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Showing 25 to 36 of 108 entries
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Differential-effects of tumor promoters and cytokines on protooncogene expression in a hematopoietic cytokine-dependent cell-line.

Oncology reports

McCubrey J, Algate P, Mayo M, Arana G, Wang X, Prevost K, White M, Steelman L.
PMID: 21607354
Oncol Rep. 1994 Mar;1(2):285-300.

In order to investigate the mechanisms by which cytokines and tumor promoters stimulate cell growth, the expression of genes implicated in the regulation of cellular proliferation were examined in an interleukin-3 (IL-3) dependent hematopoietic cell line. Upon stimulation of...

Murine bone marrow-derived macrophages.

Methods in molecular biology (Clifton, N.J.)

Stanley ER.
PMID: 21374133
Methods Mol Biol. 1990;5:299-302. doi: 10.1385/0-89603-150-0:299.

The molecular phagocytic lineage comprises, in order of increasing maturity, the committed macrophage precursor cell, the monoblast, promonocyte, monocyte and the macrophage. Methods for the preparation and culture of bone marrow-derived macrophages, developed by Stanley and colleagues (1-3), provide...

The High Yield Expansion and Megakaryocytic Differentiation of Human Umbilical Cord Blood CD133(+) Cells.

Cell journal

Nikougoftar Zarif M, Soleimani M, Abolghasemi H, Amirizade N, Abroun S, Kaviani S.
PMID: 23508472
Cell J. 2011;13(3):173-8. Epub 2011 Sep 23.

OBJECTIVE: Despite of many benefits, umbilical cord blood (UCB) hematopoietic stem cell (HSC) transplantation is associated with low number of stem cells and slow engraftment; in particular of platelets. So, expanded HSCs and co-transfusion of megakaryocyte (MK) progenitor cells...

Correlation between Plasma Interleukin-3, the α/β Globin Ratio, and Globin mRNA Stability.

Anemia

Rouhi Dehnabeh S, Mahdian R, Ajdary S, Mostafavi E, Khatami S.
PMID: 25478214
Anemia. 2014;2014:640203. doi: 10.1155/2014/640203. Epub 2014 Nov 18.

Background. Globin chain synthesis (GCS) analysis is used in the diagnosis of thalassemia. However, the wide reference range limits its use as a decisive diagnostic tool. It has been shown that α and β  globin mRNA increase through stimulation...

Interleukin 3 and colony-stimulating factors.

Immunology today

Watson JD, Prestidge RL.
PMID: 25290513
Immunol Today. 1983 Oct;4(10):278-80. doi: 10.1016/0167-5699(83)90135-4.

No abstract available.

The importance of the granulocyte-colony stimulating factor in oncology.

Clujul medical (1957)

Cetean S, Căinap C, Constantin AM, Căinap S, Gherman A, Oprean L, Hangan A, Oprean R.
PMID: 26732055
Clujul Med. 2015;88(4):468-72. doi: 10.15386/cjmed-531. Epub 2015 Nov 15.

Granulocyte-colony stimulating factor (G-CSF) is a glycoprotein, the second CSF, sharing some common effects with granulocyte macrophage-colony stimulating factor (GM-CSF), interleukin-3 (IL-3) and interleukin-5 (IL-5). G-CSF is mainly produced by fibroblasts and endothelial cells from bone marrow stroma and...

Unexpected mechanisms of action for a cytokine receptor-blocking antibody.

Molecular & cellular oncology

Hercus TR, Broughton SE, Hardy MP, Nero TL, Wilson NJ, Parker MW, Lopez AF.
PMID: 27308368
Mol Cell Oncol. 2014 Dec 31;1(4):e969129. doi: 10.4161/23288604.2014.969129. eCollection 2014.

CSL362 is a humanized interleukin-3 (IL-3)-neutralizing monoclonal antibody with enhanced effector function that binds the α subunit of the IL-3 receptor (IL3Rα). The crystal structure of an IL3Rα:CSL362 complex shows that IL3Rα adopts "open" and "closed" conformations. CSL362 blocks...

Hematopoietic Effects of Paeoniflorin and Albiflorin on Radiotherapy-Induced Myelosuppression Mice.

Evidence-based complementary and alternative medicine : eCAM

Zhu Y, Wang L, Yang Z, Wang J, Li W, Zhou J, Zhang J.
PMID: 27313650
Evid Based Complement Alternat Med. 2016;2016:5789381. doi: 10.1155/2016/5789381. Epub 2016 May 26.

Paeonia lactiflora root (baishao in Chinese) is a commonly used herb in traditional Chinese medicine (TCM). Paeoniflorin (PF) and albiflorin (AF) are two major active constituents of P. lactiflora. In this paper, we aimed to investigate the hematopoietic effects...

[Linear porokeratosis with severe itch accompanied by lesional upregulation of interleukin 31, thymic stromal lymphopoietin, and periostin].

European journal of dermatology : EJD

Hashimoto T, Moriyama Y, Satoh T.
PMID: 34463291
Eur J Dermatol. 2021 Aug 26; doi: 10.1684/ejd.2021.4083. Epub 2021 Aug 26.

No abstract available.

Cytokine combinations for human blood stem cell expansion induce cell-type- and cytokine-specific signaling dynamics.

Blood

Wang W, Zhang Y, Dettinger P, Reimann A, Kull T, Loeffler D, Manz MG, Lengerke C, Schroeder T.
PMID: 33988686
Blood. 2021 Sep 09;138(10):847-857. doi: 10.1182/blood.2020008386.

How hematopoietic stem cells (HSCs) integrate signals from their environment to make fate decisions remains incompletely understood. Current knowledge is based on either averages of heterogeneous populations or snapshot analyses, both missing important information about the dynamics of intracellular...

In vitro validation study of HER2 and HER4 mutations identified in an ad hoc secondary analysis of the LUX-Lung 8 randomized clinical trial.

Lung cancer (Amsterdam, Netherlands)

Hamada A, Suda K, Koga T, Fujino T, Nishino M, Ohara S, Chiba M, Shimoji M, Takemoto T, Soh J, Uchida T, Mitsudomi T.
PMID: 34741886
Lung Cancer. 2021 Dec;162:79-85. doi: 10.1016/j.lungcan.2021.10.014. Epub 2021 Nov 01.

OBJECTIVES: The LUX-Lung 8 randomized trial (LL8) demonstrated a prolonged progression-free survival (PFS) in patients with metastatic squamous cell carcinoma (SCC) of the lung after treatment with afatinib compared with erlotinib. A secondary analysis of the LL8 reported that...

Astrocytic interleukin-3 programs microglia and limits Alzheimer's disease.

Nature

McAlpine CS, Park J, Griciuc A, Kim E, Choi SH, Iwamoto Y, Kiss MG, Christie KA, Vinegoni C, Poller WC, Mindur JE, Chan CT, He S, Janssen H, Wong LP, Downey J, Singh S, Anzai A, Kahles F, Jorfi M, Feruglio PF, Sadreyev RI, Weissleder R, Kleinstiver BP, Nahrendorf M, Tanzi RE, Swirski FK.
PMID: 34262178
Nature. 2021 Jul;595(7869):701-706. doi: 10.1038/s41586-021-03734-6. Epub 2021 Jul 14.

Communication within the glial cell ecosystem is essential for neuronal and brain health

Showing 25 to 36 of 108 entries