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Showing 13 to 24 of 488 entries
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Oxidative damage to nuclear DNA: amelioration by melatonin. NEL Review.

Neuro endocrinology letters

Reiter RJ.
PMID: 11462105
Neuro Endocrinol Lett. 1999;20(3):145-150.

The indoleamine melatonin, a product of tryptophan metabolism in the pineal gland, is a free radical scavenger and antioxidant. This brief review summarizes melatonin's ability to protect nuclear DNA from oxidative damage. Using a variety of different cytogenetic, biochemical...

A T7 Promoter-based Versatile Expression Vector System.

Sheng wu hua xue yu sheng wu wu li xue bao Acta biochimica et biophysica Sinica

Chen CZ, Duan ZJ, Yang XY, Xia QC, Li BL, Wang YL.
PMID: 12232615
Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai). 1996;28(5):531-539.

A family of T7 promoter-based versatile expression plamides for E. coli Were constructed. These vectors were featured strong T7 promoter, translational start, stop elements, a multiple cloning site with eight unique restriction sites in all three reading frames and...

The medaka as a model for studying germ-cell mutagenesis and genomic instability.

Marine biotechnology (New York, N.Y.)

Shima A, Shimada A.
PMID: 14961312
Mar Biotechnol (NY). 2001 Jun;3:S162-7. doi: 10.1007/s10126-001-0038-x.

To study germ-cell mutagenesis from the viewpoint of biodiversity, we developed a nonmammalian specific-locus test system using the Japanese medaka, Oryzias latipes. The genetic end points available are dominant lethal mutations, total specific-locus mutations, and viable specific-locus mutations. We...

Induction of dominant mutations that cause skeletal malformations in mice.

Environmental health perspectives

Selby PB.
PMID: 17539135
Environ Health Perspect. 1978 Jun;24:101-3. doi: 10.1289/ehp.7824101.

A new approach for estimating genetic risk to humans from radiation is based upon an analysis of the frequency of induction of dominant mutations that cause skeletal abnormalities in mice. The main goal of this work is to improve...

MECHANISM OF CHEMICAL MUTAGENESIS IV. : Reaction between Triethylene Melamine and Nucleic Acid Components.

Journal of bacteriology

Lorkiewicz Z, Szybalski W.
PMID: 16561917
J Bacteriol. 1961 Aug;82(2):195-201. doi: 10.1128/jb.82.2.195-201.1961.

Lorkiewicz, Z. (University of Wisconsin, Madison), and Waclaw Szybalski. Mechanism of chemical mutagenesis. IV. Reaction between triethylene melamine and nucleic acid components. J. Bacteriol. 82: 195-201. 1961.-Triethylene melamine interacts primarily with phosphorylated intracellular deoxyribonucleic acid (DNA) precursors and not...

Theory and application of dissociative electron capture in molecular identification.

The journal of physical chemistry. A

Havey CD, Eberhart M, Jones T, Voorhees KJ, Laramée JA, Cody RB, Clougherty DP.
PMID: 16571045
J Phys Chem A. 2006 Apr 06;110(13):4413-8. doi: 10.1021/jp056166+.

The coupling of an electron monochromator (EM) to a mass spectrometer (MS) has created a new analytical technique, EM-MS, for the investigation of electrophilic compounds. This method provides a powerful tool for molecular identification of compounds contained in complex...

Somatic Crossing over in GLYCINE MAX (L.) Merrill: Effect of Some Inhibitors of DNA Synthesis on the Induction of Somatic Crossing over and Point Mutations.

Genetics

Vig BK.
PMID: 17248598
Genetics. 1973 Apr;73(4):583-96. doi: 10.1093/genetics/73.4.583.

Glycine max (soybean) is the only known higher plant with a definitely established occurrence of somatic crossing over. This material lends itself to the analysis of somatic crossing over, gross chromosomal aberrations and mutations, all of which may be...

Mammographic densities and breast cancer risk.

Breast disease

Boyd NF, Lockwood GA, Martin LJ, Knight JA, Byng JW, Yaffe MJ, Tritchler DL.
PMID: 15687568
Breast Dis. 1998 Aug;10(3):113-26. doi: 10.3233/bd-1998-103-412.

Variations between individuals in the radiographic appearance, or mammographic pattern, of the female breast arise because of differences in the relative amounts and X-ray attenuation characteristics of fat and connective and epithelial tissue. Studies using quantitative methods of assessment...

Effect of mycelial culture broth of Ganoderma lucidum on the growth characteristics of human cell lines.

Journal of bioscience and bioengineering

Chung WT, Lee SH, Kim JD, Park YS, Hwang B, Lee SY, Lee HY.
PMID: 16233144
J Biosci Bioeng. 2001;92(6):550-5. doi: 10.1263/jbb.92.550.

Two types of purified samples, water-soluble (sample A; M. W, 1.2 x 10(6) dalton) and water-insoluble (sample C; M. W., 1.0 x 10(6) dalton) samples, were obtained through consecutive separation processes from the culture broth of Ganoderma lucidia mycelium....

The colorless flavonoids of Arabidopsis thaliana (Brassicaceae). I. A model system to study the orthodihydroxy structure.

American journal of botany

Sheahan J, Cheong H, Rechnitz G.
PMID: 21684928
Am J Bot. 1998 Apr;85(4):467.

The orthodihydroxy structure may mediate flavonoid coloration or antioxidant activity, making it of interest to floral or health food industries, respectively. In the first of two companion papers, the authors demonstrate a model system to study the orthodihydroxy structure...

An exercise to estimate differential gene expression in human cells.

Biochemistry and molecular biology education : a bimonthly publication of the International Union of Biochemistry and Molecular Biology

Chaudhry MA.
PMID: 21638652
Biochem Mol Biol Educ. 2006 Mar;34(2):116-20. doi: 10.1002/bmb.2006.49403402116.

The expression of genes in cells of various tissue types varies considerably and is correlated with the function of a particular organ. The pattern of gene expression changes in diseased tissues, in response to therapy or infection and exposure...

Using DEREK to predict the activity of some carcinogens/mutagens found in foods.

Toxicology in vitro : an international journal published in association with BIBRA

Long A, Combes RD.
PMID: 20650129
Toxicol In Vitro. 1995 Aug;9(4):563-9. doi: 10.1016/0887-2333(95)00040-f.

The knowledge-based expert computer system DEREK (Deductive Estimation of Risk from Existing Knowledge) has been assessed for its potential as a screen for predicting genotoxicity and carcinogenicity of some chemicals found in foods. This was achieved by establishing databases,...

Showing 13 to 24 of 488 entries