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Showing 13 to 24 of 54 entries
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Desmin Correlated with Cx43 May Facilitate Intercellular Electrical Coupling during Chronic Heart Failure.

Evidence-based complementary and alternative medicine : eCAM

Cao J, Gao Q, Chen H, Wang C, Zhang Q, Wang Z, Li Y.
PMID: 34285704
Evid Based Complement Alternat Med. 2021 Jul 03;2021:6621132. doi: 10.1155/2021/6621132. eCollection 2021.

Desmin is one of five major intermediate filament proteins in cardiomyocytes. Desmin contributes to the maintenance of healthy muscle. The desmin content in cardiomyocytes directly affects the long-term prognosis of patients with heart failure, and lack of desmin leads...

Unweaving the role of nuclear Lamins in neural circuit integrity.

Cell stress

Deal SL, Yamamoto S.
PMID: 31223139
Cell Stress. 2018 Sep 10;2(9):219-224. doi: 10.15698/cst2018.09.151.

Lamins are type-V intermediate filament proteins that comprise the nuclear lamina. Although once considered static structural components that provide physical support to the inner nuclear envelope, recent studies are revealing additional functional and regulatory roles for Lamins in chromatin...

Role of Intermediate Filaments in Vesicular Traffic.

Cells

Margiotta A, Bucci C.
PMID: 27120621
Cells. 2016 Apr 25;5(2). doi: 10.3390/cells5020020.

Intermediate filaments are an important component of the cellular cytoskeleton. The first established role attributed to intermediate filaments was the mechanical support to cells. However, it is now clear that intermediate filaments have many different roles affecting a variety...

Discrimination of cytoskeletal elements of Paramecium by heterologous antisera: A preliminary investigation on the presence of intermediate filament-related protein.

European journal of protistology

Lai VC, Ng SF.
PMID: 23194762
Eur J Protistol. 1991 Sep 09;27(3):290-305. doi: 10.1016/S0932-4739(11)80067-2. Epub 2011 Nov 02.

The present study of the cytoskeleton of Paramecium employed a number of heterologous monoclonal antisera raised against intermediate filament proteins of higher organisms, and also an antiserum against a 49 K protein from Tetrahymena. Anti-49 K, and also monoclonal...

Effects of an immunosuppressive treatment on the rat prostate.

Drug design, development and therapy

Grabowska M, Kędzierska K, Michałek K, Słuczanowska-Głąbowska S, Grabowski M, Piasecka M, Kram A, Rotter I, Rył A, Laszczyńska M.
PMID: 27672312
Drug Des Devel Ther. 2016 Sep 12;10:2899-2915. doi: 10.2147/DDDT.S111695. eCollection 2016.

The aim of this study was to determine the influence of different combinations of immunosuppressive drugs on the morphology, ultrastructure, and expression of proliferating cell nuclear antigen and cytoskeleton proteins in the rat dorsolateral prostate. The studies were conducted...

Differential increases in the expression of intermediate filament proteins and concomitant morphological changes of transdifferentiating rat hepatic stellate cells observed in vitro.

Acta histochemica et cytochemica

Mezaki Y, Morii M, Hebiguchi T, Yoshikawa K, Yamaguchi N, Miura M, Imai K, Yoshino H, Senoo H.
PMID: 24194627
Acta Histochem Cytochem. 2013 Oct 30;46(5):137-43. doi: 10.1267/ahc.13007. Epub 2013 Oct 23.

The primary function of hepatic stellate cells (HSCs) is the storage of vitamin A. However, they are also responsible for liver fibrosis and are therapeutic targets for treatment of liver cirrhosis. Among the many molecular markers that define quiescent...

Hepatocyte-Specific Deletion of Mouse Lamin A/C Leads to Male-Selective Steatohepatitis.

Cellular and molecular gastroenterology and hepatology

Kwan R, Brady GF, Brzozowski M, Weerasinghe SV, Martin H, Park MJ, Brunt MJ, Menon RK, Tong X, Yin L, Stewart CL, Omary MB.
PMID: 28913408
Cell Mol Gastroenterol Hepatol. 2017 Jul 06;4(3):365-383. doi: 10.1016/j.jcmgh.2017.06.005. eCollection 2017 Nov.

BACKGROUND & AIMS: Lamins are nuclear intermediate filament proteins that comprise the major components of the nuclear lamina. Mutations in METHODS: To address these questions, we generated mice carrying a hepatocyte-specific deletion of RESULTS: KO hepatocytes manifested abnormal nuclear...

PDGFR-β-Positive Perivascular Adventitial Cells Expressing Nestin Contribute to Fibrotic Scar Formation in the Striatum of 3-NP Intoxicated Rats.

Frontiers in molecular neuroscience

Riew TR, Choi JH, Kim HL, Jin X, Lee MY.
PMID: 30455628
Front Mol Neurosci. 2018 Nov 05;11:402. doi: 10.3389/fnmol.2018.00402. eCollection 2018.

Perivascular cells expressing platelet-derived growth factor receptor beta (PDGFR-β) have recently been implicated in fibrotic scar formation after acute brain injury, but their precise identity and detailed morphological characteristics remain elusive. This study sought to characterize and define the...

Expression Levels of Lamin A or C Are Critical to Nuclear Maturation, Functional Responses, and Gene Expression Profiles in Differentiating Mouse Neutrophils.

ImmunoHorizons

Szymczak K, Pelletier MGH, Malu K, Barbeau AM, Giadone RM, Babroudi SC, Gaines PCW.
PMID: 35039433
Immunohorizons. 2022 Jan 17;6(1):16-35. doi: 10.4049/immunohorizons.2100072.

Neutrophils mediate critical innate immune responses by migrating to sites of infection or inflammation, phagocytosing microorganisms, and releasing an arsenal of antimicrobial agents, including reactive oxygen species. These functions are shared by other innate immune cell types, but an...

Conserved keratin gene clusters in ancient fish: An evolutionary seed for terrestrial adaptation.

Genomics

Kimura Y, Nikaido M.
PMID: 33189779
Genomics. 2021 Jan;113(1):1120-1128. doi: 10.1016/j.ygeno.2020.11.008. Epub 2020 Nov 12.

Type I and type II keratins are subgroups of intermediate filament proteins that provide toughness to the epidermis and protect it from water loss. In terrestrial vertebrates, the keratin genes form two major clusters, clusters 1 and 2, each...

Immunolocalization of cytoskeletal proteins in the previtellogenic ovarian follicle of the lizard Podarcis sicula.

Cell and tissue research

Maurizii MG, Taddei C.
PMID: 8662355
Cell Tissue Res. 1996 May 20;284(3):489-93. doi: 10.1007/s004410050610.

We report the immunolocalization of intermediate filament proteins (vimentin and cytokeratins) in the previtellogenic ovarian follicle of the lizard Podarcis sicula. Vimentin is present, in accordance with their mesenchymal origin, in all the cells of the polymorphic follicular epithelium...

Rocking the Boat: The Decisive Roles of Rho Kinases During Oocyte, Blastocyst, and Stem Cell Development.

Frontiers in cell and developmental biology

Saadeldin IM, Tukur HA, Aljumaah RS, Sindi RA.
PMID: 33505968
Front Cell Dev Biol. 2021 Jan 11;8:616762. doi: 10.3389/fcell.2020.616762. eCollection 2020.

The rho-associated coiled-coil-containing proteins (ROCKs or rho kinase) are effectors of the small rho-GTPase rhoA, which acts as a signaling molecule to regulate a variety of cellular processes, including cell proliferation, adhesion, polarity, cytokinesis, and survival. Owing to the...

Showing 13 to 24 of 54 entries