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Showing 13 to 24 of 151 entries
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CLASP promotes microtubule bundling in metaphase spindle independently of Ase1/PRC1 in fission yeast.

Biology open

Ebina H, Ji L, Sato M.
PMID: 31615768
Biol Open. 2019 Oct 24;8(10). doi: 10.1242/bio.045716.

Microtubules in the mitotic spindle are organised by microtubule-associated proteins. In the late stage of mitosis, spindle microtubules are robustly organised through bundling by the antiparallel microtubule bundler Ase1/PRC1. In early mitosis, however, it is not well characterised as...

GSK3β and Tau Protein in Alzheimer's Disease and Epilepsy.

Frontiers in cellular neuroscience

Toral-Rios D, Pichardo-Rojas PS, Alonso-Vanegas M, Campos-Peña V.
PMID: 32256316
Front Cell Neurosci. 2020 Mar 17;14:19. doi: 10.3389/fncel.2020.00019. eCollection 2020.

Alzheimer's disease (AD) is the most common form of dementia present in older adults; its etiology involves genetic and environmental factors. In recent years, epidemiological studies have shown a correlation between AD and chronic epilepsy since a considerable number...

Mutation screening of multiple Pakistani MCPH families revealed novel and recurrent protein-truncating mutations of ASPM.

Biotechnology and applied biochemistry

Hussain S, Nawaz A, Hamid M, Ullah W, Khan IN, Afshan M, Rehman A, Nawaz H, Halswick J, Rehman SU, Ahmad S, Muzammal M, Muhammad N, Jan A, Khan S, Windpassinger C, Khan MA.
PMID: 34826358
Biotechnol Appl Biochem. 2021 Nov 26; doi: 10.1002/bab.2286. Epub 2021 Nov 26.

Autosomal primary microcephaly (MCPH) is a heterogenetic disorder that affects brain's cerebral cortex size and leads to a reduction in the cranial vault. Along with the hallmark feature of reduced head circumference, microcephalic patients also exhibit a variable degree...

Microtubule-associated proteins promote microtubule generation in the absence of γ-tubulin in human colon cancer cells.

The Journal of cell biology

Tsuchiya K, Goshima G.
PMID: 34779859
J Cell Biol. 2021 Dec 06;220(12). doi: 10.1083/jcb.202104114. Epub 2021 Nov 15.

The γ-tubulin complex acts as the predominant microtubule (MT) nucleator that initiates MT formation and is therefore an essential factor for cell proliferation. Nonetheless, cellular MTs are formed after experimental depletion of the γ-tubulin complex, suggesting that cells possess...

Molecular mechanisms underlying microtubule growth dynamics.

Current biology : CB

Cleary JM, Hancock WO.
PMID: 34033790
Curr Biol. 2021 May 24;31(10):R560-R573. doi: 10.1016/j.cub.2021.02.035.

Microtubules are dynamic cytoskeletal filaments composed of αβ-tubulin heterodimers. Historically, the dynamics of single tubulin interactions at the growing microtubule tip have been inferred from steady-state growth kinetics. However, recent advances in the production of recombinant tubulin and in...

Protective effect of rapamycin against acrylamide-induced hepatotoxicity: The associations between autophagy, apoptosis, and necroptosis.

Anatomical record (Hoboken, N.J. : 2007)

Erfan OS, Sonpol HMA, Abd El-Kader M.
PMID: 33480149
Anat Rec (Hoboken). 2021 Sep;304(9):1984-1998. doi: 10.1002/ar.24587. Epub 2021 Feb 02.

Acrylamide (ACRL) was demonstrated to induce hepatotoxicity and programmed cell death (PCD). Rapamycin (RAPA)-induced autophagy had been reported to limit the progression of hepatocellular injury in experimental models. This research was designed to study two death pathways involved in...

Can Maternal Autoantibodies Play an Etiological Role in ASD Development?.

Neuropsychiatric disease and treatment

Dudova I, Horackova K, Hrdlicka M, Balastik M.
PMID: 32581542
Neuropsychiatr Dis Treat. 2020 Jun 03;16:1391-1398. doi: 10.2147/NDT.S239504. eCollection 2020.

Autism spectrum disorder (ASD) is a heterogeneous condition with multiple etiologies and risk factors - both genetic and environmental. Recent data demonstrate that the immune system plays an important role in prenatal brain development. Deregulation of the immune system...

COMPARISON OF DIFFERENT ENVIRONMENTAL CONDITIONS IN THE FOLLOW-UP OF SUBARACHNOID HEMORRHAGE: An Experimental Rat Study.

Turkish neurosurgery

Kandemir T, Ergen FB, Cosan DT, Mutlu F, Özbek Z, Coşan TE.
PMID: 30649804
Turk Neurosurg. 2018 Aug 28; doi: 10.5137/1019-5149.JTN.23942-18.2. Epub 2018 Aug 28.

AIM: We questioned the effect of different environmental conditions on the brain in rats with subarachnoid haemorrhage.MATERIAL AND METHODS: Microtubules in neurons mediate both the consciousness and memory and regulate firing. Microtubule-associated proteins (MAPs) promote microtubule organisation and dynamics....

The microtubule-associated protein She1 coordinates directional spindle positioning by spatially restricting dynein activity.

Journal of cell science

Ecklund KH, Bailey ME, Kossen KA, Dietvorst CK, Asbury CL, Markus SM.
PMID: 34854468
J Cell Sci. 2021 Dec 01;134(23). doi: 10.1242/jcs.258510. Epub 2021 Dec 02.

Dynein motors move the mitotic spindle to the cell division plane in many cell types, including in budding yeast, in which dynein is assisted by numerous factors including the microtubule-associated protein (MAP) She1. Evidence suggests that She1 plays a...

Microtubule Dynamics and Neuronal Excitability: Advances on Cytoskeletal Components Implicated in Epileptic Phenomena.

Cellular and molecular neurobiology

Gambino G, Rizzo V, Giglia G, Ferraro G, Sardo P.
PMID: 32929563
Cell Mol Neurobiol. 2020 Sep 14; doi: 10.1007/s10571-020-00963-7. Epub 2020 Sep 14.

Extensive researches have deepened knowledge on the role of synaptic components in epileptogenesis, but limited attention has been devoted to the potential implication of the cytoskeleton. The study of the development of epilepsy and hyperexcitability states involves molecular, synaptic,...

The .

Frontiers in cell and developmental biology

Xiaoxia L, Zhang J, Jinkai S, Ying L, Guodong R.
PMID: 31850345
Front Cell Dev Biol. 2019 Nov 28;7:309. doi: 10.3389/fcell.2019.00309. eCollection 2019.

Light signaling and cortical microtubule (MT) arrays are essential to the anisotropic growth of plant cells. Microtubule-associated proteins (MAPs) function as regulators that mediate plant cell expansion or elongation by altering the arrangements of the MT arrays. However, current...

Cardiomyocyte Microtubules: Control of Mechanics, Transport, and Remodeling.

Annual review of physiology

Uchida K, Scarborough EA, Prosser BL.
PMID: 34614374
Annu Rev Physiol. 2021 Oct 06; doi: 10.1146/annurev-physiol-062421-040656. Epub 2021 Oct 06.

Microtubules are essential cytoskeletal elements found in all eukaryotic cells. The structure and composition of microtubules regulate their function, and the dynamic remodeling of the network by posttranslational modifications and microtubule-associated proteins generates diverse populations of microtubules adapted for...

Showing 13 to 24 of 151 entries