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Not typical angina and mortality in women with obstructive coronary artery disease: Results from the Women's Ischemic Syndrome Evaluation study (WISE).

International journal of cardiology. Heart & vasculature

Jones E, Delia Johnson B, Shaw LJ, Bakir M, Wei J, Mehta PK, Minissian M, Pepine CJ, Reis SE, Kelsey SF, Handberg E, Bittner V, Sopko G, Noel Bairey Merz C.
PMID: 32226820
Int J Cardiol Heart Vasc. 2020 Mar 24;27:100502. doi: 10.1016/j.ijcha.2020.100502. eCollection 2020 Apr.

BACKGROUND: Women frequently present with symptoms not typical of angina (NTA) making ischemic heart disease recognition, diagnosis and treatment challenging. We compared mortality in women with obstructive coronary artery disease (CAD) with NTA vs typical angina (TA).METHODS: We studied...

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Jones E, Delia Johnson B, Shaw LJ, et al. Not typical angina and mortality in women with obstructive coronary artery disease: Results from the Women's Ischemic Syndrome Evaluation study (WISE). Int J Cardiol Heart Vasc. 2020;27:100502doi: 10.1016/j.ijcha.2020.100502.
Jones, E., Delia Johnson, B., Shaw, L. J., Bakir, M., Wei, J., Mehta, P. K., Minissian, M., Pepine, C. J., Reis, S. E., Kelsey, S. F., Handberg, E., Bittner, V., Sopko, G., & Noel Bairey Merz, C. (2020). Not typical angina and mortality in women with obstructive coronary artery disease: Results from the Women's Ischemic Syndrome Evaluation study (WISE). International journal of cardiology. Heart & vasculature, 27100502. https://doi.org/10.1016/j.ijcha.2020.100502
Jones, Erika, et al. "Not typical angina and mortality in women with obstructive coronary artery disease: Results from the Women's Ischemic Syndrome Evaluation study (WISE)." International journal of cardiology. Heart & vasculature vol. 27 (2020): 100502. doi: https://doi.org/10.1016/j.ijcha.2020.100502
Jones E, Delia Johnson B, Shaw LJ, Bakir M, Wei J, Mehta PK, Minissian M, Pepine CJ, Reis SE, Kelsey SF, Handberg E, Bittner V, Sopko G, Noel Bairey Merz C. Not typical angina and mortality in women with obstructive coronary artery disease: Results from the Women's Ischemic Syndrome Evaluation study (WISE). Int J Cardiol Heart Vasc. 2020 Mar 24;27:100502. doi: 10.1016/j.ijcha.2020.100502. eCollection 2020 Apr. PMID: 32226820; PMCID: PMC7093808.
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International prospective cohort study of microvascular angina - Rationale and design.

International journal of cardiology. Heart & vasculature

Suda A, Takahashi J, Beltrame JF, Berry C, Camici PG, Crea F, Escaned J, Ford T, Carlos Kaski J, Kiyooka T, Metha PK, Ong P, Ozaki Y, Pepine C, Rimoldi O, Safdar B, Sechtem U, Tsujita K, Yii E, Noel Bairey Merz C, Shimokawa H.
PMID: 32984497
Int J Cardiol Heart Vasc. 2020 Sep 11;31:100630. doi: 10.1016/j.ijcha.2020.100630. eCollection 2020 Dec.

BACKGROUND: Patients with signs and symptoms of myocardial ischemia and non-obstructive coronary artery disease (CAD) frequently have coronary functional abnormalities, including coronary microvascular dysfunction. Those with the latter are grouped under the term "microvascular angina" (MVA). Although diagnostic criteria...

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Suda A, Takahashi J, Beltrame JF, et al. International prospective cohort study of microvascular angina - Rationale and design. Int J Cardiol Heart Vasc. 2020;31:100630doi: 10.1016/j.ijcha.2020.100630.
Suda, A., Takahashi, J., Beltrame, J. F., Berry, C., Camici, P. G., Crea, F., Escaned, J., Ford, T., Carlos Kaski, J., Kiyooka, T., Metha, P. K., Ong, P., Ozaki, Y., Pepine, C., Rimoldi, O., Safdar, B., Sechtem, U., Tsujita, K., Yii, E., Noel Bairey Merz, C., Shimokawa, H. (2020). International prospective cohort study of microvascular angina - Rationale and design. International journal of cardiology. Heart & vasculature, 31100630. https://doi.org/10.1016/j.ijcha.2020.100630
Suda, Akira, et al. "International prospective cohort study of microvascular angina - Rationale and design." International journal of cardiology. Heart & vasculature vol. 31 (2020): 100630. doi: https://doi.org/10.1016/j.ijcha.2020.100630
Suda A, Takahashi J, Beltrame JF, Berry C, Camici PG, Crea F, Escaned J, Ford T, Carlos Kaski J, Kiyooka T, Metha PK, Ong P, Ozaki Y, Pepine C, Rimoldi O, Safdar B, Sechtem U, Tsujita K, Yii E, Noel Bairey Merz C, Shimokawa H. International prospective cohort study of microvascular angina - Rationale and design. Int J Cardiol Heart Vasc. 2020 Sep 11;31:100630. doi: 10.1016/j.ijcha.2020.100630. eCollection 2020 Dec. PMID: 32984497; PMCID: PMC7494778.
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Challenging Statin Pleiotropy: Preeclampsia.

Circulation

Wei J, Liao JK, Bairey Merz CN.
PMID: 34460319
Circulation. 2021 Aug 31;144(9):680-683. doi: 10.1161/CIRCULATIONAHA.121.056140. Epub 2021 Aug 30.

No abstract available.

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Wei J, Liao JK, Bairey Merz CN. Challenging Statin Pleiotropy: Preeclampsia. Circulation. 2021;144(9):680-683doi: 10.1161/CIRCULATIONAHA.121.056140.
Wei, J., Liao, J. K., & Bairey Merz, C. N. (2021). Challenging Statin Pleiotropy: Preeclampsia. Circulation, 144(9), 680-683. https://doi.org/10.1161/CIRCULATIONAHA.121.056140
Wei, Janet, et al. "Challenging Statin Pleiotropy: Preeclampsia." Circulation vol. 144,9 (2021): 680-683. doi: https://doi.org/10.1161/CIRCULATIONAHA.121.056140
Wei J, Liao JK, Bairey Merz CN. Challenging Statin Pleiotropy: Preeclampsia. Circulation. 2021 Aug 31;144(9):680-683. doi: 10.1161/CIRCULATIONAHA.121.056140. Epub 2021 Aug 30. PMID: 34460319; PMCID: PMC8437106.
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Somatic Versus Cognitive Depressive Symptoms as Predictors of Coronary Artery Disease among Women with Suspected Ischemia: The Women's Ischemia Syndrome Evaluation.

Heart and mind (Mumbai, India)

Emami AS, Bairey Merz CN, Eastwood JA, Pepine CJ, Handberg EM, Bittner V, Mehta PK, Krantz DS, Vaccarino V, Eteiba W, Cornell CE, Rutledge T.
PMID: 34966880
Heart Mind (Mumbai). 2021 Oct-Dec;5(4):112-118. doi: 10.4103/hm.hm_34_21. Epub 2021 Nov 30.

BACKGROUND: Depression is an established predictor of coronary artery disease (CAD) progression and mortality. "Somatic" symptoms of depression such as fatigue and sleep impairment overlap with symptoms of CAD and independently predict CAD events. Differentiating between "somatic" and "cognitive"...

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Emami AS, Bairey Merz CN, Eastwood JA, et al. Somatic Versus Cognitive Depressive Symptoms as Predictors of Coronary Artery Disease among Women with Suspected Ischemia: The Women's Ischemia Syndrome Evaluation. Heart Mind (Mumbai). 2021;5(4):112-118doi: 10.4103/hm.hm_34_21.
Emami, A. S., Bairey Merz, C. N., Eastwood, J. A., Pepine, C. J., Handberg, E. M., Bittner, V., Mehta, P. K., Krantz, D. S., Vaccarino, V., Eteiba, W., Cornell, C. E., & Rutledge, T. (2021). Somatic Versus Cognitive Depressive Symptoms as Predictors of Coronary Artery Disease among Women with Suspected Ischemia: The Women's Ischemia Syndrome Evaluation. Heart and mind (Mumbai, India), 5(4), 112-118. https://doi.org/10.4103/hm.hm_34_21
Emami, Ashley S, et al. "Somatic Versus Cognitive Depressive Symptoms as Predictors of Coronary Artery Disease among Women with Suspected Ischemia: The Women's Ischemia Syndrome Evaluation." Heart and mind (Mumbai, India) vol. 5,4 (2021): 112-118. doi: https://doi.org/10.4103/hm.hm_34_21
Emami AS, Bairey Merz CN, Eastwood JA, Pepine CJ, Handberg EM, Bittner V, Mehta PK, Krantz DS, Vaccarino V, Eteiba W, Cornell CE, Rutledge T. Somatic Versus Cognitive Depressive Symptoms as Predictors of Coronary Artery Disease among Women with Suspected Ischemia: The Women's Ischemia Syndrome Evaluation. Heart Mind (Mumbai). 2021 Oct-Dec;5(4):112-118. doi: 10.4103/hm.hm_34_21. Epub 2021 Nov 30. PMID: 34966880; PMCID: PMC8713564.
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Fat distribution and longitudinal anthropometric changes in HIV-infected men with and without clinical evidence of lipodystrophy and HIV-uninfected controls: a substudy of the Multicenter AIDS Cohort Study.

AIDS research and therapy

Brown TT, Xu X, John M, Singh J, Kingsley LA, Palella FJ, Witt MD, Margolick JB, Dobs AS.
PMID: 19439092
AIDS Res Ther. 2009 May 13;6:8. doi: 10.1186/1742-6405-6-8.

BACKGROUND: Fat abnormalities are common among HIV-infected persons, but few studies have compared regional body fat distribution, including visceral fat, in HIV-infected and HIV-uninfected persons and their subsequent trajectories in body composition over time.METHODS: Between 1999 and 2002, 33...

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Brown TT, Xu X, John M, et al. Fat distribution and longitudinal anthropometric changes in HIV-infected men with and without clinical evidence of lipodystrophy and HIV-uninfected controls: a substudy of the Multicenter AIDS Cohort Study. AIDS Res Ther. 2009;6:8doi: 10.1186/1742-6405-6-8.
Brown, T. T., Xu, X., John, M., Singh, J., Kingsley, L. A., Palella, F. J., Witt, M. D., Margolick, J. B., & Dobs, A. S. (2009). Fat distribution and longitudinal anthropometric changes in HIV-infected men with and without clinical evidence of lipodystrophy and HIV-uninfected controls: a substudy of the Multicenter AIDS Cohort Study. AIDS research and therapy, 68. https://doi.org/10.1186/1742-6405-6-8
Brown, Todd T, et al. "Fat distribution and longitudinal anthropometric changes in HIV-infected men with and without clinical evidence of lipodystrophy and HIV-uninfected controls: a substudy of the Multicenter AIDS Cohort Study." AIDS research and therapy vol. 6 (2009): 8. doi: https://doi.org/10.1186/1742-6405-6-8
Brown TT, Xu X, John M, Singh J, Kingsley LA, Palella FJ, Witt MD, Margolick JB, Dobs AS. Fat distribution and longitudinal anthropometric changes in HIV-infected men with and without clinical evidence of lipodystrophy and HIV-uninfected controls: a substudy of the Multicenter AIDS Cohort Study. AIDS Res Ther. 2009 May 13;6:8. doi: 10.1186/1742-6405-6-8. PMID: 19439092; PMCID: PMC2686733.
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Histone deacetylase inhibition results in a common metabolic profile associated with HT29 differentiation.

Metabolomics : Official journal of the Metabolomic Society

Alcarraz-Vizán G, Boren J, Lee WN, Cascante M.
PMID: 20445757
Metabolomics. 2010 Jun;6(2):229-237. doi: 10.1007/s11306-009-0192-0. Epub 2010 Jan 08.

Cell differentiation is an orderly process that begins with modifications in gene expression. This process is regulated by the acetylation state of histones. Removal of the acetyl groups of histones by specific enzymes (histone deacetylases, HDAC) usually downregulates expression...

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Alcarraz-Vizán G, Boren J, Lee WN, et al. Histone deacetylase inhibition results in a common metabolic profile associated with HT29 differentiation. Metabolomics. 2010;6(2):229-237doi: 10.1007/s11306-009-0192-0.
Alcarraz-Vizán, G., Boren, J., Lee, W. N., & Cascante, M. (2010). Histone deacetylase inhibition results in a common metabolic profile associated with HT29 differentiation. Metabolomics : Official journal of the Metabolomic Society, 6(2), 229-237. https://doi.org/10.1007/s11306-009-0192-0
Alcarraz-Vizán, Gema, et al. "Histone deacetylase inhibition results in a common metabolic profile associated with HT29 differentiation." Metabolomics : Official journal of the Metabolomic Society vol. 6,2 (2010): 229-237. doi: https://doi.org/10.1007/s11306-009-0192-0
Alcarraz-Vizán G, Boren J, Lee WN, Cascante M. Histone deacetylase inhibition results in a common metabolic profile associated with HT29 differentiation. Metabolomics. 2010 Jun;6(2):229-237. doi: 10.1007/s11306-009-0192-0. Epub 2010 Jan 08. PMID: 20445757; PMCID: PMC2862949.
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Therapy for stable angina in women.

P & T : a peer-reviewed journal for formulary management

Sarbaziha R, Sedlak T, Shufelt C, Mehta PK, Merz CN.
PMID: 22876105
P T. 2012 Jul;37(7):400-4.

Mortality rates for cardiovascular disease are higher in women than in men, but studies of women have been conducted less frequently. Current pharmacological and nonpharmacological treatment options for women with stable angina are reviewed.

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Sarbaziha R, Sedlak T, Shufelt C, et al. Therapy for stable angina in women. P T. 2012;37(7):400-4
Sarbaziha, R., Sedlak, T., Shufelt, C., Mehta, P. K., & Merz, C. N. (2012). Therapy for stable angina in women. P & T : a peer-reviewed journal for formulary management, 37(7), 400-4.
Sarbaziha, Raheleh, et al. "Therapy for stable angina in women." P & T : a peer-reviewed journal for formulary management vol. 37,7 (2012): 400-4.
Sarbaziha R, Sedlak T, Shufelt C, Mehta PK, Merz CN. Therapy for stable angina in women. P T. 2012 Jul;37(7):400-4. PMID: 22876105; PMCID: PMC3411210.
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A Randomized, Controlled Pilot Study of the Effects of Acupuncture on Circulating Endothelial Progenitor Cells in Coronary Heart Disease.

Integrative medicine (Encinitas, Calif.)

Painovich J, Phancao A, Mehta P, Chowdhury S, Dhawan S, Li N, Taylor D, Qiao Y, Brantman A, Ma X, Merz CN.
PMID: 26770089
Integr Med (Encinitas). 2014 Apr;13(2):27-33.

CONTEXT: Coronary heart disease (CHD) remains the number one killer of men and women in the United States, and despite traditional secondary prevention, individuals with the disease remain at risk. Endothelial progenitor cells (EPCs) may have beneficial effects on...

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Painovich J, Phancao A, Mehta P, et al. A Randomized, Controlled Pilot Study of the Effects of Acupuncture on Circulating Endothelial Progenitor Cells in Coronary Heart Disease. Integr Med (Encinitas). 2014;13(2):27-33
Painovich, J., Phancao, A., Mehta, P., Chowdhury, S., Dhawan, S., Li, N., Taylor, D., Qiao, Y., Brantman, A., Ma, X., & Merz, C. N. (2014). A Randomized, Controlled Pilot Study of the Effects of Acupuncture on Circulating Endothelial Progenitor Cells in Coronary Heart Disease. Integrative medicine (Encinitas, Calif.), 13(2), 27-33.
Painovich, Jeannette, et al. "A Randomized, Controlled Pilot Study of the Effects of Acupuncture on Circulating Endothelial Progenitor Cells in Coronary Heart Disease." Integrative medicine (Encinitas, Calif.) vol. 13,2 (2014): 27-33.
Painovich J, Phancao A, Mehta P, Chowdhury S, Dhawan S, Li N, Taylor D, Qiao Y, Brantman A, Ma X, Merz CN. A Randomized, Controlled Pilot Study of the Effects of Acupuncture on Circulating Endothelial Progenitor Cells in Coronary Heart Disease. Integr Med (Encinitas). 2014 Apr;13(2):27-33. PMID: 26770089; PMCID: PMC4684127.
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Phenome-wide Association Study Relating Pretreatment Laboratory Parameters With Human Genetic Variants in AIDS Clinical Trials Group Protocols.

Open forum infectious diseases

Moore CB, Verma A, Pendergrass S, Verma SS, Johnson DH, Daar ES, Gulick RM, Haubrich R, Robbins GK, Ritchie MD, Haas DW.
PMID: 25884002
Open Forum Infect Dis. 2015 Jan 09;2(1):ofu113. doi: 10.1093/ofid/ofu113. eCollection 2015 Jan.

Background.  Phenome-Wide Association Studies (PheWAS) identify genetic associations across multiple phenotypes. Clinical trials offer opportunities for PheWAS to identify pharmacogenomic associations. We describe the first PheWAS to use genome-wide genotypic data and to utilize human immunodeficiency virus (HIV) clinical...

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Moore CB, Verma A, Pendergrass S, et al. Phenome-wide Association Study Relating Pretreatment Laboratory Parameters With Human Genetic Variants in AIDS Clinical Trials Group Protocols. Open Forum Infect Dis. 2015;2(1):ofu113doi: 10.1093/ofid/ofu113.
Moore, C. B., Verma, A., Pendergrass, S., Verma, S. S., Johnson, D. H., Daar, E. S., Gulick, R. M., Haubrich, R., Robbins, G. K., Ritchie, M. D., & Haas, D. W. (2015). Phenome-wide Association Study Relating Pretreatment Laboratory Parameters With Human Genetic Variants in AIDS Clinical Trials Group Protocols. Open forum infectious diseases, 2(1), ofu113. https://doi.org/10.1093/ofid/ofu113
Moore, Carrie B, et al. "Phenome-wide Association Study Relating Pretreatment Laboratory Parameters With Human Genetic Variants in AIDS Clinical Trials Group Protocols." Open forum infectious diseases vol. 2,1 (2015): ofu113. doi: https://doi.org/10.1093/ofid/ofu113
Moore CB, Verma A, Pendergrass S, Verma SS, Johnson DH, Daar ES, Gulick RM, Haubrich R, Robbins GK, Ritchie MD, Haas DW. Phenome-wide Association Study Relating Pretreatment Laboratory Parameters With Human Genetic Variants in AIDS Clinical Trials Group Protocols. Open Forum Infect Dis. 2015 Jan 09;2(1):ofu113. doi: 10.1093/ofid/ofu113. eCollection 2015 Jan. PMID: 25884002; PMCID: PMC4396430.
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Comprehensive assessment of expression of insulin signaling pathway components in subcutaneous adipose tissue of women with and without polycystic ovary syndrome.

Journal of clinical & translational endocrinology

Xu N, Geller DH, Jones MR, Funari VA, Azziz R, Goodarzi MO.
PMID: 26236647
J Clin Transl Endocrinol. 2015 Sep;2(3):99-104. doi: 10.1016/j.jcte.2015.06.002.

OBJECTIVE: Insulin resistance is a common feature of polycystic ovary syndrome (PCOS). The insulin signaling pathway consists of two major pathways, the metabolic and the mitogenic cascades. The many components of these pathways have not been comprehensively analyzed for...

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Xu N, Geller DH, Jones MR, et al. Comprehensive assessment of expression of insulin signaling pathway components in subcutaneous adipose tissue of women with and without polycystic ovary syndrome. J Clin Transl Endocrinol. 2015;2(3):99-104doi: 10.1016/j.jcte.2015.06.002.
Xu, N., Geller, D. H., Jones, M. R., Funari, V. A., Azziz, R., & Goodarzi, M. O. (2015). Comprehensive assessment of expression of insulin signaling pathway components in subcutaneous adipose tissue of women with and without polycystic ovary syndrome. Journal of clinical & translational endocrinology, 2(3), 99-104. https://doi.org/10.1016/j.jcte.2015.06.002
Xu, Ning, et al. "Comprehensive assessment of expression of insulin signaling pathway components in subcutaneous adipose tissue of women with and without polycystic ovary syndrome." Journal of clinical & translational endocrinology vol. 2,3 (2015): 99-104. doi: https://doi.org/10.1016/j.jcte.2015.06.002
Xu N, Geller DH, Jones MR, Funari VA, Azziz R, Goodarzi MO. Comprehensive assessment of expression of insulin signaling pathway components in subcutaneous adipose tissue of women with and without polycystic ovary syndrome. J Clin Transl Endocrinol. 2015 Sep;2(3):99-104. doi: 10.1016/j.jcte.2015.06.002. PMID: 26236647; PMCID: PMC4517435.
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Extent of coronary atherosclerosis and arterial remodelling in women: the NHLBI-sponsored Women's Ischemia Syndrome Evaluation.

Cardiovascular diagnosis and therapy

Nicholls SJ, Tuzcu EM, Wolski K, Johnson BD, Sopko G, Sharaf BL, Pepine CJ, Nissen SE, Bairey Merz CN.
PMID: 30214855
Cardiovasc Diagn Ther. 2018 Aug;8(4):405-413. doi: 10.21037/cdt.2018.04.03.

BACKGROUND: Information regarding the pathogenesis of ischemic heart disease (IHD) in women is limited. Sex-specific responses to atherosclerosis and coronary arterial remodelling in women versus men have been hypothesized, but limited study exists.METHODS: Case-matched study of 174 women with...

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Nicholls SJ, Tuzcu EM, Wolski K, et al. Extent of coronary atherosclerosis and arterial remodelling in women: the NHLBI-sponsored Women's Ischemia Syndrome Evaluation. Cardiovasc Diagn Ther. 2018;8(4):405-413doi: 10.21037/cdt.2018.04.03.
Nicholls, S. J., Tuzcu, E. M., Wolski, K., Johnson, B. D., Sopko, G., Sharaf, B. L., Pepine, C. J., Nissen, S. E., & Bairey Merz, C. N. (2018). Extent of coronary atherosclerosis and arterial remodelling in women: the NHLBI-sponsored Women's Ischemia Syndrome Evaluation. Cardiovascular diagnosis and therapy, 8(4), 405-413. https://doi.org/10.21037/cdt.2018.04.03
Nicholls, Stephen J, et al. "Extent of coronary atherosclerosis and arterial remodelling in women: the NHLBI-sponsored Women's Ischemia Syndrome Evaluation." Cardiovascular diagnosis and therapy vol. 8,4 (2018): 405-413. doi: https://doi.org/10.21037/cdt.2018.04.03
Nicholls SJ, Tuzcu EM, Wolski K, Johnson BD, Sopko G, Sharaf BL, Pepine CJ, Nissen SE, Bairey Merz CN. Extent of coronary atherosclerosis and arterial remodelling in women: the NHLBI-sponsored Women's Ischemia Syndrome Evaluation. Cardiovasc Diagn Ther. 2018 Aug;8(4):405-413. doi: 10.21037/cdt.2018.04.03. PMID: 30214855; PMCID: PMC6129832.
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Can We Improve Cardiovascular Disease for Women Using Data Under Our Noses?: A Need for Changes in Policy and Focus.

JAMA cardiology

Quesada O, Shufelt C, Bairey Merz CN.
PMID: 32936208
JAMA Cardiol. 2020 Dec 01;5(12):1398-1400. doi: 10.1001/jamacardio.2020.4117.

No abstract available.

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Quesada O, Shufelt C, Bairey Merz CN. Can We Improve Cardiovascular Disease for Women Using Data Under Our Noses?: A Need for Changes in Policy and Focus. JAMA Cardiol. 2020;5(12):1398-1400doi: 10.1001/jamacardio.2020.4117.
Quesada, O., Shufelt, C., & Bairey Merz, C. N. (2020). Can We Improve Cardiovascular Disease for Women Using Data Under Our Noses?: A Need for Changes in Policy and Focus. JAMA cardiology, 5(12), 1398-1400. https://doi.org/10.1001/jamacardio.2020.4117
Quesada, Odayme, et al. "Can We Improve Cardiovascular Disease for Women Using Data Under Our Noses?: A Need for Changes in Policy and Focus." JAMA cardiology vol. 5,12 (2020): 1398-1400. doi: https://doi.org/10.1001/jamacardio.2020.4117
Quesada O, Shufelt C, Bairey Merz CN. Can We Improve Cardiovascular Disease for Women Using Data Under Our Noses?: A Need for Changes in Policy and Focus. JAMA Cardiol. 2020 Dec 01;5(12):1398-1400. doi: 10.1001/jamacardio.2020.4117. PMID: 32936208; PMCID: PMC8074640.
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