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Showing 133 to 144 of 151 entries
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Collapsin Response Mediator Proteins: Their Biological Functions and Pathophysiology in Neuronal Development and Regeneration.

Frontiers in cellular neuroscience

Nakamura F, Ohshima T, Goshima Y.
PMID: 32655376
Front Cell Neurosci. 2020 Jun 23;14:188. doi: 10.3389/fncel.2020.00188. eCollection 2020.

Collapsin response mediator proteins (CRMPs), which consist of five homologous cytosolic proteins, are one of the major phosphoproteins in the developing nervous system. The prominent feature of the CRMP family proteins is a new class of microtubule-associated proteins that...

Elevated mRNA expression levels of DLGAP5 are associated with poor prognosis in breast cancer.

Oncology letters

Xu T, Dong M, Li H, Zhang R, Li X.
PMID: 32391106
Oncol Lett. 2020 Jun;19(6):4053-4065. doi: 10.3892/ol.2020.11533. Epub 2020 Apr 10.

Breast cancer is the most commonly diagnosed type of cancer and one of the leading causes of cancer-associated mortality in women. In addition, the underlying molecular mechanisms of the occurrence and development of breast cancer requires further investigation. In...

Coexistence of a novel CCNY-ALK and ATIC-ALK double-fusion in one patient with ALK-positive NSCLC and response to crizotinib: a case report.

Translational lung cancer research

Wu X, Zhou H, He Z, Zhang Z, Feng W, Zhao J, Chen H, Wang S, Wang W, Wang Q.
PMID: 33489809
Transl Lung Cancer Res. 2020 Dec;9(6):2494-2499. doi: 10.21037/tlcr-20-1049.

Anaplastic lymphoma kinase (ALK) rearrangement, one of the common oncogene rearrangements in the mutational history of lung adenocarcinoma, occurs in approximately 5% of non-small cell lung cancer (NSCLC) patients who could be effectively treated with ALK tyrosine kinase inhibitors...

Chronic Anxiety- and Depression-Like Behaviors Are Associated With Glial-Driven Pathology Following Repeated Blast Induced Neurotrauma.

Frontiers in behavioral neuroscience

Dickerson MR, Murphy SF, Urban MJ, White Z, VandeVord PJ.
PMID: 34955781
Front Behav Neurosci. 2021 Dec 10;15:787475. doi: 10.3389/fnbeh.2021.787475. eCollection 2021.

Long-term neuropsychiatric impairments have become a growing concern following blast-related traumatic brain injury (bTBI) in active military personnel and Veterans. Neuropsychiatric impairments such as anxiety and depression are common comorbidities that Veterans report months, even years following injury. To...

Two modes of PRC1-mediated mechanical resistance to kinesin-driven microtubule network disruption.

Current biology : CB

Alfieri A, Gaska I, Forth S.
PMID: 33848456
Curr Biol. 2021 Jun 21;31(12):2495-2506.e4. doi: 10.1016/j.cub.2021.03.034. Epub 2021 Apr 12.

The proper organization of the microtubule-based spindle during cell division requires the collective activity of many different proteins. These include non-motor microtubule-associated proteins (MAPs), whose functions include crosslinking microtubules to regulate filament sliding rates and assemble microtubule arrays. One...

Adrenomedullin Contributes to Age-Related Memory Loss in Mice and Is Elevated in Aging Human Brains.

Frontiers in molecular neuroscience

Larrayoz IM, Ferrero H, Martisova E, Gil-Bea FJ, Ramírez MJ, Martínez A.
PMID: 29187812
Front Mol Neurosci. 2017 Nov 15;10:384. doi: 10.3389/fnmol.2017.00384. eCollection 2017.

Memory decline is common in elderly individuals and is the hallmark of Alzheimer's disease (AD). Memory failure follows the loss of synaptic contacts in the cerebral cortex and hippocampus, caused in part by cytoskeleton disruption. Adrenomedullin (AM) and its...

Downregulation of Autophagy-Related Proteins 1, 5, and 16 in Testicular Germ Cell Tumors Parallels Lowered LC3B and Elevated p62 Levels, Suggesting Reduced Basal Autophagy.

Frontiers in oncology

Liu H, He Z, Bode P, Moch H, Simon HU.
PMID: 30245976
Front Oncol. 2018 Sep 07;8:366. doi: 10.3389/fonc.2018.00366. eCollection 2018.

Autophagy is a cellular "self-digestion" process known to be essential for various physiological and pathological pathways, including cancer, where its role appears to be context-dependent. In this work, we aimed to investigate the level of autophagy by evaluating the...

Screening for key genes and transcription factors in ankylosing spondylitis by RNA-Seq.

Experimental and therapeutic medicine

Xu Z, Wang X, Zheng Y.
PMID: 29434723
Exp Ther Med. 2018 Feb;15(2):1394-1402. doi: 10.3892/etm.2017.5556. Epub 2017 Nov 23.

Ankylosing spondylitis (AS) is a chronic inflammatory arthritis and autoimmune disease, the etiology and pathogenesis of which remain largely unknown. In the present study, blood samples were harvested from patients with AS and from healthy volunteers as a normal...

Crosstalk between apoptosis and autophagy in prostate epithelial cells under androgen deprivation.

Experimental and therapeutic medicine

Liu RF, Li J, Zhang J, Bai PD, Yang YF, Li W, Wu Z, Zheng JX.
PMID: 29456633
Exp Ther Med. 2018 Mar;15(3):2263-2268. doi: 10.3892/etm.2018.5726. Epub 2018 Jan 09.

The present study investigated the molecular mechanism of apoptosis and autophagy in prostate epithelial cells under androgen deprivation (AD). BPH-1 cells were divided into four groups as follows: Control (Cont), AD, autophagy inhibition (AI) and AD + AI groups....

Upregulation of colonic and hepatic tumor overexpressed gene is significantly associated with the unfavorable prognosis marker of human hepatocellular carcinoma.

American journal of cancer research

Yu JX, Chen Q, Yu YQ, Li SQ, Song JF.
PMID: 27152245
Am J Cancer Res. 2016 Feb 15;6(3):690-700. eCollection 2016.

Colonic hepatic tumor overexpressed gene (ch-TOG), a member of the highly conserved XMAP215 family of microtubule-associated proteins (MAPs), plays a crucial role in bipolar mitotic spindle assembly. Here, we performed proof-of-principle studies targeting ch-TOG for the development of HCC...

β-catenin regulates effects of miR-24 on the viability and autophagy of glioma cells.

Experimental and therapeutic medicine

Chen H, Lu Q, Chen C, Di Y, Li Y, Min W, Yu Z, Dai D.
PMID: 31316620
Exp Ther Med. 2019 Aug;18(2):1285-1290. doi: 10.3892/etm.2019.7680. Epub 2019 Jun 18.

Mutations of the β-catenin gene are common in various cancer types. MicroRNA (miR)-24 suppresses gene expression during the cell cycle. However, the effects of miR-24 on the cell viability and autophagy of glioma cells, and how these biological processes...

Multicolour three dimensional structured illumination microscopy of immunolabeled plant microtubules and associated proteins.

Plant methods

Vavrdová T, Šamajová O, Křenek P, Ovečka M, Floková P, Šnaurová R, Šamaj J, Komis G.
PMID: 30899319
Plant Methods. 2019 Mar 09;15:22. doi: 10.1186/s13007-019-0406-z. eCollection 2019.

BACKGROUND: In the present work, we provide an account of structured illumination microscopy (SIM) imaging of fixed and immunolabeled plant probes. We take advantage of SIM, to superresolve intracellular structures at a considerable z-range and circumvent its low temporal...

Showing 133 to 144 of 151 entries