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Showing 13 to 24 of 13722 entries
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MicroRNA biogenesis and their functions in regulating stem cell potency and differentiation.

Biological procedures online

Yao S.
PMID: 26966421
Biol Proced Online. 2016 Mar 09;18:8. doi: 10.1186/s12575-016-0037-y. eCollection 2016.

Stem cells are unspecialized/undifferentiated cells that exist in embryos and adult tissues or can be converted from somatic differentiated cells. Use of stem cells for tissue regeneration and tissue engineering has been a cornerstone of the regenerative medicine. Stem...

Circulating micrornas associated with glycemic impairment and progression in Asian Indians.

Biomarker research

Flowers E, Gadgil M, Aouizerat BE, Kanaya AM.
PMID: 26966540
Biomark Res. 2015 Oct 13;3:22. doi: 10.1186/s40364-015-0047-y. eCollection 2015.

AIMS/HYPOTHESIS: Asian Indians have a high incidence of type 2 diabetes, but factors associated with glycemic progression in this population are not understood. MicroRNAs are emerging as important mediators of glucose homeostasis and have not been previously studied in...

MiR-15a-5p negatively regulates cell survival and metastasis by targeting CXCL10 in chronic myeloid leukemia.

American journal of translational research

Chen D, Wu D, Shao K, Ye B, Huang J, Gao Y.
PMID: 28979704
Am J Transl Res. 2017 Sep 15;9(9):4308-4316. eCollection 2017.

Chronic myeloid leukemia (CML) is a common malignant disease from hematopoietic system. Aberrant expression of microRNAs (miRNAs) has been found in CML, however, the roles of many miRNAs including miR-15a-5p in CML are still unknown. In this study, the...

miR-219-5p suppresses the proliferation and invasion of colorectal cancer cells by targeting calcyphosin.

Oncology letters

Wang Q, Zhu L, Jiang Y, Xu J, Wang F, He Z.
PMID: 28454255
Oncol Lett. 2017 Mar;13(3):1319-1324. doi: 10.3892/ol.2017.5570. Epub 2017 Jan 04.

MicroRNAs (miRNAs) are small non-coding RNAs involved in an array of biological processes, and their dysregulation is associated with tumor development and progression. One such miRNA, miR-219-5p, is abnormally expressed in patients with colorectal cancer (CRC). In the present...

Genetics and Epigenetics of Diabetic Nephropathy.

Kidney diseases (Basel, Switzerland)

Liu R, Lee K, He JC.
PMID: 27536664
Kidney Dis (Basel). 2015 May;1(1):42-51. doi: 10.1159/000381796. Epub 2015 Apr 16.

BACKGROUND: Diabetic nephropathy (DN) is the most common cause of end-stage renal disease (ESRD) in the USA and worldwide, contributing to significant morbidity and mortality in diabetic patients. A genetic factor for the development of DN is strongly implicated,...

miR-150 is downregulated in osteosarcoma and suppresses cell proliferation, migration and invasion by targeting ROCK1.

Oncology letters

Li CH, Yu TB, Qiu HW, Zhao X, Zhou CL, Qi C.
PMID: 28454380
Oncol Lett. 2017 Apr;13(4):2191-2197. doi: 10.3892/ol.2017.5709. Epub 2017 Feb 09.

Osteosarcoma (OS) is the most common form of bone malignancy in children and adolescents. A class of molecules known as microRNAs (miRNAs) have been routinely associated in the development and progression of OS. The present study was centered on...

Circulating microRNAs in patients with hormone receptor-positive, metastatic breast cancer treated with dovitinib.

Clinical and translational medicine

Shivapurkar N, Vietsch EE, Carney E, Isaacs C, Wellstein A.
PMID: 28980224
Clin Transl Med. 2017 Oct 04;6(1):37. doi: 10.1186/s40169-017-0169-y.

BACKGROUND: Serial analysis of biomarkers in the circulation of patients undergoing treatment ("liquid biopsies") can provide new insights into drug effects. In particular the analysis of cell-free, circulating nucleic acids such as microRNAs (miRs) can reveal altered expression patterns...

MiR-519d facilitates the progression and metastasis of cervical cancer through direct targeting Smad7.

Cancer cell international

Zhou JY, Zheng SR, Liu J, Shi R, Yu HL, Wei M.
PMID: 27006642
Cancer Cell Int. 2016 Mar 22;16:21. doi: 10.1186/s12935-016-0298-1. eCollection 2016.

BACKGROUND: MicroRNAs (miRNAs) play pivotal roles in the development of various cancer types, including cervical cancer.METHODS AND RESULTS: In this study, we showed that miR-519d, a miRNA within the chromosome 19 miRNA cluster, was significantly upregulated in cervical cancer...

Major Tumor Suppressor and Oncogenic Non-Coding RNAs: Clinical Relevance in Lung Cancer.

Cells

Inamura K.
PMID: 28486418
Cells. 2017 May 09;6(2). doi: 10.3390/cells6020012.

Lung cancer is the leading cause of cancer deaths worldwide, yet there remains a lack of specific and sensitive tools for early diagnosis and targeted therapies. High-throughput sequencing techniques revealed that non-coding RNAs (ncRNAs), e.g., microRNAs and long ncRNAs...

Inhibition of autophagy potentiates the proliferation inhibition activity of microRNA-7 in human hepatocellular carcinoma cells.

Oncology letters

Wang Y, Wang Q, Song J.
PMID: 28927113
Oncol Lett. 2017 Sep;14(3):3566-3572. doi: 10.3892/ol.2017.6573. Epub 2017 Jul 15.

MicroRNAs (miRNAs/miRs) are important molecules that are able to regulate multiple cellular processes in cancer cells. miR-7 has been previously identified as a tumor suppressive miRNA in several types of cancer. The aim of the present study was to...

MicroRNAs as regulators of drug abuse and immunity.

Central-European journal of immunology

Zhang K, Jing X, Wang G.
PMID: 28450806
Cent Eur J Immunol. 2016;41(4):426-434. doi: 10.5114/ceji.2016.65142. Epub 2017 Jan 24.

MicroRNAs (miRNAs) are 20-22 nucleotide non-coding RNAs that participate in gene regulation. They bind to 3'-untranslated regions of their mRNA targets, inhibiting the transcripts' translation and/or destabilizing them. Chronic drug abuse induces changes of miRNAs expression in the brain,...

MicroRNAs are key regulators of hepatocellular carcinoma (HCC) cell dissemination-what we learned from microRNA-494.

Hepatobiliary surgery and nutrition

González-Vallinas M, Breuhahn K.
PMID: 27500444
Hepatobiliary Surg Nutr. 2016 Aug;5(4):372-6. doi: 10.21037/hbsn.2016.05.07.

No abstract available.

Showing 13 to 24 of 13722 entries