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Showing 13 to 24 of 904 entries
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A-to-I RNA Editing: Current Knowledge Sources and Computational Approaches with Special Emphasis on Non-Coding RNA Molecules.

Frontiers in bioengineering and biotechnology

Nigita G, Veneziano D, Ferro A.
PMID: 25859542
Front Bioeng Biotechnol. 2015 Mar 25;3:37. doi: 10.3389/fbioe.2015.00037. eCollection 2015.

RNA editing is a dynamic mechanism for gene regulation attained through the alteration of the sequence of primary RNA transcripts. A-to-I (adenosine-to-inosine) RNA editing, which is catalyzed by members of the adenosine deaminase acting on RNA (ADAR) family of...

Metabolomic approach for identifying and visualizing molecular tissue markers in tadpoles of Xenopus tropicalis by mass spectrometry imaging.

Biology open

Goto-Inoue N, Kashiwagi A, Kashiwagi K, Mori T.
PMID: 27422901
Biol Open. 2016 Sep 15;5(9):1252-9. doi: 10.1242/bio.019646.

In developmental and cell biology it is crucial to evaluate the dynamic profiles of metabolites. An emerging frog model system using Xenopus tropicalis, whose genome sequence and inbred strains are available, is now ready for metabolomics investigation in amphibians....

High-Throughput Minigenome System for Identifying Small-Molecule Inhibitors of Ebola Virus Replication.

ACS infectious diseases

Edwards MR, Pietzsch C, Vausselin T, Shaw ML, Bukreyev A, Basler CF.
PMID: 26284260
ACS Infect Dis. 2015 Aug 14;1(8):380-7. doi: 10.1021/acsinfecdis.5b00053. Epub 2015 Jun 24.

Ebola virus (EBOV), a member of the family Filoviridae, is a nonsegmented negative-sense RNA virus that causes severe, often lethal, disease in humans. EBOV RNA synthesis is carried out by a complex that includes several viral proteins. The function...

Proximal Biceps Tenodesis: An Anatomic Study and Comparison of the Accuracy of Arthroscopic and Open Techniques Using Interference Screws.

Orthopaedic journal of sports medicine

Kovack TJ, Idoine JD, Jacob PB.
PMID: 26535300
Orthop J Sports Med. 2014 Feb 19;2(2):2325967114522198. doi: 10.1177/2325967114522198. eCollection 2014 Feb.

PURPOSE: To (1) better define the anatomy of the proximal shoulder in relation to the long head of the biceps tendon, (2) compare the length-tension relationship of the biceps tendon in the native shoulder with that after arthroscopic and...

The Golgi apparatus mediates the transport of phytohemagglutinin to the protein bodies in bean cotyledons.

Planta

Chrispeels MJ.
PMID: 24264543
Planta. 1983 Jun;158(2):140-51. doi: 10.1007/BF00397707.

When developing cotyledons of Phaseolus vulgaris L. were labeled with [(3)H]fucose, fucose-labeled phytohemagglutinin (PHA) was found in organelles with average densities of 1.13 g cm(-3) and 1.22 g cm(-3). The position of these organelles on isopycnic sucrose gradients was...

Uncovering RNA Editing Sites in Long Non-Coding RNAs.

Frontiers in bioengineering and biotechnology

Picardi E, D'Erchia AM, Gallo A, Montalvo A, Pesole G.
PMID: 25538940
Front Bioeng Biotechnol. 2014 Dec 05;2:64. doi: 10.3389/fbioe.2014.00064. eCollection 2014.

RNA editing is an important co/post-transcriptional molecular process able to modify RNAs by nucleotide insertions/deletions or substitutions. In human, the most common RNA editing event involves the deamination of adenosine (A) into inosine (I) through the adenosine deaminase acting...

Alkaloids from the Tunicate Polycarpa aurata from Chuuk Atoll.

The Journal of organic chemistry

Abas SA, Hossain MB, van Der Helm D, Schmitz FJ, Laney M, Cabuslay R, Schatzman RC.
PMID: 11667102
J Org Chem. 1996 Apr 19;61(8):2709-2712. doi: 10.1021/jo960040e.

Two new alkaloids, polycarpine (1) and N,N-didesmethylgrossularine-1 (4), have been isolated from extracts of the ascidian Polycarpa aurata collected in Chuuk, Federated States of Micronesia. Three degradation products of 1 were also isolated. The structures of 1, 2, and...

Separate de Novo and Salvage Purine Pools Are Involved in the Biosynthesis of Theobromine but Not Caffeine in Leaves of Coffea arabica L.

Plant physiology

Nazario GM, Lovatt CJ.
PMID: 12232013
Plant Physiol. 1993 Dec;103(4):1203-1210. doi: 10.1104/pp.103.4.1203.

In Coffea arabica leaves, the purine ring of theobromine (3,7-dimethylxanthine) and caffeine (1,3,7-trimethylxanthine) is provided by de novo purine biosynthesis: (a) [14C]glycine, [14C]bicarbonate, and [14C]formate were incorporated into inosine 5[prime]- monophosphate (IMP), sum of adenine nucleotides ([sigma]Ade), theobromine, and...

Structure and Function of the Golgi Complex in Rice Cells (II. Purification and Characterization of Golgi Membrane-Bound Nucleoside Diphosphatase).

Plant physiology

Mitsui T, Honma M, Kondo T, Hashimoto N, Kimura S, Igaue I.
PMID: 12232309
Plant Physiol. 1994 Sep;106(1):119-125. doi: 10.1104/pp.106.1.119.

Inosine diphosphatase bound to Golgi membranes was studied in rice (Oryza sativa L. cv Nipponkai) cells. The enzyme was solubilized with Triton X-100 from isolated rice Golgi membranes and was highly purified employing a series of chromatography steps in...

Complexation of Nickel(II) with Guanosine 5'-Monophosphate and Inosine 5'-Monophosphate: A Potentiometric and Calorimetric Study.

Inorganic chemistry

Herrero LA, Fiol JJ, Mas F, Cerdà, Terrón A.
PMID: 11666565
Inorg Chem. 1996 Jun 19;35(13):3786-3791. doi: 10.1021/ic951219v.

The constants (K(s)) and enthalpies (DeltaH(s)) for stacking interactions between purine nucleoside monophosphates were determined by calorimetry; the values thus obtained were guanosine as follows: K(s) = 2.1 +/- 0.3 M(-)(1) and DeltaH(s) = -41.8 +/- 0.8 kJ/mol for...

Purine catabolism in plants : purification and some properties of inosine nucleosidase from yellow lupin (lupinus luteus L.) seeds.

Plant physiology

Guranowski A.
PMID: 16662492
Plant Physiol. 1982 Aug;70(2):344-9. doi: 10.1104/pp.70.2.344.

Inosine nucleosidase (EC 3.2.2.2), the enzyme which hydrolyzes inosine to hypoxanthine and ribose, has been partially purified from Lupinus luteus L. cv. Topaz seeds by extraction of the seed meal with low ionic strength buffer, ammonium sulfate fractionation, and...

Mycophenolate mofetil: effects on clinical transplantation.

BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy

Holt CD, Sievers TM, Ghobrial RM, Rossi SJ, Goss JA, McDiarmid SV.
PMID: 18020609
BioDrugs. 1998 Nov;10(5):373-84. doi: 10.2165/00063030-199810050-00004.

Mycophenolate mofetil (MMF) is the morpholinoethylester prodrug of mycophenolic acid, an agent which inhibits the proliferation of B and T lymphocytes through the noncompetitive, reversible inhibition of inosine monophosphate dehydrogenase, itself a key enzyme in the de novo synthetic...

Showing 13 to 24 of 904 entries