling: Neuropsychopharmacology and Treatment.

Current psychopharmacology

Bullock SA, Potenza MN.
PMID: 24349964
Curr Psychopharmacol. 2012 Feb 01;1(1). doi: 10.2174/2211556011201010067.

Pathological gambling (PG) affects about 0.2-2% of adults and the impact extends to family members, employers and society as a whole. Recent research has identified similarities in the pathophysiologies of PG and substance use disorders (SUDs). As such, findings...

Antidepressant-like effect of Hoodia gordonii in a forced swimming test in mice: evidence for involvement of the monoaminergic system.

Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas

Citó MC, Silva MI, Santos LK, Fernandes ML, Melo FH, Aguiar JA, Lopes IS, Sousa PB, Vasconcelos SM, Macêdo DS, Sousa FC.
PMID: 25493384
Braz J Med Biol Res. 2015 Jan;48(1):57-64. doi: 10.1590/1414-431x20144215. Epub 2014 Nov 07.

Hoodia gordonii is a plant species used traditionally in southern Africa to suppress appetite. Recently, it has been associated with a significant increase in blood pressure and pulse rate in women, suggesting sympathomimetic activity. The present study investigated the...

Showing 37 to 48 of 2808 entries