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Severe adverse cutaneous reactions induced by gefitinib combined with antihypertensive and antihyperlipidemic drugs in lung cancer: a case report.

Anti-cancer drugs

Shen X, Fan G, Liu G, Wang F, Li Q, Liu X, Zhu H, Zhu Y, Lu J, Wang S.
PMID: 34459464
Anticancer Drugs. 2022 Jan 01;33(1):e802-e807. doi: 10.1097/CAD.0000000000001226.

The incidence of lung cancer is increasing yearly worldwide, and targeted medicines are the main choice for lung cancer patients. However, there has been no relevant research about the analysis and adjustment of drug combinations for cancer patients with...

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Shen X, Fan G, Liu G, et al. Severe adverse cutaneous reactions induced by gefitinib combined with antihypertensive and antihyperlipidemic drugs in lung cancer: a case report. Anticancer Drugs. 2022;33(1):e802-e807doi: 10.1097/CAD.0000000000001226.
Shen, X., Fan, G., Liu, G., Wang, F., Li, Q., Liu, X., Zhu, H., Zhu, Y., Lu, J., & Wang, S. (2022). Severe adverse cutaneous reactions induced by gefitinib combined with antihypertensive and antihyperlipidemic drugs in lung cancer: a case report. Anti-cancer drugs, 33(1), e802-e807. https://doi.org/10.1097/CAD.0000000000001226
Shen, Xiao, et al. "Severe adverse cutaneous reactions induced by gefitinib combined with antihypertensive and antihyperlipidemic drugs in lung cancer: a case report." Anti-cancer drugs vol. 33,1 (2022): e802-e807. doi: https://doi.org/10.1097/CAD.0000000000001226
Shen X, Fan G, Liu G, Wang F, Li Q, Liu X, Zhu H, Zhu Y, Lu J, Wang S. Severe adverse cutaneous reactions induced by gefitinib combined with antihypertensive and antihyperlipidemic drugs in lung cancer: a case report. Anticancer Drugs. 2022 Jan 01;33(1):e802-e807. doi: 10.1097/CAD.0000000000001226. PMID: 34459464.
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Chrono modulated multiple unit particulate systems (MUPS) via a continuous hot melt double extrusion technique: Investigation of the formulation and process suitability.

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V

Kallakunta VR, Sarabu S, Dudhipala N, Janga KY, Bandari S, Zhang F, Repka MA.
PMID: 34464695
Eur J Pharm Biopharm. 2021 Nov;168:184-194. doi: 10.1016/j.ejpb.2021.08.014. Epub 2021 Aug 28.

The current study is aimed at the development of chrono modulated multiple unit particulate systems (MUPS) of nifedipine (ND) by a continuous double extrusion process. ND, a poorly soluble drug was formulated into an amorphous solid dispersion (ASD) to...

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Kallakunta VR, Sarabu S, Dudhipala N, et al. Chrono modulated multiple unit particulate systems (MUPS) via a continuous hot melt double extrusion technique: Investigation of the formulation and process suitability. Eur J Pharm Biopharm. 2021;168:184-194doi: 10.1016/j.ejpb.2021.08.014.
Kallakunta, V. R., Sarabu, S., Dudhipala, N., Janga, K. Y., Bandari, S., Zhang, F., & Repka, M. A. (2021). Chrono modulated multiple unit particulate systems (MUPS) via a continuous hot melt double extrusion technique: Investigation of the formulation and process suitability. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 168184-194. https://doi.org/10.1016/j.ejpb.2021.08.014
Kallakunta, Venkata Raman, et al. "Chrono modulated multiple unit particulate systems (MUPS) via a continuous hot melt double extrusion technique: Investigation of the formulation and process suitability." European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V vol. 168 (2021): 184-194. doi: https://doi.org/10.1016/j.ejpb.2021.08.014
Kallakunta VR, Sarabu S, Dudhipala N, Janga KY, Bandari S, Zhang F, Repka MA. Chrono modulated multiple unit particulate systems (MUPS) via a continuous hot melt double extrusion technique: Investigation of the formulation and process suitability. Eur J Pharm Biopharm. 2021 Nov;168:184-194. doi: 10.1016/j.ejpb.2021.08.014. Epub 2021 Aug 28. PMID: 34464695; PMCID: PMC8666089.
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A Misleading Presentation of Pheochromocytoma in Pregnancy: A Case Report.

Medeniyet medical journal

Begum J, Kumari S, Ali M, Kumar Jena S, Behera K, Mishra P.
PMID: 33828893
Medeni Med J. 2021;36(1):69-74. doi: 10.5222/MMJ.2021.29660. Epub 2021 Mar 26.

Pheochromocytoma is a catecholamine-secreting adrenal tumor and also a rare cause of secondary hypertension in pregnancy. Its low prevalence, nonspecific clinical presentation, and symptoms similar to preeclampsia generate a diagnostic challenge during pregnancy. A 23-year-old hypertensive pregnant woman at...

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Begum J, Kumari S, Ali M, et al. A Misleading Presentation of Pheochromocytoma in Pregnancy: A Case Report. Medeni Med J. 2021;36(1):69-74doi: 10.5222/MMJ.2021.29660.
Begum, J., Kumari, S., Ali, M., Kumar Jena, S., Behera, K., & Mishra, P. (2021). A Misleading Presentation of Pheochromocytoma in Pregnancy: A Case Report. Medeniyet medical journal, 36(1), 69-74. https://doi.org/10.5222/MMJ.2021.29660
Begum, Jasmina, et al. "A Misleading Presentation of Pheochromocytoma in Pregnancy: A Case Report." Medeniyet medical journal vol. 36,1 (2021): 69-74. doi: https://doi.org/10.5222/MMJ.2021.29660
Begum J, Kumari S, Ali M, Kumar Jena S, Behera K, Mishra P. A Misleading Presentation of Pheochromocytoma in Pregnancy: A Case Report. Medeni Med J. 2021;36(1):69-74. doi: 10.5222/MMJ.2021.29660. Epub 2021 Mar 26. PMID: 33828893; PMCID: PMC8020182.
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Effects of dihydropyridine receptor signal on sarcoplasmic reticulum Ca2+ leakage after muscle contractions in rats.

The Journal of general physiology

Watanabe D, Wada M.
PMID: 34767008
J Gen Physiol. 2022 Sep 05;154(9). doi: 10.1085/jgp.2021ecc36. Epub 2021 Nov 12.

The purpose of this study is to investigate the mechanism underlying sarcoplasmic reticulum (SR) Ca2+ leakage at recovery phase after in vivo contractions. Rat gastrocnemius muscles were electrically stimulated in vivo, and then mechanically skinned fibers were prepared from...

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Watanabe D, Wada M. Effects of dihydropyridine receptor signal on sarcoplasmic reticulum Ca2+ leakage after muscle contractions in rats. J Gen Physiol. 2021;154(9)doi: 10.1085/jgp.2021ecc36.
Watanabe, D., & Wada, M. (2022). Effects of dihydropyridine receptor signal on sarcoplasmic reticulum Ca2+ leakage after muscle contractions in rats. The Journal of general physiology, 154(9), . https://doi.org/10.1085/jgp.2021ecc36
Watanabe, Daiki, and Wada, Masanobu. "Effects of dihydropyridine receptor signal on sarcoplasmic reticulum Ca2+ leakage after muscle contractions in rats." The Journal of general physiology vol. 154,9 (2022). doi: https://doi.org/10.1085/jgp.2021ecc36
Watanabe D, Wada M. Effects of dihydropyridine receptor signal on sarcoplasmic reticulum Ca2+ leakage after muscle contractions in rats. J Gen Physiol. 2022 Sep 05;154(9). doi: 10.1085/jgp.2021ecc36. Epub 2021 Nov 12. PMID: 34767008.
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Health Facilities' Readiness to Manage Hypertension and Diabetes Cases at Primary Health Facilities in Bidibidi Refugee Settlement, Yumbe District, Uganda.

Journal of tropical medicine

Isadru VR, Nanyonga RC, Alege JB.
PMID: 33552162
J Trop Med. 2021 Jan 22;2021:1415794. doi: 10.1155/2021/1415794. eCollection 2021.

BACKGROUND: NCDs are the greatest global contributors to morbidity and mortality and are a major health challenge in the 21st century. The global burden of NCDs remains unacceptably high. Access to care remains a challenge for the majority of...

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Isadru VR, Nanyonga RC, Alege JB. Health Facilities' Readiness to Manage Hypertension and Diabetes Cases at Primary Health Facilities in Bidibidi Refugee Settlement, Yumbe District, Uganda. J Trop Med. 2021;2021:1415794doi: 10.1155/2021/1415794.
Isadru, V. R., Nanyonga, R. C., & Alege, J. B. (2021). Health Facilities' Readiness to Manage Hypertension and Diabetes Cases at Primary Health Facilities in Bidibidi Refugee Settlement, Yumbe District, Uganda. Journal of tropical medicine, 20211415794. https://doi.org/10.1155/2021/1415794
Isadru, Vuchiri Ray, et al. "Health Facilities' Readiness to Manage Hypertension and Diabetes Cases at Primary Health Facilities in Bidibidi Refugee Settlement, Yumbe District, Uganda." Journal of tropical medicine vol. 2021 (2021): 1415794. doi: https://doi.org/10.1155/2021/1415794
Isadru VR, Nanyonga RC, Alege JB. Health Facilities' Readiness to Manage Hypertension and Diabetes Cases at Primary Health Facilities in Bidibidi Refugee Settlement, Yumbe District, Uganda. J Trop Med. 2021 Jan 22;2021:1415794. doi: 10.1155/2021/1415794. eCollection 2021. PMID: 33552162; PMCID: PMC7847353.
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Icotinib Induces Mechanism-Based Inactivation of Recombinant Human CYP3A4/5 Possibly via Heme Destruction by Ketene Intermediate.

Drug metabolism and disposition: the biological fate of chemicals

Sun C, Zhao H, Li W, Jia Y, Yang Y, Peng Y, Zheng J.
PMID: 34312304
Drug Metab Dispos. 2021 Oct;49(10):892-901. doi: 10.1124/dmd.121.000369. Epub 2021 Jul 26.

Icotinib (ICT) is an antitumor drug approved by China National Medical Products Administration and is found to be effective against non-small cell lung cancer. The present study aimed at the interaction of ICT with CYP3A. ICT exhibited time-, concentration-,...

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Sun C, Zhao H, Li W, et al. Icotinib Induces Mechanism-Based Inactivation of Recombinant Human CYP3A4/5 Possibly via Heme Destruction by Ketene Intermediate. Drug Metab Dispos. 2021;49(10):892-901doi: 10.1124/dmd.121.000369.
Sun, C., Zhao, H., Li, W., Jia, Y., Yang, Y., Peng, Y., & Zheng, J. (2021). Icotinib Induces Mechanism-Based Inactivation of Recombinant Human CYP3A4/5 Possibly via Heme Destruction by Ketene Intermediate. Drug metabolism and disposition: the biological fate of chemicals, 49(10), 892-901. https://doi.org/10.1124/dmd.121.000369
Sun, Chen, et al. "Icotinib Induces Mechanism-Based Inactivation of Recombinant Human CYP3A4/5 Possibly via Heme Destruction by Ketene Intermediate." Drug metabolism and disposition: the biological fate of chemicals vol. 49,10 (2021): 892-901. doi: https://doi.org/10.1124/dmd.121.000369
Sun C, Zhao H, Li W, Jia Y, Yang Y, Peng Y, Zheng J. Icotinib Induces Mechanism-Based Inactivation of Recombinant Human CYP3A4/5 Possibly via Heme Destruction by Ketene Intermediate. Drug Metab Dispos. 2021 Oct;49(10):892-901. doi: 10.1124/dmd.121.000369. Epub 2021 Jul 26. PMID: 34312304.
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Comparison of the effects on maternal endothelial cell activation: an in vitro study of anti-hypertensive drugs clinically used in pre-eclampsia.

Journal of human hypertension

Woolston E, Tang Y, Azizi S, Kando I, Chamley L, Stone P, Chen Q.
PMID: 33686209
J Hum Hypertens. 2021 Mar 08; doi: 10.1038/s41371-021-00497-5. Epub 2021 Mar 08.

Endothelial cell dysfunction in pregnancy, which can be induced by placental factors, is the fundamental component of the pathogenesis of pre-eclampsia. The dysfunctional vascular endothelium disrupts the balance of vasodilatory and vasoconstrictive factors, resulting in increasing blood pressure. There...

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Woolston E, Tang Y, Azizi S, et al. Comparison of the effects on maternal endothelial cell activation: an in vitro study of anti-hypertensive drugs clinically used in pre-eclampsia. J Hum Hypertens. 2021;doi: 10.1038/s41371-021-00497-5.
Woolston, E., Tang, Y., Azizi, S., Kando, I., Chamley, L., Stone, P., & Chen, Q. (2021). Comparison of the effects on maternal endothelial cell activation: an in vitro study of anti-hypertensive drugs clinically used in pre-eclampsia. Journal of human hypertension, . https://doi.org/10.1038/s41371-021-00497-5
Woolston, Esther, et al. "Comparison of the effects on maternal endothelial cell activation: an in vitro study of anti-hypertensive drugs clinically used in pre-eclampsia." Journal of human hypertension vol. (2021). doi: https://doi.org/10.1038/s41371-021-00497-5
Woolston E, Tang Y, Azizi S, Kando I, Chamley L, Stone P, Chen Q. Comparison of the effects on maternal endothelial cell activation: an in vitro study of anti-hypertensive drugs clinically used in pre-eclampsia. J Hum Hypertens. 2021 Mar 08; doi: 10.1038/s41371-021-00497-5. Epub 2021 Mar 08. PMID: 33686209.
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Improvement in Solubility and Absorption of Nifedipine Using Solid Solution: Correlations between Surface Free Energy and Drug Dissolution.

Polymers

Tubtimsri S, Weerapol Y.
PMID: 34503003
Polymers (Basel). 2021 Aug 31;13(17). doi: 10.3390/polym13172963.

Ternary solid solutions composed of nifedipine (NDP), amino methacrylate copolymer (AMCP), and polysorbate (PS) 20, 60, or 65 were prepared using a solvent evaporation method. The dissolution profiles of NDP were used to study the effect of the addition...

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Tubtimsri S, Weerapol Y. Improvement in Solubility and Absorption of Nifedipine Using Solid Solution: Correlations between Surface Free Energy and Drug Dissolution. Polymers (Basel). 2021;13(17)doi: 10.3390/polym13172963.
Tubtimsri, S., & Weerapol, Y. (2021). Improvement in Solubility and Absorption of Nifedipine Using Solid Solution: Correlations between Surface Free Energy and Drug Dissolution. Polymers, 13(17), . https://doi.org/10.3390/polym13172963
Tubtimsri, Sukannika, and Weerapol, Yotsanan. "Improvement in Solubility and Absorption of Nifedipine Using Solid Solution: Correlations between Surface Free Energy and Drug Dissolution." Polymers vol. 13,17 (2021). doi: https://doi.org/10.3390/polym13172963
Tubtimsri S, Weerapol Y. Improvement in Solubility and Absorption of Nifedipine Using Solid Solution: Correlations between Surface Free Energy and Drug Dissolution. Polymers (Basel). 2021 Aug 31;13(17). doi: 10.3390/polym13172963. PMID: 34503003; PMCID: PMC8434079.
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Drug repurposing for cancer treatment through global propagation with a greedy algorithm in a multilayer network.

Cancer biology & medicine

Cheng X, Zhao W, Zhu M, Wang B, Wang X, Yang X, Huang Y, Tan M, Li J.
PMID: 33893730
Cancer Biol Med. 2021 Apr 24; doi: 10.20892/j.issn.2095-3941.2020.0218. Epub 2021 Apr 24.

OBJECTIVE: Drug repurposing, the application of existing therapeutics to new indications, holds promise in achieving rapid clinical effects at a much lower cost than that of METHODS: Here, by targeting 4,096 human diseases, including 384 cancers, we propose a...

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Cheng X, Zhao W, Zhu M, et al. Drug repurposing for cancer treatment through global propagation with a greedy algorithm in a multilayer network. Cancer Biol Med. 2021;doi: 10.20892/j.issn.2095-3941.2020.0218.
Cheng, X., Zhao, W., Zhu, M., Wang, B., Wang, X., Yang, X., Huang, Y., Tan, M., & Li, J. (2021). Drug repurposing for cancer treatment through global propagation with a greedy algorithm in a multilayer network. Cancer biology & medicine, . https://doi.org/10.20892/j.issn.2095-3941.2020.0218
Cheng, Xi, et al. "Drug repurposing for cancer treatment through global propagation with a greedy algorithm in a multilayer network." Cancer biology & medicine vol. (2021). doi: https://doi.org/10.20892/j.issn.2095-3941.2020.0218
Cheng X, Zhao W, Zhu M, Wang B, Wang X, Yang X, Huang Y, Tan M, Li J. Drug repurposing for cancer treatment through global propagation with a greedy algorithm in a multilayer network. Cancer Biol Med. 2021 Apr 24; doi: 10.20892/j.issn.2095-3941.2020.0218. Epub 2021 Apr 24. PMID: 33893730.
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Megestrol acetate is a specific inducer of CYP3A4 mediated by human pregnane X receptor.

Cancer chemotherapy and pharmacology

Chen Y, Tang Y, Nie JZ, Zhang Y, Nie D.
PMID: 34524495
Cancer Chemother Pharmacol. 2021 Dec;88(6):985-996. doi: 10.1007/s00280-021-04352-9. Epub 2021 Sep 15.

PURPOSE: Megestrol acetate is a synthetic progestogen used to treat some cancers and cancer-associated cachexia, but its potential interactions with other drugs are not well known. This study aims to determine the regulation of drug metabolizing enzymes by megestrol...

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Chen Y, Tang Y, Nie JZ, et al. Megestrol acetate is a specific inducer of CYP3A4 mediated by human pregnane X receptor. Cancer Chemother Pharmacol. 2021;88(6):985-996doi: 10.1007/s00280-021-04352-9.
Chen, Y., Tang, Y., Nie, J. Z., Zhang, Y., & Nie, D. (2021). Megestrol acetate is a specific inducer of CYP3A4 mediated by human pregnane X receptor. Cancer chemotherapy and pharmacology, 88(6), 985-996. https://doi.org/10.1007/s00280-021-04352-9
Chen, Yakun, et al. "Megestrol acetate is a specific inducer of CYP3A4 mediated by human pregnane X receptor." Cancer chemotherapy and pharmacology vol. 88,6 (2021): 985-996. doi: https://doi.org/10.1007/s00280-021-04352-9
Chen Y, Tang Y, Nie JZ, Zhang Y, Nie D. Megestrol acetate is a specific inducer of CYP3A4 mediated by human pregnane X receptor. Cancer Chemother Pharmacol. 2021 Dec;88(6):985-996. doi: 10.1007/s00280-021-04352-9. Epub 2021 Sep 15. PMID: 34524495.
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Conflicts over calcium and the treatment of COVID-19.

Evolution, medicine, and public health

Crespi B, Alcock J.
PMID: 33732462
Evol Med Public Health. 2020 Nov 23;9(1):149-156. doi: 10.1093/emph/eoaa046. eCollection 2021.

Several recent studies have provided evidence that use of calcium channel blockers (CCBs), especially amlodipine and nifedipine, can reduce mortality from coronavirus disease 2019 (COVID-19). Moreover, hypocalcemia (a reduced level of serum ionized calcium) has been shown to be...

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Crespi B, Alcock J. Conflicts over calcium and the treatment of COVID-19. Evol Med Public Health. 2020;9(1):149-156doi: 10.1093/emph/eoaa046.
Crespi, B., & Alcock, J. (2021). Conflicts over calcium and the treatment of COVID-19. Evolution, medicine, and public health, 9(1), 149-156. https://doi.org/10.1093/emph/eoaa046
Crespi, Bernard, and Alcock, Joe. "Conflicts over calcium and the treatment of COVID-19." Evolution, medicine, and public health vol. 9,1 (2021): 149-156. doi: https://doi.org/10.1093/emph/eoaa046
Crespi B, Alcock J. Conflicts over calcium and the treatment of COVID-19. Evol Med Public Health. 2020 Nov 23;9(1):149-156. doi: 10.1093/emph/eoaa046. eCollection 2021. PMID: 33732462; PMCID: PMC7717197.
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Repurposing of nifedipine loaded in situ ophthalmic gel as a novel approach for glaucoma treatment.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

El-Feky YA, Fares AR, Zayed G, El-Telbany RFA, Ahmed KA, El-Telbany DFA.
PMID: 34385102
Biomed Pharmacother. 2021 Oct;142:112008. doi: 10.1016/j.biopha.2021.112008. Epub 2021 Aug 09.

Glaucoma is a chronic eye disease characterized by elevated intraocular pressure (IOP) which causes severe complications to the eyes and may lead to vision loss. The effective treatment of such diseases motivated the search for novel and unique drugs...

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El-Feky YA, Fares AR, Zayed G, et al. Repurposing of nifedipine loaded in situ ophthalmic gel as a novel approach for glaucoma treatment. Biomed Pharmacother. 2021;142:112008doi: 10.1016/j.biopha.2021.112008.
El-Feky, Y. A., Fares, A. R., Zayed, G., El-Telbany, R. F. A., Ahmed, K. A., & El-Telbany, D. F. A. (2021). Repurposing of nifedipine loaded in situ ophthalmic gel as a novel approach for glaucoma treatment. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 142112008. https://doi.org/10.1016/j.biopha.2021.112008
El-Feky, Yasmin A, et al. "Repurposing of nifedipine loaded in situ ophthalmic gel as a novel approach for glaucoma treatment." Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie vol. 142 (2021): 112008. doi: https://doi.org/10.1016/j.biopha.2021.112008
El-Feky YA, Fares AR, Zayed G, El-Telbany RFA, Ahmed KA, El-Telbany DFA. Repurposing of nifedipine loaded in situ ophthalmic gel as a novel approach for glaucoma treatment. Biomed Pharmacother. 2021 Oct;142:112008. doi: 10.1016/j.biopha.2021.112008. Epub 2021 Aug 09. PMID: 34385102.
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