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Bioisosteric Modification of To042: Synthesis and Evaluation of Promising Use-Dependent Inhibitors of Voltage-Gated Sodium Channels.

ChemMedChem

Milani G, Cavalluzzi MM, Altamura C, Santoro A, Perrone M, Muraglia M, Colabufo NA, Corbo F, Casalino E, Franchini C, Pisano I, Desaphy JF, Carrieri A, Carocci A, Lentini G.
PMID: 34519427
ChemMedChem. 2021 Dec 06;16(23):3588-3599. doi: 10.1002/cmdc.202100496. Epub 2021 Oct 05.

Three analogues of To042, a tocainide-related lead compound recently reported for the treatment of myotonia, were synthesized and evaluated in vitro as skeletal muscle sodium channel blockers possibly endowed with enhanced use-dependent behavior. Patch-clamp experiments on hNav1.4 expressed in...

Cite
Milani G, Cavalluzzi MM, Altamura C, et al. Bioisosteric Modification of To042: Synthesis and Evaluation of Promising Use-Dependent Inhibitors of Voltage-Gated Sodium Channels. ChemMedChem. 2021;16(23):3588-3599doi: 10.1002/cmdc.202100496.
Milani, G., Cavalluzzi, M. M., Altamura, C., Santoro, A., Perrone, M., Muraglia, M., Colabufo, N. A., Corbo, F., Casalino, E., Franchini, C., Pisano, I., Desaphy, J. F., Carrieri, A., Carocci, A., & Lentini, G. (2021). Bioisosteric Modification of To042: Synthesis and Evaluation of Promising Use-Dependent Inhibitors of Voltage-Gated Sodium Channels. ChemMedChem, 16(23), 3588-3599. https://doi.org/10.1002/cmdc.202100496
Milani, Gualtiero, et al. "Bioisosteric Modification of To042: Synthesis and Evaluation of Promising Use-Dependent Inhibitors of Voltage-Gated Sodium Channels." ChemMedChem vol. 16,23 (2021): 3588-3599. doi: https://doi.org/10.1002/cmdc.202100496
Milani G, Cavalluzzi MM, Altamura C, Santoro A, Perrone M, Muraglia M, Colabufo NA, Corbo F, Casalino E, Franchini C, Pisano I, Desaphy JF, Carrieri A, Carocci A, Lentini G. Bioisosteric Modification of To042: Synthesis and Evaluation of Promising Use-Dependent Inhibitors of Voltage-Gated Sodium Channels. ChemMedChem. 2021 Dec 06;16(23):3588-3599. doi: 10.1002/cmdc.202100496. Epub 2021 Oct 05. PMID: 34519427.
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Peripartum management of patient with long QT3 after successful implantable cardioverter defibrillator device discharge resulting in device failure: a case report.

European heart journal. Case reports

Lee MJ, Monteil DC, Spooner MT.
PMID: 34926986
Eur Heart J Case Rep. 2021 Nov 30;5(12):ytab487. doi: 10.1093/ehjcr/ytab487. eCollection 2021 Dec.

BACKGROUND: Long QT3 syndrome type 3 (LQT3) is a gain of function mutation of the SCN5A gene that is inherited in an autosomal dominant fashion. Long QT3 syndrome type 3 results in an increase in arrhythmic events during rest,...

Cite
Lee MJ, Monteil DC, Spooner MT. Peripartum management of patient with long QT3 after successful implantable cardioverter defibrillator device discharge resulting in device failure: a case report. Eur Heart J Case Rep. 2021;5(12):ytab487doi: 10.1093/ehjcr/ytab487.
Lee, M. J., Monteil, D. C., & Spooner, M. T. (2021). Peripartum management of patient with long QT3 after successful implantable cardioverter defibrillator device discharge resulting in device failure: a case report. European heart journal. Case reports, 5(12), ytab487. https://doi.org/10.1093/ehjcr/ytab487
Lee, Melissa J, et al. "Peripartum management of patient with long QT3 after successful implantable cardioverter defibrillator device discharge resulting in device failure: a case report." European heart journal. Case reports vol. 5,12 (2021): ytab487. doi: https://doi.org/10.1093/ehjcr/ytab487
Lee MJ, Monteil DC, Spooner MT. Peripartum management of patient with long QT3 after successful implantable cardioverter defibrillator device discharge resulting in device failure: a case report. Eur Heart J Case Rep. 2021 Nov 30;5(12):ytab487. doi: 10.1093/ehjcr/ytab487. eCollection 2021 Dec. PMID: 34926986; PMCID: PMC8672658.
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Showing 97 to 98 of 98 entries