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Showing 25 to 36 of 3221 entries
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Mechanical transduction by ion channels: A cautionary tale.

World journal of neurology

Sachs F.
PMID: 28078202
World J Neurol. 2015 Sep 28;5(3):74-87. doi: 10.5316/wjn.v5.i3.74.

Mechanical transduction by ion channels occurs in all cells. The physiological functions of these channels have just begun to be elaborated, but if we focus on the upper animal kingdom, these channels serve the common sensory services such as...

Biobetters From an Integrated Computational/Experimental Approach.

Computational and structural biotechnology journal

Kuyucak S, Kayser V.
PMID: 28179976
Comput Struct Biotechnol J. 2017 Jan 16;15:138-145. doi: 10.1016/j.csbj.2017.01.003. eCollection 2017.

Biobetters are new drugs designed from existing peptide or protein-based therapeutics by improving their properties such as affinity and selectivity for the target epitope, and stability against degradation. Computational methods can play a key role in such design problems-by...

Sub-cellular Electrical Heterogeneity Revealed by Loose Patch Recording Reflects Differential Localization of Sarcolemmal Ion Channels in Intact Rat Hearts.

Frontiers in physiology

Kubasov IV, Stepanov A, Bobkov D, Radwanski PB, Terpilowski MA, Dobretsov M, Gyorke S.
PMID: 29487533
Front Physiol. 2018 Feb 13;9:61. doi: 10.3389/fphys.2018.00061. eCollection 2018.

The cardiac action potential (AP) is commonly recoded as an integral signal from isolated myocytes or ensembles of myocytes (with intracellular microelectrodes and extracellular macroelectrodes, respectively). These signals, however, do not provide a direct measure of activity of ion...

mTORC1 Is a Local, Postsynaptic Voltage Sensor Regulated by Positive and Negative Feedback Pathways.

Frontiers in cellular neuroscience

Niere F, Raab-Graham KF.
PMID: 28611595
Front Cell Neurosci. 2017 May 30;11:152. doi: 10.3389/fncel.2017.00152. eCollection 2017.

The mammalian/mechanistic target of rapamycin complex 1 (mTORC1) serves as a regulator of mRNA translation. Recent studies suggest that mTORC1 may also serve as a local, voltage sensor in the postsynaptic region of neurons. Considering biochemical, bioinformatics and imaging...

Memristive Ion Channel-Doped Biomembranes as Synaptic Mimics.

ACS nano

Najem JS, Taylor GJ, Weiss RJ, Hasan MS, Rose G, Schuman CD, Belianinov A, Collier CP, Sarles SA.
PMID: 29578693
ACS Nano. 2018 May 22;12(5):4702-4711. doi: 10.1021/acsnano.8b01282. Epub 2018 Mar 29.

Solid-state neuromorphic systems based on transistors or memristors have yet to achieve the interconnectivity, performance, and energy efficiency of the brain due to excessive noise, undesirable material properties, and nonbiological switching mechanisms. Here we demonstrate that an alamethicin-doped, synthetic...

Axonal Membranes and Their Domains: Assembly and Function of the Axon Initial Segment and Node of Ranvier.

Frontiers in cellular neuroscience

Nelson AD, Jenkins PM.
PMID: 28536506
Front Cell Neurosci. 2017 May 09;11:136. doi: 10.3389/fncel.2017.00136. eCollection 2017.

Neurons are highly specialized cells of the nervous system that receive, process and transmit electrical signals critical for normal brain function. Here, we review the intricate organization of axonal membrane domains that facilitate rapid action potential conduction underlying communication...

MethodsX

Onal B, Gratz D, Hund T.
PMID: 27942465
MethodsX. 2016 Nov 28;3:589-599. doi: 10.1016/j.mex.2016.11.002. eCollection 2016.

Mathematical modeling has been used for over half a century to advance our understanding of cardiac electrophysiology and arrhythmia mechanisms. Notably, computational studies using mathematical models of the cardiac action potential (AP) have provided important insight into the fundamental...

Corrigendum to "Acid-sensing ion channels and transient-receptor potential ion channels in zebrafish taste buds" [Ann. Anat. 207C (2016) 32-37].

Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft

Levanti M, Randazzo B, Viña E, Montalbano G, Garcia-Suarez O, Germanà A, Vega JA, Abbate F.
PMID: 27725147
Ann Anat. 2016 Nov;208:241. doi: 10.1016/j.aanat.2016.09.003. Epub 2016 Oct 17.

No abstract available.

Cardiac disease and arrhythmogenesis: Mechanistic insights from mouse models.

International journal of cardiology. Heart & vasculature

Choy L, Yeo JM, Tse V, Chan SP, Tse G.
PMID: 27766308
Int J Cardiol Heart Vasc. 2016 Sep;12:1-10. doi: 10.1016/j.ijcha.2016.05.005.

The mouse is the second mammalian species, after the human, in which substantial amount of the genomic information has been analyzed. With advances in transgenic technology, mutagenesis is now much easier to carry out in mice. Consequently, an increasing...

Comprehensive thermal preference phenotyping in mice using a novel automated circular gradient assay.

Temperature (Austin, Tex.)

Touska F, Winter Z, Mueller A, Vlachova V, Larsen J, Zimmermann K.
PMID: 27227099
Temperature (Austin). 2016 Mar 02;3(1):77-91. doi: 10.1080/23328940.2015.1135689. eCollection 2016.

Currently available behavioral assays to quantify normal cold sensitivity, cold hypersensitivity and cold hyperalgesia in mice have betimes created conflicting results in the literature. Some only capture a limited spectrum of thermal experiences, others are prone to experimenter bias...

Photobiomodulation and the brain: a new paradigm.

Journal of optics (2010)

Hennessy M, Hamblin MR.
PMID: 28580093
J Opt. 2017 Jan;19(1):013003. doi: 10.1088/2040-8986/19/1/013003. Epub 2016 Dec 14.

Transcranial photobiomodulation (PBM) also known as low level laser therapy (tLLLT) relies on the use of red/NIR light to stimulate, preserve and regenerate cells and tissues. The mechanism of action involves photon absorption in the mitochondria (cytochrome c oxidase),...

Information transmission in microbial and fungal communication: from classical to quantum.

Journal of cell communication and signaling

Majumdar S, Pal S.
PMID: 29476316
J Cell Commun Signal. 2018 Jun;12(2):491-502. doi: 10.1007/s12079-018-0462-6. Epub 2018 Feb 23.

Microbes have their own communication systems. Secretion and reception of chemical signaling molecules and ion-channels mediated electrical signaling mechanism are yet observed two special ways of information transmission in microbial community. In this article, we address the aspects of...

Showing 25 to 36 of 3221 entries