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Showing 985 to 994 of 994 entries
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Extracellular matrix dysfunction in Sorsby patient-derived retinal pigment epithelium.

Experimental eye research

Engel AL, Wang Y, Khuu TH, Worrall E, Manson MA, Lim RR, Knight K, Yanagida A, Qi JH, Ramakrishnan A, Weleber RG, Klein ML, Wilson DJ, Anand-Apte B, Hurley JB, Du J, Chao JR.
PMID: 34929159
Exp Eye Res. 2021 Dec 17;215:108899. doi: 10.1016/j.exer.2021.108899. Epub 2021 Dec 17.

Sorsby Fundus Dystrophy (SFD) is a rare form of macular degeneration that is clinically similar to age-related macular degeneration (AMD), and a histologic hallmark of SFD is a thick layer of extracellular deposits beneath the retinal pigment epithelium (RPE)....

Melittin and diclofenac synergistically promote wound healing in a pathway involving TGF-β1.

Pharmacological research

Eid BG, Alhakamy NA, Fahmy UA, Ahmed OAA, Md S, Abdel-Naim AB, Caruso G, Caraci F.
PMID: 34801680
Pharmacol Res. 2022 Jan;175:105993. doi: 10.1016/j.phrs.2021.105993. Epub 2021 Nov 19.

A dysregulation of the wound healing process can lead to the development of various intractable ulcers or excessive scar formation. Therefore it is essential to identify novel pharmacological strategies to promote wound healing and restore the mechanical integrity of...

Association of Circulating Extracellular Matrix Components with Central Hemodynamics and Arterial Distensibility of Peripheral Arteries.

Journal of vascular research

Melnikov VN, Kim LB, Putyatina AN, Krivoschekov SG.
PMID: 34252903
J Vasc Res. 2021;58(6):370-378. doi: 10.1159/000516841. Epub 2021 Jul 12.

BACKGROUND: In addition to neuronal and endothelial regulators of vascular tone, the passive mechanical properties of arteries, determined by the molecular structure of extracellular matrices, are the principle modulators of vascular distensibility. Specifically, the association between collagen type IV...

Mechanism of miR-204-5p in exosomes derived from bronchoalveolar lavage fluid on the progression of pulmonary fibrosis via AP1S2.

Annals of translational medicine

Zhu L, Chen Y, Chen M, Wang W.
PMID: 34422980
Ann Transl Med. 2021 Jul;9(13):1068. doi: 10.21037/atm-20-8033.

BACKGROUND: Exosomes are nanoscale vesicles secreted by various types of cells that are responsible for intracellular communication. Despite that bronchoalveolar lavage fluid (BALF) has been proven to involve in tumor development, more efforts are required to investigate the impact...

Inhibitory effects of somatostatin analogue in bleomycin-induced pulmonary fibrosis.

Experimental lung research

Hosono T, Bando M, Mizushina Y, Sata M, Hagiwara K, Sugiyama Y.
PMID: 33899633
Exp Lung Res. 2021 May-Aug;47(6):280-288. doi: 10.1080/01902148.2021.1916650. Epub 2021 Apr 24.

BACKGROUND AND OBJECTIVES: Idiopathic pulmonary fibrosis (IPF) is a progressive and lethal lung disease. An increased expression of somatostatin receptor subtype 2 in patients with IPF was identified and lung fibroblasts expressed somatostatin receptors METHODS: C57BL/6 mice received a...

Functional characterization of hydroxyproline-O-galactosyltransferases for Arabidopsis arabinogalactan-protein synthesis.

BMC plant biology

Kaur D, Held MA, Smith MR, Showalter AM.
PMID: 34903166
BMC Plant Biol. 2021 Dec 13;21(1):590. doi: 10.1186/s12870-021-03362-2.

BACKGROUND: Arabinogalactan-proteins (AGPs) are structurally complex hydroxyproline-rich cell wall glycoproteins ubiquitous in the plant kingdom. AGPs biosynthesis involves a series of post-translational modifications including the addition of type II arabinogalactans to non-contiguous Hyp residues. To date, eight Hyp-galactosyltransferases (Hyp-GALTs;...

Collagen-Derived Di-Peptide, Prolylhydroxyproline (Pro-Hyp): A New Low Molecular Weight Growth-Initiating Factor for Specific Fibroblasts Associated With Wound Healing.

Frontiers in cell and developmental biology

Sato K, Asai TT, Jimi S.
PMID: 33330443
Front Cell Dev Biol. 2020 Nov 27;8:548975. doi: 10.3389/fcell.2020.548975. eCollection 2020.

Many cells and soluble factors are involved in the wound healing process, which can be divided into inflammatory, proliferative, and remodeling phases. Fibroblasts play a crucial role in wound healing, especially during the proliferative phase, and show heterogeneity depending...

Effect of Rhus coriaria L. methanolic fruit extract on wound healing in diabetic and non-diabetic rats.

Journal of cosmetic dermatology

Alsarayreh AZ, Oran SA, Shakhanbeh JM.
PMID: 34928525
J Cosmet Dermatol. 2021 Dec 20; doi: 10.1111/jocd.14668. Epub 2021 Dec 20.

AIM: This study assessed the effects of topical application of R. coriaria extract on the rate of wound closure. The rate of wound contraction was used to assess the wound healing efficacy of the R. coriaria fruit methanolic extract.METHODS:...

Search for evolutionary roots of land plant arabinogalactan-proteins in charophytes: presence of a rhamnogalactan-protein in Spirogyra pratensis (Zygnematophyceae).

The Plant journal : for cell and molecular biology

Pfeifer L, Utermöhlen J, Happ K, Permann C, Holzinger A, von Schwartzenberg K, Classen B.
PMID: 34767672
Plant J. 2021 Nov 12; doi: 10.1111/tpj.15577. Epub 2021 Nov 12.

Charophyte green algae (CGA) are assigned to be the closest relatives of land plants and therefore enlighten processes in the colonization of terrestrial habitats. For the transition from water to land, plants needed significant physiological and structural changes, as...

Changes to dentin extracellular matrix following treatment with plant-based polyphenols.

Journal of the mechanical behavior of biomedical materials

Omar H, Gao F, Yoo H, Bim O, Garcia C, LePard KJ, Mitchell JC, Agostini-Walesch G, Carrilho MR.
PMID: 34929591
J Mech Behav Biomed Mater. 2021 Dec 16;126:105055. doi: 10.1016/j.jmbbm.2021.105055. Epub 2021 Dec 16.

This study investigated whether treatment with plant-based polyphenols (PB-P) affected the biochemical and/or biomechanical properties of dentin extracellular matrix (ECM). Three PB-Ps were evaluated: luteolin (LT), galangin (GL), and proanthocyanidin (PAC). Because dentin ECM requires demineralization before treatment, this...

Showing 985 to 994 of 994 entries