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Showing 13 to 24 of 110 entries
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Isomorphism: 'molecular similarity to crystal structure similarity' in multicomponent forms of analgesic drugs tolfenamic and mefenamic acid.

IUCrJ

Ranjan S, Devarapalli R, Kundu S, Saha S, Deolka S, Vangala VR, Reddy CM.
PMID: 32148846
IUCrJ. 2020 Jan 07;7:173-183. doi: 10.1107/S205225251901604X. eCollection 2020 Mar 01.

The non-steroidal anti-inflammatory drugs mefenamic acid (MFA) and tolfenamic acid (TFA) have a close resemblance in their molecular scaffold, whereby a methyl group in MFA is substituted by a chloro group in TFA. The present study demonstrates the isomorphous...

Occurrence of Pharmaceutically Active Compounds and Potential Ecological Risks in Wastewater from Hospitals and Receiving Waters in Sri Lanka.

Environmental toxicology and chemistry

Goswami P, Guruge KS, Tanoue R, Tamamura YA, Jinadasa KBSN, Nomiyama K, Kunisue T, Tanabe S.
PMID: 34529856
Environ Toxicol Chem. 2021 Sep 16; doi: 10.1002/etc.5212. Epub 2021 Sep 16.

The presence of pharmaceutically active compounds (PACs) in the environment and their associated hazards is a major global health concern; however, data on these compounds are scarce in developing nations. In the present study, the existence of 39 non-antimicrobial...

Fasted intestinal solubility limits and distributions applied to the biopharmaceutics and developability classification systems.

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V

Abuhassan Q, Khadra I, Pyper K, Augustijns P, Brouwers J, Halbert GW.
PMID: 34923138
Eur J Pharm Biopharm. 2022 Jan;170:160-169. doi: 10.1016/j.ejpb.2021.12.006. Epub 2021 Dec 16.

After oral administration, a drug's solubility in intestinal fluid is an important parameter influencing bioavailability and if the value is known it can be applied to estimate multiple biopharmaceutical parameters including the solubility limited absorbable dose. Current in vitro...

Status of pharmaceuticals in the Korle Lagoon and their toxicity to non-target organisms.

Ecotoxicology (London, England)

Asare EA.
PMID: 34981244
Ecotoxicology. 2022 Jan 04; doi: 10.1007/s10646-021-02507-1. Epub 2022 Jan 04.

The availability of pharmaceutically active compounds (PhACs) in surface waters and suspended solids/sediments presents an ecological hazard of chronic exposure to non-target organisms. Thus, water and sediment samples were collected from the Korle Lagoon in the west of Accra-Ghana...

Carbon-Based Sorbent Coatings for the Determination of Pharmaceutical Compounds by Bar Adsorptive Microextraction.

ACS applied bio materials

Ahmad SM, Mestre AS, Neng NR, Ania CO, Carvalho AP, Nogueira JMF.
PMID: 35025329
ACS Appl Bio Mater. 2020 Apr 20;3(4):2078-2091. doi: 10.1021/acsabm.9b01206. Epub 2020 Mar 09.

Thirteen carbon materials comprising commercial activated carbons and lab-made materials (activated carbons, hydrochars, and low-T and high-T activated hydrochars) were assayed as sorbent coatings in bar adsorptive microextration (BAμE) to monitor trace levels of ten common pharmaceutical compounds (PhCs)...

Preparation of Ethylene Glycol Dimethacrylate (EGDMA)-Based Terpolymer as Potential Sorbents for Pharmaceuticals Adsorption.

Polymers

Shaipulizan NS, Md Jamil SNA, Kamaruzaman S, Subri NNS, Adeyi AA, Abdullah AH, Abdullah LC.
PMID: 32059354
Polymers (Basel). 2020 Feb 12;12(2). doi: 10.3390/polym12020423.

Ethylene glycol dimethacrylate (EGDMA) is used as a crosslinker in poly(acrylonitrile (AN)-

Nanocellulose/TiO.

Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology

Rathod M, Moradeeya PG, Haldar S, Basha S.
PMID: 30090894
Photochem Photobiol Sci. 2018 Oct 10;17(10):1301-1309. doi: 10.1039/c8pp00156a.

Nanocellulose (NC)-supported TiO2 nanoparticles, termed NCTs, were prepared by an ultrasonic impregnation method. The as-synthesized NCTs were thoroughly characterized and studied for the photodegradation of mefenamic acid (MEF), an anthranilic acid derivative drug. The adsorption potential of NCTs increased...

Trace analysis of mefenamic acid in human serum and pharmaceutical wastewater samples after pre-concentration with Ni-Al layered double hydroxide nano-particles.

Journal of pharmaceutical analysis

Abdolmohammad-Zadeh H, Morshedzadeh F, Rahimpour E.
PMID: 29403897
J Pharm Anal. 2014 Oct;4(5):331-338. doi: 10.1016/j.jpha.2014.04.003. Epub 2014 May 23.

In this work, the nickel-aluminum layered double hydroxide (Ni-Al LDH) with nitrate interlayer anion was synthesized and used as a solid phase extraction sorbent for the selective separation and pre-concentration of mefenamic acid prior to quantification by UV detection...

Hepatotoxicity of Nonsteroidal Anti-Inflammatory Drugs: A Systematic Review of Randomized Controlled Trials.

International journal of hepatology

Sriuttha P, Sirichanchuen B, Permsuwan U.
PMID: 29568654
Int J Hepatol. 2018 Jan 15;2018:5253623. doi: 10.1155/2018/5253623. eCollection 2018.

BACKGROUND: Nonsteroidal anti-inflammatory drugs (NSAIDs) are the most widely used medication in several countries, including Thailand. NSAIDs have been associated with hepatic side effects; however, the frequency of these side effects is uncertain.AIM OF THE REVIEW: To systematically review...

Polypharmacy leads to increased prevalence of potentially inappropriate medication in the Indonesian geriatric population visiting primary care facilities.

Therapeutics and clinical risk management

Abdulah R, Insani WN, Destiani DP, Rohmaniasari N, Mohenathas ND, Barliana MI.
PMID: 30233194
Ther Clin Risk Manag. 2018 Sep 04;14:1591-1597. doi: 10.2147/TCRM.S170475. eCollection 2018.

BACKGROUND: The geriatric population is particularly vulnerable to being prescribed potentially inappropriate medication (PIM); however, the prevalence of this occurrence remains poorly investigated in Indonesia. Thus in this research, we focused on investigating the prevalence and predictors of PIM...

Formulation and evaluation of mefenamic acid emulgel for topical delivery.

Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society

Khullar R, Kumar D, Seth N, Saini S.
PMID: 23960777
Saudi Pharm J. 2012 Jan;20(1):63-7. doi: 10.1016/j.jsps.2011.08.001. Epub 2011 Aug 22.

Emulgels have emerged as a promising drug delivery system for the delivery of hydrophobic drugs. The objective of the study was to prepare emulgel of mefenamic acid, a NSAID, using Carbapol 940 as a gelling agent. Mentha oil and...

Removal of selected NSAIDs (nonsteroidal anti-inflammatory drugs) in aqueous samples by Octolig®.

Journal of environmental science and health. Part A, Toxic/hazardous substances & environmental engineering

Martin DF, Martin JM, Word TA.
PMID: 26606390
J Environ Sci Health A Tox Hazard Subst Environ Eng. 2016 Jan 28;51(2):186-191. doi: 10.1080/10934529.2015.1087755. Epub 2015 Nov 25.

The possibility of removing representative nonsteroidal anti-inflammatory drugs (NSAIDs) from water was tested using Octolig®, a commercially available material with polyethylenediimine moieties covalently attached to high-surface area silica gel. The effectiveness of removal should depend on selected NSAIDs having...

Showing 13 to 24 of 110 entries