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Showing 877 to 888 of 904 entries
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Evaluation of Dietary Soluble Extract Hydrolysates with or without Supplementation of Inosine Monophosphate Based on Growth, Hematology, Non-Specific Immune Responses and Disease Resistance in Juvenile Nile Tilapia .

Animals : an open access journal from MDPI

Bae J, Song Y, Moniruzzaman M, Hamidoghli A, Lee S, Je H, Choi W, Min T, Bai SC.
PMID: 33921530
Animals (Basel). 2021 Apr 12;11(4). doi: 10.3390/ani11041107.

We performed an 8-week feeding trial to evaluate dietary soluble extract hydrolysates from fishery by-products, such as shrimp soluble extract (SSE) with or without inosine monophosphate (IMP), tilapia soluble extract (TSE) and squid soluble extract (SQSE), in juvenile Nile...

Mechanism of Cordyceps Cicadae in Treating Diabetic Nephropathy Based on Network Pharmacology and Molecular Docking Analysis.

Journal of diabetes research

Qian Y, Sun X, Wang X, Yang X, Fan M, Zhong J, Pei Z, Guo J.
PMID: 34621904
J Diabetes Res. 2021 Sep 28;2021:5477941. doi: 10.1155/2021/5477941. eCollection 2021.

OBJECTIVE: To systematically study the mechanism of cordyceps cicadae in the treatment of diabetic nephropathy (DN) with the method of network pharmacology and molecular docking analysis, so as to provide theoretical basis for the development of new drugs for...

A highly conserved zebrafish IMPDH retinal isoform produces the majority of guanine and forms dynamic protein filaments in photoreceptor cells.

The Journal of biological chemistry

Cleghorn WM, Burrell AL, Giarmarco MM, Brock DC, Wang Y, Chambers ZS, Du J, Kollman JM, Brockerhoff SE.
PMID: 34813793
J Biol Chem. 2021 Nov 20;298(1):101441. doi: 10.1016/j.jbc.2021.101441. Epub 2021 Nov 20.

Inosine monophosphate dehydrogenase (IMPDH) is a key regulatory enzyme in the de novo synthesis of the purine base guanine. Dominant mutations in human IMPDH1 cause photoreceptor degeneration for reasons that are unknown. Here, we sought to provide some foundational...

Biomedically Relevant Applications of Bolaamphiphiles and Bolaamphiphile-Containing Materials.

Frontiers in chemistry

Hughes JR, Miller AS, Wallace CE, Vemuri GN, Iovine PM.
PMID: 33553103
Front Chem. 2021 Jan 20;8:604151. doi: 10.3389/fchem.2020.604151. eCollection 2020.

Bolaamphiphiles (BAs) are structurally segmented molecules with rich assembly characteristics and diverse physical properties. Interest in BAs as standalone active agents or as constituents of more complex therapeutic formulations has increased substantially in recent years. The preorganized amphiphilicity of...

A highly conserved zebrafish IMPDH retinal isoform produces the majority of guanine and forms dynamic protein filaments in photoreceptor cells.

The Journal of biological chemistry

Cleghorn WM, Burrell AL, Giarmarco MM, Brock DC, Wang Y, Chambers ZS, Du J, Kollman JM, Brockerhoff SE.
PMID: 34813793
J Biol Chem. 2021 Nov 20;298(1):101441. doi: 10.1016/j.jbc.2021.101441. Epub 2021 Nov 20.

Inosine monophosphate dehydrogenase (IMPDH) is a key regulatory enzyme in the de novo synthesis of the purine base guanine. Dominant mutations in human IMPDH1 cause photoreceptor degeneration for reasons that are unknown. Here, we sought to provide some foundational...

Up-to-date role of aflibercept in the treatment of colorectal cancer.

Expert opinion on biological therapy

Saoudi Gonzalez N, Salvà F, Ros J, Baraibar I, Marmolejo D, Valdivia A, Cuadra-Urteaga JL, Mulet N, Tabernero J, Élez E.
PMID: 34085884
Expert Opin Biol Ther. 2021 Oct;21(10):1315-1324. doi: 10.1080/14712598.2021.1935231. Epub 2021 Jun 13.

No abstract available.

Global RNA editing identification and characterization during human pluripotent-to-cardiomyocyte differentiation.

Molecular therapy. Nucleic acids

Chen J, Liu HF, Qiao LB, Wang FB, Wang L, Lin Y, Liu J.
PMID: 34760335
Mol Ther Nucleic Acids. 2021 Oct 08;26:879-891. doi: 10.1016/j.omtn.2021.10.001. eCollection 2021 Dec 03.

RNA editing is widely involved in stem cell differentiation and development; however, RNA editing events during human cardiomyocyte differentiation have not yet been characterized and elucidated. Here, we identified genome-wide RNA editing sites and systemically characterized their genomic distribution...

N6-methyladenosine promotes induction of ADAR1-mediated A-to-I RNA editing to suppress aberrant antiviral innate immune responses.

PLoS biology

Terajima H, Lu M, Zhang L, Cui Q, Shi Y, Li J, He C.
PMID: 34324489
PLoS Biol. 2021 Jul 29;19(7):e3001292. doi: 10.1371/journal.pbio.3001292. eCollection 2021 Jul.

Among over 150 distinct RNA modifications, N6-methyladenosine (m6A) and adenosine-to-inosine (A-to-I) RNA editing represent 2 of the most studied modifications on mammalian mRNAs. Although both modifications occur on adenosine residues, knowledge on potential functional crosstalk between these 2 modifications...

Micro-coil probes for magnetic intracortical neural stimulation: Trade-offs in materials and design.

APL materials

Thyagarajan K, Lujan RA, Wang Q, Lu J, Kor S, Kakimoto B, Chang N, Bert JA.
PMID: 33520428
APL Mater. 2021 Jan 01;9(1):011102. doi: 10.1063/5.0023486.

Neural probes for intracortical neuromodulation in the brain have advanced with the developments in micro- and nanofabrication technologies. Most of these technologies for the intracortical stimulation have relied on the direct electrical stimulation via electrodes or arrays of electrodes....

Epitranscriptomic Modifications Modulate Normal and Pathological Functions in CNS.

Translational stroke research

Chokkalla AK, Mehta SL, Vemuganti R.
PMID: 34224107
Transl Stroke Res. 2021 Jul 05; doi: 10.1007/s12975-021-00927-z. Epub 2021 Jul 05.

RNA is more than just a combination of four genetically encoded nucleobases as it carries extra information in the form of epitranscriptomic modifications. Diverse chemical groups attach covalently to RNA to enhance the plasticity of cellular transcriptome. The reversible...

Occupational exposure to metal-rich particulate matter modifies the expression of repair genes in foundry workers.

Toxicology and industrial health

Panjali Z, Hahad O, Rajabi F, Maddah S, Zendehdel R.
PMID: 34247554
Toxicol Ind Health. 2021 Aug;37(8):504-512. doi: 10.1177/07482337211021202. Epub 2021 Jul 12.

Foundry workers are exposed to numerous occupational health hazards, which may result in increased risk of cancer, respiratory disease, and other diseases. Oxidative stress is known to be involved in the pathogenesis of such diseases. The present study aimed...

Sex education and STI fatalism, testing and infection among young African American men who have sex with women.

Sex education

Craig-Kuhn MC, Schmidt N, Lederer A, Gomes G, Watson S, Scott G, Martin DH, Kissinger P.
PMID: 34483728
Sex Educ. 2021;21(4):404-416. doi: 10.1080/14681811.2020.1809369. Epub 2020 Sep 09.

The purpose of this study was to examine the association between institution-delivered sex education given under real-world conditions and sexually transmitted infection (STI) rates, STI fatalism, and prior STI testing among African American men aged 15-24 who have sex...

Showing 877 to 888 of 904 entries